LOCUS       NM_032058               1492 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 2B
            subunit beta (Eif2b2), mRNA.
ACCESSION   NM_032058 XM_346777
VERSION     NM_032058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Kashiwagi,K., Shigeta,T., Imataka,H., Ito,T. and Yokoyama,S.
  TITLE     Expression, purification, and crystallization of
            Schizosaccharomyces pombe eIF2B
  JOURNAL   J Struct Funct Genomics 17 (1), 33-38 (2016)
   PUBMED   27023709
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Kar,A.N., MacGibeny,M.A., Gervasi,N.M., Gioio,A.E. and Kaplan,B.B.
  TITLE     Intra-axonal synthesis of eukaryotic translation initiation factors
            regulates local protein synthesis and axon growth in rat
            sympathetic neurons
  JOURNAL   J Neurosci 33 (17), 7165-7174 (2013)
   PUBMED   23616526
  REMARK    GeneRIF: Downregulation of Eif2b2 and Eif4G2 expression inhibits
            local protein synthesis and axon growth.
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Hinnebusch,A.G. and Lorsch,J.R.
  TITLE     The mechanism of eukaryotic translation initiation: new insights
            and challenges
  JOURNAL   Cold Spring Harb Perspect Biol 4 (10), a011544 (2012)
   PUBMED   22815232
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Mikami,S., Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     An efficient mammalian cell-free translation system supplemented
            with translation factors
  JOURNAL   Protein Expr Purif 46 (2), 348-357 (2006)
   PUBMED   16289705
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Ohlenbusch,A., Henneke,M., Brockmann,K., Goerg,M., Hanefeld,F.,
            Kohlschutter,A. and Gartner,J.
  TITLE     Identification of ten novel mutations in patients with
            eIF2B-related disorders
  JOURNAL   Hum Mutat 25 (4), 411 (2005)
   PUBMED   15776425
REFERENCE   6  (bases 1 to 1492)
  AUTHORS   Fabian,J.R., Kimball,S.R., Heinzinger,N.K. and Jefferson,L.S.
  TITLE     Subunit assembly and guanine nucleotide exchange activity of
            eukaryotic initiation factor-2B expressed in Sf9 cells
  JOURNAL   J Biol Chem 272 (19), 12359-12365 (1997)
   PUBMED   9139680
REFERENCE   7  (bases 1 to 1492)
  AUTHORS   Price,N.T., Mellor,H., Craddock,B.L., Flowers,K.M., Kimball,S.R.,
            Wilmer,T., Jefferson,L.S. and Proud,C.G.
  TITLE     eIF2B, the guanine nucleotide-exchange factor for eukaryotic
            initiation factor 2. Sequence conservation between the alpha, beta
            and delta subunits of eIF2B from mammals and yeast
  JOURNAL   Biochem J 318 (Pt 2) (Pt 2), 637-643 (1996)
   PUBMED   8929216
REFERENCE   8  (bases 1 to 1492)
  AUTHORS   Welsh,G.I., Miyamoto,S., Price,N.T., Safer,B. and Proud,C.G.
  TITLE     T-cell activation leads to rapid stimulation of translation
            initiation factor eIF2B and inactivation of glycogen synthase
            kinase-3
  JOURNAL   J Biol Chem 271 (19), 11410-11413 (1996)
   PUBMED   8626696
REFERENCE   9  (bases 1 to 1492)
  AUTHORS   Gilligan,M., Welsh,G.I., Flynn,A., Bujalska,I., Diggle,T.A.,
            Denton,R.M., Proud,C.G. and Docherty,K.
  TITLE     Glucose stimulates the activity of the guanine nucleotide-exchange
            factor eIF-2B in isolated rat islets of Langerhans
  JOURNAL   J Biol Chem 271 (4), 2121-2125 (1996)
   PUBMED   8567668
REFERENCE   10 (bases 1 to 1492)
  AUTHORS   Karinch,A.M., Kimball,S.R., Vary,T.C. and Jefferson,L.S.
  TITLE     Regulation of eukaryotic initiation factor-2B activity in muscle of
            diabetic rats
  JOURNAL   Am J Physiol 264 (1 Pt 1), E101-E108 (1993)
   PUBMED   8430778
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070506.1.
            
            On Dec 8, 2007 this sequence version replaced NM_032058.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070506.1, U31880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1492
                     /gene="Eif2b2"
                     /note="eukaryotic translation initiation factor 2B subunit
                     beta"
                     /db_xref="GeneID:84005"
                     /db_xref="RGD:620820"
     exon            1..205
                     /gene="Eif2b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1098
                     /gene="Eif2b2"
                     /note="translation initiation factor eIF-2B subunit beta;
                     eIF-2B GDP-GTP exchange factor subunit beta; eukaryotic
                     translation initiation factor 2B, subunit 2 (beta, 39kD);
                     eukaryotic translation initiation factor 2B, subunit 2
                     beta; eukaryotic translation initiation factor 2B subunit
                     2; eIF2B GDP-GTP exchange factor subunit beta"
                     /codon_start=1
                     /product="translation initiation factor eIF2B subunit
                     beta"
                     /protein_id="NP_114447.2"
                     /db_xref="GeneID:84005"
                     /db_xref="RGD:620820"
                     /translation="MPGAAAKGSELSERIESFVETLKRGGGRRSSEDMARETLGLLRR
                     LITDHHWNNAGDLMDLIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDE
                     SDQQESLHKLLTSGGLSEDFSFHYAPLKSNIIEAINELLVELEGTTENIAAQALEHIH
                     SNEVIMTIGFSRTVEAFLREAAQKRKFHVIAAECAPFCQGHEMAVNLSEAGIETTVMT
                     DAAIFAVMSRVNKVIIGTKTILANGSLRAVAGTHTLALAAKHHSTPLIVCAPMFKLSP
                     QFPSEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPDLITLFISNIGGNAPS
                     YVYRLMSELYHPDDHVL"
     exon            206..326
                     /gene="Eif2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..475
                     /gene="Eif2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..639
                     /gene="Eif2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..735
                     /gene="Eif2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..873
                     /gene="Eif2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..940
                     /gene="Eif2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1467
                     /gene="Eif2b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcagttg aggcttctgc aagtccaggg actgtagtgg agatgccggg tgccgcggcg
       61 aagggctcgg agttgtccga gaggatcgag agcttcgtgg aaactctgaa gcgaggtggc
      121 gggcggcgca gctcggagga catggctcgg gagaccctgg ggctgctgcg ccggctcatc
      181 acggaccacc actggaacaa cgccggggac ctaatggatt tgatccgcag agagggtagg
      241 aggatgacag ccgcgcagcc ctccgagacc accgtgggaa acatggtgcg gagagtcctc
      301 aagatcatac gggaggagta tggcagactg catgggcgca gtgatgagag cgatcagcag
      361 gagtccctgc acaaactctt gacatccgga ggcctgagcg aggatttcag cttccattat
      421 gccccactta agtccaacat cattgaggcg attaatgagc tgctagtgga actggaaggc
      481 acaacggaga acattgcagc ccaagctctg gagcacatcc actccaacga ggtgatcatg
      541 accattggct tctctaggac agtcgaggct ttccttagag aggcagccca gaagaggaag
      601 ttccatgtca ttgctgcaga gtgtgctcct ttctgccagg gacatgaaat ggccgtcaat
      661 ttgtccgaag caggtatcga gacaactgtc atgaccgatg ctgccatttt tgctgttatg
      721 tcaagagtca acaaggtgat cattggtacg aagactatcc tggccaatgg ttccctgagg
      781 gctgtggcag gaactcacac tctggcactg gcagccaaac accactccac gcctctcatc
      841 gtctgcgcac ccatgttcaa gctctctcct cagttcccca gtgaagaaga ttcatttcac
      901 aagtttgtgg ctcctgaaga agtccttcct ttcacagaag gagacattct ggagaaggtc
      961 agtgtccact gtcctgtgtt tgactacgtg ccccctgacc tcattaccct ctttatctcc
     1021 aacattggtg ggaatgcacc gtcctacgtc taccgcctga tgagcgagct ctaccatcct
     1081 gacgaccatg tcctctgaca cggcctgtcc tatgcggaac cagcttagac ccggagtgga
     1141 gtggagacac agtgttgctg ctgcagtggg gactggagag tcagcctgaa ccctcagtgc
     1201 ctgtcgcctg ccttcctact catgcccagt gaggagtggt ccaggactgc tcctgccttc
     1261 tgggcttatc tgagcagcag gccttgcttc cctggcattt tggggccact ttgtgactag
     1321 gctatgtttg tttcaggaac ttcaacctcc tggctctgtg gtgtgttaca cagacatacc
     1381 atgactactt ttgctgggtc ggtgtttgct cagaaatgcc ttccagacct tttcctaggc
     1441 tgtgccaata aaagctactg gaaactcaaa aaaaaaaaaa aaaaaaaaaa aa
//
