LOCUS       NM_172029               1502 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 2B
            subunit alpha (Eif2b1), mRNA.
ACCESSION   NM_172029
VERSION     NM_172029.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1502)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1502)
  AUTHORS   Kashiwagi,K., Shigeta,T., Imataka,H., Ito,T. and Yokoyama,S.
  TITLE     Expression, purification, and crystallization of
            Schizosaccharomyces pombe eIF2B
  JOURNAL   J Struct Funct Genomics 17 (1), 33-38 (2016)
   PUBMED   27023709
REFERENCE   3  (bases 1 to 1502)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1502)
  AUTHORS   Hinnebusch,A.G. and Lorsch,J.R.
  TITLE     The mechanism of eukaryotic translation initiation: new insights
            and challenges
  JOURNAL   Cold Spring Harb Perspect Biol 4 (10), a011544 (2012)
   PUBMED   22815232
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1502)
  AUTHORS   Hussain,S.G. and Ramaiah,K.V.
  TITLE     Reduced eIF2alpha phosphorylation and increased proapoptotic
            proteins in aging
  JOURNAL   Biochem Biophys Res Commun 355 (2), 365-370 (2007)
   PUBMED   17300747
REFERENCE   6  (bases 1 to 1502)
  AUTHORS   Gilligan,M., Welsh,G.I., Flynn,A., Bujalska,I., Diggle,T.A.,
            Denton,R.M., Proud,C.G. and Docherty,K.
  TITLE     Glucose stimulates the activity of the guanine nucleotide-exchange
            factor eIF-2B in isolated rat islets of Langerhans
  JOURNAL   J Biol Chem 271 (4), 2121-2125 (1996)
   PUBMED   8567668
REFERENCE   7  (bases 1 to 1502)
  AUTHORS   Flowers,K.M., Mellor,H., Kimball,S.R. and Jefferson,L.S.
  TITLE     Structure and sequence of the gene encoding the alpha-subunit of
            rat translation initiation factor-2B
  JOURNAL   Biochim Biophys Acta 1264 (2), 163-167 (1995)
   PUBMED   7495858
REFERENCE   8  (bases 1 to 1502)
  AUTHORS   Flowers,K.M., Kimball,S.R., Feldhoff,R.C., Hinnebusch,A.G. and
            Jefferson,L.S.
  TITLE     Molecular cloning and characterization of cDNA encoding the alpha
            subunit of the rat protein synthesis initiation factor eIF-2B
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4274-4278 (1995)
   PUBMED   7753796
REFERENCE   9  (bases 1 to 1502)
  AUTHORS   Karinch,A.M., Kimball,S.R., Vary,T.C. and Jefferson,L.S.
  TITLE     Regulation of eukaryotic initiation factor-2B activity in muscle of
            diabetic rats
  JOURNAL   Am J Physiol 264 (1 Pt 1), E101-E108 (1993)
   PUBMED   8430778
REFERENCE   10 (bases 1 to 1502)
  AUTHORS   Kimball,S.R., Everson,W.V., Myers,L.M. and Jefferson,L.S.
  TITLE     Purification and characterization of eukaryotic initiation factor 2
            and a guanine nucleotide exchange factor from rat liver
  JOURNAL   J Biol Chem 262 (5), 2220-2227 (1987)
   PUBMED   3818593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081709.1.
            
            On Sep 15, 2012 this sequence version replaced NM_172029.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081709.1, U05821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..1502
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /note="eukaryotic translation initiation factor 2B subunit
                     alpha"
                     /db_xref="GeneID:64514"
                     /db_xref="RGD:620819"
     exon            1..58
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..963
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /note="translation initiation factor eIF-2B subunit alpha;
                     eIF-2Balpha; GTP-exchange protein; eIF-2B GDP-GTP exchange
                     factor subunit alpha; eukaryotic translation initiation
                     factor 2B subunit 1 alpha; eIF2B GDP-GTP exchange factor
                     subunit alpha"
                     /codon_start=1
                     /product="translation initiation factor eIF2B subunit
                     alpha"
                     /protein_id="NP_742026.1"
                     /db_xref="GeneID:64514"
                     /db_xref="RGD:620819"
                     /translation="MEDGELIKYFKSQMKGDPNMASAVAAIQTLLEFLKRDKGETIQG
                     LRAHLTKAIETLCAVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLS
                     RISLSRTKIASLCHAFIKDGARILTHAYSRVVLRVLEEAVAAKKRFSVYITESQPDLS
                     GKKMAKALCHLNVPVTVVLDAAVGYIMEKVDLVIVGAEGVVENGGIINKIGTNQMAVC
                     AKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSVQAGQDLKEEHPWVDYT
                     SPSLITLLFTDLGVLTPSAVSDELIKLYL"
     exon            59..160
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            161..297
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            298..414
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            415..527
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            528..596
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            597..672
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            673..798
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1476
                     /gene="Eif2b1"
                     /gene_synonym="eIF-2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgctttgct gctggcgggg ttgtggtccg cgtcgcgagg aagccatgga ggacggtgag
       61 ttaatcaagt actttaagtc ccagatgaaa ggagacccta acatggcctc ggcggtggct
      121 gccatccaga ccttgctgga attcttgaag agagataaag gagagacaat ccagggcctg
      181 agagcccatc tcaccaaagc catcgaaacc ctctgcgctg tggactcctc ggtggccgtg
      241 tcctcgggcg gggaactctt ccttcgcttc atcagcctca cctccctgga gtactccgac
      301 tactccaaat gtaaaaagat catgatcgag agaggagagc ttttcctgag cagaatatcc
      361 ctgtcaagaa ctaagatcgc cagtctatgc catgctttta tcaaagacgg ggcgagaatc
      421 ttgactcacg cctactccag agttgtcctg agggtcctgg aagaagccgt ggcagccaag
      481 aaacgtttca gtgtgtatat cacggagtca cagcctgatt tatctggtaa gaaaatggcc
      541 aaagccctct gccacctcaa tgtccctgtc actgtggtgc tggacgctgc tgttggctat
      601 atcatggaga aagtagacct tgtcatcgtt ggtgctgaag gagtggtaga gaatggagga
      661 attattaaca agatcggaac caaccagatg gccgtgtgtg ccaaagccca gaacaagccc
      721 ttctatgtgg ttgcagaaag tttcaagttt gtacggctct ttccactcaa ccagcaagat
      781 gtcccagata agtttaagta caaggcagac accctgaagt ctgtgcaggc tggacaggac
      841 ctcaaagagg aacacccatg ggtcgactac acctccccat ccctcatcac actgctgttt
      901 acggacttag gtgtgttgac accatccgct gtaagcgacg agctcatcaa gctgtacctg
      961 tgagcagtgc ccctcctgcc aacatgcagg gagcacatct tgtgcagggt gagcagcctt
     1021 tccactccag ccagccaggg gccaacaatg ggactttcag acctgtatgc caagggctca
     1081 tttcagaggc cctgaagaat ccttttactc ttgctgtcac atctgaagcc tggtcccagt
     1141 tctagaagca aggtgaagca accttgtggt ttttagagac tcagtctccg gaagaacaag
     1201 ttaattacag actgcaaagc tgaggagaga tggcacagga gcagggaccc cccagccgtg
     1261 ctgcatcact gagagatgcg gtgacattgg ctgagtacac accttcagtg cctcacaaga
     1321 cagcagacac tgtagctgac ggcatctggc tccatgccct cagcaggatc cagccagata
     1381 gaaaaaacac caatgcagga gccattcaca tggcactgtc acagaatgtt gtctgtaaaa
     1441 gatgcgagtt tactctaaac atgtttaaaa cctgaaaaaa aaaaaaaaaa aaaaaaaaaa
     1501 aa
//
