LOCUS       NM_001399818            2273 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus eukaryotic translation initiation factor 2A
            (Eif2a), mRNA.
ACCESSION   NM_001399818 XM_006232388
VERSION     NM_001399818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2273)
  AUTHORS   Yang,Y., Chen,Z., Deng,L., Yu,J., Wang,K., Zhang,X., Ji,G. and
            Li,F.
  TITLE     Pien Tze Huang ameliorates liver injury by inhibiting the
            PERK/eIF2alpha signaling pathway in alcohol and high-fat diet rats
  JOURNAL   Acta Histochem 120 (6), 578-585 (2018)
   PUBMED   30005895
  REMARK    GeneRIF: These results suggest that the administration of Pien Tze
            Huang ameliorated the severity of alcoholic and high-fat diet rats
            possibly by inhibiting the Hcy-induced PERK/eIF2alpha pathway.
REFERENCE   2  (bases 1 to 2273)
  AUTHORS   Dong,Z., Zhou,J., Zhang,Y., Chen,Y., Yang,Z., Huang,G., Chen,Y.,
            Yuan,Z., Peng,Y. and Cao,T.
  TITLE     Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting
            Endoplasmic Reticulum Stress and Autophagy
  JOURNAL   Cell Physiol Biochem 42 (2), 824-837 (2017)
   PUBMED   28641278
  REMARK    GeneRIF: AS-IV may attenuate inflammatory responses by disrupting
            the crosstalk between autophagy and the PERK-eIF2alpha pathway and
            may be an ideal agent for treating inflammatory pulmonary diseases.
REFERENCE   3  (bases 1 to 2273)
  AUTHORS   Hong,M.N., Nam,K.Y., Kim,K.K., Kim,S.Y. and Kim,I.
  TITLE     The small molecule
            '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine
            oxalate' and its derivatives regulate global protein synthesis by
            inactivating eukaryotic translation initiation factor 2-alpha
  JOURNAL   Cell Stress Chaperones 21 (3), 485-497 (2016)
   PUBMED   26873011
  REMARK    GeneRIF: We suggest from these data that AMC-01 and its derivative
            compounds can be used as chemical probes in future studies of the
            role of eIF2-alpha in protein synthesis-related cell physiology.
REFERENCE   4  (bases 1 to 2273)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2273)
  AUTHORS   Yang,Z., Xu,Y., Xu,L., Maccauro,G., Rossi,B., Chen,Y., Li,H.,
            Zhang,J., Sun,H., Yang,Y., Xu,D. and Liu,X.
  TITLE     Regulation of autophagy via PERK-eIF2alpha effectively relieve the
            radiation myelitis induced by iodine-125
  JOURNAL   PLoS One 8 (11), e76819 (2013)
   PUBMED   24223705
  REMARK    GeneRIF: Autophagy induced by (125)I radiation was involved in
            endoplasmic reticulum stress and mainly dependent on PERK-eIF2alpha
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2273)
  AUTHORS   Williams,B.L. and Lipkin,W.I.
  TITLE     Endoplasmic reticulum stress and neurodegeneration in rats
            neonatally infected with borna disease virus
  JOURNAL   J Virol 80 (17), 8613-8626 (2006)
   PUBMED   16912310
REFERENCE   7  (bases 1 to 2273)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   8  (bases 1 to 2273)
  AUTHORS   Zoll,W.L., Horton,L.E., Komar,A.A., Hensold,J.O. and Merrick,W.C.
  TITLE     Characterization of mammalian eIF2A and identification of the yeast
            homolog
  JOURNAL   J Biol Chem 277 (40), 37079-37087 (2002)
   PUBMED   12133843
REFERENCE   9  (bases 1 to 2273)
  AUTHORS   Anthony,T.G., Reiter,A.K., Anthony,J.C., Kimball,S.R. and
            Jefferson,L.S.
  TITLE     Deficiency of dietary EAA preferentially inhibits mRNA translation
            of ribosomal proteins in liver of meal-fed rats
  JOURNAL   Am J Physiol Endocrinol Metab 281 (3), E430-E439 (2001)
   PUBMED   11500297
REFERENCE   10 (bases 1 to 2273)
  AUTHORS   Ito,T., Jagus,R. and May,W.S.
  TITLE     Interleukin 3 stimulates protein synthesis by regulating
            double-stranded RNA-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7455-7459 (1994)
   PUBMED   7519779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 14, 2022 this sequence version replaced XM_006232388.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.8156.1,
                                           SRR26643295.9048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000002.1  144911360-144911403
            45-114              JAXUCZ010000002.1  144917814-144917883
            115-189             JAXUCZ010000002.1  144923971-144924045
            190-308             JAXUCZ010000002.1  144925964-144926082
            309-408             JAXUCZ010000002.1  144928136-144928235
            409-491             JAXUCZ010000002.1  144928725-144928807
            492-565             JAXUCZ010000002.1  144932268-144932341
            566-710             JAXUCZ010000002.1  144932461-144932605
            711-827             JAXUCZ010000002.1  144932733-144932849
            828-1399            JAXUCZ010000002.1  144934753-144935324
            1400-1513           JAXUCZ010000002.1  144938162-144938275
            1514-1630           JAXUCZ010000002.1  144942399-144942515
            1631-1696           JAXUCZ010000002.1  144943605-144943670
            1697-2273           JAXUCZ010000002.1  144944129-144944705
FEATURES             Location/Qualifiers
     source          1..2273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..2273
                     /gene="Eif2a"
                     /note="eukaryotic translation initiation factor 2A"
                     /db_xref="GeneID:502531"
                     /db_xref="RGD:1589591"
     exon            1..44
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1762
                     /gene="Eif2a"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2A"
                     /protein_id="NP_001386747.1"
                     /db_xref="GeneID:502531"
                     /db_xref="RGD:1589591"
                     /translation="MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPREPGKNCKVYTF
                     SKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDG
                     TAGTPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNT
                     IANKLHLQKVNDFNLSPGTQPFKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSF
                     FKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPI
                     YDVAWNPSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGF
                     GNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHY
                     TGSLLYKYDVPSNGELWQVSWQPFLDGIFPAKTITYQAVPSEVPSEEPKVATAYRPPA
                     LRNKPVTSSKLHEEEPPQNMKPHPSSDKPLSKTALKNQRKHEAKKAAKQEARNDLAPT
                     PVPQSAPRSTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQK
                     ETALLQELEDLELGV"
     exon            45..114
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            115..189
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            190..308
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            309..408
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            409..491
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            492..565
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            566..710
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            711..827
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1399
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1513
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1630
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1696
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..2273
                     /gene="Eif2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctttccgg gacaagatgg cgccgtccac accgctgttg acagtcagag gatcagaagg
       61 actgtacatg gtgaatggac ccccacactt cacagagagc acagtgcttc caagagaacc
      121 tggaaaaaat tgcaaagtct atacttttag taaggatggg acattgtttg cctggagcaa
      181 tggagaaaaa gtgaatataa tcaatgtcgc taacaaggga ctactgcact cctttgacct
      241 cccaaaagca gtttgccttg aattttcacc aaacaacact gtcctggcaa cgtggcagcc
      301 ttacactact tctaaagatg gtacagctgg gacccctaac ctacaacttt atgacgtgaa
      361 gactggaaca tgtttaaaat ctttcataca gaaaaaaatg cagaattggt gtccttcctg
      421 gtcagatgat gaaattattt gtgcccggaa tgttaacaat gaagttcact tctttgagaa
      481 caacaatttt aacacaattg caaataaatt acatttgcaa aaagttaatg actttaattt
      541 atcacctgga acccaacctt ttaaggtcgc agtttatgtc cctggaagta aaggtgcacc
      601 ttcatttgtt agattatatc agtaccccaa ctttgctgga ccccaagccg cactggccaa
      661 taaaagcttc tttaaagccg ataaggttac gatgctgtgg aataaaaaag ctactgctgt
      721 gctggtaata gccagtacag atgttgacaa gacaggcgct tcctactatg gggaacaaac
      781 actgcactac attgcgacaa atggagaaag tgctgtagta caattaccca aaaatggccc
      841 aatttatgat gtagcttgga atcctagttc tacggagttt tgtgctgttt atggttttat
      901 gcctgcgaaa gcaacagttt ttaacctgaa gtgtgatcct gtgtttgact ttgggactgg
      961 tcctcgcaac gcagcattct atagccctca tggacatata ttagtactgg ctggatttgg
     1021 aaaccttcga ggacaaatgg aagtatggga tgttaaaaac tacaagctta tttctaagcc
     1081 tgtggcttct gattctacat attttgcctg gtgcccagat ggtgagcata tcttaacagc
     1141 cacgtgtgct cctaggttac gtgttaataa tgggtataag atttggcatt acactggctc
     1201 tctcttgtat aagtatgatg tgccatccaa tggcgaattg tggcaggttt cttggcagcc
     1261 atttttggat ggaatatttc cagcaaaaac gataacgtac caagcagttc caagtgaagt
     1321 gcctagtgag gagcctaaag ttgcaacagc ttatagacct ccagccttaa gaaataaacc
     1381 agtcaccagt tccaagctgc atgaagagga acctccccag aatatgaagc cacatccatc
     1441 aagtgacaag ccattatcaa aaacagccct taaaaatcaa aggaagcatg aagctaaaaa
     1501 agctgcaaaa caggaggcaa gaaatgattt ggctcctact cctgtcccac agagtgcacc
     1561 acggagcact gtcacccagt ctgcttcggg tgatcctgaa gtagacaaaa aaattaagaa
     1621 tctaaagaag aaactgaaag cgatagagca gctgaaagag caggcagccg ctgggaagca
     1681 gctagagaaa aatcagttgg agaaaattca aaaagagaca gcccttctcc aagaacttga
     1741 agatttggaa ttgggagttt gaagactcac agaaagcgaa tttgttagca ggaaacacta
     1801 taagcaagtc tgttaatccc atggtgttta tggaattacc acaggtccac cattaacatc
     1861 agtctatgtc tttaaccatt tatccaaggt tgatatgtgt aattatttaa tgatgtcttt
     1921 tcaattgact tttacatctg cattctgtat catgtcagta tataataaag agagatgatt
     1981 ttttccagat aagcttaata aattgacaga cttttttaaa tggttaatag tatttcctat
     2041 ataaaaaaaa ataaagacat tttaaatttg ttttgcctcc aagttaaaaa gttctataaa
     2101 acctggctgt agtggcagac atctttaatc ccagcagtca gaaggcagag gcaggtggat
     2161 ctctgagatc agtggctacc ttgtctatag agtgagttat aggacaacca gggctacata
     2221 aagaaacgct gtctcagaaa accaaaaata aatagttctt tattataaat tta
//
