LOCUS       NP_001386747             581 aa            linear   ROD 31-MAR-2024
DEFINITION  eukaryotic translation initiation factor 2A [Rattus norvegicus].
ACCESSION   NP_001386747 XP_006232450
VERSION     NP_001386747.1
DBSOURCE    REFSEQ: accession NM_001399818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 581)
  AUTHORS   Yang,Y., Chen,Z., Deng,L., Yu,J., Wang,K., Zhang,X., Ji,G. and
            Li,F.
  TITLE     Pien Tze Huang ameliorates liver injury by inhibiting the
            PERK/eIF2alpha signaling pathway in alcohol and high-fat diet rats
  JOURNAL   Acta Histochem 120 (6), 578-585 (2018)
   PUBMED   30005895
  REMARK    GeneRIF: These results suggest that the administration of Pien Tze
            Huang ameliorated the severity of alcoholic and high-fat diet rats
            possibly by inhibiting the Hcy-induced PERK/eIF2alpha pathway.
REFERENCE   2  (residues 1 to 581)
  AUTHORS   Dong,Z., Zhou,J., Zhang,Y., Chen,Y., Yang,Z., Huang,G., Chen,Y.,
            Yuan,Z., Peng,Y. and Cao,T.
  TITLE     Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting
            Endoplasmic Reticulum Stress and Autophagy
  JOURNAL   Cell Physiol Biochem 42 (2), 824-837 (2017)
   PUBMED   28641278
  REMARK    GeneRIF: AS-IV may attenuate inflammatory responses by disrupting
            the crosstalk between autophagy and the PERK-eIF2alpha pathway and
            may be an ideal agent for treating inflammatory pulmonary diseases.
REFERENCE   3  (residues 1 to 581)
  AUTHORS   Hong,M.N., Nam,K.Y., Kim,K.K., Kim,S.Y. and Kim,I.
  TITLE     The small molecule
            '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine
            oxalate' and its derivatives regulate global protein synthesis by
            inactivating eukaryotic translation initiation factor 2-alpha
  JOURNAL   Cell Stress Chaperones 21 (3), 485-497 (2016)
   PUBMED   26873011
  REMARK    GeneRIF: We suggest from these data that AMC-01 and its derivative
            compounds can be used as chemical probes in future studies of the
            role of eIF2-alpha in protein synthesis-related cell physiology.
REFERENCE   4  (residues 1 to 581)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 581)
  AUTHORS   Yang,Z., Xu,Y., Xu,L., Maccauro,G., Rossi,B., Chen,Y., Li,H.,
            Zhang,J., Sun,H., Yang,Y., Xu,D. and Liu,X.
  TITLE     Regulation of autophagy via PERK-eIF2alpha effectively relieve the
            radiation myelitis induced by iodine-125
  JOURNAL   PLoS One 8 (11), e76819 (2013)
   PUBMED   24223705
  REMARK    GeneRIF: Autophagy induced by (125)I radiation was involved in
            endoplasmic reticulum stress and mainly dependent on PERK-eIF2alpha
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 581)
  AUTHORS   Williams,B.L. and Lipkin,W.I.
  TITLE     Endoplasmic reticulum stress and neurodegeneration in rats
            neonatally infected with borna disease virus
  JOURNAL   J Virol 80 (17), 8613-8626 (2006)
   PUBMED   16912310
REFERENCE   7  (residues 1 to 581)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   8  (residues 1 to 581)
  AUTHORS   Zoll,W.L., Horton,L.E., Komar,A.A., Hensold,J.O. and Merrick,W.C.
  TITLE     Characterization of mammalian eIF2A and identification of the yeast
            homolog
  JOURNAL   J Biol Chem 277 (40), 37079-37087 (2002)
   PUBMED   12133843
REFERENCE   9  (residues 1 to 581)
  AUTHORS   Anthony,T.G., Reiter,A.K., Anthony,J.C., Kimball,S.R. and
            Jefferson,L.S.
  TITLE     Deficiency of dietary EAA preferentially inhibits mRNA translation
            of ribosomal proteins in liver of meal-fed rats
  JOURNAL   Am J Physiol Endocrinol Metab 281 (3), E430-E439 (2001)
   PUBMED   11500297
REFERENCE   10 (residues 1 to 581)
  AUTHORS   Ito,T., Jagus,R. and May,W.S.
  TITLE     Interleukin 3 stimulates protein synthesis by regulating
            double-stranded RNA-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7455-7459 (1994)
   PUBMED   7519779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 14, 2022 this sequence version replaced XP_006232450.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.8156.1,
                                           SRR26643295.9048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     Protein         1..581
                     /product="eukaryotic translation initiation factor 2A"
                     /calculated_mol_wt=64248
     Region          44..567
                     /region_name="COG5354"
                     /note="Uncharacterized protein, contains Trp-Asp (WD)
                     repeat [General function prediction only]"
                     /db_xref="CDD:227657"
     Region          216..411
                     /region_name="eIF2A"
                     /note="Eukaryotic translation initiation factor eIF2A;
                     pfam08662"
                     /db_xref="CDD:462552"
     Region          277..311
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          318..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          360..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..581
                     /gene="Eif2a"
                     /coded_by="NM_001399818.1:17..1762"
                     /db_xref="GeneID:502531"
                     /db_xref="RGD:1589591"
ORIGIN      
        1 mapstplltv rgseglymvn gpphftestv lprepgknck vytfskdgtl fawsngekvn
       61 iinvankgll hsfdlpkavc lefspnntvl atwqpyttsk dgtagtpnlq lydvktgtcl
      121 ksfiqkkmqn wcpswsddei icarnvnnev hffennnfnt ianklhlqkv ndfnlspgtq
      181 pfkvavyvpg skgapsfvrl yqypnfagpq aalanksffk adkvtmlwnk katavlvias
      241 tdvdktgasy ygeqtlhyia tngesavvql pkngpiydva wnpsstefca vygfmpakat
      301 vfnlkcdpvf dfgtgprnaa fysphghilv lagfgnlrgq mevwdvknyk liskpvasds
      361 tyfawcpdge hiltatcapr lrvnngykiw hytgsllyky dvpsngelwq vswqpfldgi
      421 fpaktityqa vpsevpseep kvatayrppa lrnkpvtssk lheeeppqnm kphpssdkpl
      481 sktalknqrk heakkaakqe arndlaptpv pqsaprstvt qsasgdpevd kkiknlkkkl
      541 kaieqlkeqa aagkqleknq lekiqketal lqeledlelg v
//
