LOCUS       NM_001025660            2115 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus EI24, autophagy associated transmembrane protein
            (Ei24), mRNA.
ACCESSION   NM_001025660 XM_217105
VERSION     NM_001025660.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Yuan,L., Wang,H., Liu,Q., Wang,Z., Zhang,M., Zhao,Y., Liang,K.,
            Chen,L., Xu,T. and Xu,P.
  TITLE     Etoposide-induced protein 2.4 functions as a regulator of the
            calcium ATPase and protects pancreatic beta-cell survival
  JOURNAL   J Biol Chem 293 (26), 10128-10140 (2018)
   PUBMED   29769309
  REMARK    GeneRIF: Etoposide-induced protein 2.4 functions as a regulator of
            the calcium ATPase and protects pancreatic beta-cell survival
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Lieu,K.G., Shim,E.H., Wang,J., Lokareddy,R.K., Tao,T.,
            Cingolani,G., Zambetti,G.P. and Jans,D.A.
  TITLE     The p53-induced factor Ei24 inhibits nuclear import through an
            importin beta-binding-like domain
  JOURNAL   J Cell Biol 205 (3), 301-312 (2014)
   PUBMED   24821838
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Sung,Y.H., Jin,Y., Kang,Y., Devkota,S., Lee,J., Roh,J.I. and
            Lee,H.W.
  TITLE     Ei24, a novel E2F target gene, affects p53-independent cell death
            upon ultraviolet C irradiation
  JOURNAL   J Biol Chem 288 (43), 31261-31267 (2013)
   PUBMED   24014029
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Zhao,Y.G., Zhao,H., Miao,L., Wang,L., Sun,F. and Zhang,H.
  TITLE     The p53-induced gene Ei24 is an essential component of the basal
            autophagy pathway
  JOURNAL   J Biol Chem 287 (50), 42053-42063 (2012)
   PUBMED   23074225
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Mork,C.N., Faller,D.V. and Spanjaard,R.A.
  TITLE     Loss of putative tumor suppressor EI24/PIG8 confers resistance to
            etoposide
  JOURNAL   FEBS Lett 581 (28), 5440-5444 (2007)
   PUBMED   17981155
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Gu,Z., Flemington,C., Chittenden,T. and Zambetti,G.P.
  TITLE     ei24, a p53 response gene involved in growth suppression and
            apoptosis
  JOURNAL   Mol Cell Biol 20 (1), 233-241 (2000)
   PUBMED   10594026
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098721.1.
            
            [WARNING] On Aug 7, 2024 this sequence was replaced by
            NM_001025660.2.
            
            On Jul 22, 2005 this sequence version replaced XM_217105.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2115
                     /gene="Ei24"
                     /note="EI24, autophagy associated transmembrane protein"
                     /db_xref="GeneID:300514"
                     /db_xref="RGD:1309868"
     exon            1..52
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            53..88
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            89..198
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1179
                     /gene="Ei24"
                     /note="etoposide induced 2.4 mRNA"
                     /codon_start=1
                     /product="etoposide-induced protein 2.4 homolog"
                     /protein_id="NP_001020831.1"
                     /db_xref="GeneID:300514"
                     /db_xref="RGD:1309868"
                     /translation="MADSVKTFLQDLGRGIKDSIWGICTISKLDARIQQKREEQRRRR
                     ASSLLAQRRAQSVERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFYRVFIPVLQSVTA
                     RVIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRK
                     PHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFE
                     YRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIIS
                     ANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSSSAEKFPSPHPSPAKL
                     KAAAGH"
     exon            199..344
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            345..405
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            406..472
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            473..597
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            598..717
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            718..829
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            830..941
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1016
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..2094
                     /gene="Ei24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaacctcgg tgggcgagcg ccggggctgg agccgcgggg gtcggtggcg ggagctgggg
       61 accgaaccca gggccttgcg cttcttaggc cttccatgat gagtgatttg ggggcacttc
      121 cctctctctg taattgatag tctgggcagt gaagagatgg ctgacagtgt caaaaccttt
      181 ctgcaggacc ttggcagggg aatcaaagac tccatctggg gcatctgtac catctcaaag
      241 ctagatgctc ggatccagca gaagagagag gagcagcgtc gaaggagggc aagtagcctc
      301 ttggcccaga ggagagccca gagtgtagag cggaagcaag agagtgagcc acgtattgtt
      361 agtagaattt tccagtgctg tgcttggaat ggtggagtat tctggttcag tctcctcttg
      421 ttttaccgag tgtttattcc tgtgcttcaa tcagtaacag cccgggttat tggtgatccg
      481 tcactacatg gagatgtttg gtcatggctg gaattcttcc tcacatcaat tttcagtgct
      541 ctttgggtgc tgcccctgtt tgtgcttagc aaagttgtga atgccatttg gttccaagat
      601 atagctgact tggcatttga ggtatcaggg aggaaacctc atccattccc cagtgtcagc
      661 aaaataattg ctgacatgct cttcaacctt ttgctacagg cacttttcct tattcagggg
      721 atgtttgtga gtctcttccc catccatctt gtgggtcagc tggttagttt gctgcatatg
      781 tctcttctct actcactcta ctgctttgag taccgttggt tcaacaaagg aattgaaatg
      841 caccagcgat tgtcaaacat agaaaggaac tggccttact actttgggtt tggcttgccc
      901 ttggctttcc tcacagcaat gcaatcctcc tacattatca gtggctgcct cttttctatc
      961 ctgtttcctt tattcatcat cagcgccaat gaagcaaaga ctcctggaaa agcatatctt
     1021 ttccagttgc gcctcttctc cttggtggtc tttttaagca acagactttt ccacaagacg
     1081 gtctacctac agtcggccct gagcagctca tcctccgcag agaaattccc ttcgccacat
     1141 ccttctcctg ccaaactgaa agctgctgca ggccactgag tcctgctgtc aaaggggacg
     1201 ggtgggactg ggtggaggat gtggcagctc ttttcttggt tttcctcccc tgctgtggaa
     1261 ggcaggaccc actgccaagg ggcctctgca tattcctttg tctttgaatt ggaatcttcc
     1321 tgactccggt atgtggattt ttaccaccac cctaggtctg gaaggaccag ttttccagct
     1381 gttttttagc ttttgccagc tcctgtgcct ggactgattt gagtactccc ccctcccttg
     1441 tgtcatttac cttcccacct cctcctgcct cccagcaccc ctgggtgaat gggctttgta
     1501 attttaactg ttgtattttg tgaatttgtt gttactgttt cctgtgaagc acataccttg
     1561 tatgtgggag gtaaaggagc acgccagctg ctccatgtca ctccctctat agccatcact
     1621 gtcttgtttt tttgtaactc aggttaggtt ttggtcttta ctgctctgct gcagaaaagg
     1681 aaaggaatgg gggaaaggag cctaagagat gggacagata gacctcagcc aaactggttg
     1741 ggttttgagg agtcatgttc tttgttcccc ttgaagggga aacaggtttt ttcactggta
     1801 catttaaagt tccccagcta tgggaaggta ccagttctgg acaagtgcca ctgcatcata
     1861 gcaactctga agatgaaact tactgttggc cactgccagg tcagactcgt gttttaagga
     1921 atactgggtg cttcatatag gaactgaagg ggtaaactta ctaaaccatt caacctgtga
     1981 ttggtgatgt ttttctgtca ttttaagagt cgacacatgg ggtgggaggg cagatgtaaa
     2041 aaaacttgta caattttaaa atcacaatta aacgtgagct ggtttcccat aaaaaaaaaa
     2101 aaaaaaaaaa aaaaa
//
