LOCUS       NM_212463               4023 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus euchromatic histone lysine methyltransferase 2
            (Ehmt2), mRNA.
ACCESSION   NM_212463 XM_579740
VERSION     NM_212463.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4023)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   2  (bases 1 to 4023)
  AUTHORS   Yan,F., Chen,Z. and Cui,W.
  TITLE     H3K9me2 regulation of BDNF expression via G9a partakes in the
            progression of heart failure
  JOURNAL   BMC Cardiovasc Disord 22 (1), 182 (2022)
   PUBMED   35439934
  REMARK    GeneRIF: H3K9me2 regulation of BDNF expression via G9a partakes in
            the progression of heart failure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4023)
  AUTHORS   Shan,W., Wu,Y., Han,X., Chen,Q. and Wu,J.
  TITLE     The mechanism of sevoflurane post-treatment alleviating
            hypoxic-ischemic encephalopathy by affecting histone
            methyltransferase G9a in rats
  JOURNAL   Bioengineered 12 (2), 9790-9805 (2021)
   PUBMED   34672892
  REMARK    GeneRIF: The mechanism of sevoflurane post-treatment alleviating
            hypoxic-ischemic encephalopathy by affecting histone
            methyltransferase G9a in rats.
REFERENCE   4  (bases 1 to 4023)
  AUTHORS   Sharifulina,S., Dzreyan,V., Guzenko,V. and Demyanenko,S.
  TITLE     Histone Methyltransferases SUV39H1 and G9a and DNA
            Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after
            Photothrombotic Stroke
  JOURNAL   Int J Mol Sci 22 (22), 12483 (2021)
   PUBMED   34830365
  REMARK    GeneRIF: Histone Methyltransferases SUV39H1 and G9a and DNA
            Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after
            Photothrombotic Stroke.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4023)
  AUTHORS   Li,Q., Xiang,Y.H., Liang,X.J., Zhang,Y., Zhao,P.P., Wang,M.,
            Bao,X.M., Zhu,X.B. and Deng,A.C.
  TITLE     Expression of G9a in Auditory Cortex Is Downregulated in a Rat
            Model of Age-Related Hearing Loss
  JOURNAL   J Mol Neurosci 71 (2), 409-418 (2021)
   PUBMED   32671696
  REMARK    GeneRIF: Expression of G9a in Auditory Cortex Is Downregulated in a
            Rat Model of Age-Related Hearing Loss.
REFERENCE   6  (bases 1 to 4023)
  AUTHORS   Ueda,J., Tachibana,M., Ikura,T. and Shinkai,Y.
  TITLE     Zinc finger protein Wiz links G9a/GLP histone methyltransferases to
            the co-repressor molecule CtBP
  JOURNAL   J Biol Chem 281 (29), 20120-20128 (2006)
   PUBMED   16702210
REFERENCE   7  (bases 1 to 4023)
  AUTHORS   Wu,R., Terry,A.V., Singh,P.B. and Gilbert,D.M.
  TITLE     Differential subnuclear localization and replication timing of
            histone H3 lysine 9 methylation states
  JOURNAL   Mol Biol Cell 16 (6), 2872-2881 (2005)
   PUBMED   15788566
REFERENCE   8  (bases 1 to 4023)
  AUTHORS   Tachibana,M., Ueda,J., Fukuda,M., Takeda,N., Ohta,T., Iwanari,H.,
            Sakihama,T., Kodama,T., Hamakubo,T. and Shinkai,Y.
  TITLE     Histone methyltransferases G9a and GLP form heteromeric complexes
            and are both crucial for methylation of euchromatin at H3-K9
  JOURNAL   Genes Dev 19 (7), 815-826 (2005)
   PUBMED   15774718
REFERENCE   9  (bases 1 to 4023)
  AUTHORS   Ohhata,T., Tachibana,M., Tada,M., Tada,T., Sasaki,H., Shinkai,Y.
            and Sado,T.
  TITLE     X-inactivation is stably maintained in mouse embryos deficient for
            histone methyl transferase G9a
  JOURNAL   Genesis 40 (3), 151-156 (2004)
   PUBMED   15493016
REFERENCE   10 (bases 1 to 4023)
  AUTHORS   Xin,Z., Tachibana,M., Guggiari,M., Heard,E., Shinkai,Y. and
            Wagstaff,J.
  TITLE     Role of histone methyltransferase G9a in CpG methylation of the
            Prader-Willi syndrome imprinting center
  JOURNAL   J Biol Chem 278 (17), 14996-15000 (2003)
   PUBMED   12586828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883045.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4023
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4023
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /note="euchromatic histone lysine methyltransferase 2"
                     /db_xref="GeneID:361798"
                     /db_xref="RGD:1302972"
     CDS             1..3792
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /EC_number="2.1.1.354"
                     /note="HLA-B associated transcript 8, rat orthologue;
                     euchromatic histone-lysine N-methyltransferase 2;
                     histone-lysine N-methyltransferase, H3 lysine-9 specific
                     3"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EHMT2"
                     /protein_id="NP_997628.1"
                     /db_xref="GeneID:361798"
                     /db_xref="RGD:1302972"
                     /translation="MRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLS
                     LPRAQASWAPQLPAGLTGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHGSLGDTS
                     HSEETLPKANPDSLEPTGPSSPASVTVTVGDEGADTPVGATPLIGEEPENLEGDGGRI
                     LLGHATKSFPSSPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAGP
                     EPPPATTAGQEGQPKVHRARKTMSKPSNGQPPVPEKRPPEVQHFRMSDDMHLGKVTSD
                     VAKRRKLTSGSLSEDLGSAGGSGEVILEKGEPRPLEEWETVVGDDFSLYYDAYSVDER
                     VDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGR
                     RKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSE
                     GTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGE
                     LLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLECHPDF
                     RVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPVGTVAPAPPPLAHD
                     APGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPPGPGR
                     EALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRT
                     PLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVY
                     SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRM
                     LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARE
                     SYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTE
                     KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCV
                     DDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSG
                     IKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKD
                     GEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELG
                     FDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPPIN
                     T"
     exon            1..280
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            281..487
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            488..744
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            745..826
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            827..864
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1020
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1158
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1273
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1375
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1524
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1668
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1904
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2087
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2170
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2277
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2400
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2502
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2607
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2762
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2930
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3075
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3153
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3269
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3356
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3435
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3611
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..4023
                     /gene="Ehmt2"
                     /gene_synonym="Bat8; G9a; Ng36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcggggtc tgccgagagg gagggggctg atgcgggccc gggggcgggg gcgtgcggcc
       61 cccacgggcg gccgcggccg gggtcgcggg ggcgcccacc gtggacgagg taggccccga
      121 agcctgctct cgctgcccag ggcccaggcg tcttgggccc cccagctgcc tgccgggctg
      181 accggccctc cggtcccttg tctcccctcc cagggggagg cccccgctga gatgggggcg
      241 ctgctgctgg agaaggagcc ccgaggagcc gccgagagag ttcatggctc tttgggggac
      301 acctctcata gtgaggagac ccttcccaag gccaaccccg actccttgga gcctaccggc
      361 ccctcctctc cggcctctgt cactgtcacc gtcggcgatg agggggctga cacccctgtc
      421 ggggccacac cgctcatcgg ggaggaaccc gagaacctgg agggagatgg gggtcgaatc
      481 ctgctgggcc atgccacaaa gtcattcccc tcttccccca gcaagggggg tgcctgtccc
      541 agtcgggcca aaatgtcaat gacaggggca ggaaagtcgc ccccctcggt ccagagtttg
      601 gccatgaggc tgttgagcat gcctggggcc cagggagctg caactgctgg gcctgagccc
      661 cctccggcaa caactgccgg ccaggagggg cagcccaaag tacaccgagc tcggaaaacc
      721 atgtccaagc ctagcaacgg acagcctcca gtccctgaga agcggccccc tgaagtccag
      781 catttccgca tgagtgacga catgcatctg ggaaaggtga cttcagatgt ggccaaacgg
      841 aggaagttga cctcgggcag cctgtcagag gacttgggct ctgctggggg ctcaggagaa
      901 gtgatcctgg agaagggaga gcccaggcct ctggaggagt gggagacggt ggtgggcgat
      961 gacttcagcc tgtactatga cgcgtactct gtggatgagc gggtggactc tgacagcaag
     1021 tctgaagtcg aagctctagc tgaacagttg agtgaagagg aggaggagga agaggaggaa
     1081 gaagaagagg aagaggagga agaggaggag gaggaagagg aggaggagga tgaggagtcg
     1141 ggcaaccagt cagacaggag tggctctagc ggccgacgca aggccaagaa gaaatggcgg
     1201 aaagacagcc catgggtgaa gccatccagg aaacggcgga agcgagagcc tccgagggcc
     1261 aaggagccca gaggagtgaa tggtgtgggt tcctcagggc ccagtgagta catggaggtt
     1321 cctctggggt ccctggagct gcccagcgag gggaccctct cccccaacca cgctggggtc
     1381 tccaatgaca cgtcttcgct ggagacggag cgtgggtttg aggagctgcc cctctgcagc
     1441 tgccgcatgg aggcgcccaa gattgaccgc atcagcgaga gagcaggaca caagtgtatg
     1501 gccaccgaaa gtgtggacgg agagctgctg ggttgcaatg ccgccatctt gaagcgggag
     1561 accatgcggc cgtctagccg tgtggcgctg atggtactgt gtgaggccca tcgagcccgc
     1621 atggtcaagc accattgctg cccaggctgt ggctacttct gcacggcggg caccttcctg
     1681 gagtgtcacc ccgacttccg tgtagctcac cgcttccata aggcctgcgt gtcccagctc
     1741 aatgggatgg ttttctgtcc ccactgtggg gaggacgcct cagaggccca ggaggtgacc
     1801 atccctcggg gcgatggggg aacacccccg gttggcactg tggcgcctgc cccgccaccc
     1861 ctggcacacg acgccccagg gcgagcggat acctcccagc ccagtgcccg aatgcgagga
     1921 cacggagagc caaggcgccc accctgtgat cccctggccg acaccattga cagctcgggg
     1981 ccttctctga ctctgcctaa tggcggctgc ctctcagctg tgggtctgcc cccagggcca
     2041 ggccgggaag ccctggaaaa agccttggtc atccaggagt ccgagaggag gaagaagctg
     2101 cggttccacc cgcggcagct ctacctgtcg gtgaagcagg gggagctgca gaaggtgatc
     2161 ctcatgctgc tcgacaacct ggaccccaac ttccagagcg accagcagag caagcgcacg
     2221 cccctgcacg cagccgccca gaaggggtcc gtggagatct gtcacgtgct gctacaggca
     2281 ggagccaaca tcaacgccgt ggataagcag cagcgcaccc cgctgatgga ggccgtggtg
     2341 aacaaccacc tggaggtggc tcgctacatg gtgcagctgg gcggctgtgt gtacagcaag
     2401 gaagaggatg gctctacctg tctccatcat gcggccaaaa ttgggaactt ggaaatggtc
     2461 agcctgctgc tgagcacagg gcaggtggac gtcaatgccc aggacagtgg gggctggaca
     2521 cccatcatct gggcagccga gcacaagcac atcgacgtga tccgtatgct gctgacccgg
     2581 ggcgccgacg tcacccttac cgacaacgag gaaaacatct gcctgcactg ggcttccttc
     2641 acgggtagtg ccgctattgc cgaggtcctc ctgaatgccc agtgcgacct ccatgctgtc
     2701 aactaccacg gggacacgcc cctgcacata gccgccaggg agagctacca tgactgcgtt
     2761 ctgttgttcc tgtcccgtgg agccaaccct gagcttcgga acaaagaagg ggacacggcg
     2821 tgggatctga ccccagagcg ctccgatgtg tggtttgcac tgcagctcaa tcgcaagctt
     2881 aggctcgggg tagggaaccg ggctgtccgc accgagaaga tcatctgccg ggatgtagcc
     2941 cgaggctatg agaatgtgcc cattccctgt gtcaatggcg tggatgggga gccatgccca
     3001 gaggactata agtacatctc cgagaactgt gaaacgtcca ccatgaacat cgaccgaaac
     3061 atcactcacc tgcagcactg cacgtgtgtt gacgactgct ccagctccaa ctgcctgtgt
     3121 ggccagctaa gcatccgatg ctggtatgat aaggacgggc ggctgctcca ggagtttaac
     3181 aagatcgagc cccccctgat ctttgagtgt aaccaggcat gctcctgctg gagaagctgc
     3241 aagaaccgcg tggtgcagag cggcatcaag gtgcggctgc agctctaccg gacggccaag
     3301 atgggctggg gggtccgtgc cttgcagacc attccccagg gcacgttcat ctgcgagtac
     3361 gtcggggagc tgatctccga cgccgaggca gacgtgagag aggatgattc ttacctcttc
     3421 gacttagaca acaaggatgg tgaggtctac tgcattgatg cccgttacta tggcaacatc
     3481 agccgcttca ttaaccacct gtgcgacccc aacatcatcc ctgttcgggt cttcatgctg
     3541 catcaagacc tacggttccc tcgcatcgcc ttcttcagct ccagggacat ccggaccggg
     3601 gaggagctgg ggtttgacta cggcgaccgg ttctgggata tcaagagcaa gtatttcacc
     3661 tgccagtgtg gctctgagaa gtgcaagcat tcagctgagg ccatcgccct ggagcagagc
     3721 cgcctggccc gtctggaccc ccacccggag ctgctccctg acctcagctc cctgcccccc
     3781 atcaacacct gaggactgtt aaaatccagg ccggggcact gcccctcaga cattccccca
     3841 tcggaggacc ccagtaaggc ctggaaggtt tacagcccct ctcccagagc tggtttctca
     3901 ctgggagtga gtgacttcag ggctggccta ccccactgag cctggcctca gttcgctcat
     3961 tgaagttggg cctctgccaa ctgattttct gtgctctcaa taaatgttgg gtttggtaat
     4021 aaa
//
