LOCUS       NM_139324               3428 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus EH-domain containing 4 (Ehd4), mRNA.
ACCESSION   NM_139324
VERSION     NM_139324.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3428)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3428)
  AUTHORS   Philippidou,P., Valdez,G., Akmentin,W., Bowers,W.J., Federoff,H.J.
            and Halegoua,S.
  TITLE     Trk retrograde signaling requires persistent, Pincher-directed
            endosomes
  JOURNAL   Proc Natl Acad Sci U S A 108 (2), 852-857 (2011)
   PUBMED   21187387
  REMARK    GeneRIF: Retrograde signaling through Pincher-generated
            Trk-multivesicular bodies is distinctively refractory to signal
            termination by lysosomal processing
REFERENCE   3  (bases 1 to 3428)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 3428)
  AUTHORS   Gudmundsson,H., Hund,T.J., Wright,P.J., Kline,C.F., Snyder,J.S.,
            Qian,L., Koval,O.M., Cunha,S.R., George,M., Rainey,M.A.,
            Kashef,F.E., Dun,W., Boyden,P.A., Anderson,M.E., Band,H. and
            Mohler,P.J.
  TITLE     EH domain proteins regulate cardiac membrane protein targeting
  JOURNAL   Circ Res 107 (1), 84-95 (2010)
   PUBMED   20489164
REFERENCE   5  (bases 1 to 3428)
  AUTHORS   Yap,C.C., Lasiecka,Z.M., Caplan,S. and Winckler,B.
  TITLE     Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM
            endocytosis in neurons and disrupt axonal targeting
  JOURNAL   J Neurosci 30 (19), 6646-6657 (2010)
   PUBMED   20463227
  REMARK    GeneRIF: balanced levels of EHD1 and EHD4 are important for NgCAM
            endocytosis in neurons; suggest that EHD1 plays roles in both
            endosomal recycling and a specialized endocytosis pathway in
            neurons used by NgCAM
REFERENCE   6  (bases 1 to 3428)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3428)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 3428)
  AUTHORS   George,M., Ying,G., Rainey,M.A., Solomon,A., Parikh,P.T., Gao,Q.,
            Band,V. and Band,H.
  TITLE     Shared as well as distinct roles of EHD proteins revealed by
            biochemical and functional comparisons in mammalian cells and C.
            elegans
  JOURNAL   BMC Cell Biol 8, 3 (2007)
   PUBMED   17233914
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3428)
  AUTHORS   Shao,Y., Akmentin,W., Toledo-Aral,J.J., Rosenbaum,J., Valdez,G.,
            Cabot,J.B., Hilbush,B.S. and Halegoua,S.
  TITLE     Pincher, a pinocytic chaperone for nerve growth factor/TrkA
            signaling endosomes
  JOURNAL   J Cell Biol 157 (4), 679-691 (2002)
   PUBMED   12011113
REFERENCE   10 (bases 1 to 3428)
  AUTHORS   Rotem-Yehudar,R., Galperin,E. and Horowitz,M.
  TITLE     Association of insulin-like growth factor 1 receptor with EHD1 and
            SNAP29
  JOURNAL   J Biol Chem 276 (35), 33054-33060 (2001)
   PUBMED   11423532
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY094093.1, BC083175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676809, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000003.1  127575507-127575763 c
            258-434             JAXUCZ010000003.1  127558848-127559024 c
            435-532             JAXUCZ010000003.1  127549688-127549785 c
            533-945             JAXUCZ010000003.1  127525999-127526411 c
            946-1110            JAXUCZ010000003.1  127519290-127519454 c
            1111-3428           JAXUCZ010000003.1  127511973-127514290 c
FEATURES             Location/Qualifiers
     source          1..3428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..3428
                     /gene="Ehd4"
                     /gene_synonym="Past2"
                     /note="EH-domain containing 4"
                     /db_xref="GeneID:192204"
                     /db_xref="RGD:628883"
     exon            1..257
                     /gene="Ehd4"
                     /gene_synonym="Past2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1647
                     /gene="Ehd4"
                     /gene_synonym="Past2"
                     /note="pinocytic chaperone; pincher"
                     /codon_start=1
                     /product="EH domain-containing protein 4"
                     /protein_id="NP_647540.1"
                     /db_xref="GeneID:192204"
                     /db_xref="RGD:628883"
                     /translation="MFSWMGRQAGGRERSGGMDAVQTVTGGLRSLYQRKVLPLEEAYR
                     FHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIA
                     VMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISIIDSPGI
                     LSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIR
                     VVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEA
                     EAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPSMFGKENKKREL
                     IFRLPEIYVQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLTNK
                     ISSLMSLISQEEMNMPTQMVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPV
                     YDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAK
                     HLIKIKLDGYELPNSLPPHLVPPSHRKSLPKAD"
     exon            258..434
                     /gene="Ehd4"
                     /gene_synonym="Past2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..532
                     /gene="Ehd4"
                     /gene_synonym="Past2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..945
                     /gene="Ehd4"
                     /gene_synonym="Past2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1110
                     /gene="Ehd4"
                     /gene_synonym="Past2"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..3428
                     /gene="Ehd4"
                     /gene_synonym="Past2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaagttgt cgggcggcgg catgttcagc tggatggggc ggcaggcggg cgggcgcgag
       61 cgctcgggcg gtatggacgc ggtgcagacg gtgacgggag gcctgcgctc actctaccaa
      121 cgcaaggtgc tgccgctgga agaggcgtac cgcttccacg agttccactc gccagcgctg
      181 gaggacgccg acttcgaaaa caagcccatg atcctgctgg tgggccagta cagcacgggc
      241 aagaccactt tcatcagata cttactggag caagatttcc caggcatgag aattggtcca
      301 gagccaacca cagattcctt cattgctgtg atgtatgggg agaccgaggg aagtacccct
      361 gggaatgctt tagttgtgga tcccaaaaag ccattccgaa agctcagtcg ctttggaaat
      421 gctttcctga acagattcat gtgctcacag ctgcccaacc aggttctgaa gagcatcagc
      481 atcatcgaca gtcctggcat cctgtctggg gaaaagcagc gcattagccg agggtatgac
      541 ttctgccagg tcttacagtg gtttgccgag agggttgaca ggatcatcct gctctttgat
      601 gctcacaaat tggacatctc agatgagttc tcagaggcga tcaaagcctt ccggggccag
      661 gatgacaaaa tccgagtggt actgaacaag gctgaccaag tggacacaca gcagctgatg
      721 cgagtctatg gggccctcat gtggtctctg ggtaaggtca tcaacacacc cgaagtactt
      781 cgagtctaca ttggctcctt ttgggcacag cctctgcaga atacagacaa ccgccggctc
      841 tttgaggctg aagcacagga cctcttcaga gacatccaga gcctgcccca gaaggctgca
      901 gtgcgcaaac tcaatgacct catcaagcga gcaaggttgg ccaaagtcca cgcctacatc
      961 atcagctacc tgaagaagga aatgcccagt atgtttggaa aagaaaataa gaagcgagaa
     1021 cttatcttca gacttccaga aatctatgtt cagctgcagc gagaatacca gatttctgca
     1081 ggggacttcc ctgaggtcaa ggccatgcag gagcagcttg agaactatga cttcaccaag
     1141 ttccactcac tgaagcccaa gctgatcgag gctgtggaca acatgctgac caacaagatc
     1201 tcatccctga tgagcctcat tagccaggag gagatgaaca tgcccacgca aatggtgcag
     1261 ggtggtgcct tcgatggcac cacagagggg cccttcaacc agggctatgg ggagggagcc
     1321 aaggagggtg ctgatgagga agagtgggtc gtggctaaag acaagcctgt gtatgatgaa
     1381 ctcttttata cactgtcacc catcaatggc aagatatcag gtgtcaatgc caagaaggaa
     1441 atggtgacct ccaagctgcc caacagtgtc ctgggcaaga tctggaagct ggccgactgt
     1501 gactgcgatg gcatgctgga cgaagaggag tttgcactgg ccaagcacct catcaagatc
     1561 aagttggatg gctatgagct cccaaacagc ctgccccctc accttgtgcc cccctcgcac
     1621 aggaagtccc tgccaaaggc tgactgagag tacagagctg ggatgggagg ggtggtgcct
     1681 gggcctgaag tctgctctgc cactgacttg ctgaatgtcc ttggccaaga ttctgtcctc
     1741 tccgtgactc agtttcctca tatgtagggc agggagggca gattctggac actagataat
     1801 gtccttatac ctctaaagtc cctaagtttc tatcaaaata ttaagaagac aaaaaataaa
     1861 aaaaaattaa gaagagcaat atatagatat gaagataaag gtctaagaag aaaaagaaat
     1921 tatccaaaga atataggtgt gacacaggct ggcgaactct ggggactcag ggagtgagga
     1981 agctcattgg agtcttcagg gctgtgctgg acagttcatt accatgaacc tctgtccttc
     2041 acaggcactg agaggcggca aatgacctaa tttatttttc ttactgtgtt tcctgctcta
     2101 gctagagagg gaacagagca gagagcttct gctctccaca gactgacacc aaagagaaga
     2161 ctgatcccca ggtttgaaag aggatgtgcc atgtctgtgg gccatctgca gcccccagca
     2221 gagtaggcag ccaggccagg agagccagtg ttgtcccagc acctgctgcc tgatcctgcc
     2281 aagcctcccg ctcagcaaag tcggaattca caaactgtgg ccccctggaa gacctctaga
     2341 cctcaaatca cgctgaagcc cgggcactgc ctccttgcat ttcatccata ggttacagca
     2401 gagctaattt atcagacgta aggaaagaga cagttcctgt ctgtcactaa gtgtgccctt
     2461 tgaccactga atgtccccaa ggcttttggg taggtggtag aatttaaatt caataaagcc
     2521 atgtcttgat ttgtgtggag tcccagagcc tttggaccca agtaaagaga ccagccccat
     2581 cctgagccat caatggaaga gatcagtgtc ttggtattga tgctttggtt tgatttttaa
     2641 agaaaaaaat gcattttatt gtgtccagtt gtgtttttct cacacaatga agcctgtgca
     2701 gaaatctctc tgtaacacct tttcttccaa gctatacact tcacatcagg agtgcccatc
     2761 tggggccagg atcaggctgc ttctgactgc tcagtgttct ctcccaagcc cttgaatttc
     2821 tctgccccac ttattcaggc acaggggctg cttctactgt accctgctct gtggcacagc
     2881 tgaggagcac tgtcaccatc actgacaaag caggagtcac agcacagcag tgaccacatg
     2941 gcccagcccc aacagcacca gaaatgaatg aatgtgaacc ttcacaaaaa cactccaacc
     3001 cctaattgtt tgcctctggc aacctcaggg tcagaaccag tgacaagaga aaatgctaga
     3061 agctcacccc tgttatccca gcacttgaga ggcaaatgga gggggattac catgagttcg
     3121 aagccagcct gagctacatc cttagtgtta tggtagtctg tgtaaaacaa gagtacttac
     3181 gtcatcactc acgttcccta tcttactgtc taaataattg ctctaagaga aacatggtgc
     3241 cctttactct gaaagcatgt tcttactaat tggacacaca caggtgaaca tttgatcctg
     3301 gggctgtaac tgaatgtggg catttttgtg gtgtgaagac cctggtgtcc acagagtggt
     3361 gatgccttgg ggctgccttt cctcccaagt gtcttctgct ttctctgcac agttggcata
     3421 tatctacc
//
