LOCUS       NM_138890               2107 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus EH-domain containing 3 (Ehd3), mRNA.
ACCESSION   NM_138890
VERSION     NM_138890.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Curran,J., Musa,H., Kline,C.F., Makara,M.A., Little,S.C.,
            Higgins,J.D., Hund,T.J., Band,H. and Mohler,P.J.
  TITLE     Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type
            Ca2+ Channel Targeting and Function in the Atria
  JOURNAL   J Biol Chem 290 (19), 12210-12221 (2015)
   PUBMED   25825486
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Lu,Q., Insinna,C., Ott,C., Stauffer,J., Pintado,P.A., Rahajeng,J.,
            Baxa,U., Walia,V., Cuenca,A., Hwang,Y.S., Daar,I.O., Lopes,S.,
            Lippincott-Schwartz,J., Jackson,P.K., Caplan,S. and Westlake,C.J.
  TITLE     Early steps in primary cilium assembly require EHD1/EHD3-dependent
            ciliary vesicle formation
  JOURNAL   Nat Cell Biol 17 (3), 228-240 (2015)
   PUBMED   25686250
  REMARK    Erratum:[Nat Cell Biol. 2015 Apr;17(4):531. doi: 10.1038/ncb3155..
            PMID: 25812525]
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Kotowski,S.J., Hopf,F.W., Seif,T., Bonci,A. and von Zastrow,M.
  TITLE     Endocytosis promotes rapid dopaminergic signaling
  JOURNAL   Neuron 71 (2), 278-290 (2011)
   PUBMED   21791287
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 2107)
  AUTHORS   Gudmundsson,H., Hund,T.J., Wright,P.J., Kline,C.F., Snyder,J.S.,
            Qian,L., Koval,O.M., Cunha,S.R., George,M., Rainey,M.A.,
            Kashef,F.E., Dun,W., Boyden,P.A., Anderson,M.E., Band,H. and
            Mohler,P.J.
  TITLE     EH domain proteins regulate cardiac membrane protein targeting
  JOURNAL   Circ Res 107 (1), 84-95 (2010)
   PUBMED   20489164
REFERENCE   6  (bases 1 to 2107)
  AUTHORS   Patrakka,J., Xiao,Z., Nukui,M., Takemoto,M., He,L., Oddsson,A.,
            Perisic,L., Kaukinen,A., Szigyarto,C.A., Uhlen,M., Jalanko,H.,
            Betsholtz,C. and Tryggvason,K.
  TITLE     Expression and subcellular distribution of novel
            glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and
            2310066E14Rik
  JOURNAL   J Am Soc Nephrol 18 (3), 689-697 (2007)
   PUBMED   17251388
REFERENCE   7  (bases 1 to 2107)
  AUTHORS   George,M., Ying,G., Rainey,M.A., Solomon,A., Parikh,P.T., Gao,Q.,
            Band,V. and Band,H.
  TITLE     Shared as well as distinct roles of EHD proteins revealed by
            biochemical and functional comparisons in mammalian cells and C.
            elegans
  JOURNAL   BMC Cell Biol 8, 3 (2007)
   PUBMED   17233914
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2107)
  AUTHORS   Park,S.Y., Ha,B.G., Choi,G.H., Ryu,J., Kim,B., Jung,C.Y. and Lee,W.
  TITLE     EHD2 interacts with the insulin-responsive glucose transporter
            (GLUT4) in rat adipocytes and may participate in insulin-induced
            GLUT4 recruitment
  JOURNAL   Biochemistry 43 (23), 7552-7562 (2004)
   PUBMED   15182197
  REMARK    GeneRIF: EHD2 also interacted with the clathrin adaptor middle
            chain subunit micro(1), micro(2)
REFERENCE   9  (bases 1 to 2107)
  AUTHORS   Galperin,E., Benjamin,S., Rapaport,D., Rotem-Yehudar,R.,
            Tolchinsky,S. and Horowitz,M.
  TITLE     EHD3: a protein that resides in recycling tubular and vesicular
            membrane structures and interacts with EHD1
  JOURNAL   Traffic 3 (8), 575-589 (2002)
   PUBMED   12121420
REFERENCE   10 (bases 1 to 2107)
  AUTHORS   Rotem-Yehudar,R., Galperin,E. and Horowitz,M.
  TITLE     Association of insulin-like growth factor 1 receptor with EHD1 and
            SNAP29
  JOURNAL   J Biol Chem 276 (35), 33054-33060 (2001)
   PUBMED   11423532
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138890.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF494093.2, SRR26643429.22844.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               JAXUCZ010000006.1  27416824-27417445   c
            623-799             JAXUCZ010000006.1  27406168-27406344   c
            800-897             JAXUCZ010000006.1  27401633-27401730   c
            898-1310            JAXUCZ010000006.1  27394552-27394964   c
            1311-1475           JAXUCZ010000006.1  27393902-27394066   c
            1476-2107           JAXUCZ010000006.1  27392709-27393340   c
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2107
                     /gene="Ehd3"
                     /gene_synonym="Ehd2"
                     /note="EH-domain containing 3"
                     /db_xref="GeneID:192249"
                     /db_xref="RGD:621762"
     exon            1..622
                     /gene="Ehd3"
                     /gene_synonym="Ehd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..2003
                     /gene="Ehd3"
                     /gene_synonym="Ehd2"
                     /codon_start=1
                     /product="EH domain-containing protein 3"
                     /protein_id="NP_620245.2"
                     /db_xref="GeneID:192249"
                     /db_xref="RGD:621762"
                     /translation="MFSWLGNDDRRKKDPEVFQTVSEGLKKLYKTKLLPLEEYYRFHE
                     FHSPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQ
                     GDVEGIIPGNALVVDPKKPFRKLNAFGNAFLNRFVCAQLPNAVLESISVIDTPGILSG
                     EKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVL
                     NKADQIETQQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQ
                     DLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPSVFGKDTKKKELVNN
                     LAEIYGRIEREHQISPGDFPNLKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQ
                     LMVLVRQEETQRPVQMVKGGAFEGTLQGPFGHGYGEGAGEGIDDAEWVVARDKPMYDE
                     IFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDEEFALANHLI
                     KVKLEGHELPSELPAHLLPPSKRKVAE"
     exon            623..799
                     /gene="Ehd3"
                     /gene_synonym="Ehd2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..897
                     /gene="Ehd3"
                     /gene_synonym="Ehd2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1310
                     /gene="Ehd3"
                     /gene_synonym="Ehd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1475
                     /gene="Ehd3"
                     /gene_synonym="Ehd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..2107
                     /gene="Ehd3"
                     /gene_synonym="Ehd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctgcacgt ctagcattta aacgagcgcc gggggcggcg ggatgctgct gcggatgcgg
       61 agctgtgtgc gcctccacct actcccagca gcctggacac cgcagcagcg gggctccaga
      121 atcctttagc cacctaactg gggagaccca gaactcatgc ttcggcttcc cggcaggttc
      181 gtctttaatt tccaaggttg cagttctcct gacacgatcc gcagcatcct cttccccaac
      241 cccgctgtgg atgaagctgg ggctggactg gatccagcag ctggggcagc cccggccatg
      301 gtgtatctga gccccgagct ctggtaaggc agctgtggcg gcgtggttcg agctaggcgg
      361 gtgccactcc cgggagcctt cttccagctg ccacaatgtt cagctggctg ggtaacgatg
      421 atcgccgcaa gaaggaccct gaggtcttcc agaccgtgag cgaggggctc aagaaactct
      481 acaagaccaa gctgctgcct ctggaagagt attaccgctt ccacgagttc cactcgccgg
      541 ccttggagga tgctgatttc gacaacaagc ccatggtcct gttggtgggc caatactcta
      601 ctggcaagac caccttcatc aggtacctgc tggaacagga ttttccaggc atgaggattg
      661 ggcctgagcc aaccactgat tccttcatag cagtgatgca gggagatgtg gaggggatca
      721 tccctgggaa cgccctggtg gtggatccga agaaaccctt cagaaagctc aacgccttcg
      781 gcaatgcctt cttgaacagg tttgtgtgtg cgcagctgcc caacgctgtt ctagaaagta
      841 tcagtgtcat cgacacaccg gggatcctct ctggtgagaa acagaggatc agccgagggt
      901 atgattttgc tgctgtcctc gaatggtttg ctgagcgggt ggaccgaatc atcctgctct
      961 ttgacgccca caagcttgac atctctgatg agttctcaga agtcatcaag gccctcaaga
     1021 accacgagga caagatgcga gtggtgttga acaaggctga ccagattgag acccagcagc
     1081 tgatgcgggt gtatggggcc ctcatgtggt ccctggggaa gattgtgaac acaccagagg
     1141 tgatccgggt ctacattggc tccttctggt cccaccctct cctcattcct gacaacagga
     1201 agctctttga agctgaagag caagacttgt tcaaagacat tcagagtcta ccccgtaatg
     1261 ctgctcttcg aaagctcaat gatctcatca agagagcccg gctggccaag gtccatgcct
     1321 atatcatcag ctccctaaaa aaggagatgc cctcagtgtt tgggaaggac accaaaaaga
     1381 aagagctggt gaacaacctg gctgagatct atggccggat tgagcgagaa caccagatct
     1441 cccctgggga cttccccaac ctgaagagga tgcaggatca gctgcaggcc caggacttca
     1501 gcaaattcca accactgaag agcaagctgc tagaagtggt tgatgacatg ctggcccatg
     1561 acattgccca gctcatggtg ctggtacgcc aggaagagac ccagcggcct gttcagatgg
     1621 tgaagggcgg agcatttgag ggaaccctcc aagggccctt tgggcatggc tatggagagg
     1681 gagctgggga gggcattgat gatgccgagt gggtggtggc ccgggacaag cctatgtatg
     1741 atgaaatctt ctacacctta tccccggtgg atggcaagat tacgggcgcc aatgccaaaa
     1801 aggagatggt gcgctccaag ttgcccaaca gcgtcctggg gaagatctgg aagctagccg
     1861 acattgacaa ggatggcatg ttggatgatg aggagtttgc cctggccaac caccttatca
     1921 aagtcaagct agaggggcat gagctgccca gtgagctgcc tgcccatctc ctccctccat
     1981 ctaagaggaa agtagcggag tgagagagcc aggcagcttc agacagacag tgtcaaaaga
     2041 gaggatagac gtgatgacca cacacacaca cacacacaca cacacacaca cacacacaca
     2101 cacacac
//
