LOCUS       NM_001024897            2057 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus EH-domain containing 2 (Ehd2), mRNA.
ACCESSION   NM_001024897 XM_341794
VERSION     NM_001024897.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2057)
  AUTHORS   Yang,H.Q., Jana,K., Rindler,M.J. and Coetzee,W.A.
  TITLE     The trafficking protein, EHD2, positively regulates cardiac
            sarcolemmal KATP channel surface expression: role in
            cardioprotection
  JOURNAL   FASEB J 32 (3), 1613-1625 (2018)
   PUBMED   29133341
  REMARK    GeneRIF: EHD2 may be cardioprotective as a dominant-negative EHD2
            mutant sensitized cardiomyocytes to ischemic damage. Our findings
            highlight EHD2 as a potential pharmacologic target in the treatment
            of diseases with KATP channel trafficking defects
REFERENCE   2  (bases 1 to 2057)
  AUTHORS   Shah,C., Hegde,B.G., Moren,B., Behrmann,E., Mielke,T., Moenke,G.,
            Spahn,C.M.T., Lundmark,R., Daumke,O. and Langen,R.
  TITLE     Structural insights into membrane interaction and caveolar
            targeting of dynamin-like EHD2
  JOURNAL   Structure 22 (3), 409-420 (2014)
   PUBMED   24508342
REFERENCE   3  (bases 1 to 2057)
  AUTHORS   Ke,K., Rui,Y., Li,L., Zheng,H., Xu,W., Tan,X., Cao,J., Wu,X.,
            Cui,G. and Cao,M.
  TITLE     Upregulation of EHD2 after intracerebral hemorrhage in adult rats
  JOURNAL   J Mol Neurosci 54 (2), 171-180 (2014)
   PUBMED   24664435
  REMARK    GeneRIF: EHD2 expression was upregulated in the perihematomal
            caudate in adult rats after intracerebral hemorrhage.
REFERENCE   4  (bases 1 to 2057)
  AUTHORS   Ludwig,A., Howard,G., Mendoza-Topaz,C., Deerinck,T., Mackey,M.,
            Sandin,S., Ellisman,M.H. and Nichols,B.J.
  TITLE     Molecular composition and ultrastructure of the caveolar coat
            complex
  JOURNAL   PLoS Biol 11 (8), e1001640 (2013)
   PUBMED   24013648
REFERENCE   5  (bases 1 to 2057)
  AUTHORS   Posey,A.D. Jr., Pytel,P., Gardikiotes,K., Demonbreun,A.R.,
            Rainey,M., George,M., Band,H. and McNally,E.M.
  TITLE     Endocytic recycling proteins EHD1 and EHD2 interact with
            fer-1-like-5 (Fer1L5) and mediate myoblast fusion
  JOURNAL   J Biol Chem 286 (9), 7379-7388 (2011)
   PUBMED   21177873
REFERENCE   6  (bases 1 to 2057)
  AUTHORS   Guilherme,A., Soriano,N.A., Furcinitti,P.S. and Czech,M.P.
  TITLE     Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated
            GLUT4 recycling in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 279 (38), 40062-40075 (2004)
   PUBMED   15247266
REFERENCE   7  (bases 1 to 2057)
  AUTHORS   Park,S.Y., Ha,B.G., Choi,G.H., Ryu,J., Kim,B., Jung,C.Y. and Lee,W.
  TITLE     EHD2 interacts with the insulin-responsive glucose transporter
            (GLUT4) in rat adipocytes and may participate in insulin-induced
            GLUT4 recruitment
  JOURNAL   Biochemistry 43 (23), 7552-7562 (2004)
   PUBMED   15182197
REFERENCE   8  (bases 1 to 2057)
  AUTHORS   Guilherme,A., Soriano,N.A., Bose,S., Holik,J., Bose,A.,
            Pomerleau,D.P., Furcinitti,P., Leszyk,J., Corvera,S. and Czech,M.P.
  TITLE     EHD2 and the novel EH domain binding protein EHBP1 couple
            endocytosis to the actin cytoskeleton
  JOURNAL   J Biol Chem 279 (11), 10593-10605 (2004)
   PUBMED   14676205
REFERENCE   9  (bases 1 to 2057)
  AUTHORS   Rotem-Yehudar,R., Galperin,E. and Horowitz,M.
  TITLE     Association of insulin-like growth factor 1 receptor with EHD1 and
            SNAP29
  JOURNAL   J Biol Chem 276 (35), 33054-33060 (2001)
   PUBMED   11423532
REFERENCE   10 (bases 1 to 2057)
  AUTHORS   Suzuki,K., Olvera,J. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein L9
  JOURNAL   Gene 93 (2), 297-300 (1990)
   PUBMED   2227441
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097385.1.
            
            On Jun 17, 2005 this sequence version replaced XM_341794.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097385.1, SRR8487231.63233.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2057
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2057
                     /gene="Ehd2"
                     /gene_synonym="MGEPS"
                     /note="EH-domain containing 2"
                     /db_xref="GeneID:361512"
                     /db_xref="RGD:1560856"
     exon            1..27
                     /gene="Ehd2"
                     /gene_synonym="MGEPS"
                     /inference="alignment:Splign:2.1.0"
     exon            28..487
                     /gene="Ehd2"
                     /gene_synonym="MGEPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1715
                     /gene="Ehd2"
                     /gene_synonym="MGEPS"
                     /note="putative eps protein"
                     /codon_start=1
                     /product="EH domain-containing protein 2"
                     /protein_id="NP_001020068.1"
                     /db_xref="GeneID:361512"
                     /db_xref="RGD:1560856"
                     /translation="MFSWLKKGGARGQRSEAIRTVTSSLKELYRTKLLPLEEHYRFGS
                     FHSPALEDADFDGKPMVLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMH
                     GETEGTVPGNALVVDPEKPFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSG
                     AKQRVSRGYDFPAVLRWFAERVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVL
                     NKADMVETQQLMRVYGALMWALGKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQ
                     DLFRDIQGLPRHAALRKLNDLVKRARLVRVHAYIISYLKKEMPSVFGKENKKKQLIFK
                     LPVIFAKIQLEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDEMLTHDIAK
                     LMPLLRQEELESVEAGVQGGAFEGTRMGPFVERGPDEAIEDGEEGSEDDAEWVVTKDK
                     SKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFAL
                     ASHLIEAKLEGHGLPTNLPRRLVPPSKRRQKGSAE"
     exon            488..585
                     /gene="Ehd2"
                     /gene_synonym="MGEPS"
                     /inference="alignment:Splign:2.1.0"
     exon            586..998
                     /gene="Ehd2"
                     /gene_synonym="MGEPS"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1163
                     /gene="Ehd2"
                     /gene_synonym="MGEPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..2028
                     /gene="Ehd2"
                     /gene_synonym="MGEPS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgctctg cgctccccag atccctggtg agctctgcac ccagtagtct ctttgggtga
       61 cccagtgggc atcgaaagtc accatgttca gctggctgaa gaagggtggg gctcggggcc
      121 agcgatctga ggccatccgc accgtgacct cgtctctcaa ggagctgtat cgcacaaagc
      181 ttctgcccct ggaggaacac taccgtttcg ggtctttcca ttcaccagcc ctcgaagatg
      241 ctgacttcga tggtaaaccc atggtgctgg tggctggcca gtatagcacc ggcaaaacca
      301 gcttcatcca gtacctcctg gagcaggagg tccctggctc ccgcgtgggt cctgagccca
      361 ccaccgactg cttcgtggct gtcatgcacg gcgagacaga gggtaccgtg cctggaaatg
      421 ctctcgttgt ggacccagag aagcccttcc gcaaactcaa cccttttgga aacactttcc
      481 tcaacaggtt tatgtgtgcc caactcccca accaggtcct ggagagcatc agcatcatcg
      541 acacgcccgg catcctatca ggtgccaagc agagagtgag ccggggctac gacttcccag
      601 ctgtcttgcg ctggtttgct gagcgcgtgg acctcatcat cttgctcttt gacgcccaca
      661 agctggagat ttctgatgaa ttctcagagg ccattggtgc cttgcgtggc cacgaggaca
      721 agatccgcgt ggtactcaac aaggcagaca tggtggagac acagcagctg atgcgcgtct
      781 atggggcgct catgtgggcg ctgggcaagg tggtgggcac gcctgaagtc cttcgtgtct
      841 acatcggctc cttctggtcc cagccgctcc ttgtgccaga caaccggcgt ctcttcgagc
      901 tggaggaaca ggacctcttc cgtgatatcc aaggcctacc gcgccacgcg gcgctgcgga
      961 agctcaatga cctagtgaag cgggcgcggc tggtgcgggt gcacgcttac atcatcagct
     1021 acctgaagaa ggagatgccc tcggtgttcg gaaaggaaaa caaaaagaag cagctgatct
     1081 tcaagctgcc tgtcatcttc gccaagatcc agctagagca ccacatctcc ccaggagact
     1141 tccctgactg ccagaagatg caggagctgc tgatggcaca tgacttcacc aagttccact
     1201 ccctaaagcc gaagctgctg gaggcgctgg acgagatgct gacccacgac attgccaagc
     1261 ttatgccgct gcttcggcag gaggagctgg agagtgtcga ggctggcgtg cagggtggtg
     1321 cgtttgaggg cacccgcatg ggccccttcg tggagcgggg ccctgacgaa gcaatagaag
     1381 atggcgagga gggctcagaa gatgatgccg aatgggtggt gaccaaggac aagtccaaat
     1441 acgatgaaat cttctacaat ttagcgcctg ctgatggcaa gctgagtggc tctaaggcca
     1501 aaacctggat ggtgggcacc aagctaccca actccgtgct ggggcgaatc tggaagctga
     1561 gcgatgtcga ccgagatggc atgctggatg atgaggagtt cgccctggcc agccacctca
     1621 ttgaggctaa gctcgaaggc catgggctac ccaccaacct accccgccgc ctggtgccac
     1681 cttctaagcg acgacagaag ggctctgctg agtgagacag cagggactgc tggcccaccc
     1741 tcccactttg ccctgcggtg gctccccagc tccagtcagc tacacggcta cacgcggatc
     1801 cctgctctgg cccactgacc ctgcctaccc accctgtctg gctataagga cttgaggggg
     1861 aagcttctct cctacaccag acattcagtc aaggcactta tagaggacca ggtgggggag
     1921 tgacaaacct tctctgtctg tccttcacct tcacatacac aagggcttat cacagaaaca
     1981 cacacatcca tccagccatc attcatataa agactttttt ttcttttaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaa
//
