LOCUS       NM_001011939            3250 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus EH-domain containing 1 (Ehd1), mRNA.
ACCESSION   NM_001011939 XM_215154
VERSION     NM_001011939.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Martins-Marques,T., Catarino,S., Goncalves,A., Miranda-Silva,D.,
            Goncalves,L., Antunes,P., Coutinho,G., Leite Moreira,A., Falcao
            Pires,I. and Girao,H.
  TITLE     EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac
            Diseases
  JOURNAL   Circ Res 126 (10), e97-e113 (2020)
   PUBMED   32138615
  REMARK    GeneRIF: EHD1 Modulates Cx43 Gap Junction Remodeling Associated
            With Cardiac Diseases.
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Wu,C., Bao,G., Xu,G., Sun,Y., Wang,L., Chen,J., Zhang,J., Chen,C.,
            Zhu,Q. and Cui,Z.
  TITLE     Triad1 regulates the expression and distribution of EHD1
            contributing to the neurite outgrowth of neurons after spinal cord
            injury
  JOURNAL   J Cell Biochem 120 (4), 5355-5366 (2019)
   PUBMED   30320922
  REMARK    GeneRIF: Our data delineate a novel interaction between Triad1 and
            EHD1 that may contribute to the regulation of neurite outgrowth for
            neurons after the spinal cord injury.
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Wu,C., Cui,Z., Liu,Y., Zhang,J., Ding,W., Wang,S., Bao,G., Xu,G.,
            Sun,Y. and Chen,J.
  TITLE     The importance of EHD1 in neurite outgrowth contributing to the
            functional recovery after spinal cord injury
  JOURNAL   Int J Dev Neurosci 52, 24-32 (2016)
   PUBMED   27211346
  REMARK    GeneRIF: This study demonstrated that EHD1 was up-regulated in rat
            spinal cord injury model.
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Lu,Q., Insinna,C., Ott,C., Stauffer,J., Pintado,P.A., Rahajeng,J.,
            Baxa,U., Walia,V., Cuenca,A., Hwang,Y.S., Daar,I.O., Lopes,S.,
            Lippincott-Schwartz,J., Jackson,P.K., Caplan,S. and Westlake,C.J.
  TITLE     Early steps in primary cilium assembly require EHD1/EHD3-dependent
            ciliary vesicle formation
  JOURNAL   Nat Cell Biol 17 (3), 228-240 (2015)
   PUBMED   25686250
  REMARK    Erratum:[Nat Cell Biol. 2015 Apr;17(4):531. doi: 10.1038/ncb3155..
            PMID: 25812525]
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Guilherme,A., Soriano,N.A., Furcinitti,P.S. and Czech,M.P.
  TITLE     Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated
            GLUT4 recycling in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 279 (38), 40062-40075 (2004)
   PUBMED   15247266
REFERENCE   7  (bases 1 to 3250)
  AUTHORS   Naslavsky,N., Boehm,M., Backlund,P.S. Jr. and Caplan,S.
  TITLE     Rabenosyn-5 and EHD1 interact and sequentially regulate protein
            recycling to the plasma membrane
  JOURNAL   Mol Biol Cell 15 (5), 2410-2422 (2004)
   PUBMED   15020713
REFERENCE   8  (bases 1 to 3250)
  AUTHORS   Galperin,E., Benjamin,S., Rapaport,D., Rotem-Yehudar,R.,
            Tolchinsky,S. and Horowitz,M.
  TITLE     EHD3: a protein that resides in recycling tubular and vesicular
            membrane structures and interacts with EHD1
  JOURNAL   Traffic 3 (8), 575-589 (2002)
   PUBMED   12121420
REFERENCE   9  (bases 1 to 3250)
  AUTHORS   Rotem-Yehudar,R., Galperin,E. and Horowitz,M.
  TITLE     Association of insulin-like growth factor 1 receptor with EHD1 and
            SNAP29
  JOURNAL   J Biol Chem 276 (35), 33054-33060 (2001)
   PUBMED   11423532
REFERENCE   10 (bases 1 to 3250)
  AUTHORS   Lin,S.X., Grant,B., Hirsh,D. and Maxfield,F.R.
  TITLE     Rme-1 regulates the distribution and function of the endocytic
            recycling compartment in mammalian cells
  JOURNAL   Nat Cell Biol 3 (6), 567-572 (2001)
   PUBMED   11389441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV120970.1, BC082030.1, CO571196.1 and BQ192279.1.
            
            On Oct 22, 2008 this sequence version replaced NM_001011939.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160908.1, SRR8487230.65133.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                CV120970.1         1-46
            47-1982             BC082030.1         1-1936
            1983-2668           CO571196.1         13-698
            2669-3250           BQ192279.1         1-582               c
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3250
                     /gene="Ehd1"
                     /gene_synonym="RGD1306960"
                     /note="EH-domain containing 1"
                     /db_xref="GeneID:293692"
                     /db_xref="RGD:1309017"
     exon            1..477
                     /gene="Ehd1"
                     /gene_synonym="RGD1306960"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1678
                     /gene="Ehd1"
                     /gene_synonym="RGD1306960"
                     /codon_start=1
                     /product="EH domain-containing protein 1"
                     /protein_id="NP_001011939.1"
                     /db_xref="GeneID:293692"
                     /db_xref="RGD:1309017"
                     /translation="MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHE
                     FHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMH
                     GPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSG
                     EKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVL
                     NKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQ
                     DLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNN
                     LGEIYQKIEREHQISSGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIAR
                     LMVMVRQEESLMPSQAVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDE
                     IFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLI
                     KVKLEGHELPADLPPHLIPPSKRRHE"
     exon            478..575
                     /gene="Ehd1"
                     /gene_synonym="RGD1306960"
                     /inference="alignment:Splign:2.1.0"
     exon            576..988
                     /gene="Ehd1"
                     /gene_synonym="RGD1306960"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1153
                     /gene="Ehd1"
                     /gene_synonym="RGD1306960"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..3235
                     /gene="Ehd1"
                     /gene_synonym="RGD1306960"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctcggcc gcgcgctcca gtcccgctca gccgccgctc ggtcctgtag cagccagctc
       61 tgtctccggc agcatgttca gctgggtgag caaggatgcc cgccgcaaga aggagccgga
      121 gctcttccag acggtggccg aggggctgcg gcagctgtac gcgcagaagc tgctgccgct
      181 ggaggagcac tatcgcttcc acgagttcca ttcgccggct ctggaggacg ctgacttcga
      241 caacaaaccc atggtgctcc tggtcggcca gtacagcacc ggcaagacca ccttcatccg
      301 ccacttgatc gagcaggact tcccagggat gcgcatcggg ccggagccca ccaccgactc
      361 cttcatcgca gtcatgcatg gccccaccga gggcgtggtg cccggcaacg cgctcgtcgt
      421 ggacccgcgg cgccccttcc gcaagcttaa cgccttcggc aacgccttcc tcaacaggtt
      481 catgtgtgca cagctgccta acccagtatt ggacagcatt agcatcattg acactcctgg
      541 aatcctgtct ggagagaagc agcgcatcag ccgaggttat gactttgcgg ctgtccttga
      601 gtggttcgca gagcgtgtgg accgcatcat tctgctcttt gacgcccaca agctagacat
      661 ctcagatgaa ttttcagaag tcatcaaggc cctcaaaaat cacgaggaca agatccgtgt
      721 ggtgctgaac aaagctgacc aaattgagac acagcagctg atgcgagtgt acggagctct
      781 catgtggtcg ctggggaaga tcatcaacac ccctgaggtg gtccgtgtct acattggctc
      841 cttctggtca cacccactgc tcatccctga caaccggaag ctctttgagg cagaggagca
      901 ggacctcttc aaagacatcc agtctctacc aagaaatgct gcccttagga agctcaatga
      961 cttaatcaag cgggccaggc tggccaaggt ccatgcctac atcatcagct ccctcaagaa
     1021 ggagatgccc aatgtctttg ggaaagagag caagaagaaa gagctggtga acaacttggg
     1081 agagatctac cagaaaattg agcgggagca ccagatctcc tccggcgact tcccaagcct
     1141 gcgtaagatg caggaacttc tgcagacgca ggacttcagc aagttccagg ccttgaagcc
     1201 caagctgctg gatacggtgg atgatatgct ggccaacgat atagctcggc tgatggtgat
     1261 ggtgcgccag gaggagtccc tgatgccctc acaggctgtg aagggtggtg cttttgatgg
     1321 caccatgaat gggccctttg ggcatgggta tggcgagggg gctggcgagg gcattgatga
     1381 tgttgagtgg gtagttggca aggacaagcc cacctatgat gagatcttct acacactgtc
     1441 tcctgtcaat ggcaagatca cgggcgctaa tgccaagaag gagatggtga agtccaagct
     1501 gcctaacaca gtgctgggga agatctggaa gctggctgat gtggacaagg atggcctgct
     1561 agatgacgag gagtttgccc tggccaacca ccttatcaag gtcaagctag agggccatga
     1621 gctgcccgct gaccttcctc cacatctcat cccaccctcc aaacggaggc atgagtgact
     1681 tctgtgcctg agatacccca cacctccagg gctgctggca ctttctaccc gccagttctt
     1741 tgtctgccca ggtgggctgg ggcctggagg ggcagagatt gggggaggga aggggtcacc
     1801 atttttcaag gtccataaag actgagcggt gtttccttag ctcttgaata ggaaaaccac
     1861 catctttctt ttaaagctgt tctagggttc agaggggagg catgggtgat gcttggatgt
     1921 gaacagtggg attttgtgca caagaaccat gatattttta atatataacg ttagaggcag
     1981 ctgcctttct tgcctcttct gtctgacaca gccccacact cagcctctcc cctatcccag
     2041 ctaggcagga cagtgactct gggaaccacc tctccaaccc accctggcac ccccatgtct
     2101 gctgccccag ggctctgtaa gcaggaggcc tccagcccct ttggtttgtt ttcagactgg
     2161 ggcttcctta tggggcagcg gttatttcct actagctgtg ttctgcactt gggtaagctg
     2221 ctccagtcct ctgctgtggt ctggagtgca caccttcctt tttccatatc ccctgacacc
     2281 ccagccagca cagcatccac aggtagaaga cccaaccact gctaatgttg tggggactgg
     2341 aggagagaga ccgtgtcata tagggaaatg tataagctag tcagttcact gtaaagtgac
     2401 actttatact tgaccaaggt tttcagtagc ttttacatca cttattcaaa gctgtgattt
     2461 tttgtctcct cttgcctata ctccaggagc tccaccccag agccagcata gagcagacct
     2521 ccttgggctt gagtttgctt tctgtctgag gggaggtcgt cccagcttct gctcagaggg
     2581 gtccaaaatg taccccctaa agtcagtctt tatggcagct tcctggagcc ctctctgcct
     2641 tggggcaggc tgtgggccct gtgacctggg gatggtctgg ggctgctaag aggaagcctg
     2701 tgtctctggc ctgggttagt gtccatgctg caggataggg gaaaacccag ccccttccct
     2761 caccctgtca tttccttcct ctcctcctct gctgagccaa ggaggtctgg gtgtcctgag
     2821 agccccagac tgagcagtaa gaagccagag ctagcaagtg accactttag ccatcccaca
     2881 gtagcctggg agacctgacc acaccctctg gccagtggtt ggctgccagg gtgggcttta
     2941 tactgaggtg ggcagggaag tgcagcttgc tcatctggca ctacaggtgg gcttcaggga
     3001 gctgcctgcc atcccccagc actgtgctgg gccctgctga gggtgcgctc cagcctggcc
     3061 tgttaccttc tgcctcagcc ctccactcct ccattcctgt ccttggctga gggtgagtga
     3121 gatgtctttc tcacaggttc actgcttaaa gtccagcgag ctctgtcctc acctgtgggg
     3181 agagtggctg agtgaggact gtttcttgca ttaaagaaag tttaattgtg ccaaaaaaaa
     3241 aaaaaaaaaa
//
