LOCUS       NM_019137               2145 bp    mRNA    linear   ROD 19-MAR-2023
DEFINITION  Rattus norvegicus early growth response 4 (Egr4), mRNA.
ACCESSION   NM_019137
VERSION     NM_019137.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Niu RN, Shang XP and Teng JF.
  TITLE     Overexpression of Egr2 and Egr4 protects rat brains against
            ischemic stroke by downregulating JNK signaling pathway
  JOURNAL   Biochimie 149, 62-70 (2018)
   PUBMED   29580816
  REMARK    GeneRIF: pregulation of Egr2 and Egr4 could demote the activation
            of JNK/c-JUN pathway and the expression of pro-inflammatory
            cytokines in MCAO rats, so that Egr2 and Egr4 might be potential
            targets for ischemic stroke in future
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P,
            Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM,
            Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E,
            Kivioja T and Taipale J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Mengozzi M, Cervellini I, Villa P, Erbayraktar Z, Gokmen N, Yilmaz
            O, Erbayraktar S, Manohasandra M, Van Hummelen P, Vandenabeele P,
            Chernajovsky Y, Annenkov A and Ghezzi P.
  TITLE     Erythropoietin-induced changes in brain gene expression reveal
            induction of synaptic plasticity genes in experimental stroke
  JOURNAL   Proc Natl Acad Sci U S A 109 (24), 9617-9622 (2012)
   PUBMED   22645329
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J,
            Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz
            TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ and Jacob
            HJ.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Decker EL, Nehmann N, Kampen E, Eibel H, Zipfel PF and Skerka C.
  TITLE     Early growth response proteins (EGR) and nuclear factors of
            activated T cells (NFAT) form heterodimers and regulate
            proinflammatory cytokine gene expression
  JOURNAL   Nucleic Acids Res 31 (3), 911-921 (2003)
   PUBMED   12560487
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Crosby SD, Veile RA, Donis-Keller H, Baraban JM, Bhat RV, Simburger
            KS and Milbrandt J.
  TITLE     Neural-specific expression, genomic structure, and chromosomal
            localization of the gene encoding the zinc-finger transcription
            factor NGFI-C
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4739-4743 (1992)
   PUBMED   1584812
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6663. PMID:
            1631170]
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Crosby SD, Puetz JJ, Simburger KS, Fahrner TJ and Milbrandt J.
  TITLE     The early response gene NGFI-C encodes a zinc finger
            transcriptional activator and is a member of the GCGGGGGCG (GSG)
            element-binding protein family
  JOURNAL   Mol Cell Biol 11 (8), 3835-3841 (1991)
   PUBMED   2072895
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M92433.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_019137.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M65008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2145
                     /gene="Egr4"
                     /gene_synonym="Egr4l1; NGFI-C"
                     /note="early growth response 4"
                     /db_xref="GeneID:25129"
                     /db_xref="RGD:2546"
     exon            1..324
                     /gene="Egr4"
                     /gene_synonym="Egr4l1; NGFI-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1628
                     /gene="Egr4"
                     /gene_synonym="Egr4l1; NGFI-C"
                     /function="transcriptional regulator"
                     /note="EGR-4; early response protein NGFI-C; nerve growth
                     factor-induced protein C; zinc-finger transcription factor
                     NGFI-C (early response gene)"
                     /codon_start=1
                     /product="early growth response protein 4"
                     /protein_id="NP_062010.1"
                     /db_xref="GeneID:25129"
                     /db_xref="RGD:2546"
                     /translation="MLHLSDFSGPDALLSKPTEGCAHTSPELPRLPARDAPSAAAYPG
                     GDFLSWALSTCGAGGDLTDSCFLEGPAPTPPSGLSYSGSFFIQAVPEHPHDPEALFNL
                     MSGILGLAPFPSPEAAASRSPLDVPFPAGPDALLPDLYSPDLSSAAFPEAFWEAAPSA
                     GAPSQCLFEPQLSPPDVKPGLRAPPASPALDAAASAFKGPYAPWELLSAGAPGNCGSQ
                     GSFQTTPEARFSAVGTKVEDLLSISCPAELPGPASRLYPPGAYDAFSLAPGDLGEGTE
                     GLPALLTPPGGEGGSGGEGGEFLAVPQAQLSPLGLRGAATADFSKALVADLPGGSGVA
                     APSSPATSFPAAKARRKGRRGGKCSARCFCPRPHVKAFACPVESCVRTFARSDELNRH
                     LRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSK
                     VHLKQKARAEERLKGLGFYSLGLSFAAL"
     exon            325..2145
                     /gene="Egr4"
                     /gene_synonym="Egr4l1; NGFI-C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcccggttg cactttggag aaaccaggag ccgccgcccg aggcaggtgc gggcgagcca
       61 gggcgccgcg gccccccaac cctcgtcccc gagccaagcg ccgggagcct ggagctgggg
      121 cgcccggatt ccctgccagc cacgcgcgcc ccagcccagc gaggccccgg gcgccccgcc
      181 gccaccacgc catgctccac ctgagcgact tctccggccc cgacgcgctc ctctccaagc
      241 ccaccgaagg ctgcgcccac accagccccg agctgccccg gctgcctgct agggacgctc
      301 cctcggccgc cgcgtatcct ggaggcgact tcttgagctg ggctctgagc acctgcggcg
      361 ccggggggga cttaacagac tcctgcttcc tggagggccc tgcacccacg cccccttcgg
      421 gcctcagcta cagcggcagc ttcttcatcc aggcggttcc cgaacacccg cacgacccgg
      481 aggccctctt caacctcatg tctggcatct tgggcttggc acccttccct agccccgagg
      541 cggcagcgtc tcggtccccc ctggatgtcc ctttccccgc gggtcccgat gccttgttgc
      601 cggaccttta ctccccggat ctgagttcgg ccgccttccc ggaggcgttt tgggaggccg
      661 cgccttcggc gggcgctccc tcgcagtgcc tgttcgagcc ccagctctcc ccgcccgacg
      721 tcaagcccgg gctgagggcg cctcccgctt cgccagcgct ggacgctgct gcttcggcct
      781 tcaaagggcc ctacgccccc tgggagctgc tgtcggccgg ggctccgggg aactgtgggt
      841 cgcagggaag cttccagacc accccggagg cacgcttttc cgccgtgggg accaaggtcg
      901 aggacctgct gtccatcagc tgccccgccg agctgcccgg tccggctagc agactctacc
      961 cgccaggggc ctacgatgcc ttctcgctgg ccccaggtga cttaggggag gggaccgagg
     1021 gcctcccggc gctgctgacc cctccgggcg gggagggagg gagcggcggc gaaggcggag
     1081 agttcctggc cgtccctcaa gcgcagctgt ccccgctggg cctgcgcggc gccgccacgg
     1141 cagacttctc caaagccctg gtggccgacc tcccgggggg cagcggagtg gcggcgcctt
     1201 catcccccgc cacctccttc cccgcggcca aagcccggcg caagggacgc cggggcggca
     1261 agtgcagcgc gcgctgcttc tgcccgcggc cgcacgtcaa ggccttcgcc tgccccgtgg
     1321 agagctgcgt gcggacgttc gcgcgctccg acgagctcaa ccgccacctg cgcatccaca
     1381 cgggccacaa gcccttccag tgccgcatct gcctgcgcaa cttcagccgc agcgaccacc
     1441 tcaccacgca cgtgcgcacc cacaccggcg agaagccctt cgcctgcgac gtgtgcggcc
     1501 gccgcttcgc gcgcagcgac gagaagaagc gacacagcaa ggtgcacctc aagcagaagg
     1561 cgcgcgccga ggagcgcctc aagggcctgg gcttctactc gctgggcctc tctttcgccg
     1621 cgctgtagcc ggagctggct ccgtaggtcg gcgccgccgg ccgtcggcgc acgcgacacg
     1681 gtcctgccgc tccctcgtcc ctgctgcctt ccctgcctct tccacgcacg tccggggcca
     1741 cccgcagccc agctccagtt cccccgaagc gcccgccgct cacgcccttc agcacgggct
     1801 ccgcggacag cgcccgctgt tttcggagcc gccttcctct agccacccgc tctggggact
     1861 gtcctctcgg tccacccaca gagcaggcga taccttagga ctgaagagag tttttgtaac
     1921 tggcgtacgc cccacgcctt cctctttatc ccttcccaga gtcaagctgg ggatgtaccg
     1981 agccggtctc tcaagaactt tgtacagcaa gtccagcaag cctttggatg tgatgtcttt
     2041 gctttggggt tatttccttt ttgttgtcgt tcattttttg taaagcagac gctactctca
     2101 agcatttgac aaaactgttt atttttgcaa ttaaaattat tgtgc
//
