LOCUS       NM_017086               3939 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus early growth response 3 (Egr3), mRNA.
ACCESSION   NM_017086
VERSION     NM_017086.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3939)
  AUTHORS   Mitra,S., Thomas,S.A., Martin,J.A., Williams,J., Woodhouse,K.,
            Chandra,R., Li,J.X., Lobo,M.K., Sim,F.J. and Dietz,D.M.
  TITLE     EGR3 regulates opioid-related nociception and motivation in male
            rats
  JOURNAL   Psychopharmacology (Berl) 239 (11), 3539-3550 (2022)
   PUBMED   36098762
  REMARK    GeneRIF: EGR3 regulates opioid-related nociception and motivation
            in male rats.
REFERENCE   2  (bases 1 to 3939)
  AUTHORS   Gao,W., Li,G., Han,X., Song,Z., Zhao,S., Sun,F., Ma,H., Cui,A.,
            Wang,Y., Liu,X., Chen,Y., Zhang,L., Ma,G. and Tang,X.
  TITLE     Regional brain network and behavioral alterations in EGR3 gene
            transfected rat model of schizophrenia
  JOURNAL   Brain Imaging Behav 15 (5), 2606-2615 (2021)
   PUBMED   33723811
  REMARK    GeneRIF: Regional brain network and behavioral alterations in EGR3
            gene transfected rat model of schizophrenia.
REFERENCE   3  (bases 1 to 3939)
  AUTHORS   Engeln,M., Mitra,S., Chandra,R., Gyawali,U., Fox,M.E., Dietz,D.M.
            and Lobo,M.K.
  TITLE     Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny
            Neurons Following Long-Term Abstinence From Cocaine
            Self-administration
  JOURNAL   Biol Psychiatry 87 (11), 992-1000 (2020)
   PUBMED   31858986
  REMARK    GeneRIF: Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium
            Spiny Neurons Following Long-Term Abstinence From Cocaine
            Self-administration.
REFERENCE   4  (bases 1 to 3939)
  AUTHORS   Lopez-Lopez,D., Gomez-Nieto,R., Herrero-Turrion,M.J.,
            Garcia-Cairasco,N., Sanchez-Benito,D., Ludena,M.D. and Lopez,D.E.
  TITLE     Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in
            two strains of rodents susceptible to audiogenic seizures
  JOURNAL   Epilepsy Behav 71 (Pt B), 226-237 (2017)
   PUBMED   26775236
  REMARK    GeneRIF: Overexpression of EGR3 gene in an animal model of
            audiogenic seizures contributes to neuronal viability.
REFERENCE   5  (bases 1 to 3939)
  AUTHORS   Song,T., Nie,B., Ma,E., Che,J., Sun,S., Wang,Y., Shan,B., Liu,Y.,
            Luo,S., Ma,G. and Li,K.
  TITLE     Functional magnetic resonance imaging reveals abnormal brain
            connectivity in EGR3 gene transfected rat model of schizophrenia
  JOURNAL   Biochem Biophys Res Commun 460 (3), 678-683 (2015)
   PUBMED   25817788
  REMARK    GeneRIF: successfully created a rat model of schizophrenia by the
            transfection of EGR3 gene into rat brain. We then investigated the
            connectivity density of schizophrenia susceptible regions in rat
            brain using functional magnetic resonance imaging
REFERENCE   6  (bases 1 to 3939)
  AUTHORS   Roberts,D.S., Raol,Y.H., Bandyopadhyay,S., Lund,I.V., Budreck,E.C.,
            Passini,M.A., Wolfe,J.H., Brooks-Kayal,A.R. and Russek,S.J.
  TITLE     Egr3 stimulation of GABRA4 promoter activity as a mechanism for
            seizure-induced up-regulation of GABA(A) receptor alpha4 subunit
            expression
  JOURNAL   Proc Natl Acad Sci U S A 102 (33), 11894-11899 (2005)
   PUBMED   16091474
  REMARK    GeneRIF: Egr3 as a major regulator of gamma-aminobutyric acid
            (GABA-A) receptor, subunit alpha 4 in developing neurons and in
            epilepsy
            Erratum:[Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13351.
            Passini, MJ [corrected to Passini, MA]]
REFERENCE   7  (bases 1 to 3939)
  AUTHORS   Whitehead,J., Keller-Peck,C., Kucera,J. and Tourtellotte,W.G.
  TITLE     Glial cell-line derived neurotrophic factor-dependent fusimotor
            neuron survival during development
  JOURNAL   Mech Dev 122 (1), 27-41 (2005)
   PUBMED   15582775
REFERENCE   8  (bases 1 to 3939)
  AUTHORS   Droin,N.M., Pinkoski,M.J., Dejardin,E. and Green,D.R.
  TITLE     Egr family members regulate nonlymphoid expression of Fas ligand,
            TRAIL, and tumor necrosis factor during immune responses
  JOURNAL   Mol Cell Biol 23 (21), 7638-7647 (2003)
   PUBMED   14560009
REFERENCE   9  (bases 1 to 3939)
  AUTHORS   Chen,H.H., Tourtellotte,W.G. and Frank,E.
  TITLE     Muscle spindle-derived neurotrophin 3 regulates synaptic
            connectivity between muscle sensory and motor neurons
  JOURNAL   J Neurosci 22 (9), 3512-3519 (2002)
   PUBMED   11978828
REFERENCE   10 (bases 1 to 3939)
  AUTHORS   Yamagata,K., Kaufmann,W.E., Lanahan,A., Papapavlou,M., Barnes,C.A.,
            Andreasson,K.I. and Worley,P.F.
  TITLE     Egr3/Pilot, a zinc finger transcription factor, is rapidly
            regulated by activity in brain neurons and colocalizes with
            Egr1/zif268
  JOURNAL   Learn Mem 1 (2), 140-152 (1994)
   PUBMED   10467592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000272.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_017086.3.
            
            On Sep 13, 2022 this sequence version replaced NM_017086.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U12428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               JACYVU010000272.1  1633916-1634197
            283-3939            JACYVU010000272.1  1635491-1639147
FEATURES             Location/Qualifiers
     source          1..3939
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..3939
                     /gene="Egr3"
                     /gene_synonym="EGR-3"
                     /note="early growth response 3"
                     /db_xref="GeneID:25148"
                     /db_xref="RGD:2545"
     exon            1..282
                     /gene="Egr3"
                     /gene_synonym="EGR-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1292
                     /gene="Egr3"
                     /gene_synonym="EGR-3"
                     /codon_start=1
                     /product="early growth response protein 3"
                     /protein_id="NP_058782.1"
                     /db_xref="GeneID:25148"
                     /db_xref="RGD:2545"
                     /translation="MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVA
                     HYTQMATENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNI
                     ISLMSAGILGVPPASGALSTQTTTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSF
                     HDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPI
                     RVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHA
                     CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFA
                     CEFCGRKFARSDERKRHAKIHLKQKEKKSEKGGAPSASSAPTVSLAPVVTTCA"
     exon            283..3939
                     /gene="Egr3"
                     /gene_synonym="EGR-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctctcgca tgcttttccc ctgcaccacg gatcgcctct cggatgccgc tagcctggaa
       61 gctgcgttag gaacaggcgg cggcggtggc ggcggcggcg gcggtggcgg ctgtagctcg
      121 ggagtgctat gaccggcaaa ctcgccgaga agctgccggt gaccatgagc agtttgctaa
      181 atcaattgcc tgacaatctg taccccgagg agatccccag cgcgctcaac ctcttctccg
      241 gcagcagtga ctcggtagcc cattacactc agatggctac agagaatgtg atggacatcg
      301 gtctgaccaa cgagaagccc aatccggaac tctcttattc gggctctttc cagccagccc
      361 caggcaacaa gaccgtgacc tacttgggaa agttcgcttt cgactctcct tccaactggt
      421 gccaggacaa catcattagc ctcatgagtg ccggcatctt gggggtgccc ccggcctcag
      481 gggcgctcag tacgcagacg accacggcta gcatggtgca gcctcctcag ggagacgtgg
      541 aggccatgta tccggcgctg cccccctatt ccaactgcgg cgacctctac tcggagccgg
      601 tgtctttcca cgacccccag gggaacccag ggctcgccta ttccccccag gattaccaat
      661 cggccaagcc ggccttggac agcaatcttt tccccatgat tcctgactac aacctgtatc
      721 accaccccaa cgacatgggc tccattccag aacacaagcc cttccagggc atggacccca
      781 ttcgggtcaa cccaccccct attacccctc tggagaccat caaggccttc aaagacaagc
      841 agatccaccc gggcttcggc agcttgcccc aaccgccgct tactctcaag cccatccggc
      901 cccgcaagta ccccaatcgg cctagcaaga ccccactcca cgagcggccc cacgcgtgtc
      961 ccgcggaagg ctgtgaccgg cgtttcagcc gctcggacga gctgacccgg cacctgcgca
     1021 tccacacggg ccacaagccc ttccagtgtc ggatctgcat gcgcagcttc agccgcagcg
     1081 accacctcac tactcacatc cgcacgcaca ccggggagaa gccctttgcc tgtgagttct
     1141 gtgggcgcaa gtttgcgcgc agcgacgagc gcaagcgcca cgccaagatc cacctcaagc
     1201 aaaaggagaa gaagtcggag aaagggggtg cgccctctgc atcctcggcg cccaccgtgt
     1261 ccctggcccc tgtggtcacc acctgcgcct gaggatccgc ctctcagatc ccttcttttc
     1321 ccttccagtg cctcctggct ggtcgcctga aagcagcggg aaaagccagt caccgaggcg
     1381 caggggccgc gccctgatct cgccctggac gtgcggcccc cttgcctcct cttcgacgcc
     1441 ccctatttcc accctttcac accggccggc ggttgggggc tagggctaga ggcactttct
     1501 ccttgctgcc ccctcttaac caaggcgtgg gggtagaaag gtggcgtcta gcccgctttg
     1561 ttcagttagg atcgccttga tccaggggcc gctgggccac gccaaggacc tgcgggggac
     1621 tgaaggcggg gcccatgcaa ccttcgccag acccaagcac ctcactgttt ccccctccag
     1681 tgtctccctg tgttccccct cgaacacccg agagggggag ggggtaagga gcgcaccaaa
     1741 gcgcagagct tgctgcccgc cgcacgcacg cgcgcttgcg tgcggtgatg cgcgcgagtg
     1801 tgtgcgtgct cgcctgtgtg tagtgtgcgt gtgtatgtgt gtgagtgtgt tgtgtgcgcg
     1861 cgcacacgtg tgtgtgagac tcttgagctg aactgggctg tgtctactcc taaactcttc
     1921 ttcacagaag gtccccaagc ctttgggaga tgtcccaagc taaggaccag caagtgaccg
     1981 gaggagatgg tcttccatct gctccttaat gtttcttaca gaaatgcctc ggatgcagct
     2041 actgctgcat cgggtttgac cccgtagaac cccctccctt tccgagcgct tccctcttag
     2101 gcctcggggc agtttgatct ttgggggagt aagagccacc ttttttttaa aaaaagaaat
     2161 catttgctca gccccacttt tcaaaacctg tgttctcaag cttgccctct gcctctgcct
     2221 cccccacccc accccgcgcg agccccatct tctccttttc cctctcaggt tcgcactgcg
     2281 tctctcaaca tctttaccca gaaggcaggc ctcaaccacc caagtgtttg tctctgttac
     2341 atacccattc cccattactg ggaaggctgg ctctattcat ttgccctctg tgatcaccaa
     2401 cacaacagaa gcgaagtgta tgtatatgat gttggcgtgt gtatgtagat gtatgtgtgt
     2461 gtttctttat acacatatgt ttacataaca tgcactctgt attcctagca aaatcaaatc
     2521 taaggcattt ggttatccag tgcagtgcac tggaataaag agaatttgta ggcatataca
     2581 gcttaaatga tttattttta tgaaaaggta aactgatgag attattatct acctgtgtgt
     2641 gtggatatat gttgcacacg tgtatatata tgcatacaca ttctgtcaaa ttttcctcaa
     2701 aactagatgg ggacttttgc attaatctgt gttgctgaat gaagcacatc tgtttcatgg
     2761 ccccatcgca cctccccacc ctacctcacc tcttctcagg agccctctac cccagctgtc
     2821 ctgcccagcc cttcctcaca cagggtggcc cttttgacgt ggagacttag agaagggtgc
     2881 tccttgacac agcttccagc acggtcttga ttgaatgtac tgttcctatt agcgtccttt
     2941 ctcccgtggc cagtaagctg cccaaagaga agggacaaag gtctggagtt tacagaatgt
     3001 ctgtttttaa agtcacttta tgcgtttccc actttttttt ttaattaaaa aagcaccgtc
     3061 ttttggtggt ggataaataa tactaaacgg actacagtgc aagggaggaa agactcgaag
     3121 agcggggatt gtggggatcc tggggggatt gtgggggatt gtgagtttcc aggtactcgg
     3181 gctttttgta gaaggagaag tttgctagga gggcccatat tttttcagct gaagggtaaa
     3241 atctttcttt gcagagacag tattttgctg aatacttttt ataatgtgat gattatttaa
     3301 aaatacacaa tttggtcagt tcaaagctgg aaggaggaat caaatatcct ttaatatttt
     3361 tttcttcctc cttctggagt atgcatggca ctgcatggta actctgactt tttcctttgt
     3421 tttaataaaa ctgttctcag acatttaagc taaactaaga gaaaaaaaaa actttgttgc
     3481 caaaaggttg tgctatccca attttttata tgtctgcatg tttgaaaaca caaaaaaaaa
     3541 aaaaaaaaaa caaaagaaaa tgcactctaa cttatgtgaa ctgagagaaa aaaaatcagg
     3601 ttttaaaaag gaaaaaccca tggggaatga tattttttga aagacttttg tatacagttg
     3661 agtacttaga aaaagacgaa ccagatgtaa tatattttgt ggatgttttt atttcttgga
     3721 tttatagtac cttatactaa ggttaaaaaa atgcttgata ttgtgaaaag gtgagattct
     3781 tcaccaacat ttcatttact tcttgtcaca ttgttatgcc aatataatat agttaatgaa
     3841 aacagcattt ttaaaagcaa ttattgaaac ggtgtaatgt tgtaccattt gccctgtgag
     3901 caaatgcgaa tacagtaaat atattgtgtt tgctgacaa
//
