LOCUS       NM_053633               2963 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus early growth response 2 (Egr2), mRNA.
ACCESSION   NM_053633
VERSION     NM_053633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2963)
  AUTHORS   Han,S.H., Kim,Y.H., Park,S.J., Cho,J.G., Shin,Y.K., Hong,Y.B.,
            Yun,J., Han,J.Y., Park,H.T. and Park,J.I.
  TITLE     COUP-TFII plays a role in cAMP-induced Schwann cell differentiation
            and in vitro myelination by up-regulating Krox20
  JOURNAL   J Neurochem 165 (5), 660-681 (2023)
   PUBMED   36648143
  REMARK    GeneRIF: COUP-TFII plays a role in cAMP-induced Schwann cell
            differentiation and in vitro myelination by up-regulating Krox20.
REFERENCE   2  (bases 1 to 2963)
  AUTHORS   Grosz,B.R., Golovchenko,N.B., Ellis,M., Kumar,K., Nicholson,G.A.,
            Antonellis,A. and Kennerson,M.L.
  TITLE     A de novo EGR2 variant, c.1232A > G p.Asp411Gly, causes severe
            early-onset Charcot-Marie-Tooth Neuropathy Type 3 (Dejerine-Sottas
            Neuropathy)
  JOURNAL   Sci Rep 9 (1), 19336 (2019)
   PUBMED   31852952
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2963)
  AUTHORS   Niu,R.N., Shang,X.P. and Teng,J.F.
  TITLE     Overexpression of Egr2 and Egr4 protects rat brains against
            ischemic stroke by downregulating JNK signaling pathway
  JOURNAL   Biochimie 149, 62-70 (2018)
   PUBMED   29580816
  REMARK    GeneRIF: pregulation of Egr2 and Egr4 could demote the activation
            of JNK/c-JUN pathway and the expression of pro-inflammatory
            cytokines in MCAO rats, so that Egr2 and Egr4 might be potential
            targets for ischemic stroke in future
REFERENCE   4  (bases 1 to 2963)
  AUTHORS   Jin,H., Won,M., Shin,E., Kim,H.M., Lee,K. and Bae,J.
  TITLE     EGR2 is a gonadotropin-induced survival factor that controls the
            expression of IER3 in ovarian granulosa cells
  JOURNAL   Biochem Biophys Res Commun 482 (4), 877-882 (2017)
   PUBMED   27890615
  REMARK    GeneRIF: Analysis of consensus EGR-binding elements (EBEs) showed
            that the immediate early response 3 gene (IER3) is a novel
            transcriptional target gene of EGR2 as confirmed by the luciferase
            assay, electrophoretic mobility-shift assay (EMSA), chromatin
            immunoprecipitation (ChIP), and western blot analysis.
REFERENCE   5  (bases 1 to 2963)
  AUTHORS   Reddy,M.A., Das,S., Zhuo,C., Jin,W., Wang,M., Lanting,L. and
            Natarajan,R.
  TITLE     Regulation of Vascular Smooth Muscle Cell Dysfunction Under
            Diabetic Conditions by miR-504
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (5), 864-873 (2016)
   PUBMED   26941017
REFERENCE   6  (bases 1 to 2963)
  AUTHORS   Inokuchi,K., Murayama,A. and Ozawa,F.
  TITLE     mRNA differential display reveals Krox-20 as a neural
            plasticity-regulated gene in the rat hippocampus
  JOURNAL   Biochem Biophys Res Commun 221 (2), 430-436 (1996)
   PUBMED   8619872
REFERENCE   7  (bases 1 to 2963)
  AUTHORS   Levi,G., Topilko,P., Schneider-Maunoury,S., Lasagna,M., Mantero,S.,
            Cancedda,R. and Charnay,P.
  TITLE     Defective bone formation in Krox-20 mutant mice
  JOURNAL   Development 122 (1), 113-120 (1996)
   PUBMED   8565822
REFERENCE   8  (bases 1 to 2963)
  AUTHORS   Topilko,P., Schneider-Maunoury,S., Levi,G., Baron-Van
            Evercooren,A., Chennoufi,A.B., Seitanidou,T., Babinet,C. and
            Charnay,P.
  TITLE     Krox-20 controls myelination in the peripheral nervous system
  JOURNAL   Nature 371 (6500), 796-799 (1994)
   PUBMED   7935840
REFERENCE   9  (bases 1 to 2963)
  AUTHORS   Schneider-Maunoury,S., Topilko,P., Seitandou,T., Levi,G.,
            Cohen-Tannoudji,M., Pournin,S., Babinet,C. and Charnay,P.
  TITLE     Disruption of Krox-20 results in alteration of rhombomeres 3 and 5
            in the developing hindbrain
  JOURNAL   Cell 75 (6), 1199-1214 (1993)
   PUBMED   7903221
REFERENCE   10 (bases 1 to 2963)
  AUTHORS   Sham,M.H., Vesque,C., Nonchev,S., Marshall,H., Frain,M.,
            Gupta,R.D., Whiting,J., Wilkinson,D., Charnay,P. and Krumlauf,R.
  TITLE     The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during
            hindbrain segmentation
  JOURNAL   Cell 72 (2), 183-196 (1993)
   PUBMED   8093858
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053633.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032420.1, U78102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               JAXUCZ010000020.1  21053931-21054441   c
            512-2963            JAXUCZ010000020.1  21050149-21052600   c
FEATURES             Location/Qualifiers
     source          1..2963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..2963
                     /gene="Egr2"
                     /gene_synonym="Krox20"
                     /note="early growth response 2"
                     /db_xref="GeneID:114090"
                     /db_xref="RGD:621608"
     exon            1..511
                     /gene="Egr2"
                     /gene_synonym="Krox20"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1755
                     /gene="Egr2"
                     /gene_synonym="Krox20"
                     /note="early growth response protein 2; EGR-2; zinc finger
                     protein Krox-20; E3 SUMO-protein transferase ERG2"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase EGR2"
                     /protein_id="NP_446085.1"
                     /db_xref="GeneID:114090"
                     /db_xref="RGD:621608"
                     /translation="MMTAKAVDKIPVTLSGFMHQLPDSLYPVEDLAAPSVTIFPNGEL
                     GGPFDQMNGVAGDGMINIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMGKFSIDPQY
                     PGASCYPEGIINIVSAGILQGVTPPASTTASSSVTSASPNPLATGPLGVCTMSQTQPE
                     LDHLYSPPPPPPPYSGCTGDLYQDPSAFLSPPPTTSTSSLAYQPPPSYPSPKPAMDPG
                     LIPMIPDYPGFFPSPCQRDPHGAAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGP
                     SAGVTGPGASGGGEGPRLPGSGSAAVTATPYNPHHLPLRPILRPRKYPNRPSKTPVHE
                     RPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGE
                     KPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSSSASAQSSASGPGGSQAGGSL
                     CGNSAIGGPLASCTSRTRTP"
     exon            512..2963
                     /gene="Egr2"
                     /gene_synonym="Krox20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgattcatt aattgctggg cgaggggaca cactgactgt tataataaca ctacatcagc
       61 aactcctggc tccccaacag ccggatccca ggcaggagag agtcagtggc agatagccat
      121 ttttttttct tccttaagaa gccaacaact tggttgctag ttttatttct gttagaattt
      181 tttttttgtg tgtgtgtgga tgtgtggtgg tggtggtctt ttctaagtgt ggagggcaaa
      241 aggagatacc atcccaggct cagtccaacc cctctccaaa aacggcttct ctggcactcc
      301 aggtagcgag ggagttgggt ctccaggttg tgcgaggagc aaatgatgac cgccaaggcc
      361 gtagacaaaa tcccagtaac tctcagtggt tttatgcacc agctgcctga cagcctctac
      421 ccggtggaag acctcgccgc cccgtcggtg accatcttcc ccaatggtga actgggaggc
      481 ccctttgatc agatgaacgg agtggctgga gatggcatga tcaacattga catgaccgga
      541 gagaagaggc ccttggatct cccatatccg agtagcttcg ctcccatctc tgcgcctaga
      601 aaccagacct tcacttacat gggcaaattc tccattgacc ctcagtaccc tggtgccagc
      661 tgctacccag aaggcatcat caatattgtg agtgcgggca tcttgcaagg ggtcacccct
      721 ccagcttcaa ccacagcctc ttccagcgtc acctctgcct cccccaaccc actggccacg
      781 ggacccctgg gtgtgtgtac catgtcccag actcagcctg aactggacca cctctactct
      841 ccaccaccac ctcctcctcc ttattcgggc tgtacaggag acctctacca ggatccttca
      901 gcattcttat cgccgccacc caccacttcc acctcctctc tggcctacca gccacctcct
      961 tcctacccat cccccaagcc ggctatggac ccaggtctca ttcctatgat cccagactat
     1021 cctggatttt ttccatctcc gtgccagaga gatccacatg gcgcggctgg ccctgatcga
     1081 aagccgttcc cctgccctct ggactccctg cgggtccccc ctccgctcac gccactctcc
     1141 accatccgta attttactct tggggggccc agtgctggcg tcacgggacc aggggcaagt
     1201 ggaggcggtg agggtccccg actgcctggc agtgggtctg cagcagtgac tgctaccccc
     1261 tacaatccgc accacctgcc tttaaggccc atcctgagac ctcgaaagta ccccaacagg
     1321 cccagcaaga cgccagtgca cgaaaggccg tacccctgcc cagcagaggg ttgcgacagg
     1381 aggttctcac gctctgatga gctgaccagg cacatccgaa tccacaccgg tcacaagccc
     1441 ttccagtgtc ggatctgcat gcgaaacttc agccgaagtg accacctcac cactcacatc
     1501 cgcacccaca ccggggagaa gccctttgcc tgtgactatt gtggccgtaa gtttgcccgg
     1561 agtgacgaaa ggaagcgcca caccaagatc caccttcgcc agaaggagag gaagagcagt
     1621 gccccctcgt catctgcatc cgcccagtct tcagcctctg gtcctggggg ctcgcaggcc
     1681 gggggcagcc tgtgcggtaa cagcgccatt ggaggaccac tggcctcctg cacctctcgg
     1741 accaggaccc cgtgagatga agctccagct gacacaccag tttcttcagg ccccagaggc
     1801 cctctatcca ctcgagctgc aaacactacc gcccttctgt gttcttcccc gtgatcccgt
     1861 gaacctgtga tcctgggcaa aggaccctaa tggagcccag ctctgtccca ccttctcaca
     1921 gacggccttc tgaaaactta ggccatttta aaggagttga ctgtcactcc aagaaatggg
     1981 gagccagaag agggctgggc gagggcccct ggcctacagg gctgtgctct aaccctgaca
     2041 gagagatgtt tgactatggt ctgcgagccc ttccctttga ccctcgatgc cagttgctct
     2101 gagacttttt ctacaatagg ttgggagttg ttgattcctt tgagcaagga cagcgaaaaa
     2161 gactaaatta aagcaaaacc gatgtggcac tttaatggct tgggacggac ttggggtagg
     2221 ggtggggggt tgtacagtga gcacagttta gccctggcct ggccgcagca ctctgtggcc
     2281 ctagaacagt gaatggaagt ttctcgagcc atctcagccc ttaagcaata tgtcctataa
     2341 actcaagaga acgaacggaa gtgcaatgtc gggaaggaca aagcaatatt ggctcctttt
     2401 tgttgagaaa caaagattat ttttccagtg tatatccatt tagatttttg tgtatttttt
     2461 tttttttgat gtgcactgtt ctccgagttc tgaacctttg ggaaaaaagt gtaaaacatt
     2521 tatgatctct tgaatcgagt caaaagttaa cttatttaaa ggggggtgta cataggatgc
     2581 atgcagtggt gttgcaagtg tcctctgtgc cttgtgtgat gtgggcagtg ttacagggtc
     2641 tgcatgtgta caggatgcct tactatgaaa aaaaaatcac tccctgggtt taagtatggc
     2701 tgtatatttc tgcctattaa tatttggaat ttttttagaa agtatatttt tgtatgctct
     2761 gttttgtgac ttgaaagtgt taccttcgca gtcaaatttc agatgagagt gtgcttaacg
     2821 tcactgcagc tgacttgttt ggttattagc tcttaatagt tgtggaaaga ttaaacaatc
     2881 tattctaaca cagaaccact aactggagtt cagatatcgg acggcttatg gcaatggtgt
     2941 aaaataaata cttttcaaca ata
//
