LOCUS       NP_446085                470 aa            linear   ROD 05-MAY-2025
DEFINITION  E3 SUMO-protein ligase EGR2 [Rattus norvegicus].
ACCESSION   NP_446085
VERSION     NP_446085.1
DBSOURCE    REFSEQ: accession NM_053633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 470)
  AUTHORS   Han,S.H., Kim,Y.H., Park,S.J., Cho,J.G., Shin,Y.K., Hong,Y.B.,
            Yun,J., Han,J.Y., Park,H.T. and Park,J.I.
  TITLE     COUP-TFII plays a role in cAMP-induced Schwann cell differentiation
            and in vitro myelination by up-regulating Krox20
  JOURNAL   J Neurochem 165 (5), 660-681 (2023)
   PUBMED   36648143
  REMARK    GeneRIF: COUP-TFII plays a role in cAMP-induced Schwann cell
            differentiation and in vitro myelination by up-regulating Krox20.
REFERENCE   2  (residues 1 to 470)
  AUTHORS   Grosz,B.R., Golovchenko,N.B., Ellis,M., Kumar,K., Nicholson,G.A.,
            Antonellis,A. and Kennerson,M.L.
  TITLE     A de novo EGR2 variant, c.1232A > G p.Asp411Gly, causes severe
            early-onset Charcot-Marie-Tooth Neuropathy Type 3 (Dejerine-Sottas
            Neuropathy)
  JOURNAL   Sci Rep 9 (1), 19336 (2019)
   PUBMED   31852952
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 470)
  AUTHORS   Niu,R.N., Shang,X.P. and Teng,J.F.
  TITLE     Overexpression of Egr2 and Egr4 protects rat brains against
            ischemic stroke by downregulating JNK signaling pathway
  JOURNAL   Biochimie 149, 62-70 (2018)
   PUBMED   29580816
  REMARK    GeneRIF: pregulation of Egr2 and Egr4 could demote the activation
            of JNK/c-JUN pathway and the expression of pro-inflammatory
            cytokines in MCAO rats, so that Egr2 and Egr4 might be potential
            targets for ischemic stroke in future
REFERENCE   4  (residues 1 to 470)
  AUTHORS   Jin,H., Won,M., Shin,E., Kim,H.M., Lee,K. and Bae,J.
  TITLE     EGR2 is a gonadotropin-induced survival factor that controls the
            expression of IER3 in ovarian granulosa cells
  JOURNAL   Biochem Biophys Res Commun 482 (4), 877-882 (2017)
   PUBMED   27890615
  REMARK    GeneRIF: Analysis of consensus EGR-binding elements (EBEs) showed
            that the immediate early response 3 gene (IER3) is a novel
            transcriptional target gene of EGR2 as confirmed by the luciferase
            assay, electrophoretic mobility-shift assay (EMSA), chromatin
            immunoprecipitation (ChIP), and western blot analysis.
REFERENCE   5  (residues 1 to 470)
  AUTHORS   Reddy,M.A., Das,S., Zhuo,C., Jin,W., Wang,M., Lanting,L. and
            Natarajan,R.
  TITLE     Regulation of Vascular Smooth Muscle Cell Dysfunction Under
            Diabetic Conditions by miR-504
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (5), 864-873 (2016)
   PUBMED   26941017
REFERENCE   6  (residues 1 to 470)
  AUTHORS   Inokuchi,K., Murayama,A. and Ozawa,F.
  TITLE     mRNA differential display reveals Krox-20 as a neural
            plasticity-regulated gene in the rat hippocampus
  JOURNAL   Biochem Biophys Res Commun 221 (2), 430-436 (1996)
   PUBMED   8619872
REFERENCE   7  (residues 1 to 470)
  AUTHORS   Levi,G., Topilko,P., Schneider-Maunoury,S., Lasagna,M., Mantero,S.,
            Cancedda,R. and Charnay,P.
  TITLE     Defective bone formation in Krox-20 mutant mice
  JOURNAL   Development 122 (1), 113-120 (1996)
   PUBMED   8565822
REFERENCE   8  (residues 1 to 470)
  AUTHORS   Topilko,P., Schneider-Maunoury,S., Levi,G., Baron-Van
            Evercooren,A., Chennoufi,A.B., Seitanidou,T., Babinet,C. and
            Charnay,P.
  TITLE     Krox-20 controls myelination in the peripheral nervous system
  JOURNAL   Nature 371 (6500), 796-799 (1994)
   PUBMED   7935840
REFERENCE   9  (residues 1 to 470)
  AUTHORS   Schneider-Maunoury,S., Topilko,P., Seitandou,T., Levi,G.,
            Cohen-Tannoudji,M., Pournin,S., Babinet,C. and Charnay,P.
  TITLE     Disruption of Krox-20 results in alteration of rhombomeres 3 and 5
            in the developing hindbrain
  JOURNAL   Cell 75 (6), 1199-1214 (1993)
   PUBMED   7903221
REFERENCE   10 (residues 1 to 470)
  AUTHORS   Sham,M.H., Vesque,C., Nonchev,S., Marshall,H., Frain,M.,
            Gupta,R.D., Whiting,J., Wilkinson,D., Charnay,P. and Krumlauf,R.
  TITLE     The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during
            hindbrain segmentation
  JOURNAL   Cell 72 (2), 183-196 (1993)
   PUBMED   8093858
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032420.1, U78102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     Protein         1..470
                     /product="E3 SUMO-protein ligase EGR2"
                     /note="early growth response protein 2; EGR-2; zinc finger
                     protein Krox-20; E3 SUMO-protein transferase ERG2"
                     /calculated_mol_wt=49718
     Region          94..189
                     /region_name="DUF3446"
                     /note="Early growth response N-terminal domain; pfam11928"
                     /db_xref="CDD:463400"
     Region          126..153
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51774.2)"
     Region          159..178
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51774.2)"
     Region          184..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51774.2)"
     Site            247
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:P08152; propagated from
                     UniProtKB/Swiss-Prot (P51774.2)"
     Region          275..344
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51774.2)"
     Region          337..361
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          339..361
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(346,348,350,352..353,356..357,360,374,376,380..381,
                     384..385,388,402,404,406,408..409,412..413,416)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          365..>421
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          369..389
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          397..417
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          408..470
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51774.2)"
     CDS             1..470
                     /gene="Egr2"
                     /gene_synonym="Krox20"
                     /coded_by="NM_053633.2:343..1755"
                     /db_xref="GeneID:114090"
                     /db_xref="RGD:621608"
ORIGIN      
        1 mmtakavdki pvtlsgfmhq lpdslypved laapsvtifp ngelggpfdq mngvagdgmi
       61 nidmtgekrp ldlpypssfa pisaprnqtf tymgkfsidp qypgascype giinivsagi
      121 lqgvtppast tasssvtsas pnplatgplg vctmsqtqpe ldhlyspppp pppysgctgd
      181 lyqdpsafls pppttstssl ayqpppsyps pkpamdpgli pmipdypgff pspcqrdphg
      241 aagpdrkpfp cpldslrvpp pltplstirn ftlggpsagv tgpgasggge gprlpgsgsa
      301 avtatpynph hlplrpilrp rkypnrpskt pvherpypcp aegcdrrfsr sdeltrhiri
      361 htghkpfqcr icmrnfsrsd hltthirtht gekpfacdyc grkfarsder krhtkihlrq
      421 kerkssapss sasaqssasg pggsqaggsl cgnsaiggpl asctsrtrtp
//
