LOCUS       NM_012551               3128 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus early growth response 1 (Egr1), mRNA.
ACCESSION   NM_012551
VERSION     NM_012551.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Zheng,S.K., Zhao,X.K., Wu,H., He,D.W., Xiong,L. and Cheng,X.G.
  TITLE     Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated
            nucleus pulposus cells apoptosis in intervertebral disc
            degeneration
  JOURNAL   Aging (Albany NY) 16 (12), 10216-10238 (2024)
   PUBMED   38943627
  REMARK    GeneRIF: Oxidative stress-induced EGR1 upregulation promotes
            NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral
            disc degeneration.
REFERENCE   2  (bases 1 to 3128)
  AUTHORS   Li,L., Fu,G., Liu,C. and Liu,Y.
  TITLE     ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced
            autophagy and inflammation in cardiomyocytes
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (3), 125-129 (2024)
   PUBMED   38650141
  REMARK    GeneRIF: ATF3/EGR1 regulates myocardial ischemia/reperfusion injury
            induced autophagy and inflammation in cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3128)
  AUTHORS   Yakmaz,F., Bozkurt,A.S. and Gorucu Yilmaz,S.
  TITLE     PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1,
            and Rev-erbalpha gene regulation, behavioral analysis, and
            antioxidant capacity of Gum Arabic
  JOURNAL   Mol Biol Rep 51 (1), 279 (2024)
   PUBMED   38324049
  REMARK    GeneRIF: PTZ-kindled rat model; evaluation of seizure, hippocampal
            EGR-1, and Rev-erbalpha gene regulation, behavioral analysis, and
            antioxidant capacity of Gum Arabic.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3128)
  AUTHORS   Wu,F., Zhang,P. and Zhou,G.
  TITLE     The involvement of EGR1 in neuron apoptosis in the in vitro model
            of spinal cord injury via BTG2 up-regulation
  JOURNAL   Neurol Res 45 (7), 646-654 (2023)
   PUBMED   36759943
  REMARK    GeneRIF: The involvement of EGR1 in neuron apoptosis in the in
            vitro model of spinal cord injury via BTG2 up-regulation.
REFERENCE   5  (bases 1 to 3128)
  AUTHORS   Rauschner,M., Reime,S., Riemann,A. and Thews,O.
  TITLE     Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in
            Experimental Tumours In Vivo
  JOURNAL   Adv Exp Med Biol 1395, 243-248 (2022)
   PUBMED   36527644
  REMARK    GeneRIF: Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and
            in Experimental Tumours In Vivo.
REFERENCE   6  (bases 1 to 3128)
  AUTHORS   Huang,R.P., Liu,C., Fan,Y., Mercola,D. and Adamson,E.D.
  TITLE     Egr-1 negatively regulates human tumor cell growth via the
            DNA-binding domain
  JOURNAL   Cancer Res 55 (21), 5054-5062 (1995)
   PUBMED   7585551
REFERENCE   7  (bases 1 to 3128)
  AUTHORS   Morris,J.F., Madden,S.L., Tournay,O.E., Cook,D.M., Sukhatme,V.P.
            and Rauscher,F.J. 3rd.
  TITLE     Characterization of the zinc finger protein encoded by the WT1
            Wilms' tumor locus
  JOURNAL   Oncogene 6 (12), 2339-2348 (1991)
   PUBMED   1662794
REFERENCE   8  (bases 1 to 3128)
  AUTHORS   Bonventre,J.V., Sukhatme,V.P., Bamberger,M., Ouellette,A.J. and
            Brown,D.
  TITLE     Localization of the protein product of the immediate early growth
            response gene, Egr-1, in the kidney after ischemia and reperfusion
  JOURNAL   Cell Regul 2 (3), 251-260 (1991)
   PUBMED   1859855
REFERENCE   9  (bases 1 to 3128)
  AUTHORS   Changelian,P.S., Feng,P., King,T.C. and Milbrandt,J.
  TITLE     Structure of the NGFI-A gene and detection of upstream sequences
            responsible for its transcriptional induction by nerve growth
            factor
  JOURNAL   Proc Natl Acad Sci U S A 86 (1), 377-381 (1989)
   PUBMED   2492104
REFERENCE   10 (bases 1 to 3128)
  AUTHORS   Milbrandt,J.
  TITLE     A nerve growth factor-induced gene encodes a possible
            transcriptional regulatory factor
  JOURNAL   Science 238 (4828), 797-799 (1987)
   PUBMED   3672127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Jul 15, 2022 this sequence version replaced NM_012551.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M18416.1, SRR26643286.44017.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-589               JAXUCZ010000018.1  26737078-26737666
            590-3128            JAXUCZ010000018.1  26738339-26740877
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3128
                     /gene="Egr1"
                     /gene_synonym="Krox-24; Ngf1; Ngfi; NGFI-A; zif-268"
                     /note="early growth response 1"
                     /db_xref="GeneID:24330"
                     /db_xref="RGD:2544"
     exon            1..589
                     /gene="Egr1"
                     /gene_synonym="Krox-24; Ngf1; Ngfi; NGFI-A; zif-268"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1893
                     /gene="Egr1"
                     /gene_synonym="Krox-24; Ngf1; Ngfi; NGFI-A; zif-268"
                     /note="transcription factor Zif268; nerve growth
                     factor-induced protein A; zinc finger protein Krox-24"
                     /codon_start=1
                     /product="early growth response protein 1"
                     /protein_id="NP_036683.2"
                     /db_xref="GeneID:24330"
                     /db_xref="RGD:2544"
                     /translation="MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNG
                     APQFLGAAGTPEGSGGNNSSSSSSSSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTT
                     ESFSDIALNNEKALVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSG
                     LVSMTNPPTSSSSAPSPAASSSSSASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIF
                     PEPQSQAFPGSAGTALQYPPPAYPATKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQ
                     GLENRTQQPSLTPLSTIKAFATQSGSQDLKALNNTYQSQLIKPSRMRKYPNRPSKTPP
                     HERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHT
                     GEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSAASSLSSYPSPVATS
                     YPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGFPSPSVATTYASVPPAFPAQVSTFQS
                     AGVSNSFSTSTGLSDMTATFSPRTIEIC"
     exon            590..3128
                     /gene="Egr1"
                     /gene_synonym="Krox-24; Ngf1; Ngfi; NGFI-A; zif-268"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagatccc agcgcgcaga acttggggag ccgccgccgc gattcgccgc cgccgccagc
       61 ttccgccgcc gcaagatcgg cccctgcccc agcctccgcg gcagccctgc gtccaccacg
      121 ggccgcggcc accgccagcc tgggggccca cctacactcc ccgcagtgtg cccctgcacc
      181 ccgcatgtaa cccggccaac atccggcgag tgtgccctca gtagcttcgg ccccgggctg
      241 cgcccaccac ccaacatcag ctctccagct cgcacgtccg ggatggcagc ggccaaggcc
      301 gagatgcaat tgatgtctcc gctgcagatc tctgacccgt tcggctcctt tcctcactca
      361 cccaccatgg acaactaccc caaactggag gagatgatgc tgctgagcaa cggggctccc
      421 cagttcctcg gtgctgccgg aaccccagag ggcagcggcg gcaataacag cagcagcagc
      481 agcagcagca gcagcggggg cggtggtggg ggcggcagca acagcggcag cagcgctttc
      541 aatcctcaag gggagccgag cgaacaaccc tacgagcacc tgaccacaga gtccttttct
      601 gacatcgctc tgaataacga gaaggcgctg gtggagacaa gttatcccag ccaaactacc
      661 cggttgcctc ccatcaccta tactggccgc ttctccctgg agcctgcacc caacagtggc
      721 aacactttgt ggcctgaacc ccttttcagc ctagtcagtg gccttgtgag catgaccaac
      781 cctccaacct cttcatcctc agcgccttct ccagctgctt catcgtcttc ctctgcctcc
      841 cagagcccac ccctgagctg tgccgtgccg tccaacgaca gcagtcccat ttactcagct
      901 gcacccacct ttcctactcc caacactgac atttttcctg agccccaaag ccaggccttt
      961 cctggctctg caggcacagc cttgcagtac ccgcctcctg cctaccctgc caccaagggt
     1021 ggtttccagg ttcccatgat ccctgactat ctgtttccac aacaacaggg agacctgagc
     1081 ctgggcaccc cagaccagaa gcccttccag ggtctggaga accgtaccca gcagccttcg
     1141 ctcactccac tatccactat caaagccttc gccactcagt cgggctccca ggacttaaag
     1201 gctcttaata acacctacca gtcccaactc atcaaaccca gccgcatgcg caagtacccc
     1261 aaccggccca gcaagacacc cccccatgaa cgcccgtatg cttgccctgt tgagtcctgc
     1321 gatcgccgct tttctcgctc ggatgagctt acacgccaca tccgcatcca tacaggccag
     1381 aagcccttcc agtgtcgaat ctgcatgcgt aatttcagtc gtagtgacca ccttaccacc
     1441 cacatccgca cccacacagg cgagaagcct tttgcctgtg acatttgtgg gagaaagttt
     1501 gccaggagtg atgaacgcaa gaggcatacc aaaatccact taagacagaa ggacaagaaa
     1561 gcagacaaaa gtgtcgtggc ctcctcagct gcctcttccc tctcttccta cccatcccca
     1621 gtggctacct cctacccatc ccccgccacc acctcatttc catccccagt gcccacctct
     1681 tactcctctc cgggctcctc tacctacccg tctcctgcac acagtggctt cccatcgccc
     1741 tcggtggcca ccacctatgc ctccgtccca cctgctttcc ctgcccaggt cagcaccttc
     1801 cagtctgcag gggtcagcaa ctccttcagc acctcaacgg gtctttcaga catgacagca
     1861 accttttctc ctaggacaat tgaaatttgc taaagggaat gaaagagagc aaagggaggg
     1921 gagcgcgaga gacaataaag gacaggaggg aagaaatggc ccgcaagagg ggctgcctct
     1981 taggtcagat ggaagatctc agagccaagt ccttctagtc agtagaaggc ccgttggcca
     2041 ccagcccttt cacttagcgt ccctgccctc cccagtcccg gtccttttga cttcagctgc
     2101 ctgaaacagc cacgtccaag ttcttcacct ctatccaaag gacttgattt gcatggtatt
     2161 ggataaacca tttcagcatc atctccacca catgcctggc ccttgctccc ttcagcacta
     2221 gaacatcaag ttggctgaaa aaaaaaaatg ggtctgggcc ctcagaaccc tgccctgtat
     2281 ctttgtacag catctgtgcc atggattttg ttttccttgg ggtattcttg atgtgaagat
     2341 aatttgcata ctctattgta ctatttggag ttaaattctc actttggggg agggggagca
     2401 aagccaagca aaccaatggt gatcctctat tttgtgatga tcctgctgtg acattaggtt
     2461 tgaaactttt tttttttttt gaagcagcag tcctaggtat taactggagc atgtgtcaga
     2521 gtgttgttcc gttaattttg taaatactgc tcgactgtaa ctctcacatg tgacaaaata
     2581 cggtttgttt ggttgggttt tttgttgttt ttgaaaaaaa aatttttttt ttgcccgtcc
     2641 ctttggtttc aaaagtttca cgtcttggtg cctttgtgtg acacaccttg ccgatggctg
     2701 gacatgtgca atcgtgaggg gacacgctca cctctagcct taagggggta ggagtgatgt
     2761 ttcaggggag gctttagagc acgatgagga agagggctga gctgagcttt ggttctccag
     2821 aatgtaagaa gaaaaaattt aaaacaaaaa tctgaactct caaaagtcta tttttttaac
     2881 tgaaaatgta gatttatcca tgttcgggag ttggaatgct gcggttacct actgagtagg
     2941 cggtgacttt tgtatgctat gaacatgaag ttcattattt tgtggtttta ttttacttcg
     3001 tacttgtgtt tgcttaaaca aagtgacttg tttggcttat aaacacattg aatgcgcttt
     3061 actgcccatg ggatatgtgg tgtgtatcct tcagaaaaat taaaaggaaa ataaagaaac
     3121 taactggt
//
