LOCUS       NM_019371               2817 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus egl-9 family hypoxia-inducible factor 3 (Egln3),
            mRNA.
ACCESSION   NM_019371 XM_346767
VERSION     NM_019371.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Fong,L.Y., Taccioli,C., Palamarchuk,A., Tagliazucchi,G.M., Jing,R.,
            Smalley,K.J., Fan,S., Altemus,J., Fiehn,O., Huebner,K., Farber,J.L.
            and Croce,C.M.
  TITLE     Abrogation of esophageal carcinoma development in miR-31 knockout
            rats
  JOURNAL   Proc Natl Acad Sci U S A 117 (11), 6075-6085 (2020)
   PUBMED   32123074
  REMARK    GeneRIF: In a dietary Zn deficiency-promoted rat esophageal
            squamous cell carcinoma (ESCC) model with miR-31-controlled
            inflammation pathway up-regulation, systemic antimiR-31 suppressed
            ESCC development. Egln3 was identified as a direct miR-31 target.
            miR-31 genetic knockout prevents Zn deficiency-associated ESCC by
            eliminating or greatly reducing the entire
            miR-31-EGLN3/STK40-NF-kappaB-controlled inflammatory process.
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Chu,H.X. and Jones,N.M.
  TITLE     Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl
            Hydroxylase (PHD) Enzymes Following Hypoxic-Ischemic Injury in the
            Neonatal Rat
  JOURNAL   Neurochem Res 41 (3), 515-522 (2016)
   PUBMED   26108712
  REMARK    GeneRIF: 24 h after HI, there was a significant increase in PHD3
            protein and an increase of HIF-1alpha compared to controls
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Xie,L., Pi,X., Wang,Z., He,J., Willis,M.S. and Patterson,C.
  TITLE     Depletion of PHD3 protects heart from ischemia/reperfusion injury
            by inhibiting cardiomyocyte apoptosis
  JOURNAL   J Mol Cell Cardiol 80, 156-165 (2015)
   PUBMED   25633836
  REMARK    GeneRIF: depletion of PHD3 leads to increased stabilization of
            HIF-1alpha and inhibition of DNA damage response, both of which may
            contribute to the cardioprotective effect seen with depletion of
            PHD3.
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Bondeva,T., Heinzig,J., Ruhe,C. and Wolf,G.
  TITLE     Advanced glycated end-products affect HIF-transcriptional activity
            in renal cells
  JOURNAL   Mol Endocrinol 27 (11), 1918-1933 (2013)
   PUBMED   24030251
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Garcia-Donas,J., Leandro-Garcia,L.J., Gonzalez Del Alba,A.,
            Morente,M., Alemany,I., Esteban,E., Arranz,J.A., Climent,M.A.,
            Gallardo,E., Castellano,D.E., Bellmunt,J., Mellado,B., Puente,J.,
            Moreno,F., Font,A., Hernando,S., Robledo,M. and Rodriguez-Antona,C.
  TITLE     Prospective study assessing hypoxia-related proteins as markers for
            the outcome of treatment with sunitinib in advanced clear-cell
            renal cell carcinoma
  JOURNAL   Ann Oncol 24 (9), 2409-2414 (2013)
   PUBMED   23788753
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Bruick,R.K. and McKnight,S.L.
  TITLE     A conserved family of prolyl-4-hydroxylases that modify HIF
  JOURNAL   Science 294 (5545), 1337-1340 (2001)
   PUBMED   11598268
REFERENCE   7  (bases 1 to 2817)
  AUTHORS   Epstein,A.C., Gleadle,J.M., McNeill,L.A., Hewitson,K.S.,
            O'Rourke,J., Mole,D.R., Mukherji,M., Metzen,E., Wilson,M.I.,
            Dhanda,A., Tian,Y.M., Masson,N., Hamilton,D.L., Jaakkola,P.,
            Barstead,R., Hodgkin,J., Maxwell,P.H., Pugh,C.W., Schofield,C.J.
            and Ratcliffe,P.J.
  TITLE     C. elegans EGL-9 and mammalian homologs define a family of
            dioxygenases that regulate HIF by prolyl hydroxylation
  JOURNAL   Cell 107 (1), 43-54 (2001)
   PUBMED   11595184
REFERENCE   8  (bases 1 to 2817)
  AUTHORS   Lipscomb,E.A., Sarmiere,P.D. and Freeman,R.S.
  TITLE     SM-20 is a novel mitochondrial protein that causes
            caspase-dependent cell death in nerve growth factor-dependent
            neurons
  JOURNAL   J Biol Chem 276 (7), 5085-5092 (2001)
   PUBMED   11060309
REFERENCE   9  (bases 1 to 2817)
  AUTHORS   Lipscomb,E.A., Sarmiere,P.D., Crowder,R.J. and Freeman,R.S.
  TITLE     Expression of the SM-20 gene promotes death in nerve growth
            factor-dependent sympathetic neurons
  JOURNAL   J Neurochem 73 (1), 429-432 (1999)
   PUBMED   10386996
REFERENCE   10 (bases 1 to 2817)
  AUTHORS   Wax,S.D., Rosenfield,C.L. and Taubman,M.B.
  TITLE     Identification of a novel growth factor-responsive gene in vascular
            smooth muscle cells
  JOURNAL   J Biol Chem 269 (17), 13041-13047 (1994)
   PUBMED   8175725
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019371.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U06713.1, SRR26360176.97459.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-891               JAXUCZ010000006.1  77410125-77411015   c
            892-1011            JAXUCZ010000006.1  77391151-77391270   c
            1012-1148           JAXUCZ010000006.1  77390221-77390357   c
            1149-1222           JAXUCZ010000006.1  77388160-77388233   c
            1223-2817           JAXUCZ010000006.1  77385549-77387143   c
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..2817
                     /gene="Egln3"
                     /gene_synonym="PHD-3; PHD3; SM-20"
                     /note="egl-9 family hypoxia-inducible factor 3"
                     /db_xref="GeneID:54702"
                     /db_xref="RGD:71019"
     exon            1..891
                     /gene="Egln3"
                     /gene_synonym="PHD-3; PHD3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1254
                     /gene="Egln3"
                     /gene_synonym="PHD-3; PHD3; SM-20"
                     /EC_number="1.14.11.29"
                     /note="egl nine homolog 3, mitochondrial; HIF-PH3;
                     HIF-prolyl hydroxylase 3; hypoxia-inducible factor prolyl
                     hydroxylase 3; HPH-3; factor-responsive smooth muscle
                     protein; prolyl hydroxylase domain-containing protein 3"
                     /codon_start=1
                     /product="prolyl hydroxylase EGLN3"
                     /protein_id="NP_062244.2"
                     /db_xref="GeneID:54702"
                     /db_xref="RGD:71019"
                     /translation="MTLRSRRGFLSFLPGLRPPRRWLRISKRGPPTSHWASPALGGRT
                     LHYSCRSQSGTPFSSEFQATFPAFAAKVARGPWLPQVVEPPARLSASPLCVRSGQALG
                     ACTLGVPRLGSVSEMPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVL
                     ERVKQLHYNGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAINFLLSLIDRLV
                     LYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKL
                     HGGVLRIFPEGKSFVADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEER
                     AEAKKKFRNLTRKTESALAKD"
     exon            892..1011
                     /gene="Egln3"
                     /gene_synonym="PHD-3; PHD3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1148
                     /gene="Egln3"
                     /gene_synonym="PHD-3; PHD3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1222
                     /gene="Egln3"
                     /gene_synonym="PHD-3; PHD3; SM-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..2817
                     /gene="Egln3"
                     /gene_synonym="PHD-3; PHD3; SM-20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatccaggtt ttcaagtttg ttaggggatt taatgcaaat caatatgcaa acagagagca
       61 ttgaaaaaaa aatccagtcc tttctccggt cacacacagg ttagctaatg tggagctcgc
      121 ccagatgctc tgcagcacca gctcaagggg aagggccagg aggagggcag tcccgggggc
      181 gggaccatga cgttgaggtc aaggcggggc ttcctctcgt tcctccccgg gctgcggccg
      241 ccgcggcggt ggctccgcat ctccaaaagg ggccctccga cttctcactg ggccagtccg
      301 gcgctgggtg gcagaactct acactactcc tgccggtctc agagcgggac tcccttctct
      361 tcagagtttc aagcaacttt ccccgccttt gcagctaaag tggctcgggg accgtggctg
      421 ccgcaggtgg tagagccccc ggcccggctc tctgcatctc cgctgtgcgt tcgctctggg
      481 caagccctcg gtgcgtgcac cctgggggtc ccccgcctcg gctctgtgag cgagatgcct
      541 ctgggacaca tcatgaggct ggatctggag aagatcgccc tggagtacat cgtgccctgt
      601 ctgcacgagg tcggcttctg ctacctggac aacttcctag gcgaggtggt gggcgactgc
      661 gtactggagc gagtcaagca gctgcattac aacggggccc tgcgtgacgg ccagctggcg
      721 gggccccgcg ccggcgtctc caagcggcac ctgcgaggcg accagatcac gtggatcggg
      781 ggcaacgagg agggctgcga ggccatcaac ttcctcctgt ccctcatcga caggctggtc
      841 ctgtactgcg ggagccgcct gggcaaatac tatgtcaagg agcggtccaa ggcgatggtg
      901 gcttgctatc caggaaatgg aacaggttat gttcgtcatg tggacaaccc caatggtgat
      961 ggccgctgta tcacctgtat ctactacctg aataagaatt gggacgccaa gttacatgga
     1021 ggggtcctgc ggatatttcc agaaggaaaa tcatttgtag cagacgtgga gcccattttt
     1081 gatagactcc tgttcttctg gtcagaccgc aggaatccac atgaagttca gccctcctat
     1141 gccaccaggt acgccatgac tgtctggtac ttcgatgctg aagaaagggc agaagccaaa
     1201 aagaaattca ggaatctaac tagaaaaact gaatctgctc ttgctaaaga ctgacggtgg
     1261 tgtgaagtcc gctgggcgca ttcgtttagt gacagttcct gaaatgttaa gtgtcaagat
     1321 ccaaagactc tgtccaatcc cctgcctacc gcctgcatcg tttggctccc taccttgttt
     1381 gtggtacttc gtgttttctt gctgggaatg cgttgccctc cagacactct ctttgccgga
     1441 tgaactcatt tgctaactcc agaaacacct gcagacatcc tagctggcca gcggtttaac
     1501 ggatagatct gggaatggat agatatggga atgcagctgt tcagcccagg attgcctcgt
     1561 gttcgcactt tatgcatact tcctggtctg ataggaggag gtttgcgaag aaataaactg
     1621 gtgacagatg ccacaaagag gcacccttga aaccctaaca gcaagaaaga gaaagatctg
     1681 aactatttcc agatgttgtt aacccgagac tggacgatta cggacaacct gatgacatta
     1741 tcgcctctag aaagggctgc tgtcatagcg atcgatttat aagtgtccca cggtggatgc
     1801 tcctttttcc tggtcctaca acctgttctt tttgaaggtc attgctaaat tgatgctctc
     1861 ttgtcgaaga cgaccccagc ctgtatgctc catttttact tcttacttgg ggatcctaat
     1921 tatccagaga ataaaactca ccaggtagtt tgggttgttt tttctggtac tgaaatttga
     1981 agttaaatga gaggacagga agcgtcctgg taatttagct tctgctaact ctgtgggaag
     2041 agcaaagcct agcggtatgc gataaccatg catacggtga gcagttcgag agggagatgt
     2101 ggttggaagt gcagacagcc ccctttcatc atgttccctt taactgttct tcgttcatgg
     2161 ctaagaacag catgttgtac tcttaaaaga tatggaaata aaaagacctc aaagctatcg
     2221 agttctccca cattgtctgc tctgccagcc tcgctttagc cgtcttgatc cttgagagca
     2281 actggttggt agtgcagcca gtgttgtgga atttcctaga actgtgggag gttctcctgc
     2341 tgcaggatgc aggtgccgct tcccccagaa ctctgtacga aacacccatt ttacggaagt
     2401 tagccatcct agttttcgct gctacttccc catctttcga acctctttaa tttccttgct
     2461 agaatcccac aagcagcaca gacccgagag tgttttattt catcgtgttc agccatgcag
     2521 actttccaag aaagaagttg atactttttt ttttttggga aagtgtccag gaagaactgt
     2581 cattccttcc cccatggctc tgttttgttt tatttcccac cttctaactt acaatgtcat
     2641 ttccttattt attatgttta ttgtcttgta gcctatgatg tctagagtgt taaacacaac
     2701 gaaggcaggg attttgtacg tttttgatcc atgcagcatg ttcccagcac ctaagctaac
     2761 atacagtaag caacggctta ccaaacacat gttcaataaa ctcagtctcc tctgtaa
//
