LOCUS       NM_001004083            2013 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus egl-9 family hypoxia-inducible factor 2 (Egln2),
            mRNA.
ACCESSION   NM_001004083
VERSION     NM_001004083.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Li,S., Fu,J., Wang,Y., Hu,C. and Xu,F.
  TITLE     LncRNA MIAT enhances cerebral ischaemia/reperfusion injury in rat
            model via interacting with EGLN2 and reduces its ubiquitin-mediated
            degradation
  JOURNAL   J Cell Mol Med 25 (21), 10140-10151 (2021)
   PUBMED   34687132
  REMARK    GeneRIF: LncRNA MIAT enhances cerebral ischaemia/reperfusion injury
            in rat model via interacting with EGLN2 and reduces its
            ubiquitin-mediated degradation.
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Chen,Y.F., Pandey,S., Day,C.H., Chen,Y.F., Jiang,A.Z., Ho,T.J.,
            Chen,R.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     Synergistic effect of HIF-1alpha and FoxO3a trigger cardiomyocyte
            apoptosis under hyperglycemic ischemia condition
  JOURNAL   J Cell Physiol 233 (4), 3660-3671 (2018)
   PUBMED   29030976
  REMARK    GeneRIF: that combined function of HIF-1alpha and FoxO3a under high
            glucose plus hypoxia condition lead to enhanced expression of BNIP3
            inducing cardiomyocyte death
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Ahmed,S., Ayscough,A., Barker,G.R., Canning,H.E., Davenport,R.,
            Downham,R., Harrison,D., Jenkins,K., Kinsella,N., Livermore,D.G.,
            Wright,S., Ivetac,A.D., Skene,R., Wilkens,S.J., Webster,N.A. and
            Hendrick,A.G.
  TITLE     1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1
            (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction
  JOURNAL   J Med Chem 60 (13), 5663-5672 (2017)
   PUBMED   28594552
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Laitala,A., Aro,E., Walkinshaw,G., Maki,J.M., Rossi,M.,
            Heikkila,M., Savolainen,E.R., Arend,M., Kivirikko,K.I., Koivunen,P.
            and Myllyharju,J.
  TITLE     Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase
            regulating EPO production and erythropoiesis
  JOURNAL   Blood 120 (16), 3336-3344 (2012)
   PUBMED   22955912
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Hsieh,Y.L., Chou,L.W., Chang,P.L., Yang,C.C., Kao,M.J. and
            Hong,C.Z.
  TITLE     Low-level laser therapy alleviates neuropathic pain and promotes
            function recovery in rats with chronic constriction injury:
            possible involvements in hypoxia-inducible factor 1alpha
            (HIF-1alpha)
  JOURNAL   J Comp Neurol 520 (13), 2903-2916 (2012)
   PUBMED   22351621
  REMARK    GeneRIF: In conclusion, a low-level laser could modulate HIF-1alpha
            activity in nerve entrapment neuropathy
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Metzen,E., Berchner-Pfannschmidt,U., Stengel,P., Marxsen,J.H.,
            Stolze,I., Klinger,M., Huang,W.Q., Wotzlaw,C., Hellwig-Burgel,T.,
            Jelkmann,W., Acker,H. and Fandrey,J.
  TITLE     Intracellular localisation of human HIF-1 alpha hydroxylases:
            implications for oxygen sensing
  JOURNAL   J Cell Sci 116 (Pt 7), 1319-1326 (2003)
   PUBMED   12615973
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   McNeill,L.A., Hewitson,K.S., Gleadle,J.M., Horsfall,L.E.,
            Oldham,N.J., Maxwell,P.H., Pugh,C.W., Ratcliffe,P.J. and
            Schofield,C.J.
  TITLE     The use of dioxygen by HIF prolyl hydroxylase (PHD1)
  JOURNAL   Bioorg Med Chem Lett 12 (12), 1547-1550 (2002)
   PUBMED   12039559
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Seth,P., Krop,I., Porter,D. and Polyak,K.
  TITLE     Novel estrogen and tamoxifen induced genes identified by SAGE
            (Serial Analysis of Gene Expression)
  JOURNAL   Oncogene 21 (5), 836-843 (2002)
   PUBMED   11850811
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Bruick,R.K. and McKnight,S.L.
  TITLE     A conserved family of prolyl-4-hydroxylases that modify HIF
  JOURNAL   Science 294 (5545), 1337-1340 (2001)
   PUBMED   11598268
REFERENCE   10 (bases 1 to 2013)
  AUTHORS   Epstein,A.C., Gleadle,J.M., McNeill,L.A., Hewitson,K.S.,
            O'Rourke,J., Mole,D.R., Mukherji,M., Metzen,E., Wilson,M.I.,
            Dhanda,A., Tian,Y.M., Masson,N., Hamilton,D.L., Jaakkola,P.,
            Barstead,R., Hodgkin,J., Maxwell,P.H., Pugh,C.W., Schofield,C.J.
            and Ratcliffe,P.J.
  TITLE     C. elegans EGL-9 and mammalian homologs define a family of
            dioxygenases that regulate HIF by prolyl hydroxylation
  JOURNAL   Cell 107 (1), 43-54 (2001)
   PUBMED   11595184
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2013
                     /gene="Egln2"
                     /gene_synonym="HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1"
                     /note="egl-9 family hypoxia-inducible factor 2"
                     /db_xref="GeneID:308457"
                     /db_xref="RGD:631376"
     exon            1..40
                     /gene="Egln2"
                     /gene_synonym="HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..1137
                     /gene="Egln2"
                     /gene_synonym="HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1518
                     /gene="Egln2"
                     /gene_synonym="HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1"
                     /EC_number="1.14.11.29"
                     /note="HIF-1alpha prolyl-4-hydroxylase-1; HIF-prolyl
                     hydroxylase 1; hypoxia-inducible factor prolyl hydroxylase
                     1; prolyl hydroxylase domain-containing protein 1"
                     /codon_start=1
                     /product="prolyl hydroxylase EGLN2"
                     /protein_id="NP_001004083.1"
                     /db_xref="GeneID:308457"
                     /db_xref="RGD:631376"
                     /translation="MDSPCQPQALNQALPQLPGSVSESLEPSRARMGVESYLPCPLLP
                     SYHRSGASGEASAGNGTPRTTATATTTTASPLREGFGGQDGGELWPLQSEGAAALVTK
                     ECQRLAAQGARPEAPKRKWAKDGGDAPSPSKRPWARQENQEAKGESGVGCDSGGGSSN
                     STTHSSGEASSRLREEAQPSAPERLALDYIVPCMRYYGICVKDNFLGAVLGGRVLAEV
                     EALKWGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCA
                     GRLGNYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGL
                     LQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAR
                     DKYQLASGQKGVQVPVSQPATPT"
     exon            1138..1257
                     /gene="Egln2"
                     /gene_synonym="HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1394
                     /gene="Egln2"
                     /gene_synonym="HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1462
                     /gene="Egln2"
                     /gene_synonym="HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1988
                     /gene="Egln2"
                     /gene_synonym="HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcagtccg tccgtctggc aggacctccc ttccggctgg ccacccccat caatcctttc
       61 tcaagctcct agggacaact gtggacttgg ggatcagcga gcacccccag agcactaaag
      121 gagcccctgc tgcctgccct gcctcaccct gccccacacg aggcccagcg gccccgggct
      181 gcatcaagtg gaggaggagg aggcggagga gggtggcacc atgggcccgg gccgtgccct
      241 ccatgcccgg gggatgaaga cactgctgcc atggacagcc cgtgccagcc gcaggccctg
      301 aatcaagctc tccctcagtt gccagggtct gtgtcagagt ccttggagcc tagccgagcc
      361 aggatggggg tggagagtta cctgccctgt cctctgctcc cctcctacca ccgttcagga
      421 gcatctgggg aggcctcggc tggcaacggg acccccagaa ccacagccac tgctactact
      481 accactgcca gtcccctgcg ggagggcttt ggtgggcagg atggtggtga gctgtggcca
      541 ctgcagagtg aaggtgctgc tgcgttggtt accaaggagt gccagcgact ggcggcccag
      601 ggtgcccgac ctgaggcccc caaacggaag tgggccaagg atggtgggga tgccccttca
      661 cccagcaagc gaccgtgggc caggcaagag aaccaggagg ccaaggggga aagtggtgtg
      721 ggctgtgaca gcggtggcgg cagcagcaac agcactaccc atagcagtgg cgaggcaagt
      781 tctaggctga gggaggaagc ccagccctct gcacctgagc gcctggcctt ggactatatt
      841 gtgccttgca tgcggtacta tggtatctgc gtcaaggaca acttcttggg ggcagtactg
      901 ggtggccgtg tgctggctga ggtggaagcc ctgaagtggg gcgggcgtct acgtgatggg
      961 caactagtga gccagcgggc gatcccaccg cgcagcattc gtggggacca gattgcctgg
     1021 gtagaaggcc acgagccagg ctgccggagc attggtgccc tcatggctca tgtggacgca
     1081 gtaatccgcc actgtgcagg gcggctgggc aactacgtca tcaatgggcg caccaaggcc
     1141 atggtggcgt gttacccagg caatgggctc gggtacgtga ggcatgttga caatccccac
     1201 ggcgatgggc gctgcatcac ctgtatctat tacctgaatc agaactggga tgttaaggtg
     1261 catggcggcc tgctgcagat cttccctgag ggtcggccag tggtagccaa catcgagcca
     1321 ctctttgacc ggttgctcat tttctggtct gaccgacgga atccacatga ggtgaagcca
     1381 gcctatgcca ccaggtacgc catcactgtc tggtattttg atgccaagga gcgggcagca
     1441 gccagagaca agtatcagct agcatcggga cagaaaggtg ttcaagtacc cgtgtcacag
     1501 ccagctacac ctacctaatg gccagcccca gagctgcatg ggccagcagc tcctgccttg
     1561 aggggagcct cagtgcccgc cccttccctg acactgctgc tgcttctggc ttgcctctgg
     1621 atgtgtggtg tggagggcac tgagtgtcac tgaggagcaa caaggagagg cctctgctgc
     1681 cccgtgagca gtggccagta tggctggtgg cctatgtcct gccatgtctg gtccattgcg
     1741 tgttgagctg aggggaggca ggatttgggg ttgaggtgag tcatggcctc ttgctggcaa
     1801 aggtctgttg ggggggtcat ctcaccccct ccccactcct ccagcctgga atgtgaagtg
     1861 gctccccaac ccccttgctg tggcacttta tggactgggc tgccactgtt tgcagagtac
     1921 agtgccatga ggaacatggg tatggaggtc ctgccagcca agaaataaaa gtttacctca
     1981 gagctgcaaa aaaaaaaaaa aaaaaaaaaa aaa
//
