LOCUS       NM_001399187            1776 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus EGF-like-domain, multiple 7 (Egfl7), transcript
            variant 1, mRNA.
ACCESSION   NM_001399187 XM_006233668
VERSION     NM_001399187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1776)
  AUTHORS   Xian,Y., Wang,X., Yu,Y. and Chen,X.
  TITLE     The mechanism of EGFL7 regulating neovascularization in diabetic
            retinopathy through the PI3K/AKT/VEGFA pathway
  JOURNAL   Life Sci 340, 122483 (2024)
   PUBMED   38307238
  REMARK    GeneRIF: The mechanism of EGFL7 regulating neovascularization in
            diabetic retinopathy through the PI3K/AKT/VEGFA pathway.
REFERENCE   2  (bases 1 to 1776)
  AUTHORS   Wang,X.H. and Huang,W.M.
  TITLE     Astragalus polysaccharides exert protective effects in newborn rats
            with bronchopulmonary dysplasia by upregulating the expression of
            EGFL7 in lung tissue
  JOURNAL   Int J Mol Med 34 (6), 1529-1536 (2014)
   PUBMED   25270395
  REMARK    GeneRIF: Data show that Astragalus polysaccharides reduce airway
            remodeling and alveolar damage by upregulating the expression of
            epidermal growth factor-like domains protein 7 (EGFL7) and exert
            protective effects against dysplasia in neonatal rats.
REFERENCE   3  (bases 1 to 1776)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   4  (bases 1 to 1776)
  AUTHORS   Nichol,D., Shawber,C., Fitch,M.J., Bambino,K., Sharma,A.,
            Kitajewski,J. and Stuhlmann,H.
  TITLE     Impaired angiogenesis and altered Notch signaling in mice
            overexpressing endothelial Egfl7
  JOURNAL   Blood 116 (26), 6133-6143 (2010)
   PUBMED   20947685
  REMARK    Erratum:[Blood. 2011 Jun 16;117(24):6738-9]
REFERENCE   5  (bases 1 to 1776)
  AUTHORS   Fitch,M.J., Campagnolo,L., Kuhnert,F. and Stuhlmann,H.
  TITLE     Egfl7, a novel epidermal growth factor-domain gene expressed in
            endothelial cells
  JOURNAL   Dev Dyn 230 (2), 316-324 (2004)
   PUBMED   15162510
REFERENCE   6  (bases 1 to 1776)
  AUTHORS   Parker,L.H., Schmidt,M., Jin,S.W., Gray,A.M., Beis,D., Pham,T.,
            Frantz,G., Palmieri,S., Hillan,K., Stainier,D.Y., De Sauvage,F.J.
            and Ye,W.
  TITLE     The endothelial-cell-derived secreted factor Egfl7 regulates
            vascular tube formation
  JOURNAL   Nature 428 (6984), 754-758 (2004)
   PUBMED   15085134
REFERENCE   7  (bases 1 to 1776)
  AUTHORS   Soncin,F., Mattot,V., Lionneton,F., Spruyt,N., Lepretre,F.,
            Begue,A. and Stehelin,D.
  TITLE     VE-statin, an endothelial repressor of smooth muscle cell migration
  JOURNAL   EMBO J 22 (21), 5700-5711 (2003)
   PUBMED   14592969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006233668.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078725.1, SRR26360176.535693.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000003.1  29805631-29805749
            120-282             JAXUCZ010000003.1  29807258-29807420
            283-407             JAXUCZ010000003.1  29810773-29810897
            408-524             JAXUCZ010000003.1  29811061-29811177
            525-652             JAXUCZ010000003.1  29812142-29812269
            653-748             JAXUCZ010000003.1  29812449-29812544
            749-913             JAXUCZ010000003.1  29812697-29812861
            914-978             JAXUCZ010000003.1  29813419-29813483
            979-1141            JAXUCZ010000003.1  29814053-29814215
            1142-1776           JAXUCZ010000003.1  29814332-29814966
FEATURES             Location/Qualifiers
     source          1..1776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1776
                     /gene="Egfl7"
                     /note="EGF-like-domain, multiple 7"
                     /db_xref="GeneID:245963"
                     /db_xref="RGD:708507"
     exon            1..119
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     exon            120..282
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     exon            283..407
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1164
                     /gene="Egfl7"
                     /note="EGF-like domain-containing protein 7; epidermal
                     growth factor-like protein 7; multiple EGF-like domain
                     protein 7; multiple epidermal growth factor-like domain
                     protein 7; EGF-like protein 7; multiple EGF-like domains
                     protein 7; multiple epidermal growth factor-like domains
                     protein 7; Estrogen-regulated protein CBL20, 20.4kD;
                     EGF-like domain 7"
                     /codon_start=1
                     /product="epidermal growth factor-like protein 7
                     precursor"
                     /protein_id="NP_001386116.1"
                     /db_xref="GeneID:245963"
                     /db_xref="RGD:708507"
                     /translation="MQTMWGSGELLVAWFLVLAAGGTTEHVYRPSRRVCTVGVSGGSI
                     SETFVQRVYQPYLTTCDGHRACSTYRTIYRTAYRIAYRHSPGLTPSRPRYACCPGWKR
                     TNGLPGACGAAICQPPCGNEGSCIRPGRCRCPVGWQGDTCQIDVDECSTGEARCPQRC
                     VNTVGSYWCQCWEGQSPSADGVLCLPKEGPSPVAPSPTPGVDSVVREEVYKLQARVDV
                     LEQKLQLVLAPLHSLASRSPEHGLQDPGSLLAHSFQQLDRIDSLSEQVSFLEEQLGSC
                     SCKKDL"
     exon            408..524
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     exon            525..652
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     exon            653..748
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     exon            749..913
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     exon            914..978
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1141
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1776
                     /gene="Egfl7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaggctt cggctgacag gagaggcatg cagacctcaa gcagacgctc ccttgaaggg
       61 caggttgcat tcatggttgg ttcatggagg cggccttggc taggcctggg cggcatcagc
      121 ctccaacagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag
      181 caggagcagc agcagcagca gcagcaaggc gctggccgtt ccgctcaccc acaagaacag
      241 ctgccaccag taccctgggg atgactagag gccggaccac aggccacaaa aagaagaagg
      301 ctaccccact tacagatgca gaccatgtgg gggtccggag agctgcttgt agcgtggttt
      361 ctagtactgg cagcaggtgg tactactgag catgtctaca gacccagccg tagagtgtgt
      421 accgtggggg tttccggagg ctccatctca gagacctttg tgcagcgtgt ataccagcct
      481 tacctcacca cttgtgatgg acacagagcc tgtagcacct accgaaccat ctaccggact
      541 gcctaccgga ttgcctatcg ccatagcccg gggctgactc ccagcaggcc tcgctatgcc
      601 tgctgccctg gttggaagag gaccaacggg ctccctggag cttgtggagc agcaatatgc
      661 cagccaccgt gtgggaatga agggagttgc atccgcccag gccgctgccg ctgccctgtg
      721 ggatggcagg gagatacttg ccagatagat gttgatgaat gcagtacagg agaggccagg
      781 tgtccccagc gctgtgtcaa tactgtggga agttactggt gccagtgttg ggaggggcag
      841 agcccatctg cagatggggt gctctgcctg cctaaggagg ggccctcccc ggtggcacca
      901 agtcccacgc caggagtgga cagcgtggtg agagaggagg tgtacaagct gcaggcccgg
      961 gttgatgtat tagaacagaa actgcagctg gtgctggccc cactgcacag cctggcctct
     1021 cggtccccgg agcatgggct gcaagatcct ggcagcctgc tggcccactc cttccagcag
     1081 ctggaccgga ttgactcact gagcgagcag gtctccttcc tggaggaaca gctggggtcc
     1141 tgctcttgca aaaaagacct gtgatggctt ctcagtgccc atgttggatt gagctgttac
     1201 ccctacgtcc cttctagcct gagttcaagt gctgtccggt ggtgcctgtg agcagaaggc
     1261 cctgcttgtt tatccctctc tcttaggagg ttcctaggcc ctgggcatgg ggaggggggt
     1321 cttgtgtggc tcttaagtga ggcttccggg aaaggaataa gatctccctg cctaagaagt
     1381 gaggtggggg ctgtctccac ctttgtcata ttaaagctgg gacttgagct gctgtcactg
     1441 ggtgagtcgg actgtgtaca cactgtacta ctgccatgta ggagctgcag tgggcagtcc
     1501 tgaggctctc ttcagcctat gctgatgctg ccaagcccgt ggtctgcaca cccttcagtt
     1561 ctgtggaccc tgcattcact gagcaaagca atgctggctg atcacagctc acctgcaggc
     1621 agttagggag gagggagctc agacaccgca gccccaggga tcgattcaca caccatcttt
     1681 cccacccttc atccctggat ggggacttgg gaagaactct taccaccctc tggtctctag
     1741 gcacttctga gttcatttat aaaaaaaaga accaaa
//
