LOCUS       NM_012842               4799 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus epidermal growth factor (Egf), mRNA.
ACCESSION   NM_012842 XM_003749222 XM_039101779
VERSION     NM_012842.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4799)
  AUTHORS   de Santi,F., Beltrame,F.L., Rodrigues,B.M., Scaramele,N.F.,
            Lopes,F.L., Cerri,P.S. and Sasso-Cerri,E.
  TITLE     Venlafaxine-induced adrenergic signaling stimulates Leydig cells
            steroidogenesis via Nur77 overexpression: A possible role of EGF
  JOURNAL   Life Sci 289, 120069 (2022)
   PUBMED   34688693
  REMARK    GeneRIF: Venlafaxine-induced adrenergic signaling stimulates Leydig
            cells steroidogenesis via Nur77 overexpression: A possible role of
            EGF.
REFERENCE   2  (bases 1 to 4799)
  AUTHORS   Talaveron,R., Matarredona,E.R., Herrera,A., Medina,J.M. and
            Tabernero,A.
  TITLE     Connexin43 Region 266-283, via Src Inhibition, Reduces Neural
            Progenitor Cell Proliferation Promoted by EGF and FGF-2 and
            Increases Astrocytic Differentiation
  JOURNAL   Int J Mol Sci 21 (22), 8852 (2020)
   PUBMED   33238452
  REMARK    GeneRIF: Connexin43 Region 266-283, via Src Inhibition, Reduces
            Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and
            Increases Astrocytic Differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4799)
  AUTHORS   Niu,J., Li,W., Liang,C., Wang,X., Yao,X., Yang,R.H., Zhang,Z.S.,
            Liu,H.F., Liu,F.Y., Pei,S.H., Li,W.Q., Sun,H., Fang,D. and Xie,S.Q.
  TITLE     EGF promotes DKK1 transcription in hepatocellular carcinoma by
            enhancing the phosphorylation and acetylation of histone H3
  JOURNAL   Sci Signal 13 (657) (2020)
   PUBMED   33172955
  REMARK    GeneRIF: EGF promotes DKK1 transcription in hepatocellular
            carcinoma by enhancing the phosphorylation and acetylation of
            histone H3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4799)
  AUTHORS   Li,C., Zhuang,M., Zhu,B., Li,Y., Zhang,W., Yan,H., Zhang,P., Li,D.,
            Yang,J., Sun,Y., Chen,H., Cui,Q., Jin,P. and Sun,Y.
  TITLE     Epidermal growth factor regulation by autophagy-mediated lncRNA H19
            in murine intestinal tract after severe burn
  JOURNAL   J Cell Mol Med 24 (10), 5878-5887 (2020)
   PUBMED   32301281
  REMARK    GeneRIF: Epidermal growth factor regulation by autophagy-mediated
            lncRNA H19 in murine intestinal tract after severe burn.
REFERENCE   5  (bases 1 to 4799)
  AUTHORS   Mukherjee,T., Udupa,V.A.V., Prakhar,P., Chandra,K., Chakravortty,D.
            and Balaji,K.N.
  TITLE     Epidermal Growth Factor Receptor-Responsive Indoleamine
            2,3-Dioxygenase Confers Immune Homeostasis During Shigella flexneri
            Infection
  JOURNAL   J Infect Dis 219 (11), 1841-1851 (2019)
   PUBMED   30615126
REFERENCE   6  (bases 1 to 4799)
  AUTHORS   Saggi,S.J., Safirstein,R. and Price,P.M.
  TITLE     Cloning and sequencing of the rat preproepidermal growth factor
            cDNA: comparison with mouse and human sequences
  JOURNAL   DNA Cell Biol 11 (6), 481-487 (1992)
   PUBMED   1524680
REFERENCE   7  (bases 1 to 4799)
  AUTHORS   North,D., Lakshmanan,J., Reviczky,A., Kaser,M. and Fisher,D.A.
  TITLE     Ontogeny of epidermal growth factor, transforming growth
            factor-alpha, epidermal growth factor receptor, and thyroid hormone
            receptor RNA levels in rat kidney and changes in those levels
            induced by early thyroxine treatment
  JOURNAL   Pediatr Res 31 (4 Pt 1), 330-334 (1992)
   PUBMED   1570198
REFERENCE   8  (bases 1 to 4799)
  AUTHORS   Yamanaka,Y.
  TITLE     The immunohistochemical expressions of epidermal growth factors,
            epidermal growth factor receptors and c-erbB-2 oncoprotein in human
            pancreatic cancer
  JOURNAL   Nihon Ika Daigaku Zasshi 59 (1), 51-61 (1992)
   PUBMED   1347773
REFERENCE   9  (bases 1 to 4799)
  AUTHORS   Schaudies,R.P., Grimes,J., Wray,H.L. and Koldovsky,O.
  TITLE     Identification and partial characterization of multiple forms of
            biologically active EGF in rat milk
  JOURNAL   Am J Physiol 259 (6 Pt 1), G1056-G1061 (1990)
   PUBMED   2260661
REFERENCE   10 (bases 1 to 4799)
  AUTHORS   Mayo,K.H., Cavalli,R.C., Peters,A.R., Boelens,R. and Kaptein,R.
  TITLE     Sequence-specific 1H-n.m.r. assignments and peptide backbone
            conformation in rat epidermal growth factor
  JOURNAL   Biochem J 257 (1), 197-205 (1989)
   PUBMED   2784052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Feb 4, 2021 this sequence version replaced
            XM_039101779.1, NM_012842.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062030.1, SRR26643297.9498.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               JAXUCZ010000002.1  220975793-220976297 c
            506-705             JAXUCZ010000002.1  220960094-220960293 c
            706-887             JAXUCZ010000002.1  220957858-220958039 c
            888-1115            JAXUCZ010000002.1  220957246-220957473 c
            1116-1318           JAXUCZ010000002.1  220956373-220956575 c
            1319-1444           JAXUCZ010000002.1  220944360-220944485 c
            1445-1567           JAXUCZ010000002.1  220942502-220942624 c
            1568-1690           JAXUCZ010000002.1  220939617-220939739 c
            1691-1816           JAXUCZ010000002.1  220938284-220938409 c
            1817-1953           JAXUCZ010000002.1  220937162-220937298 c
            1954-2102           JAXUCZ010000002.1  220934618-220934766 c
            2103-2207           JAXUCZ010000002.1  220931057-220931161 c
            2208-2431           JAXUCZ010000002.1  220929255-220929478 c
            2432-2599           JAXUCZ010000002.1  220924702-220924869 c
            2600-2749           JAXUCZ010000002.1  220923468-220923617 c
            2750-2875           JAXUCZ010000002.1  220920009-220920134 c
            2876-2992           JAXUCZ010000002.1  220915266-220915382 c
            2993-3118           JAXUCZ010000002.1  220914290-220914415 c
            3119-3241           JAXUCZ010000002.1  220911265-220911387 c
            3242-3386           JAXUCZ010000002.1  220909197-220909341 c
            3387-3554           JAXUCZ010000002.1  220905119-220905286 c
            3555-3672           JAXUCZ010000002.1  220902077-220902194 c
            3673-3778           JAXUCZ010000002.1  220896684-220896789 c
            3779-4799           JAXUCZ010000002.1  220893660-220894680 c
FEATURES             Location/Qualifiers
     source          1..4799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..4799
                     /gene="Egf"
                     /note="epidermal growth factor"
                     /db_xref="GeneID:25313"
                     /db_xref="RGD:2542"
     exon            1..505
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..3774
                     /gene="Egf"
                     /note="pro-epidermal growth factor"
                     /codon_start=1
                     /product="pro-epidermal growth factor precursor"
                     /protein_id="NP_036974.2"
                     /db_xref="GeneID:25313"
                     /db_xref="RGD:2542"
                     /translation="MLFSLTFLSVFLKITVLSVTAQQTRNCQSGPLERSGTSTYAAAG
                     PPRFLIFLQGNSIFRINTDGTNHQQLVVDAGVSVVMDFHYKEERLYWVDLERQLLQRV
                     FFNGSGQETVCKVDKNVSGLAINWIDGEILRTDRWKGVITVTDMNGNNSRVLLSSLKR
                     PANILVDPTERLIFWSSVVTGNLHRADLGGMDVKTLLEAPERISVLILDILDKRLFWA
                     QDGREGSHGYIHSCDYDGGSIHHIRHQARHDLLTMAIFGDKILYSALKEKAIWIADKH
                     TGKNVVRVNLDPASVPPRELRVVHLHAQPGTENRAQASDSERCKQRRGQCLYSLSERD
                     PNSDSCACAEGYTLSRDRKYCEDVNECALQNHGCTLGCENIPGSYYCTCPTGFVLLPD
                     GKRCHELVACPGNRSECSHDCILTSDGPLCICPAGSVLGKDGKTCTGCSSPDNGGCSQ
                     ICLPLSLASWECDCFPGYDLQLDRKSCAASGPQPFLLFANSQDIRHMHFDGTDYKTLL
                     SRQMGMVFALDYDPVESKIYFAQTALKWIERANLDGSQRERLITEGVDTPEGLAVDWI
                     GRRIYWTDSGKSVIEGSDLSGKHHQIIIKESISRPRGIAVHPKARRLFWTDTGMSPRI
                     ESSSLQGSDRTLIASSNLLEPSGIAIDYLTDTLYWCDTKLSVIEMADLDGSKRRRLTQ
                     NDVGHPFSLAVFEDHVWFSDWAIPSVIRVNKRTGQNRVRLRGSMLKPSSLVVVHPLAK
                     PGADPCLHRNGGCEHICQESLGTAQCLCREGFVKAPDGKMCLTRKDDQILAGDNADLS
                     KEVASLDNSPKAYVPDDDRTESSTLVAEIMVSGLNYEDDCGPGGCGSHAHCISEGEAA
                     VCQCLKGFAGDGNLCSDIDECELGSSDCPPTSSRCINTEGGYVCQCSEGYEGDGIYCL
                     DVDECQQGSHGCSENATCTNTEGGYNCTCAGCPSAPGLPCPDSTSPSLLGKDGCHWVR
                     NSITGCPPSYDGYCLNGGVCMYVESVDRYVCNCVIGYIGERCQHRDLRWWKLRHADYG
                     QRHDITVVSVCVVALALLLLLGMWGTYYYRTRKQLSESSKKPSEESSSNVSSNGPDSS
                     GAGVSSGPQPWFVVLEEHQQPKNGRLPAAGTNGAVVEAGLSSSL"
     exon            506..705
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            706..887
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1115
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1318
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1444
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1567
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1690
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1816
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1953
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2102
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2207
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2431
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2599
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2749
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2875
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2992
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3118
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3241
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3386
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3554
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3672
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3778
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..4799
                     /gene="Egf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcagggaa ggaatcctat ctgcatattt cgtctttagc cccatccctc attcccggtg
       61 gggtttggaa ctttccatca attctttccc tgtctcattt ctctttgagc ctttgcctag
      121 ctgtgcctgt cacagcgaga aatcagtcac cctcggcctt ccagcactct taggctctga
      181 gaaatttggc atacgggtgt caggtattaa aacagctaaa taaaagatgc cctggggctg
      241 aaggccagcg tggctggaag ttctgggggt cagaagcctg actccgcctg ctccaagctc
      301 tagcaattta agtcacccag gggttttttg ttttggtttg gtttggtttt tcttgacctt
      361 agaaccaccg agaccatgct gttctcgctc accttcctgt cggtgttttt aaagattact
      421 gtactcagtg tcacagcaca gcagaccagg aactgtcagt caggtcctct cgagagaagc
      481 gggacttcca cgtatgccgc cgccggtcct cccaggttcc tgattttctt acaaggaaac
      541 agcatctttc ggattaacac agatggaaca aatcaccagc aattggtggt ggatgccggc
      601 gtctcagtgg tcatggattt tcattacaag gaagagagac tctattgggt ggatttagaa
      661 agacaacttt tgcaaagagt tttctttaat gggtcaggac aagagacagt gtgcaaggtg
      721 gataagaatg tttctgggct ggccataaac tggatagatg gggagattct ccggacggac
      781 cgatggaagg gagtcatcac agtaacagat atgaacggga acaattcccg tgttcttctg
      841 agttccttaa aacgtcctgc aaatatatta gtggatccaa cagagaggtt gatattttgg
      901 tcttcagtgg tgactggcaa ccttcacaga gcagatctcg ggggtatgga tgtaaaaaca
      961 ctgctggagg caccagagag gatatcagtg ctgattctgg atatcctgga caaaaggctc
     1021 ttctgggctc aggacggtag agaaggaagc cacggttaca ttcactcctg tgactatgac
     1081 ggtggctcca tccatcatat cagacatcaa gcacggcacg atttgcttac tatggccatt
     1141 ttcggtgaca agatcttata ctcagcactg aaagagaagg cgatttggat agccgacaaa
     1201 cacactggga agaatgtggt tcgagttaac ctcgatccag cctctgtgcc gccaagagaa
     1261 ctgagagtcg tgcacctaca tgcacagccc gggacagaga accgtgctca ggcctctgac
     1321 tccgaacgat gcaaacagag aagaggacag tgtctctaca gtctctctga gcgagacccc
     1381 aactcagact cgtgcgcatg cgctgaaggc tatacgttaa gccgagaccg gaagtactgc
     1441 gaagatgtca atgagtgtgc cttgcagaat cacggctgta ctcttgggtg tgaaaacatc
     1501 cctggatcct attactgcac atgccctaca ggctttgttc tgcttcctga tgggaaacga
     1561 tgtcacgaac ttgttgcctg tccaggcaac agatcagagt gtagccatga ttgcatcctg
     1621 acatcagatg gtcctctgtg catctgtcca gcaggttcag tgctcggaaa agatgggaag
     1681 acatgcactg gttgttcatc tcctgataat ggtggatgca gccagatctg ccttcctctc
     1741 agcctagcat cctgggaatg tgattgcttt cctgggtacg acctacaatt ggaccgaaag
     1801 agctgtgcag cttcaggacc gcagccattt ttactgtttg caaattccca ggacatacga
     1861 cacatgcatt ttgatggaac agactacaaa actctgctca gccggcagat gggaatggtt
     1921 tttgccttgg attatgaccc cgtggaaagc aagatatatt ttgcacagac agccctgaag
     1981 tggatagaga gggctaatct ggatggctcc cagcgagaaa gacttatcac ggaaggagta
     2041 gacacgccag aaggtcttgc cgtggactgg attggccgga gaatctactg gacggacagt
     2101 gggaagtccg tcattgaagg gagtgatttg agcgggaagc atcatcaaat aatcatcaaa
     2161 gagagcatct caaggccacg aggaatagct gtgcatccaa aggccaggag actattctgg
     2221 acggacacgg ggatgtctcc gcggattgaa agctcttccc ttcaaggttc tgaccggacg
     2281 ctgatagcca gctctaatct actggaaccc agtggaatcg cgattgacta cttaacagac
     2341 actttgtact ggtgtgacac caagctgtct gtgattgaaa tggccgatct agatggttcc
     2401 aaacgccgca gacttaccca gaacgatgta ggtcacccat tctctctagc tgtgtttgag
     2461 gatcacgtgt ggttctcgga ttgggctatc ccatcggtaa taagggtgaa caagaggact
     2521 ggtcaaaaca gggtacgtct ccgaggcagc atgctgaagc cctcgtcact ggttgtggtc
     2581 cacccattgg caaaaccagg tgcagacccc tgcttacaca ggaatggagg ctgtgaacac
     2641 atctgccaag agagcctggg cacggctcag tgtctgtgtc gggaaggatt cgtgaaggcc
     2701 ccagatggga aaatgtgtct cactcggaag gatgatcaga tactggccgg tgacaatgct
     2761 gatcttagta aagaggtagc atcgttggac aactccccta aggcttatgt accagacgat
     2821 gacaggacag agtcctccac actagtggct gagatcatgg tgtcagggct gaactatgaa
     2881 gatgactgcg gccctggtgg gtgtggcagc catgcccact gtatttcaga gggagaggca
     2941 gctgtgtgtc agtgtttgaa aggatttgct ggcgatggaa acctgtgttc tgatatagac
     3001 gaatgtgagc tgggtagctc agactgtcct cccacctcgt ccaggtgcat caacaccgaa
     3061 ggtggctatg tctgccaatg ctcagaaggc tacgagggag atgggatcta ctgtctcgac
     3121 gttgatgagt gccagcaggg gtcgcacggc tgcagcgaga atgccacctg caccaacacg
     3181 gagggaggct acaactgcac ctgtgcaggc tgcccatcag cacctggact gccttgccct
     3241 gactctacct caccctctct ccttggaaaa gatggctgcc actgggtccg aaacagtatc
     3301 acaggatgcc cgccgtcgta cgatgggtac tgcctcaatg gtggcgtgtg catgtatgtt
     3361 gaatccgtgg accgctacgt gtgcaactgt gtcattggct atattggaga acgatgtcag
     3421 caccgagact tacgttggtg gaagctgcgc catgctgact acgggcagag gcacgacatc
     3481 actgtggtgt ctgtctgtgt ggtggcgctg gccctgctgc tcctcttagg gatgtggggg
     3541 acttactact acaggactcg gaagcagcta tcagagagct caaagaagcc ttccgaagag
     3601 tcaagcagca acgtgagcag taacgggcct gacagcagcg gggctggggt gtcttctggt
     3661 ccccaacctt ggtttgtggt cctagaggaa caccaacagc ccaagaatgg gcgtctgcct
     3721 gccgctggca cgaacggcgc agtagtagag gctggcctgt cttcctccct gtaactcggg
     3781 ccagtgcacc tgacttcctg gagacagaag ccccgcatat atgagatggg cacagagcaa
     3841 agctgctgga ttccaccatc aaatgacaaa ggaccccagg aaatggaggg gaacccccac
     3901 ttaccctcct acagggaatg gcctctagct gtgtgggctg agaagaagct gcattctctc
     3961 cagtcagcta atggatcgag tcaacaaagg gcctcagacc tgccccagca aacagagcca
     4021 gttctgtaga aactgggagc agacagaagg taccgaaagt gaaatagcaa accaggctga
     4081 agggtggtag agcggcagat ctggtactcc tgtctccacg gctaatcact gctcagggtc
     4141 ctgaagataa ctgcatagct gcatagctgc atagccgcga cttctgcttc ttgcttcaag
     4201 cagtcccgtt gaagacgatc aaaagagaag tggagaaaaa tcatcagaaa ccgaagtcaa
     4261 gacgttcacg tgttgtaagc tgtgtcttct accctggact gttgggctct tttccttgtt
     4321 gtctcagaag aaatgggtta aagcaggcga tcacatgctt tgttgattgc acagtagatg
     4381 atatgatcta catagatctt agctcactct cacggaaagg ctggaacatt atagatgctg
     4441 ctaagataca ctgcaagtgt ggcccctgct cataattttg ccttctgaat tgtgattagt
     4501 gaaaataatt gtaacttaga gtccgattta ttcagaatca gagcatttat ttttatacta
     4561 tgaaaatctt tgaatgaaga tatttaactt taaaaacatt tcctaagaga caacagtgtt
     4621 tcttaatcat tgtcttttct tcttgcagtc tttcccagtg aaaacggtaa attctgctgt
     4681 ttgcatagaa tctttaactt atttttaaga tatgagattg taaacaaatt gcttgattta
     4741 tttcaatcaa tttattctaa ttatttaaat aaaatcaccc taagacatca gcataataa
//
