LOCUS       NM_053903                768 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ephrin A5 (Efna5), mRNA.
ACCESSION   NM_053903 XM_579582
VERSION     NM_053903.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 768)
  AUTHORS   Li,S., Zhai,J., Xu,B., Liu,J., Chu,W., Wang,D., Geng,X., Chen,Z.J.
            and Du,Y.
  TITLE     Erythropoietin-producing hepatocellular receptor A7 restrains
            estrogen negative feedback of luteinizing hormone via ephrin A5 in
            the hypothalamus of female rats
  JOURNAL   Am J Physiol Endocrinol Metab 319 (1), E81-E90 (2020)
   PUBMED   32396496
  REMARK    GeneRIF: Erythropoietin-producing hepatocellular receptor A7
            restrains estrogen negative feedback of luteinizing hormone via
            ephrin A5 in the hypothalamus of female rats.
REFERENCE   2  (bases 1 to 768)
  AUTHORS   Suo,G., Shen,F., Sun,B., Song,H., Xu,M. and Wu,Y.
  TITLE     Abnormal expression of ephrin-A5 affects brain development of
            congenital hypothyroidism rats
  JOURNAL   Neuroreport 29 (11), 877-882 (2018)
   PUBMED   29762250
  REMARK    GeneRIF: that ephrin-A5 expression may be decreased in congenital
            hypothyroidism, and abnormal activation of ephrin-A5/EphA5
            signaling affects synaptogenesis during brain development
REFERENCE   3  (bases 1 to 768)
  AUTHORS   Liu,T.T., Xiao,B., Li,S.Y., Li,G.L., Lu,X.Q. and Liu,W.P.
  TITLE     [Changes in the expression of EphA5/ephrinA5 in the CA3 region of
            the hippocampus in rats with epilepsy and their role in the
            pathogenesis of temporal lobe epilepsy]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 19 (12), 1272-1277 (2017)
   PUBMED   29237529
  REMARK    GeneRIF: Downregulation of ephrinA5 and EphA5 in the CA3 region of
            the hippocampus may participate in the mechanism of mossy fiber
            sprouting and is closely associated with the development and
            progression of epilepsy.
REFERENCE   4  (bases 1 to 768)
  AUTHORS   Szepietowska,B., Horvath,T.L. and Sherwin,R.S.
  TITLE     Role of synaptic plasticity and EphA5-ephrinA5 interaction within
            the ventromedial hypothalamus in response to recurrent hypoglycemia
  JOURNAL   Diabetes 63 (3), 1140-1147 (2014)
   PUBMED   24222347
  REMARK    GeneRIF: changes in ephrinA5/EphA5 interactions and synaptic
            plasticity within the ventromedial hypothalamus may contribute to
            the impairment in glucagon secretion and counterregulatory
            responses caused by recurrent hypoglycemia.
REFERENCE   5  (bases 1 to 768)
  AUTHORS   Szepietowska,B., Zhu,W., Czyzyk,J., Eid,T. and Sherwin,R.S.
  TITLE     EphA5-EphrinA5 interactions within the ventromedial hypothalamus
            influence counterregulatory hormone release and local
            glutamine/glutamate balance during hypoglycemia
  JOURNAL   Diabetes 62 (4), 1282-1288 (2013)
   PUBMED   23274893
  REMARK    GeneRIF: Changes in ephrinA5/EphA5 interactions within the
            ventromedial hypothalamus act in concert with islets to restore
            glucose homeostasis during acute hypoglycemia, and its effect on
            counterregulation may be mediated by changes in glutamate/glutamine
            cycling.
REFERENCE   6  (bases 1 to 768)
  AUTHORS   Knoll,B., Zarbalis,K., Wurst,W. and Drescher,U.
  TITLE     A role for the EphA family in the topographic targeting of
            vomeronasal axons
  JOURNAL   Development 128 (6), 895-906 (2001)
   PUBMED   11222144
REFERENCE   7  (bases 1 to 768)
  AUTHORS   Holmberg,J., Clarke,D.L. and Frisen,J.
  TITLE     Regulation of repulsion versus adhesion by different splice forms
            of an Eph receptor
  JOURNAL   Nature 408 (6809), 203-206 (2000)
   PUBMED   11089974
REFERENCE   8  (bases 1 to 768)
  AUTHORS   Castellani,V., Yue,Y., Gao,P.P., Zhou,R. and Bolz,J.
  TITLE     Dual action of a ligand for Eph receptor tyrosine kinases on
            specific populations of axons during the development of cortical
            circuits
  JOURNAL   J Neurosci 18 (12), 4663-4672 (1998)
   PUBMED   9614241
REFERENCE   9  (bases 1 to 768)
  AUTHORS   Park,S. and Sanchez,M.P.
  TITLE     The Eek receptor, a member of the Eph family of tyrosine protein
            kinases, can be activated by three different Eph family ligands
  JOURNAL   Oncogene 14 (5), 533-542 (1997)
   PUBMED   9053851
REFERENCE   10 (bases 1 to 768)
  AUTHORS   Winslow,J.W., Moran,P., Valverde,J., Shih,A., Yuan,J.Q., Wong,S.C.,
            Tsai,S.P., Goddard,A., Henzel,W.J., Hefti,F. et al.
  TITLE     Cloning of AL-1, a ligand for an Eph-related tyrosine kinase
            receptor involved in axon bundle formation
  JOURNAL   Neuron 14 (5), 973-981 (1995)
   PUBMED   7748564
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U69279.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by NM_053903.2.
            
            On Apr 19, 2005 this sequence version replaced XM_579582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..768
                     /gene="Efna5"
                     /gene_synonym="Lerk7"
                     /note="ephrin A5"
                     /db_xref="GeneID:116683"
                     /db_xref="RGD:620391"
     exon            1..163
                     /gene="Efna5"
                     /gene_synonym="Lerk7"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..725
                     /gene="Efna5"
                     /gene_synonym="Lerk7"
                     /note="AL-1; LERK-7; eph-related receptor tyrosine kinase
                     ligand 7"
                     /codon_start=1
                     /product="ephrin-A5 precursor"
                     /protein_id="NP_446355.1"
                     /db_xref="GeneID:116683"
                     /db_xref="RGD:620391"
                     /translation="MLHVEMLTLLFLVLWMCVFSQDPGSKVVADRYAVYWNSSNPRFQ
                     RGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWEC
                     NRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRP
                     TNSCMKTIGVRDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAIL
                     LFLLAMLLTL"
     exon            164..456
                     /gene="Efna5"
                     /gene_synonym="Lerk7"
                     /inference="alignment:Splign:2.1.0"
     exon            457..522
                     /gene="Efna5"
                     /gene_synonym="Lerk7"
                     /inference="alignment:Splign:2.1.0"
     exon            523..603
                     /gene="Efna5"
                     /gene_synonym="Lerk7"
                     /inference="alignment:Splign:2.1.0"
     exon            604..768
                     /gene="Efna5"
                     /gene_synonym="Lerk7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggcgcg tcgggggctc cgccgctggc taggcgtgat gttgcacgtg gagatgttga
       61 cgctgctctt tctggtgctc tggatgtgtg tgttcagcca ggacccgggc tccaaagtcg
      121 tcgccgaccg ctacgccgtc tactggaaca gcagcaaccc cagattccag aggggtgact
      181 accacatcga tgtctgtatc aatgactacc tggatgtttt ctgccctcac tatgaggact
      241 ctgtaccaga ggataagact gagcgctatg tcctgtacat ggtgaatttt gatggctaca
      301 gtgcctgcga ccacacatcc aaagggttca agagatggga atgtaaccgg cctcactctc
      361 caaacggacc gctgaagttc tcggagaaat tccagctctt cactcccttt tctttaggat
      421 ttgaattcag gccaggccga gagtatttct acatctcctc tgcaatccca gacaatggaa
      481 gaagatcctg cctaaagctc aaagtctttg tgaggccaac aaacagctgt atgaaaacta
      541 taggtgttcg tgatcgtgtt ttcgatgtta acgacaaagt agaaaattca ttagaaccag
      601 cagatgacac cgtacatgag tcagccgagc catcccgcgg agagaacgcg gcacaaacac
      661 caaggatacc cagccgcctt ttggcaatcc tactgttcct cctggcgatg cttttgacat
      721 tatagcacag tctcctcccg tcacctgtca cagaaaacat cagggtct
//
