LOCUS       NM_001168670            1177 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ephrin A2 (Efna2), mRNA.
ACCESSION   NM_001168670 XM_001076723 XM_234903
VERSION     NM_001168670.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1177)
  AUTHORS   Kenmuir,C.L., Chiaia,N.L., Lane,R.D. and Mooney,R.D.
  TITLE     Laminar expression of ephrin-A2 in primary somatosensory cortex of
            postnatal rats
  JOURNAL   Anat Rec (Hoboken) 295 (1), 105-112 (2012)
   PUBMED   22147308
  REMARK    GeneRIF: Ephrin-A2, in concert with one or more Eph receptors, may
            be postnatally involved in arbor development of thalamocortical
            axons at cortical layer IV boundaries.
REFERENCE   2  (bases 1 to 1177)
  AUTHORS   Irie,N., Takada,Y., Watanabe,Y., Matsuzaki,Y., Naruse,C., Asano,M.,
            Iwakura,Y., Suda,T. and Matsuo,K.
  TITLE     Bidirectional signaling through ephrinA2-EphA2 enhances
            osteoclastogenesis and suppresses osteoblastogenesis
  JOURNAL   J Biol Chem 284 (21), 14637-14644 (2009)
   PUBMED   19299512
REFERENCE   3  (bases 1 to 1177)
  AUTHORS   Symonds,A.C., King,C.E., Bartlett,C.A., Sauve,Y., Lund,R.D.,
            Beazley,L.D., Dunlop,S.A. and Rodger,J.
  TITLE     EphA5 and ephrin-A2 expression during optic nerve regeneration: a
            'two-edged sword'
  JOURNAL   Eur J Neurosci 25 (3), 744-752 (2007)
   PUBMED   17328773
  REMARK    GeneRIF: The repulsive ephrin-A2 environment offers at least a
            partial explanation for the observation that only a limited number
            of retinal ganglion cell axons can exit nerve graft to enter target
            central nervous system tissue.
REFERENCE   4  (bases 1 to 1177)
  AUTHORS   Surawska,H., Ma,P.C. and Salgia,R.
  TITLE     The role of ephrins and Eph receptors in cancer
  JOURNAL   Cytokine Growth Factor Rev 15 (6), 419-433 (2004)
   PUBMED   15561600
  REMARK    Review article
REFERENCE   5  (bases 1 to 1177)
  AUTHORS   Wang,Y., Ying,G., Liu,X. and Zhou,C.
  TITLE     Semi-quantitative expression analysis of ephrin mRNAs in the
            deafferented hippocampus
  JOURNAL   Brain Res Mol Brain Res 120 (1), 79-83 (2003)
   PUBMED   14667581
  REMARK    GeneRIF: It is notable that the up-regulation of ephrin mRNAs
            occurs during the reorganization in the deafferented hippocampus,
            suggesting that ephrins may be involved in the plasticity events of
            the adult brain after lesion.
REFERENCE   6  (bases 1 to 1177)
  AUTHORS   St John,J.A., Pasquale,E.B. and Key,B.
  TITLE     EphA receptors and ephrin-A ligands exhibit highly regulated
            spatial and temporal expression patterns in the developing
            olfactory system
  JOURNAL   Brain Res Dev Brain Res 138 (1), 1-14 (2002)
   PUBMED   12234653
REFERENCE   7  (bases 1 to 1177)
  AUTHORS   Munoz,J.J., Alonso-C,L.M., Sacedon,R., Crompton,T., Vicente,A.,
            Jimenez,E., Varas,A. and Zapata,A.G.
  TITLE     Expression and function of the Eph A receptors and their ligands
            ephrins A in the rat thymus
  JOURNAL   J Immunol 169 (1), 177-184 (2002)
   PUBMED   12077243
  REMARK    GeneRIF: Ephrin A2 expression is restricted to the adult thymic
            medullary epithelial cells and some perivascular and peritrabecular
            areas.
REFERENCE   8  (bases 1 to 1177)
  AUTHORS   Lai,K.O., Ip,F.C., Cheung,J., Fu,A.K. and Ip,N.Y.
  TITLE     Expression of Eph receptors in skeletal muscle and their
            localization at the neuromuscular junction
  JOURNAL   Mol Cell Neurosci 17 (6), 1034-1047 (2001)
   PUBMED   11414792
REFERENCE   9  (bases 1 to 1177)
  AUTHORS   Matsunaga,T., Greene,M.I. and Davis,J.G.
  TITLE     Distinct expression patterns of eph receptors and ephrins relate to
            the structural organization of the adult rat peripheral vestibular
            system
  JOURNAL   Eur J Neurosci 12 (5), 1599-1616 (2000)
   PUBMED   10792438
REFERENCE   10 (bases 1 to 1177)
  AUTHORS   Park,S. and Sanchez,M.P.
  TITLE     The Eek receptor, a member of the Eph family of tyrosine protein
            kinases, can be activated by three different Eph family ligands
  JOURNAL   Oncogene 14 (5), 533-542 (1997)
   PUBMED   9053851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_234903.4, XM_001076723.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.38080.1,
                                           SRR26643299.29786.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840110,
                                           SAMN12840129 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               JAXUCZ010000007.1  10177354-10177719   c
            367-680             JAXUCZ010000007.1  10169103-10169416   c
            681-746             JAXUCZ010000007.1  10167714-10167779   c
            747-1177            JAXUCZ010000007.1  10167091-10167521   c
FEATURES             Location/Qualifiers
     source          1..1177
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1177
                     /gene="Efna2"
                     /note="ephrin A2"
                     /db_xref="GeneID:84358"
                     /db_xref="RGD:620389"
     exon            1..366
                     /gene="Efna2"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..868
                     /gene="Efna2"
                     /note="ephrin A-2"
                     /codon_start=1
                     /product="ephrin-A2 precursor"
                     /protein_id="NP_001162141.1"
                     /db_xref="GeneID:84358"
                     /db_xref="RGD:620389"
                     /translation="MAPAQRPLLPLLLLLLPLRARNEDPARANADRYAVYWNRSNPRF
                     QVSAVGDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMERYILYMVNGEGHASCDHRQ
                     RGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNLVDRPCL
                     RLKVYVRPTNETLYEAPEPIFTSNSSCSGLGGCHLFLTTVPVLWSLLGS"
     exon            367..680
                     /gene="Efna2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..746
                     /gene="Efna2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1177
                     /gene="Efna2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagagcgc cttgcgcagt gcaccgttcc ggcctctgtc ccgcgctgcg gccaccgccg
       61 ccgccgcctg gtttctcggc gcccgcggtc tacagcgggg gccgcgcgca gaggcggggc
      121 ggcggatctc caagcgcgcg gcgctccgcc cgctccgcgg cggaggcgga ggcggagacg
      181 gcggggccag gcggcggctg gagagcgagg gagcgagcgc ggcggcagca ccggggccat
      241 ggcgcccgcg cagcgcccgc tgctgccgct gctgctgttg ctgctgccgc tgcgtgcgcg
      301 caacgaggac ccggcccgtg ccaacgctga ccgctacgca gtctactgga accgcagcaa
      361 ccccaggttt caggtgagcg ctgtgggtga tggcggcggc tacaccgtgg aggtcagcat
      421 caatgactac ctggacatct attgcccgca ctatggggcg ccactgcccc cggcagagcg
      481 catggaacgg tacatcctat acatggtgaa cggcgagggc catgcctcct gtgaccaccg
      541 gcagcgaggc ttcaagcgct gggaatgcaa ccggcccgct gcgcctgggg gacccctcaa
      601 attctccgag aagttccaac tcttcacccc cttttccctg ggctttgagt tccgacctgg
      661 acacgagtac tactacatct ctgccacacc ccccaacctt gtggaccgac cctgcctgcg
      721 gctgaaagtt tacgtgcgtc caaccaatga gaccctgtat gaggccccag agcccatctt
      781 caccagtaac agctcctgca gcggcctggg tggctgccac ctcttcctca ctacagtccc
      841 tgtgctgtgg tccctactgg gctcctagtg tccagcccca cctggacccc ttgaccttcg
      901 ccctctgacc tgccacggcc acctccgaga caaaatcctt gctgcttctc tttcatggtg
      961 ctgtccctcc ggaggaggcc atcgaccggt ccctgggatg caacatgggg tcccagtgcc
     1021 tgagactgag atccaggctg agccactttt gccaggacca ccagggccgt ccagtgttgt
     1081 ttgattacgg tcagaaagac ttagggtttc tcttttaatt taatttattc cctgatattg
     1141 ctggtgacat tgggaaggaa acaagtcaca ggggtga
//
