LOCUS       NM_053599               1495 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ephrin A1 (Efna1), mRNA.
ACCESSION   NM_053599
VERSION     NM_053599.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1495)
  AUTHORS   Harboe,M., Torvund-Jensen,J., Kjaer-Sorensen,K. and Laursen,L.S.
  TITLE     Ephrin-A1-EphA4 signaling negatively regulates myelination in the
            central nervous system
  JOURNAL   Glia 66 (5), 934-950 (2018)
   PUBMED   29350423
  REMARK    GeneRIF: In myelinating co-cultures and in zebrafish, we find that
            the number of mature oligodendrocytes does not change as result of
            manipulating signaling through the ephrinA1-EphA4 system. However,
            in both systems, inhibition of EphA4 signaling leads to a higher
            number of myelin sheaths formed by each oligodendrocyte. In
            isolated oligodendrocyte cultures, activation of EphA4 reduced
            process extension.
REFERENCE   2  (bases 1 to 1495)
  AUTHORS   Li,M., Wang,B., Wu,Z., Zhang,J., Shi,X., Cheng,W. and Han,S.
  TITLE     A novel recombinant protein of ephrinA1-PE38/GM-CSF activate
            dendritic cells vaccine in rats with glioma
  JOURNAL   Tumour Biol 36 (7), 5497-5503 (2015)
   PUBMED   25677907
  REMARK    GeneRIF: The findings that ephrinA1-PE38/GM-CSF had a high efficacy
            in the activation of the dendritic cells would facilitate the
            development of in vivo dendritic-cell vaccines for the treatment of
            gliomas in rats
REFERENCE   3  (bases 1 to 1495)
  AUTHORS   Lai,W.B., Wang,B.J., Hu,M.K., Hsu,W.M., Her,G.M. and Liao,Y.F.
  TITLE     Ligand-dependent activation of EphA4 signaling regulates the
            proteolysis of amyloid precursor protein through a Lyn-mediated
            pathway
  JOURNAL   Mol Neurobiol 49 (2), 1055-1068 (2014)
   PUBMED   24217950
REFERENCE   4  (bases 1 to 1495)
  AUTHORS   Arocho,L.C., Figueroa,J.D., Torrado,A.I., Santiago,J.M., Vera,A.E.
            and Miranda,J.D.
  TITLE     Expression profile and role of EphrinA1 ligand after spinal cord
            injury
  JOURNAL   Cell Mol Neurobiol 31 (7), 1057-1069 (2011)
   PUBMED   21603973
  REMARK    GeneRIF: Data suggest that ephrinA1 ligands play a role in the
            pathophysiology of spinal cord injury.
REFERENCE   5  (bases 1 to 1495)
  AUTHORS   Frieden,L.A., Townsend,T.A., Vaught,D.B., Delaughter,D.M.,
            Hwang,Y., Barnett,J.V. and Chen,J.
  TITLE     Regulation of heart valve morphogenesis by Eph receptor ligand,
            ephrin-A1
  JOURNAL   Dev Dyn 239 (12), 3226-3234 (2010)
   PUBMED   20960543
REFERENCE   6  (bases 1 to 1495)
  AUTHORS   Deroanne,C., Vouret-Craviari,V., Wang,B. and Pouyssegur,J.
  TITLE     EphrinA1 inactivates integrin-mediated vascular smooth muscle cell
            spreading via the Rac/PAK pathway
  JOURNAL   J Cell Sci 116 (Pt 7), 1367-1376 (2003)
   PUBMED   12615978
  REMARK    GeneRIF: The Rac/PAK pathwayis involved in ephrinA1-mediated
            inhibition of cell spreading. In this way, ephrinA1, alone or in
            synergy with S1P, can participate in blood vessel destabilization,
            a prerequisite for angiogenesis.
REFERENCE   7  (bases 1 to 1495)
  AUTHORS   Munoz,J.J., Alonso-C,L.M., Sacedon,R., Crompton,T., Vicente,A.,
            Jimenez,E., Varas,A. and Zapata,A.G.
  TITLE     Expression and function of the Eph A receptors and their ligands
            ephrins A in the rat thymus
  JOURNAL   J Immunol 169 (1), 177-184 (2002)
   PUBMED   12077243
  REMARK    GeneRIF: Ephrin A1 is expressed in adult thymic connective tissue
            trabeculae, most cortical epithelial cells, and both cortical and
            medullary thymocytes.
REFERENCE   8  (bases 1 to 1495)
  AUTHORS   Naruse-Nakajima,C., Asano,M. and Iwakura,Y.
  TITLE     Involvement of EphA2 in the formation of the tail notochord via
            interaction with ephrinA1
  JOURNAL   Mech Dev 102 (1-2), 95-105 (2001)
   PUBMED   11287184
REFERENCE   9  (bases 1 to 1495)
  AUTHORS   Miao,H., Burnett,E., Kinch,M., Simon,E. and Wang,B.
  TITLE     Activation of EphA2 kinase suppresses integrin function and causes
            focal-adhesion-kinase dephosphorylation
  JOURNAL   Nat Cell Biol 2 (2), 62-69 (2000)
   PUBMED   10655584
REFERENCE   10 (bases 1 to 1495)
  AUTHORS   Takahashi,H. and Ikeda,T.
  TITLE     Molecular cloning and expression of rat and mouse B61 gene:
            implications on organogenesis
  JOURNAL   Oncogene 11 (5), 879-883 (1995)
   PUBMED   7675446
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 25, 2022 this sequence version replaced NM_053599.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070514.1, SRR26643292.9467.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000002.1  176986631-176986821 c
            192-487             JAXUCZ010000002.1  176983358-176983653 c
            488-553             JAXUCZ010000002.1  176980648-176980713 c
            554-604             JAXUCZ010000002.1  176980489-176980539 c
            605-1495            JAXUCZ010000002.1  176979434-176980324 c
FEATURES             Location/Qualifiers
     source          1..1495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1495
                     /gene="Efna1"
                     /gene_synonym="B61"
                     /note="ephrin A1"
                     /db_xref="GeneID:94268"
                     /db_xref="RGD:620388"
     exon            1..191
                     /gene="Efna1"
                     /gene_synonym="B61"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..717
                     /gene="Efna1"
                     /gene_synonym="B61"
                     /note="LERK-1; immediate early response protein B61;
                     EPH-related receptor tyrosine kinase ligand 1"
                     /codon_start=1
                     /product="ephrin-A1 precursor"
                     /protein_id="NP_446051.2"
                     /db_xref="GeneID:94268"
                     /db_xref="RGD:620388"
                     /translation="MEFLWAPLLGLCCSLAAADRHIVFWNSSNPKFREEDYTVHVQLN
                     DYLDIICPHYEDDSVADAAMERYTLYMVEHQEYVTCEPQSKDQVRWKCNQPSAKHGPE
                     KLSEKFQRFTPFTLGKEFKEGHSYYYISKPIYHQETQCLKLKVTVNGKITHSPHAHAN
                     PQEKRLQADDPEVQVLHSIGHSAAPRLFPLVWAVLLLPLLLLQTQ"
     exon            192..487
                     /gene="Efna1"
                     /gene_synonym="B61"
                     /inference="alignment:Splign:2.1.0"
     exon            488..553
                     /gene="Efna1"
                     /gene_synonym="B61"
                     /inference="alignment:Splign:2.1.0"
     exon            554..604
                     /gene="Efna1"
                     /gene_synonym="B61"
                     /inference="alignment:Splign:2.1.0"
     exon            605..1495
                     /gene="Efna1"
                     /gene_synonym="B61"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatttgtga tcgtggtgcc tactgtaccg tggagaagcc agtgggaacc ttacactgcg
       61 gagctttcgt cctggcctgg cccggcccgg ccccgcgcta tggagttcct ttgggcccct
      121 ctcttgggtc tgtgctgcag tctggccgct gctgaccgcc acatcgtctt ctggaacagt
      181 tcaaatccca agttccgaga ggaggactac accgtgcacg tgcagctgaa tgactatctg
      241 gacatcatct gcccacatta cgaggacgac tctgtggcag atgctgccat ggagagatac
      301 acgctgtaca tggtggaaca ccaggagtat gtgacatgcg agccccagtc caaggaccag
      361 gttcgctgga agtgcaacca gcccagtgcc aagcacggcc cggagaagct gtctgagaaa
      421 ttccagcgct tcacgccttt caccttgggc aaggagttca aggaaggaca cagctactac
      481 tacatctcca aacctatcta ccatcaggaa acccagtgcc tgaagttgaa ggtgactgtc
      541 aatggcaaaa tcactcacag cccccacgcc catgccaacc cacaggagaa gagactccaa
      601 gcagatgacc cggaagtgca ggttttgcac agcattggtc acagcgccgc cccccgcctc
      661 ttcccattgg tctgggcagt attgctccta ccactgctgc tgctgcaaac tcagtgaagg
      721 tatttgcttg ccctggctta cggattggaa cgggactaag gggcagggtt aagcaccccc
      781 aaagccccag ccctgggaac ctctcccact acacgcacaa gacgccacca cgaagcctca
      841 gaaaggttca gtattaaggg ttttaaccga aaggagttca accagcccaa ctgggccatc
      901 cctgcctcca cttcagaggg atggagaaag aagtggagaa ggtcctttcc ctgtggtttc
      961 tacctttaag ccaaagaaac aagctgtgcg gacctggccc attaagagca cccactggga
     1021 gatgcgctga aagagcctga ggccatgcag ttggacactg aacttggtaa aaatgtcctt
     1081 ccccaaggaa gccataatgt gcagatgaac tgaccaaagg aaaagcttga gacagcttcc
     1141 tgcggggaag ccaggtacaa gagagacagc ttgggctgac ccagcatctc tgcaagattt
     1201 ccacctgctg ggctgccaga gagttttgta gcccggcact gactgcatcc tccccttccc
     1261 tggggcagca ttccctgaag ctgtgccagc aggaggacta tagcagcctg gttttggagt
     1321 atagctgtaa gggcagtgcc catgtgtata gtctgtggag tttagcttaa agggcagggc
     1381 ccacatgtac agtgtctgta tataaacgtg ctgtctgttc atttctacga ctggaggttt
     1441 tttatacagt gttcttggat tcataataaa gtgatgtttt tggtttttta atgga
//
