LOCUS       NM_001031648            2135 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus EF-hand domain family, member D2 (Efhd2), mRNA.
ACCESSION   NM_001031648 XM_216579
VERSION     NM_001031648.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Giricz,Z., Makkos,A., Schreckenberg,R., Poling,J., Lorchner,H.,
            Kiss,K., Bencsik,P., Braun,T., Schulz,R., Ferdinandy,P. and
            Schluter,K.D.
  TITLE     Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and
            Post-Infarct Repair: Effect of Ischemic Conditioning
  JOURNAL   Int J Mol Sci 21 (9), 3359 (2020)
   PUBMED   32397496
  REMARK    GeneRIF: Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and
            Post-Infarct Repair: Effect of Ischemic Conditioning.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Nippert,F., Schreckenberg,R., Hess,A., Weber,M. and Schluter,K.D.
  TITLE     The Effects of Swiprosin-1 on the Formation of Pseudopodia-Like
            Structures and beta-Adrenoceptor Coupling in Cultured Adult Rat
            Ventricular Cardiomyocytes
  JOURNAL   PLoS One 11 (12), e0167655 (2016)
   PUBMED   27992454
  REMARK    GeneRIF: Study reports that adult rat ventricular cardiomyocytes
            (ARVC) constitutively express swiprosin-1 on mRNA and protein level
            and that swiprosin-1 is required to initiate the formation of
            pseudopodia-like structures (spreading), a process necessary to
            adapt to culture conditions. Also, the expression level of
            swiprosin-1 is associated to that of GRK2 and thereby to
            beta-adrenoceptor responsiveness.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Vega,I.E., Traverso,E.E., Ferrer-Acosta,Y., Matos,E., Colon,M.,
            Gonzalez,J., Dickson,D., Hutton,M., Lewis,J. and Yen,S.H.
  TITLE     A novel calcium-binding protein is associated with tau proteins in
            tauopathy
  JOURNAL   J Neurochem 106 (1), 96-106 (2008)
   PUBMED   18346207
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098936.1.
            
            On Aug 12, 2005 this sequence version replaced XM_216579.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098936.1, DN932671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2135
                     /gene="Efhd2"
                     /note="EF-hand domain family, member D2"
                     /db_xref="GeneID:298609"
                     /db_xref="RGD:1307585"
     exon            1..332
                     /gene="Efhd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..747
                     /gene="Efhd2"
                     /note="swiprosin-1; EF hand domain containing 2"
                     /codon_start=1
                     /product="EF-hand domain-containing protein D2"
                     /protein_id="NP_001026818.1"
                     /db_xref="GeneID:298609"
                     /db_xref="RGD:1307585"
                     /translation="MATDELASKLSRRLQMEDEGGEATEQPGLNGAAAAAAEAPDETA
                     QALGSADDELSAKLLRRADLNQGIGEPQSPSRRVFNPYTEFKEFSRKQIKDMEKMFKQ
                     YDAGKDGFIDLMELKLMMEKLGAPQTHLGLKSMIQEVDEDFDSKLSFREFLLIFRKAA
                     AGELQEDSGLHVLARLSEIDVSTEGVKGAKNFFEAKVQAINVSSRFEEEIKAEQEERK
                     KQAEEVKQRKAAFKELQSTFK"
     exon            333..480
                     /gene="Efhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..615
                     /gene="Efhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            616..2108
                     /gene="Efhd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgaggca acggtgcgcg ggccaccatg gccacggacg agctggccag caagctgagt
       61 cggaggctgc agatggagga cgagggcggc gaggcgacgg agcagccggg gctcaacggg
      121 gcggcagcgg cggcggccga ggctcccgac gagactgccc aggcgttggg cagcgcggac
      181 gacgagctga gcgccaagct gctgcggcgc gcggacctca accagggcat cggcgagccg
      241 cagtcgccca gccgccgcgt cttcaacccc tacaccgagt tcaaggagtt ctccaggaag
      301 cagatcaaag acatggagaa gatgttcaaa cagtatgatg cgggcaagga tggcttcatc
      361 gacctgatgg agctgaaact catgatggag aagctggggg ccccccagac gcacctgggc
      421 ctgaagagta tgatccaaga ggtggatgag gattttgaca gcaaactcag cttccgggag
      481 ttccttctga tcttccgcaa ggcggcagca ggggagttgc aggaagacag tggcttgcac
      541 gtcctggccc gcctctccga gattgatgtc tccacagagg gcgtcaaggg tgccaagaac
      601 ttcttcgagg ccaaggtgca ggccatcaac gtgtccagcc gctttgagga agagatcaaa
      661 gccgagcagg aggaaaggaa gaagcaggct gaggaggtga agcagcgaaa agcggccttt
      721 aaggagctgc agtccacatt caagtagcca gagccaaggc caagacctgg cccggcccca
      781 tgtgcagtct gggggtacgg gtcggtccag gagacctgtg ggagactagc tcccaggtcc
      841 tggtctctgt gcctggacca ctatgaaaac gcaaactgta tgtgaccgga tctcatccgg
      901 gagtctcctc agtggttggt ccaggccctg ctcccatccg ctgttcatgc ggctgtgaca
      961 ccagccacca gcatcctctt tggccatccc tacgtctctt gttctctggc cactctgctg
     1021 cctgctctag cccaactcca gcccattcac gcccctgcct ttggtaccag ctactttctc
     1081 cactcatcac ctacccttaa ctataggccg ccctgccatg gtccagcaga aagtgagacc
     1141 ctccccagga ctcttccttt cagatcggcc ccatctccgc tgaaggtgga gggactccta
     1201 tattgatgag gagatccagg gactcttata gtagtgagga gatccaggcc ctactactct
     1261 aagctgatat aaatggggcc cagccaggca gggtgaaggc cactgagcga atctacctca
     1321 caggctacac tctgtcaggc atgccacggg ggatgtgagt gatagggttc cgtggggagg
     1381 gtcccaaggg gctgtggaga ggggggtggg gttccaaagg gattggcctt ttcagggtag
     1441 acttcagcac tctgccttga ctccccacgg agtgcctgat gtgtttatgt gcactggcaa
     1501 taggacacgg ggcggcaccc ctttcacgct acccttcctt gagtttgtca ccagcgatgg
     1561 cactcgtcag caccagatcg catggggact ccctgtcacc agacaggccg tagtgaaacc
     1621 cgtgccgctg ctccatagct catgtgcttg cttcacgctt tacgtgtgtg tacgtgcgtg
     1681 tcccttgctg tgttgtggaa ctgtgacgtc accccagtct aagtgaacgg ccaccggggc
     1741 caccgttatg caatgttcct cgtgtcactg ctcgtgaaac tcgatgactc tttgttttac
     1801 tacaatgcct caagagcccc cgggacccct gcaggacttg caaaggtttt attttttcgg
     1861 tcttagaacc tgtgagaatc ggaggggcca agcccagccc agctcagcag ccgtggccct
     1921 ggcttgtttg ccttagtgga tatgtttata cagaggaata taaattccct ttacttttgg
     1981 ctgtttgcat tttatttttg gttcccccct ctcaacacct ctcccccgac cccactcccc
     2041 caaaaaatga aaaaagcttc attcggtggt acgattattt tttttaacta aaaggagata
     2101 aaattctaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
