LOCUS       NM_001122947            2158 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus EF-hand domain containing 1 (Efhc1), mRNA.
ACCESSION   NM_001122947 XM_001070813 XM_217363
VERSION     NM_001122947.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Raju PK, Satishchandra P, Nayak S, Iyer V, Sinha S and Anand A.
  TITLE     Microtubule-associated defects caused by EFHC1 mutations in
            juvenile myoclonic epilepsy
  JOURNAL   Hum Mutat 38 (7), 816-826 (2017)
   PUBMED   28370826
REFERENCE   2  (bases 1 to 2158)
  AUTHORS   de Nijs L, Wolkoff N, Coumans B, Delgado-Escueta AV, Grisar T and
            Lakaye B.
  TITLE     Mutations of EFHC1, linked to juvenile myoclonic epilepsy, disrupt
            radial and tangential migrations during brain development
  JOURNAL   Hum Mol Genet 21 (23), 5106-5117 (2012)
   PUBMED   22926142
REFERENCE   3  (bases 1 to 2158)
  AUTHORS   de Nijs L, Leon C, Nguyen L, Loturco JJ, Delgado-Escueta AV, Grisar
            T and Lakaye B.
  TITLE     EFHC1 interacts with microtubules to regulate cell division and
            cortical development
  JOURNAL   Nat Neurosci 12 (10), 1266-1274 (2009)
   PUBMED   19734894
  REMARK    GeneRIF: EFHC1 is a regulator of cell division and neuronal
            migration during cortical development.
REFERENCE   4  (bases 1 to 2158)
  AUTHORS   Conte FF, Ribeiro PA, Marchesini RB, Pascoal VD, Silva JM, Oliveira
            AR, Gilioli R, Sbragia L, Bittencourt JC and Lopes-Cendes I.
  TITLE     Expression profile and distribution of Efhc1 gene transcript during
            rodent brain development
  JOURNAL   J Mol Neurosci 39 (1-2), 69-77 (2009)
   PUBMED   19191033
  REMARK    GeneRIF: Data report the expression profile and distribution of
            Efhc1 messenger RNA during mouse and rat brain development, and
            suggest that Efhc1 expression is more important during initial
            phases of brain development.
REFERENCE   5  (bases 1 to 2158)
  AUTHORS   Ikeda T, Ikeda K, Enomoto M, Park MK, Hirono M and Kamiya R.
  TITLE     The mouse ortholog of EFHC1 implicated in juvenile myoclonic
            epilepsy is an axonemal protein widely conserved among organisms
            with motile cilia and flagella
  JOURNAL   FEBS Lett 579 (3), 819-822 (2005)
   PUBMED   15670853
REFERENCE   6  (bases 1 to 2158)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 2158)
  AUTHORS   Suzuki T, Delgado-Escueta AV, Aguan K, Alonso ME, Shi J, Hara Y,
            Nishida M, Numata T, Medina MT, Takeuchi T, Morita R, Bai D, Ganesh
            S, Sugimoto Y, Inazawa J, Bailey JN, Ochoa A, Jara-Prado A,
            Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Inoue Y,
            Osawa M, Kaneko S, Oguni H, Mori Y and Yamakawa K.
  TITLE     Mutations in EFHC1 cause juvenile myoclonic epilepsy
  JOURNAL   Nat Genet 36 (8), 842-849 (2004)
   PUBMED   15258581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000213.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001122947.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001122947.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               JACYVU010000213.1  12726377-12726485
            110-331             JACYVU010000213.1  12731050-12731271
            332-619             JACYVU010000213.1  12735135-12735422
            620-769             JACYVU010000213.1  12736245-12736394
            770-962             JACYVU010000213.1  12738440-12738632
            963-1183            JACYVU010000213.1  12742373-12742593
            1184-1324           JACYVU010000213.1  12744482-12744622
            1325-1538           JACYVU010000213.1  12748560-12748773
            1539-1686           JACYVU010000213.1  12749325-12749472
            1687-1921           JACYVU010000213.1  12762838-12763072
            1922-2158           JACYVU010000213.1  12764584-12764820
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..2158
                     /gene="Efhc1"
                     /note="EF-hand domain containing 1"
                     /db_xref="GeneID:301295"
                     /db_xref="RGD:1587365"
     exon            1..109
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1993
                     /gene="Efhc1"
                     /note="EF-hand domain (C-terminal) containing 1"
                     /codon_start=1
                     /product="EF-hand domain-containing protein 1"
                     /protein_id="NP_001116419.2"
                     /db_xref="GeneID:301295"
                     /db_xref="RGD:1587365"
                     /translation="MVTNPVHGLPLLPGSSFTDSTKTAFHRSQTLGYRNGYAFVRRPT
                     MGIGGDRLPYNQLSPAELDELANKAPILTYGPLKQAAPAEFVPAHVAFDKKVLKFSAY
                     FQEDVPISMEEHYRIRRVNIYYYLEDDSMSVIEPVVENSGIPQGKLVKRQRLAKNDVG
                     DHYHWKDLNRGINLTIYGKTFRIVDCDRFTQDFLESQGIELNPSEKMPLDPYTELRKE
                     PVRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSLFGECRHYIIHYYLMDDTVEIR
                     EVHERNNGRDPFPLLMNRQRMPKVLVDNGKNFPQCVLEISDQEVLEWYTAKDFIVGKP
                     LTILGRTFFIYDCDPFTRQFYKDKFGMSDLPRVDVSKKEPPPVKQELPPYNGYGLIED
                     SAQNCFALVPKAPRKDIVKMLMNDNKVLRYLAALESPIPEDKDRRFVFSYFLATDMIS
                     IFEPPVRNSGIIGGKFLGRTKVVKSFSPVDNPIYYGPSDFFIGAVIEVFGHRFVILDT
                     DEYVLKYMESNASQYSPEALASIQNRIRKQDSPAPELECKQATEETKALATEELKAQG
                     LDKLIEKIQMHLKDISCKDNLRERFQVYDKEESGYVDKETFFKVCETLNVPVDDSLIK
                     ELIRLCTHGEGRINYYNFVRAFSD"
     exon            110..331
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..619
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..769
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..962
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1183
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1324
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1538
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1686
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1921
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2158
                     /gene="Efhc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacccgagcg gcagaaggca accgtggcgg caactgcggg gcagcgatgg tgaccaaccc
       61 ggtgcacggc ctgcccttac tcccgggctc gtcctttacg gactccacga aaacagcatt
      121 ccacagaagc cagacactcg gctacaggaa tggctatgca tttgtccgac gtccaaccat
      181 gggcataggt ggagaccggc tcccctacaa ccaactgtct ccggctgagc tggatgagtt
      241 ggccaataag gcacccatct tgacttatgg cccactcaag caggccgcac cagcagagtt
      301 tgttcctgcg catgtggctt ttgacaaaaa ggtgctgaaa tttagcgcct acttccaaga
      361 agatgttccc atatcaatgg aggagcatta ccgaatccgc cgggtgaaca tttactacta
      421 cctagaggat gacagcatgt ctgtcatcga gcctgtcgtg gagaactctg ggatcccaca
      481 aggcaagcta gtcaaacgcc agcgactagc caagaatgat gtgggagacc actaccactg
      541 gaaggacctg aaccgtggaa tcaaccttac aatttatggc aaaaccttcc gcattgttga
      601 ctgcgaccga ttcactcagg attttttgga aagtcaaggc attgaattaa atccatcaga
      661 gaagatgcct ctagaccctt acactgaact ccgaaaagaa cctgttcgaa aatatgtcac
      721 cccatcagac tttgaccaac tgaagcagtt tctcaccttt gacaaacaag tccttcgatt
      781 ctacgcgatc tgggacgaca cggatagctt gtttggagag tgtcgccact acatcattca
      841 ttactacctc atggatgaca ctgtggagat ccgtgaggtc cacgaacgga acaacgggag
      901 ggaccccttc ccactcctca tgaaccgaca gcgcatgccc aaagttttgg tggataacgg
      961 aaagaatttc cctcagtgtg tgctggaaat ctccgatcaa gaggtgttag agtggtacac
     1021 tgccaaggac ttcatcgtgg gaaagccact caccatcctc gggaggacct tcttcattta
     1081 tgactgtgat ccgttcaccc gacagttcta caaagacaag tttggaatgt ccgatttacc
     1141 acgagttgac gtgagcaaga aggagccgcc tcctgtaaaa caggagttgc ctccttataa
     1201 tggttatggg ctaatcgaag actctgctca gaattgtttt gctctcgttc ccaaagctcc
     1261 cagaaaagat attgttaaga tgctgatgaa cgacaacaag gtgctccgct acctggcggc
     1321 actggaatcc cctatcccag aagacaaaga ccgtcgcttt gtcttctctt attttcttgc
     1381 cacagatatg atcagtatct ttgagccacc tgttcgaaat tctgggatca tcggaggcaa
     1441 attcctgggc aggactaaag ttgttaaatc attctctcca gtcgacaacc ccatctacta
     1501 tggaccaagt gacttcttca tcggtgctgt gattgaggtg ttcggtcatc ggtttgttat
     1561 ccttgataca gatgagtatg ttttaaaata catggagagc aatgcttccc agtactcacc
     1621 agaagccctc gcctcaatcc agaaccgtat ccggaagcag gattctcctg caccagaact
     1681 ggaatgcaag caagctacag aagaaaccaa ggcactggct acagaggaac tcaaggcaca
     1741 gggcctggac aaactgatag aaaaaatcca gatgcacctg aaggacattt catgcaaaga
     1801 caacctccgg gaaaggttcc aagtatacga caaggaggaa tcgggatatg tggacaaaga
     1861 gacgttcttt aaagtctgcg aaactcttaa tgtcccagtc gacgactcgt tgattaagga
     1921 gttgatcagg ctgtgcaccc atggagaagg caggattaac tactataact ttgttcgagc
     1981 tttctcggac tgacccgaac gagagaactg aatacatttt tgacactgaa ccgacattga
     2041 gaaatccacc acacaagcct ttaaatcacc ccggaagggg gtctttctcc cccccccccc
     2101 cactcttcta tttcacgatt actcaagtct aaaataaatt aatatttaaa gaatcgga
//
