LOCUS       NM_001012039            2038 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus EGF containing fibulin extracellular matrix
            protein 1 (Efemp1), mRNA.
ACCESSION   NM_001012039 XM_223725
VERSION     NM_001012039.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Zhang,N., Liao,Z., Wu,P., Fang,H. and Cai,G.
  TITLE     Hypermethylation of EFEMP1 in the Hippocampus May Be Related to the
            Deficit in Spatial Memory of Rat Neonates Triggered by Repeated
            Administration of Propofol
  JOURNAL   Biomed Res Int 2020, 8851480 (2020)
   PUBMED   33381589
  REMARK    GeneRIF: Hypermethylation of EFEMP1 in the Hippocampus May Be
            Related to the Deficit in Spatial Memory of Rat Neonates Triggered
            by Repeated Administration of Propofol.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Chen,J.M., Guo,R.R., Gao,Y., Wang,C.X. and Yuan,P.N.
  TITLE     Mechanism of action of Profilin-1 and Fibulin-3 in vascular
            remodeling in hypertensive rats
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (18), 8101-8108 (2019)
   PUBMED   31599437
  REMARK    GeneRIF: Mechanism of action of Profilin-1 and Fibulin-3 in
            vascular remodeling in hypertensive rats.
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   de Visser,H.M., Sanchez,C., Mastbergen,S.C., Lafeber,F.P.J.G.,
            Henrotin,Y.E. and Weinans,H.
  TITLE     Fib3-3 as a Biomarker for Osteoarthritis in a Rat Model with
            Metabolic Dysregulation
  JOURNAL   Cartilage 10 (3), 329-334 (2019)
   PUBMED   29366335
  REMARK    GeneRIF: the study showed that in the rat groove model combined
            with high-fat diet-induced metabolic dysregulation an increased
            Fib3-3 concentration was observed systemically, which is associated
            with local joint degeneration. This suggests that systemic Fib3-3
            concentrations can indicate the status of joint degeneration and
            function as a biomarker in osteoarthritis.
REFERENCE   4  (bases 1 to 2038)
  AUTHORS   Chen,Y., Gilbert,M.A., Grochowski,C.M., McEldrew,D., Llewellyn,J.,
            Waisbourd-Zinman,O., Hakonarson,H., Bailey-Wilson,J.E., Russo,P.,
            Wells,R.G., Loomes,K.M., Spinner,N.B. and Devoto,M.
  TITLE     A genome-wide association study identifies a susceptibility locus
            for biliary atresia on 2p16.1 within the gene EFEMP1
  JOURNAL   PLoS Genet 14 (8), e1007532 (2018)
   PUBMED   30102696
  REMARK    GeneRIF: Efemp1 transcripts had higher expression in cholangiocytes
            and portal fibroblasts as compared with other cell types in normal
            rat liver.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2038)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 2038)
  AUTHORS   Marmorstein,L.Y., McLaughlin,P.J., Peachey,N.S., Sasaki,T. and
            Marmorstein,A.D.
  TITLE     Formation and progression of sub-retinal pigment epithelium
            deposits in Efemp1 mutation knock-in mice: a model for the early
            pathogenic course of macular degeneration
  JOURNAL   Hum Mol Genet 16 (20), 2423-2432 (2007)
   PUBMED   17664227
REFERENCE   7  (bases 1 to 2038)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   8  (bases 1 to 2038)
  AUTHORS   Marmorstein,L.Y., Munier,F.L., Arsenijevic,Y., Schorderet,D.F.,
            McLaughlin,P.J., Chung,D., Traboulsi,E. and Marmorstein,A.D.
  TITLE     Aberrant accumulation of EFEMP1 underlies drusen formation in
            Malattia Leventinese and age-related macular degeneration
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13067-13072 (2002)
   PUBMED   12242346
REFERENCE   9  (bases 1 to 2038)
  AUTHORS   Stone,E.M., Lotery,A.J., Munier,F.L., Heon,E., Piguet,B.,
            Guymer,R.H., Vandenburgh,K., Cousin,P., Nishimura,D.,
            Swiderski,R.E., Silvestri,G., Mackey,D.A., Hageman,G.S., Bird,A.C.,
            Sheffield,V.C. and Schorderet,D.F.
  TITLE     A single EFEMP1 mutation associated with both Malattia Leventinese
            and Doyne honeycomb retinal dystrophy
  JOURNAL   Nat Genet 22 (2), 199-202 (1999)
   PUBMED   10369267
REFERENCE   10 (bases 1 to 2038)
  AUTHORS   Ozaki,T., Kondo,K., Nakamura,Y., Ichimiya,S., Nakagawara,A. and
            Sakiyama,S.
  TITLE     Interaction of DA41, a DAN-binding protein, with the epidermal
            growth factor-like protein, S(1-5)
  JOURNAL   Biochem Biophys Res Commun 237 (2), 245-250 (1997)
   PUBMED   9268694
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079455.1.
            
            On Feb 11, 2005 this sequence version replaced XM_223725.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..2038
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /note="EGF containing fibulin extracellular matrix protein
                     1"
                     /db_xref="GeneID:305604"
                     /db_xref="RGD:1308528"
     exon            1..57
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            58..96
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            97..186
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1587
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /note="FIBL-3; fibulin-3; epidermal growth
                     factor-containing fibulin-like extracellular matrix
                     protein 1; EGF-containing fibulin-like extracellular
                     matrix protein 1"
                     /codon_start=1
                     /product="EGF-containing fibulin-like extracellular matrix
                     protein 1 precursor"
                     /protein_id="NP_001012039.1"
                     /db_xref="GeneID:305604"
                     /db_xref="RGD:1308528"
                     /translation="MLQTVFLTMLTLALVKSQVTEETITYTQCTDGYEWDPVRQQCKD
                     IDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETPAAEASSGAATGTI
                     AARSMATSGVIPGGGFIASATAVAGPEVQTGRNNFVIRRNPADPQRIPSNPSHRIQCA
                     AGYEQSEHNVCQDIDECTSGTHNCRLDQVCINLRGSFTCHCLPGYQKRGEQCVDIDEC
                     SVPPYCHQGCVNTPGSFYCQCNPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFI
                     CQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQD
                     INECETTNECREDEMCWNYHGGFRCYPQNPCQDPYVLTSENRCVCPVSNTMCRDVPQS
                     IVYKYMNIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLV
                     LVKSLTGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF"
     exon            187..235
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            236..622
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            623..745
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            746..865
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            866..985
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1105
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1229
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1425
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..2012
                     /gene="Efemp1"
                     /gene_synonym="T16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcccctg cgcactcctt cgctgccggg gctggattgc cgcgcggctc cccgcaggta
       61 tcttttgctg agctgggcac ggaacttcag ctagagagaa tcacgatgtt gcaaacagtt
      121 ttcctaacta tgctgactct ggctctggtc aagtcacagg tcacggagga aaccattaca
      181 tacacgcaat gcaccgatgg atatgaatgg gaccctgtaa gacagcagtg caaagatatt
      241 gatgagtgtg acattgtacc agatgcttgc aaaggtggaa tgaaatgtgt caaccactat
      301 ggaggatacc tctgccttcc taaaacagcc caaattattg tcaataacga acagcctcag
      361 caagaaacac cagctgccga agcatcgtcg ggtgctgcca ctgggaccat agctgccagg
      421 agcatggcta ccagtggtgt gatccctggg ggtggcttca tagccagtgc tactgcagtt
      481 gctggtcctg aagttcagac aggccgaaat aacttcgtca ttcggaggaa cccggctgac
      541 cctcagcgca tcccttccaa cccttcccac cggatccagt gtgcagcagg ctatgaacag
      601 agtgagcata atgtgtgcca agacattgat gagtgcacct cagggaccca caattgtaga
      661 ttggaccaag tgtgcatcaa tttacgtggt tccttcacat gccactgtct tcctgggtat
      721 cagaagcgag gcgaacagtg tgtggatata gatgagtgct cagtgccccc atactgccac
      781 caaggatgtg tgaacacccc gggttccttt tactgtcagt gcaatcccgg gtttcagctg
      841 gcagcaaaca actacacttg tgtggatata aatgaatgtg atgccagcaa ccagtgcgct
      901 cagcaatgct acaacattct tggctcattc atctgtcagt gcaaccaagg atatgaactg
      961 agcagtgaca gactcaactg tgaagacatc gatgaatgca gaacctcaag ctacctgtgc
     1021 cagtatcaat gtgtcaatga acctgggaag ttctcatgta tgtgtcctca gggttaccaa
     1081 gtggtgcgaa gcagaacctg tcaggatata aatgaatgtg agaccaccaa tgaatgccga
     1141 gaagatgaaa tgtgctggaa ttaccatggt ggcttccgct gttacccaca aaacccatgt
     1201 caagatccct atgttctaac gtcagaaaac cgatgcgttt gcccggtctc aaacaccatg
     1261 tgccgagacg tgccccagtc tatagtctac aaatacatga acatccgatc tgacaggtcc
     1321 gtgccatcag acatcttcca gatacaggca acaacgattt atgcaaacac cattaatact
     1381 tttcggatta aatctggaaa tgaaaatgga gagttctacc tacgacaaac aagccctgtg
     1441 agtgcaatgc tggtgcttgt gaagtcgcta acaggaccaa gagaacacat cgtggacctg
     1501 gagatgctga cagtcagtag tatagggacc ttccgcacaa gctctgtgtt aagattgaca
     1561 ataatagtgg ggccgttttc attttaaact tttattcaca taaagcctac cacaggcatt
     1621 taaatcagcc aaagaatatc attacattaa agtttatttt atttatagct ctatctagta
     1681 catctatatt caaacagcta gactatggta ggaagtgggc atttaatcca taagagtcaa
     1741 catttatctt tatcactgtg tgtaaattag acattagtcc aacattcttc ttgaagagag
     1801 ctaagcatat attatctagt gaaacttgga ttctttccta caaaaatggg accaagcaat
     1861 gatactgttc tgtggtgaat agagaaatat acacctccac aaacaatctc atgaggattg
     1921 gccatctaaa catcaagagc aagaagggtt tttttttaac ttctttgtaa gaaaatggaa
     1981 aaaagtcaat aaagatatat ttctttagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
