LOCUS       NM_001106975            1672 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus eukaryotic elongation factor 2 lysine
            methyltransferase (Eef2kmt), mRNA.
ACCESSION   NM_001106975 XM_001079029 XM_220157
VERSION     NM_001106975.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Davydova E, Ho AYY, Malecki J, Moen A, Enserink JM, Jakobsson ME,
            Loenarz C and Falnes PO.
  TITLE     Identification and characterization of a novel evolutionarily
            conserved lysine-specific methyltransferase targeting eukaryotic
            translation elongation factor 2 (eEF2)
  JOURNAL   J Biol Chem 289 (44), 30499-30510 (2014)
   PUBMED   25231979
REFERENCE   2  (bases 1 to 1672)
  AUTHORS   Cloutier P, Lavallee-Adam M, Faubert D, Blanchette M and Coulombe
            B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474017.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001079029.1, XM_220157.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132280,
                              SAMD00132291 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1672
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /note="eukaryotic elongation factor 2 lysine
                     methyltransferase"
                     /db_xref="GeneID:302931"
                     /db_xref="RGD:1304969"
     exon            1..117
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1029
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /note="family with sequence similarity 86, member A"
                     /codon_start=1
                     /product="protein-lysine N-methyltransferase EEF2KMT"
                     /protein_id="NP_001100445.1"
                     /db_xref="GeneID:302931"
                     /db_xref="RGD:1304969"
                     /translation="MAPEDHEGATSLLQSFERRFLAARALPSFPWQSLEEKLREPSGS
                     ELLLAILQKTVKHPVCVQHGPSLKYSRCFLSKLIKKHEAVPMEPLDALYEALAEVLMA
                     RESTQCHRSYLLPSGDSVTLSESTAIVSHGTTGLVTWDAALYLAEWAIENPAAFTDRT
                     ILELGSGAGLTGLAICKACYPRAYVFSDCHAQVLEQLRRNVLLNGFSLELHTPIDSGS
                     PKVTVAQLDWDEVTSSQLSAFQADTVIAADVLYCGEVTLSLVRVLRMLTDCQRKKAPD
                     VYVAYTIRSQDTGKLFITELDRAGIHWEEVAPHTGKLFPYEEHSAIVILKLTLTGRHG
                     V"
     exon            118..180
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /inference="alignment:Splign:2.1.0"
     exon            181..261
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /inference="alignment:Splign:2.1.0"
     exon            262..363
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /inference="alignment:Splign:2.1.0"
     exon            364..497
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /inference="alignment:Splign:2.1.0"
     exon            498..763
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /inference="alignment:Splign:2.1.0"
     exon            764..910
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1672
                     /gene="Eef2kmt"
                     /gene_synonym="Fam86a; RGD1304969"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaccctggc cccgccccgc gatggcgcct gaggaccacg agggggccac gtctctgctg
       61 cagagtttcg agcgccgctt cctggcggct cgcgcgctgc cctcttttcc ctggcagagc
      121 ctagaagaaa aactaaggga gccctcaggt tctgagctgt tgctggctat tttgcagaag
      181 actgtgaagc accctgtgtg tgtccagcat gggccctctc tgaagtattc ccgctgcttt
      241 ctctcgaagc tcatcaaaaa gcatgaggcc gtacccatgg agcctttgga tgcactgtat
      301 gaggcgctgg cagaagttct gatggccaga gagtccaccc agtgccaccg gagctatttg
      361 ctgccttcag gagactcagt cacactctct gagagcacag ccatcgtgtc ccatggcacc
      421 acaggcttgg ttacatggga cgctgctctc tacctggcag aatgggccat cgagaaccca
      481 gcagccttca ctgacaggac tatcctggag ctaggcagcg gagctggcct cacaggcctg
      541 gccatttgca aagcatgcta ccccagagca tacgtcttca gcgactgtca tgcccaagtg
      601 cttgagcagc tccgtagaaa cgttctcctc aacggcttct ccttagagct gcacactccc
      661 attgactcag gcagcccgaa ggtgacagtg gcccagctgg actgggacga ggtgacatcc
      721 tctcagctct ctgccttcca ggcagacact gtcattgcag cagatgtact gtactgcggg
      781 gaagtgacac tgtcactggt cagggtcctg aggatgctca ctgactgcca gaggaagaag
      841 gctcctgacg tctatgtggc ctatacgatc cgcagccagg acacgggcaa gctgttcatc
      901 acagagctgg accgcgctgg gatacactgg gaagaggtgg cccctcacac tggcaaactg
      961 ttcccttatg aagagcattc ggccatcgta atcctgaagc tcacgctgac cggtcgccat
     1021 ggtgtttgaa ggtgatctga aaactgagat ggctgtggtg ggaaagcgga cagctcctgt
     1081 taacaaccac aatgcacagg aagcacaggc tgtgacgctg gtgcctgccc tcggcagctc
     1141 actggggtgg acacaggctc agagcaagca ttccactgta caaataaata tgtaaattta
     1201 ttaactatga ctgtcctgtc agctcagcct tgctcagcta agccgggtga acacaggata
     1261 tcccagagct cacagcagcc agcagaacca gaatacaagg aatgtgaaga gtccagaaac
     1321 aaaaacccag gatgaagaag ttggttggca gggtcaccgg aagtaacaaa agtcctcagt
     1381 tcggaagagc ttctcagatg ctggatgatt cttttcctgg gtgtaaccac tgccgtcctc
     1441 aggcttctga ccactagggg gcactcaaga gccctggcag gaagggtggg cacaggatgg
     1501 atggggccta ccctctgggc ctggaggtca tttgtgagtg accaacaacg gcagcacagt
     1561 ctgctgccag ctctcatccc atcgtagctg ctctgactcc tggagtctct tccggaactg
     1621 gctcagcttc ccagcagggt cgggaaactt tgagaaaagc atctagagga aa
//
