LOCUS       NM_012947               6416 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus eukaryotic elongation factor-2 kinase (Eef2k),
            mRNA.
ACCESSION   NM_012947 XM_006230156 XM_347287
VERSION     NM_012947.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6416)
  AUTHORS   Kodama,T., Otani,K., Okada,M. and Yamawaki,H.
  TITLE     Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits
            perivascular sympathetic nerve stimulation-induced vasoconstriction
            in isolated renal artery
  JOURNAL   Eur J Pharmacol 926, 175042 (2022)
   PUBMED   35598844
  REMARK    GeneRIF: Eukaryotic elongation factor 2 kinase inhibitor, A484954
            inhibits perivascular sympathetic nerve stimulation-induced
            vasoconstriction in isolated renal artery.
REFERENCE   2  (bases 1 to 6416)
  AUTHORS   Kodama,T., Otani,K., Okada,M. and Yamawaki,H.
  TITLE     Age-dependent increase in activity of eukaryotic elongation factor
            2 kinase in mesenteric arteries from spontaneously hypertensive
            rats
  JOURNAL   J Vet Med Sci 83 (1), 42-47 (2021)
   PUBMED   33191388
  REMARK    GeneRIF: Age-dependent increase in activity of eukaryotic
            elongation factor 2 kinase in mesenteric arteries from
            spontaneously hypertensive rats.
REFERENCE   3  (bases 1 to 6416)
  AUTHORS   Gladulich,L.F.H., Peixoto-Rodrigues,M.C., Campello-Costa,P.,
            Paes-de-Carvalho,R. and Cossenza,M.
  TITLE     NMDA-induced nitric oxide generation and CREB activation in central
            nervous system is dependent on eukaryotic elongation factor 2
            kinase
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1867 (10), 118783 (2020)
   PUBMED   32569665
  REMARK    GeneRIF: NMDA-induced nitric oxide generation and CREB activation
            in central nervous system is dependent on eukaryotic elongation
            factor 2 kinase.
REFERENCE   4  (bases 1 to 6416)
  AUTHORS   Kameshima,S., Okada,M. and Yamawaki,H.
  TITLE     Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective
            roles against glucose deprivation-induced cell death in H9c2
            cardiomyoblasts
  JOURNAL   Apoptosis 24 (3-4), 359-368 (2019)
   PUBMED   30737648
  REMARK    GeneRIF: EEF2K/eEF2 axis under GD condition mediates the inhibition
            of apoptotic H9c2 cell death.
REFERENCE   5  (bases 1 to 6416)
  AUTHORS   Gu,H., Chen,J., Song,Y. and Shao,H.
  TITLE     Gastric Adenocarcinoma Predictive Long Intergenic Non-Coding RNA
            Promotes Tumor Occurrence and Progression in Non-Small Cell Lung
            Cancer via Regulation of the miR-661/eEF2K Signaling Pathway
  JOURNAL   Cell Physiol Biochem 51 (5), 2136-2147 (2018)
   PUBMED   30522114
REFERENCE   6  (bases 1 to 6416)
  AUTHORS   Horman,S., Browne,G., Krause,U., Patel,J., Vertommen,D.,
            Bertrand,L., Lavoinne,A., Hue,L., Proud,C. and Rider,M.
  TITLE     Activation of AMP-activated protein kinase leads to the
            phosphorylation of elongation factor 2 and an inhibition of protein
            synthesis
  JOURNAL   Curr Biol 12 (16), 1419-1423 (2002)
   PUBMED   12194824
REFERENCE   7  (bases 1 to 6416)
  AUTHORS   Diggle,T.A., Redpath,N.T., Heesom,K.J. and Denton,R.M.
  TITLE     Regulation of protein-synthesis elongation-factor-2 kinase by cAMP
            in adipocytes
  JOURNAL   Biochem J 336 (Pt 3) (Pt 3), 525-529 (1998)
   PUBMED   9841860
REFERENCE   8  (bases 1 to 6416)
  AUTHORS   Ryazanov,A.G., Ward,M.D., Mendola,C.E., Pavur,K.S., Dorovkov,M.V.,
            Wiedmann,M., Erdjument-Bromage,H., Tempst,P., Parmer,T.G.,
            Prostko,C.R., Germino,F.J. and Hait,W.N.
  TITLE     Identification of a new class of protein kinases represented by
            eukaryotic elongation factor-2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 4884-4889 (1997)
   PUBMED   9144159
REFERENCE   9  (bases 1 to 6416)
  AUTHORS   Redpath,N.T., Price,N.T. and Proud,C.G.
  TITLE     Cloning and expression of cDNA encoding protein synthesis
            elongation factor-2 kinase
  JOURNAL   J Biol Chem 271 (29), 17547-17554 (1996)
   PUBMED   8663182
REFERENCE   10 (bases 1 to 6416)
  AUTHORS   Albarracin,C.T., Palfrey,H.C., Duan,W.R., Rao,M.C. and Gibori,G.
  TITLE     Prolactin regulation of the calmodulin-dependent protein kinase III
            elongation factor-2 system in the rat corpus luteum
  JOURNAL   J Biol Chem 269 (10), 7772-7776 (1994)
   PUBMED   8126003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 13, 2022 this sequence version replaced
            XM_006230156.4, NM_012947.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X96426.1, SRR26643290.3672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000001.1  184824420-184824636
            218-559             JAXUCZ010000001.1  184842808-184843149
            560-660             JAXUCZ010000001.1  184859395-184859495
            661-721             JAXUCZ010000001.1  184862329-184862389
            722-759             JAXUCZ010000001.1  184864026-184864063
            760-931             JAXUCZ010000001.1  184864472-184864643
            932-1081            JAXUCZ010000001.1  184868607-184868756
            1082-1214           JAXUCZ010000001.1  184869347-184869479
            1215-1342           JAXUCZ010000001.1  184869838-184869965
            1343-1544           JAXUCZ010000001.1  184870731-184870932
            1545-1612           JAXUCZ010000001.1  184872116-184872183
            1613-1690           JAXUCZ010000001.1  184873519-184873596
            1691-1753           JAXUCZ010000001.1  184873995-184874057
            1754-1888           JAXUCZ010000001.1  184875628-184875762
            1889-2077           JAXUCZ010000001.1  184875896-184876084
            2078-2202           JAXUCZ010000001.1  184878924-184879048
            2203-2381           JAXUCZ010000001.1  184880990-184881168
            2382-6416           JAXUCZ010000001.1  184884014-184888048
FEATURES             Location/Qualifiers
     source          1..6416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..6416
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /note="eukaryotic elongation factor-2 kinase"
                     /db_xref="GeneID:25435"
                     /db_xref="RGD:2538"
     exon            1..217
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            218..559
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..2491
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /EC_number="2.7.11.20"
                     /function="protein kinase"
                     /note="elongation factor 2 kinase; eukaroytic elongation
                     factor 2 kinase; eEF-2K; eEF-2 kinase;
                     calcium/calmodulin-dependent eukaryotic elongation factor
                     2 kinase"
                     /codon_start=1
                     /product="eukaryotic elongation factor 2 kinase"
                     /protein_id="NP_037079.1"
                     /db_xref="GeneID:25435"
                     /db_xref="RGD:2538"
                     /translation="MADEDLIFRLEGVDGGGSSGAGRHGDSDTDSDDDEGYFICPITD
                     DHMSNQNVNSKGQGYYNNLLKTECGSTGSPASSFHFKEAWKHAIEKAKHMPDPWAEFH
                     LEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQHW
                     KGASNYVAKRYLEPVDRSVYFEDVQLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKD
                     RQGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQG
                     VGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRICQSMGLAPFDLSPREQDA
                     VNQSTKLLQSAKTILRGTEEKCGSPRIRTLSGSRPPLLLRLSENSGDENMSDVTFDSL
                     PSSPSSATPHSQKLDHLHWPVFGDLDNMGPRDHDRMDNHRDSENSGDSGYPSEKRSDL
                     DDPEPREHGHSNGNRRPESDEDSLGSSGRVCVETWNLLNPSRLHLPRPSAVALEVQRL
                     NALDLGRKIGKSVLGKVHLAMVRYHEGGRFCEKDEEWDQESAIFHLEHAADLGELEAI
                     VGLGLMYSQLPHHILADVSLEETEENKTKGFDYLLKAAEAGDRQSMILVARAFDTGLN
                     LSPDRCQDWSEALHWYNTALETTDCDEGGEYDGIQDEPQYALLAREAEMLLTGGFGLD
                     KNPQRSGDLYTQAAEAAMEAMKGRLANQYYEKAEEAWAQMEE"
     exon            560..660
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            661..721
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            722..759
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            760..931
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1081
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1214
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1342
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1544
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1612
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1690
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1753
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1888
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2077
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2202
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2381
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..6416
                     /gene="Eef2k"
                     /gene_synonym="SMEF2K"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaacagccc cagctccagc cggcgctccg ctccagcgct cggacgtctc caggcacccc
       61 actgcggctg cgggcctggc tctctgtcgc gtgcgctcgt accccaggat tctcctcccg
      121 ccctgcaccc tggagcgtcc ggccgccagc ctctgccagc tcctcgggat ccttgcggcc
      181 gtgggcagcg gctgtcgcgc ctgtcccact ttgggaggac catccttgct gcgcgtgcgc
      241 agtaacttcg gctgcacgtg cgcattaact ctggctgcac agcgaagccc tgggataaca
      301 ccggcgcccc cgcaacatgg cagacgaaga cctcatcttc cgcctggaag gtgttgacgg
      361 tggcgggtcc tccggagctg gccgccatgg ggactctgac acagacagtg acgatgatga
      421 gggctacttc atctgcccca tcactgatga ccacatgtcc aaccagaatg tcaactccaa
      481 aggccagggc tactacaaca acctactgaa aacggagtgt ggctccacag ggtcaccagc
      541 cagctccttc cacttcaagg aggcctggaa gcatgcgatc gagaaggcca agcacatgcc
      601 cgacccctgg gctgaattcc atctggagga catcgccaca gagcatgcta ctcggcacag
      661 gtacaatgct gtcaccgggg agtggctgaa agacgaggtt ctgatcaaga tggcatctca
      721 gcccttcggc cgtggagcaa tgagggagtg cttcaggacg aagaaactct ccaacttctt
      781 gcatgcccag cattggaagg gggcctccaa ctacgtggca aaacgctacc tcgagccagt
      841 ggacaggagc gtgtactttg aggatgtgca gctccagatg gaagcgaagc tctgggggga
      901 ggagtacaac cggcacaagc cccccaagca ggtagatatc atgcagatgt gcatcattga
      961 gctaaaggac agacaaggac agcccctctt ccacctggag cactacattg agggcaagta
     1021 catcaagtat aattccaact caggctttgt ccgtgatgac aacatcagac taacaccaca
     1081 ggccttcagc catttcacat ttgaacgttc tggtcatcag ctgattgtag tggacatcca
     1141 gggtgtgggc gacctttata ctgacccaca gatccacact gagaaaggca ctgactttgg
     1201 agatggtaac cttggtgtcc ggggaatggc tctcttcttc tactctcatg cctgcaaccg
     1261 tatttgccag agcatgggcc ttgcgccctt tgacctctcc ccacgggagc aggatgccgt
     1321 gaaccagagc accaagctgt tgcaatcagc caagaccatc ttgaggggga cagaggagaa
     1381 gtgtgggagt ccccgcataa ggacactctc tggcagccgg ccccccttgc tccttcgcct
     1441 gtcagagaac tctggggatg agaacatgag tgatgtgacc tttgactctc tgccttcctc
     1501 cccgtcttca gccacaccac acagccagaa gttggaccac ctccattggc cagtgtttgg
     1561 tgacctcgat aacatgggcc ctagagacca tgaccgcatg gacaatcacc gggactctga
     1621 gaatagtggg gacagtgggt atccaagcga gaagcgaagt gacctggatg atcctgagcc
     1681 ccgagaacac ggccactcca atggcaaccg aaggcctgaa tctgatgagg acagcctggg
     1741 cagctctgga cgggtctgtg tggagacgtg gaacctgctc aatccctccc gcctgcacct
     1801 gcccaggccc tcggccgtgg ccctagaagt gcaaaggtta aatgctctgg accttggaag
     1861 gaaaatcggg aagtctgttt tggggaaggt ccatctggcc atggtacggt accacgaggg
     1921 cgggcgcttc tgcgagaagg atgaggaatg ggatcaagag tctgccatct tccatctgga
     1981 gcatgcagcc gacctgggag aactggaggc catcgtgggc ctaggcctca tgtactctca
     2041 gctgccccac cacatcctgg ctgatgtctc tctggaggag acagaagaga acaagacaaa
     2101 aggctttgat tacctcctga aggccgcaga agctggtgac aggcagtcca tgattttagt
     2161 ggctcgagct tttgacaccg gcctgaacct cagcccagac aggtgtcaag actggtcgga
     2221 agccttacac tggtacaaca cggccctgga gacgacggac tgcgatgaag gcggggagta
     2281 tgacggaata caggacgagc cccagtatgc actgctggcc agggaggcag agatgttgct
     2341 caccggtgga tttggactgg acaagaaccc ccaaagatca ggagacttgt acacccaggc
     2401 agccgaggca gcaatggaag ccatgaaggg ccggctagcc aaccagtact atgagaaggc
     2461 ggaagaggcc tgggcgcaaa tggaggaata actgtccaca ggatcactgc cgaggagaag
     2521 ggctggggag gggaggatgg gacccatttc ttttgggagg ggagaagtag ttttactatg
     2581 gtataaattc acttttgtat tgcctttttt tgactcttga cagtctttgc agctggcaga
     2641 gacattataa ctgccctttt aggggtggta ttttggggga gtggggggtt gaagatgcag
     2701 cctaatgaat tctttttccc cctgtttttc tttttttctg tcctgagatg taagcaagtg
     2761 tctttctgtc cgaatgaaca gacagtatca gggcttctct cgccgacctt tgcagacagg
     2821 actcacatcc tggggtctcc aggatactgg gaacccaaat ggaggacaga gacctttctg
     2881 ttaactttcc accatggttc tttctttcct ccagtggaag tgagatggtt caatacccag
     2941 gctccttcac actgggggag acagttgtga gagtctttca cataatgtcc ttccactgag
     3001 ctcatgactt cctggcatcc attcaaattc cttttttttt ttttagacct tcaatctgtt
     3061 acagatttta cagaacaggt ttggccttat acatgcatat ttactacctc tgagtcctgc
     3121 atctgtggat gtggaagcag atgtacctca aagctttcaa aagccatgac ttaggagctg
     3181 ggtgactatt ctccagacag aagtactctc tgcaccccat ggccacatcc actatgggac
     3241 cgaagcatcc ttgtacagaa ttctgtggcc gttccttagt gtgatgtttc ctggactctc
     3301 ctcaacctgc tctccttggc attttctgct tgaaactagg ttttacttac ttgacactag
     3361 gtcatctgca gcaagtggct tccagccgca gccccttggg atttgtctaa gatgtttgag
     3421 aatgaggagc gagagtgtaa acactgactg agtctgggca tttccccagg gtcaggctgg
     3481 gattttaatg agctttctct tttaaaagag ttcagattaa tgagagtgtg attttagcca
     3541 cagggaaatg gcccgctttg atccactact gataccttta aaaaacagaa cagcagagtg
     3601 ggacatgcca gccattctca cctgttgctt aaaacaggcc ttttaagggt ttcactgctg
     3661 agtctgcccg gtcaaaaaca tgtagaagca ttagattgta aagtctagag tatacatcct
     3721 ttgaggaaaa atcagattca ttaatcttga ggactgggag ccatggtata cacttgtagt
     3781 cccagcatac aggtggtaga ggcagaagga gcaaagatta aggccaacct gggctacatg
     3841 atgagaccct gtccccaaaa caaacaacaa aaggagctgg tgagatggct cggtacatga
     3901 agctcctgcc aaccgtggcc agacaatctg agttctgttc ctgggaccca tgtgtggaca
     3961 gaggggacca actcctgcaa ggtgtcttct gatcttcacc tgtgtggtgt gtcacaaggg
     4021 agcactctct ctctctctct ctctctctct ctctctctct ctctcacaca cacacacaca
     4081 cacacacaca cacacacaca cacacacaaa actgtaagag aaatgaaata gcaaaaacta
     4141 cccttgaata ctttcatcta tctgcaagtt ataaaatcgc caggtttaca tttgaagcca
     4201 taacatcggg ttctctatga tgggttggcc cttgtccggc tttatcagta ccagaacagt
     4261 agctggcttg cgttgtcctg catgtgttaa acgtaagaag caatttatta tgacataatc
     4321 tctcagagta actgtcatgt aagttgtggt gtatgtctgt gtgtgtgtgc gtgtgtgtgt
     4381 gtgtgtgtgc tggtcagcag acaacctcaa ttttgttcct caggagctgg ccatctcctt
     4441 ccattgagtc tctcactggt ctagaacttg ccaaataagc tgtgctgcct taccagtgaa
     4501 ctccagagat atgtctgtct atccttccta attctggaat tacaaactca cattctctac
     4561 ccgttgatta gtccttgtct ggatcactta aagcctcagg cctgaaattc ccccaccaca
     4621 tggccttaat tcgaggaagt ggtctcgtgc tcctccaaga ggctgggatg gcctggtgca
     4681 cagctaagca aatgcttctt caaggaccct tgcagatgac aagggagctt tgagagcctg
     4741 ctgtatgtat gatgctagct agcacttgga ggccaaggct ggattatgag tttgaagcca
     4801 ccctggacta tttactgact gtctaaaaaa gaaaaaaaag ccctgggggc tggagagatg
     4861 cctcagtggt taagatcatt gctgctctcc cctaagaccc aggttcaatt cgcagccccc
     4921 atatggcagc tcacacctgt ctaaccccag ttctgaggga tccgatgctc acacaaacat
     4981 gcaggcaaac caccaaggaa cataaaagta aaaataaatc ataagggatt ggggatttag
     5041 ctcagtggta gagcgcttgc ctagcaagct caaggccctg ggttcagtcc ccagctctga
     5101 aaaaaagaaa aaagaaaaaa aaatcattaa aaaaattgta gtttgggggg tgggaatggg
     5161 agaggggaga aaaggggata acatttgaaa tgtaaataca taaaatatcc aagaaaaata
     5221 aaatttaaaa aatacatagt tcaaacctgt catgtcagca ctgtacttgg gaagctgagg
     5281 tgtgagggtc actgagtttt atgctggttt gggctacata atgacttgca gttatgcctg
     5341 aggtactgag actttcatgc agaagtggct atttctcctt ccaaacctaa gtcttacacc
     5401 ttcaaaagct ggtcagggca ctttctcttt ctgtatatgc tgggcatgac aagaacaagc
     5461 caacaggatt cagctcccag gcagggagac accagtgccc ggcatctatg atcaattctg
     5521 ctttccagag cttgaagcag gtaacagcct cgattcatgg acctgatatg tgtactttca
     5581 tctcagagac agaaaccagg cttcagtggt gctgctcact aggggctaag caggtgctgg
     5641 gggccagaga gctgccgttt ccagaggact ctgggaataa aaacatctaa ctgtaatgtg
     5701 atggcgtatt ccattttgca acatagatag agaaatttaa atgagataga attggagtga
     5761 gtatgtgctt agcatacagt caacatacaa gctttatggg tataaaaaag agaaacactg
     5821 ttcgactcac tgcttcagaa taaccctgct ccctgcacgc cggaccagcc tgacaggcga
     5881 gctgccttga ctgcttagtg attccccatc tgtccttgct gtccatcatc ccggcatctt
     5941 cgtgtcagca ggtgtggttt gcagattcac acacacaggt atatgctgct tgagatgtga
     6001 gtgggggaca tatgtgccta ttccttgctt ggacttgtgc ctcttcctta cattttgtct
     6061 ctgacctcct caaggcaact ggccgaagag caggggcaat tgtgtgtaca tcagattctg
     6121 gcttagcttc cccaacagtt tggttttttt gaactgtctc aaacccacac atctccctcg
     6181 ctttgaaaac aaatcaagaa atgagggaag tttgtatcta catagaggct gaagtgagcc
     6241 accgggggca cggatcgaag agcaggtctg ctcaccttca acatgagttc catcgcctgg
     6301 agtgtaggcc caactcggtt ccgtgctggc ttttcacagt aggaaaacgt cttaatgtgg
     6361 tgcctcttga tttctaacat ctgtaataaa ttctaataaa ggaagcctgg ccctta
//
