LOCUS       NM_012660               2035 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus eukaryotic translation elongation factor 1 alpha
            2 (Eef1a2), mRNA.
ACCESSION   NM_012660
VERSION     NM_012660.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Becker,M., Kuhse,J. and Kirsch,J.
  TITLE     Effects of two elongation factor 1A isoforms on the formation of
            gephyrin clusters at inhibitory synapses in hippocampal neurons
  JOURNAL   Histochem Cell Biol 140 (6), 603-609 (2013)
   PUBMED   23839781
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Jeganathan,S., Morrow,A., Amiri,A. and Lee,J.M.
  TITLE     Eukaryotic elongation factor 1A2 cooperates with
            phosphatidylinositol-4 kinase III beta to stimulate production of
            filopodia through increased phosphatidylinositol-4,5 bisphosphate
            generation
  JOURNAL   Mol Cell Biol 28 (14), 4549-4561 (2008)
   PUBMED   18474610
  REMARK    GeneRIF: Study finds that eEF1A2 stimulates formation of filopodia
            by increasing the cellular abundance of cytosolic and plasma
            membrane-bound phosphatidylinositol-4,5 bisphosphate.
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Moon,I.S., Cho,S.J., Lee,H., Seog,D.H., Jung,Y.W., Jin,I. and
            Walikonis,R.
  TITLE     Upregulation by KCl treatment of eukaryotic translation elongation
            factor 1A (eEF1A) mRNA in the dendrites of cultured rat hippocampal
            neurons
  JOURNAL   Mol Cells 25 (4), 538-544 (2008)
   PUBMED   18443410
REFERENCE   4  (bases 1 to 2035)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   5  (bases 1 to 2035)
  AUTHORS   Jeganathan,S. and Lee,J.M.
  TITLE     Binding of elongation factor eEF1A2 to phosphatidylinositol
            4-kinase beta stimulates lipid kinase activity and
            phosphatidylinositol 4-phosphate generation
  JOURNAL   J Biol Chem 282 (1), 372-380 (2007)
   PUBMED   17088255
  REMARK    GeneRIF: there is a physical and functional relationship between
            eEF1A2 and PI4KIIIbeta
REFERENCE   6  (bases 1 to 2035)
  AUTHORS   McClatchy,D.B., Knudsen,C.R., Clark,B.F., Kahn,R.A., Hall,R.A. and
            Levey,A.I.
  TITLE     Novel interaction between the M4 muscarinic acetylcholine receptor
            and elongation factor 1A2
  JOURNAL   J Biol Chem 277 (32), 29268-29274 (2002)
   PUBMED   12048193
REFERENCE   7  (bases 1 to 2035)
  AUTHORS   Ruest,L.B., Marcotte,R. and Wang,E.
  TITLE     Peptide elongation factor eEF1A-2/S1 expression in cultured
            differentiated myotubes and its protective effect against
            caspase-3-mediated apoptosis
  JOURNAL   J Biol Chem 277 (7), 5418-5425 (2002)
   PUBMED   11724805
REFERENCE   8  (bases 1 to 2035)
  AUTHORS   Kristensen,P., Lund,A., Clark,B.F., Cavallius,J. and Merrick,W.C.
  TITLE     Purification and characterisation of a tissue specific elongation
            factor 1 alpha (EF-1 alpha 2) from rabbit muscle
  JOURNAL   Biochem Biophys Res Commun 245 (3), 810-814 (1998)
   PUBMED   9588196
REFERENCE   9  (bases 1 to 2035)
  AUTHORS   Poirier,J., Beffert,U., Dea,D., Alonso,R., O'Donnell,D. and
            Boksa,P.
  TITLE     Increased levels of statin, a marker of cell cycle arrest, in
            response to hippocampal neuronal injury
  JOURNAL   Brain Res Mol Brain Res 34 (1), 57-64 (1995)
   PUBMED   8750861
REFERENCE   10 (bases 1 to 2035)
  AUTHORS   Ann,D.K., Moutsatsos,I.K., Nakamura,T., Lin,H.H., Mao,P.L.,
            Lee,M.J., Chin,S., Liem,R.K. and Wang,E.
  TITLE     Isolation and characterization of the rat chromosomal gene for a
            polypeptide (pS1) antigenically related to statin
  JOURNAL   J Biol Chem 266 (16), 10429-10437 (1991)
   PUBMED   1709933
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC074016.1.
            
            On Jul 8, 2004 this sequence version replaced NM_012660.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074016.1, M62751.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..2035
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /note="eukaryotic translation elongation factor 1 alpha 2"
                     /db_xref="GeneID:24799"
                     /db_xref="RGD:3781"
     exon            1..252
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /inference="alignment:Splign:2.1.0"
     exon            253..471
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1719
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /note="eEF1A-2; EF-1-alpha-2; elongation factor 1 A-2;
                     statin-S1; eukaryotic elongation factor 1 A-2; Statin-like
                     protein"
                     /codon_start=1
                     /product="elongation factor 1-alpha 2"
                     /protein_id="NP_036792.2"
                     /db_xref="GeneID:24799"
                     /db_xref="RGD:3781"
                     /translation="MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEK
                     EAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNM
                     ITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEP
                     AYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVER
                     KEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGM
                     VVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKADPP
                     QEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPK
                     SLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGK
                     VTKSAQKAQKAGK"
     exon            472..651
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /inference="alignment:Splign:2.1.0"
     exon            652..948
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1099
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1356
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1591
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..2014
                     /gene="Eef1a2"
                     /gene_synonym="EEF1AL; Ps10; RATPS10; STN; Stnl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagctgc gtcctctcgg atcctcgtta cgccggccgg cgtccgtggg tgcgcggccc
       61 ctgcgtccgc gcatcgttcg caccccatct gccagcctcc cggcgcccgc ctcccccctc
      121 cggtaccgca ttgccgtact gcaggggcgc agtgcattgc gccggcaccg tcaataggtg
      181 gaccccctcc tagagagata aaaccgccgg cgccagcgcc accagtccct ctgactgaga
      241 cctcggctct ggagttcctg cccagcaaat accctcaacc cagagccaga gcccccacag
      301 tgccagcccg tccctcactc aggcagaatg ggcaaggaga agacacacat caacattgtg
      361 gtcattggcc acgtggactc aggcaagtct accacgacag gccatctcat ctacaaatgt
      421 ggcggcatcg acaagcggac catcgagaag tttgagaagg aggcagcaga gatggggaag
      481 ggctccttta aatatgcctg ggtgctggac aagctgaagg cagagcggga gcgcggcatc
      541 accatcgaca tctccctctg gaagtttgag accaccaagt actacatcac catcattgat
      601 gctccaggcc accgggactt catcaagaac atgattactg gcacatccca ggccgactgt
      661 gcagtactga tcgtggcagc gggcgtgggc gagtttgagg cgggcatctc caaaaacggg
      721 caaacccggg aacacgcact cctggcctac actctgggtg tgaaacagct cattgtgggt
      781 gtcaacaaga tggactccac ggaaccagcc tacagcgaga agcgctacga tgagattgtc
      841 aaggaggtca gcgcctacat caagaagatc ggctacaacc cagccacggt gcccttcgtg
      901 cccatctcgg gctggcacgg tgacaacatg ctggaacctt cacctaatat gccatggttc
      961 aagggctgga aggtagagcg taaggaagga aatgcaagcg gcgtgtccct gctggaagcc
     1021 ctggacacaa tcctgccccc cacccgcccc accgacaagc cccttcgtct accgctgcag
     1081 gatgtataca agattggtgg cattgggact gtacctgtgg gcagagtgga gaccggtatc
     1141 ctccgtcctg gtatggtggt gacctttgcg ccagtcaaca tcaccacaga ggtgaagtct
     1201 gtggaaatgc accacgaggc gctcagcgag gccctgcctg gtgacaatgt tgggttcaac
     1261 gtgaagaatg tgtctgtcaa ggacattcgc cggggcaatg tctgtgggga cagcaaagct
     1321 gacccccctc aggaggccgc ccagttcacc tctcaggtta tcatcctgaa ccaccctggg
     1381 caaatcagcg ctggctactc gccagtcatc gactgtcaca cagcccacat cgcctgcaag
     1441 tttgccgagc taaaggagaa gattgaccgt cgctctggca agaagctgga ggacaatccc
     1501 aagtccctga agtctgggga tgccgccatt gttgagatgg tcccaggaaa acccatgtgt
     1561 gtggagagct tctcacagta cccacccctc ggccgcttcg ccgtgcgcga catgcggcag
     1621 actgtggccg tgggcgtcat caagaacgtg gagaagaaga gcggcggcgc cggcaaggtc
     1681 accaagtccg cacagaaggc gcagaaagcg ggcaagtgaa gcgcgggcgc ccgcggcgtg
     1741 gccctcccca acggcgccgc gccgcgcccc cagccccgcc cccggcactg gccccgtccc
     1801 ctcccccgcc ccaggcgcgg cccctccgcc ccgccccccc gccaggcgca tgtctgcacc
     1861 tccgcttgta agaggctcta cgtcagcgac tggatgctcg ccatcaaagt ccagtggaaa
     1921 ttcttcaaga ggaaaagcgc ccccacccca ggcttccgcg ccagtgctga ccacgctcag
     1981 tgcccgtttt cccaataaac tgagcgaccc cagaaaaaaa aaaaaaaaaa aaaaa
//
