LOCUS       NM_001106278            2046 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus embryonic ectoderm development (Eed), mRNA.
ACCESSION   NM_001106278 XM_001061674 XM_214996
VERSION     NM_001106278.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Wright H, Aylwin CF, Toro CA, Ojeda SR and Lomniczi A.
  TITLE     Polycomb represses a gene network controlling puberty via
            modulation of histone demethylase Kdm6b expression
  JOURNAL   Sci Rep 11 (1), 1996 (2021)
   PUBMED   33479437
  REMARK    GeneRIF: Polycomb represses a gene network controlling puberty via
            modulation of histone demethylase Kdm6b expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2046)
  AUTHORS   Ragazzini R, Perez-Palacios R, Baymaz IH, Diop S, Ancelin K,
            Zielinski D, Michaud A, Givelet M, Borsos M, Aflaki S, Legoix P,
            Jansen PWTC, Servant N, Torres-Padilla ME, Bourc'his D, Fouchet P,
            Vermeulen M and Margueron R.
  TITLE     EZHIP constrains Polycomb Repressive Complex 2 activity in germ
            cells
  JOURNAL   Nat Commun 10 (1), 3858 (2019)
   PUBMED   31451685
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2046)
  AUTHORS   Imagawa E, Higashimoto K, Sakai Y, Numakura C, Okamoto N, Matsunaga
            S, Ryo A, Sato Y, Sanefuji M, Ihara K, Takada Y, Nishimura G,
            Saitsu H, Mizuguchi T, Miyatake S, Nakashima M, Miyake N, Soejima H
            and Matsumoto N.
  TITLE     Mutations in genes encoding polycomb repressive complex 2 subunits
            cause Weaver syndrome
  JOURNAL   Hum Mutat 38 (6), 637-648 (2017)
   PUBMED   28229514
REFERENCE   4  (bases 1 to 2046)
  AUTHORS   He D, Wang J, Lu Y, Deng Y, Zhao C, Xu L, Chen Y, Hu YC, Zhou W and
            Lu QR.
  TITLE     lncRNA Functional Networks in Oligodendrocytes Reveal
            Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in
            the CNS
  JOURNAL   Neuron 93 (2), 362-378 (2017)
   PUBMED   28041882
REFERENCE   5  (bases 1 to 2046)
  AUTHORS   Zhou L, Sun K, Zhao Y, Zhang S, Wang X, Li Y, Lu L, Chen X, Chen F,
            Bao X, Zhu X, Wang L, Tang LY, Esteban MA, Wang CC, Jauch R, Sun H
            and Wang H.
  TITLE     Linc-YY1 promotes myogenic differentiation and muscle regeneration
            through an interaction with the transcription factor YY1
  JOURNAL   Nat Commun 6, 10026 (2015)
   PUBMED   26658965
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2046)
  AUTHORS   Erhardt S, Su IH, Schneider R, Barton S, Bannister AJ, Perez-Burgos
            L, Jenuwein T, Kouzarides T, Tarakhovsky A and Surani MA.
  TITLE     Consequences of the depletion of zygotic and embryonic enhancer of
            zeste 2 during preimplantation mouse development
  JOURNAL   Development 130 (18), 4235-4248 (2003)
   PUBMED   12900441
REFERENCE   7  (bases 1 to 2046)
  AUTHORS   Mager J, Montgomery ND, de Villena FP and Magnuson T.
  TITLE     Genome imprinting regulated by the mouse Polycomb group protein Eed
  JOURNAL   Nat Genet 33 (4), 502-507 (2003)
   PUBMED   12627233
REFERENCE   8  (bases 1 to 2046)
  AUTHORS   Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire
            G, Caceres JF and Bickmore WA.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   9  (bases 1 to 2046)
  AUTHORS   Tie F, Furuyama T, Prasad-Sinha J, Jane E and Harte PJ.
  TITLE     The Drosophila Polycomb Group proteins ESC and E(Z) are present in
            a complex containing the histone-binding protein p55 and the
            histone deacetylase RPD3
  JOURNAL   Development 128 (2), 275-286 (2001)
   PUBMED   11124122
REFERENCE   10 (bases 1 to 2046)
  AUTHORS   van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T and
            Wientjens E.
  TITLE     Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2
            with Eed: indication for separate Pc-G complexes
  JOURNAL   Mol Cell Biol 18 (6), 3572-3579 (1998)
   PUBMED   9584197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC168872.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001106278.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168872.1, SRR8487227.15873.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2046
                     /gene="Eed"
                     /note="embryonic ectoderm development"
                     /db_xref="GeneID:293104"
                     /db_xref="RGD:1309782"
     exon            1..537
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..1749
                     /gene="Eed"
                     /codon_start=1
                     /product="polycomb protein EED"
                     /protein_id="NP_001099748.1"
                     /db_xref="GeneID:293104"
                     /db_xref="RGD:1309782"
                     /translation="MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSI
                     ESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFN
                     WHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSH
                     PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW
                     NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
                     SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG
                     KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLE
                     VEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR"
     exon            538..690
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            691..783
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            784..849
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            850..975
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1057
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1149
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1283
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1389
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1548
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1622
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..2014
                     /gene="Eed"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caattgcgga cgaaacgtct gggcaaggaa gggggtgagg gagcagccct ttgagttccg
       61 cctcctctct aggcgctggt ggggaagggg gactaggaaa ccctgccctc tgagccagca
      121 ggtccgacgc ctcggtgcaa agtgccgaga gggcggcggg aaaaccgccc gccgggacca
      181 ggggacggga agcagccagg aagccgtacg ggagggcgcg cgcgcgcgcg cccctttttc
      241 agcagtgtgg cggggtcgca cgcacgcccg cctcggcggc tgggcgcgat ttgcgacagt
      301 ggggggagcg gcggcggtgg cggtgccggc agctttgcgg caggctccgg ccgggcgtgc
      361 ttgacggcgg tgtggcggag gccccgcccg aggcggcaag aacctggagg gaggcggagg
      421 aatatgtctg agagggaagt gtcgactgcg ccggcgggaa cagacatgcc ggcggccaag
      481 aagcagaagt tgagcagcga cgagaacagc aacccggacc tctcgggaga cgagaatgac
      541 gatgctgtca gtatcgagag tggcacaaac acagaacgcc cggacacacc cacaaataca
      601 ccaaatgcac caggaaggaa aagctgggga aagggaaaat ggaagtcgaa gaaatgcaaa
      661 tattctttca aatgtgtgaa cagcctcaag gaagatcaca accagccatt gtttggagtt
      721 cagtttaact ggcacagtaa agaaggagat cctctggtgt ttgcaactgt gggaagcaac
      781 agagtaacct tatatgaatg ccattctcaa ggggaaatac ggttattgca gtcctatgta
      841 gatgctgatg cagatgaaaa cttttacact tgtgcatgga cctatgatag caacaccagc
      901 caccctctgc tagcagttgc tggatctaga ggcataataa gaataattaa tcctataaca
      961 atgcagtgta taaagcacta tgttggccat gggaatgcta tcaatgagct gaaattccac
     1021 ccacgagacc caaaccttct cctgtcagta agtaaagatc atgctttacg attatggaat
     1081 atccaaacag acactcttgt ggcaatattc ggaggtgtgg aagggcacag agatgaagtg
     1141 ctgagtgctg attatgatct tttgggtgaa aaaataatgt cctgtggtat ggatcactct
     1201 cttaaactgt ggagaatcaa ctcaaagaga atgatgaatg cgattaagga atcttacgat
     1261 tataacccaa acaaaactaa caggccattt atttcccaga aaatccactt tcctgatttt
     1321 tctaccagag acatacatag gaattatgtt gattgtgtac gatggttagg cgatttgata
     1381 ctttccaagt cttgtgaaaa tgccattgta tgctggaaac ctggcaaaat ggaggatgat
     1441 atagataaaa ttaaacctag tgagtctaat gtgactattc ttgggcgatt tgattacagc
     1501 cagtgtgaca tttggtacat gaggttttct atggatttct ggcaaaagat gcttgcattg
     1561 ggcaatcagg ttggcaaact gtatgtttgg gatttagaag tagaagatcc tcataaagcc
     1621 aaatgcacaa cactgaccca tcataaatgt ggcgctgcta ttcgacaaac cagttttagc
     1681 agggatagca gcatcctcat agctgtctgc gatgatgcca gcatttggcg ttgggatcga
     1741 cttcgataaa ctatttttcc ctagtaaaaa ttagaatatg ttgtctgtgt aaaatagaat
     1801 taatgtatct tgctagcaaa gggactagag catttagact tgtctttcag catccgatca
     1861 ggctgagctg aatgtagtgg tgtttacatt gtttacattc tttgtactgt cttcctgctc
     1921 agactttact gcttttaata aaaatttatt tttgtaaagc tgtgttattt ttattgtgat
     1981 ggaaacaaac tggaagaaat aaagttatac cataaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaa
//
