LOCUS       NM_017333               2018 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus endothelin receptor type B (Ednrb), mRNA.
ACCESSION   NM_017333 XM_344451
VERSION     NM_017333.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Yang,P., Wu,Y., Li,F., Tang,J., Zheng,Z. and Tian,Q.
  TITLE     Activation of ETAR and ETBR in myocardial tissue characterizes
            heart failure induced by experimental autoimmune myocarditis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 11 (2024)
   PUBMED   38166688
  REMARK    GeneRIF: Activation of ETAR and ETBR in myocardial tissue
            characterizes heart failure induced by experimental autoimmune
            myocarditis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Yang,P., Li,F., Tang,J., Tian,Q. and Zheng,Z.
  TITLE     ET-1 receptor type B (ETBR) overexpression associated with ICAM-1
            downregulation leads to inflammatory attenuation in experimental
            autoimmune myocarditis
  JOURNAL   PeerJ 11, e16320 (2023)
   PUBMED   37901475
  REMARK    GeneRIF: ET-1 receptor type B (ETBR) overexpression associated with
            ICAM-1 downregulation leads to inflammatory attenuation in
            experimental autoimmune myocarditis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Becker,B.K., Grady,C.M., Markl,A.E., Torres Rodriguez,A.A. and
            Pollock,D.M.
  TITLE     Elevated renal afferent nerve activity in a rat model of endothelin
            B receptor deficiency
  JOURNAL   Am J Physiol Renal Physiol 325 (2), F235-F247 (2023)
   PUBMED   37348026
  REMARK    GeneRIF: Elevated renal afferent nerve activity in a rat model of
            endothelin B receptor deficiency.
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Cassinotti,L., Guil,M., Bianciotti,L. and Vatta,M.
  TITLE     Role of Brain Endothelin Receptor Type B (ETB) in the Regulation of
            Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt
            Hypertensive Rats
  JOURNAL   Curr Vasc Pharmacol 21 (4), 246-256 (2023)
   PUBMED   37349999
  REMARK    GeneRIF: Role of Brain Endothelin Receptor Type B (ETB) in the
            Regulation of Tyrosine Hydroxylase in the Olfactory Bulb of
            DOCA-Salt Hypertensive Rats.
REFERENCE   5  (bases 1 to 2018)
  AUTHORS   Chen,K.C., Chen,K.C., Song,Z.M. and Croaker,G.D.
  TITLE     Structural heart defects associated with ETB mutation, a cause of
            Hirschsprung disease
  JOURNAL   BMC Cardiovasc Disord 21 (1), 475 (2021)
   PUBMED   34600481
  REMARK    GeneRIF: Structural heart defects associated with ETB mutation, a
            cause of Hirschsprung disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2018)
  AUTHORS   Puffenberger,E.G., Hosoda,K., Washington,S.S., Nakao,K., deWit,D.,
            Yanagisawa,M. and Chakravart,A.
  TITLE     A missense mutation of the endothelin-B receptor gene in multigenic
            Hirschsprung's disease
  JOURNAL   Cell 79 (7), 1257-1266 (1994)
   PUBMED   8001158
REFERENCE   7  (bases 1 to 2018)
  AUTHORS   Hori,S., Komatsu,Y., Shigemoto,R., Mizuno,N. and Nakanishi,S.
  TITLE     Distinct tissue distribution and cellular localization of two
            messenger ribonucleic acids encoding different subtypes of rat
            endothelin receptors
  JOURNAL   Endocrinology 130 (4), 1885-1895 (1992)
   PUBMED   1312429
REFERENCE   8  (bases 1 to 2018)
  AUTHORS   Sakamoto,A., Yanagisawa,M., Sakurai,T., Takuwa,Y., Yanagisawa,H.
            and Masaki,T.
  TITLE     Cloning and functional expression of human cDNA for the ETB
            endothelin receptor
  JOURNAL   Biochem Biophys Res Commun 178 (2), 656-663 (1991)
   PUBMED   1713452
REFERENCE   9  (bases 1 to 2018)
  AUTHORS   Sakurai,T., Yanagisawa,M., Takuwa,Y., Miyazaki,H., Kimura,S.,
            Goto,K. and Masaki,T.
  TITLE     Cloning of a cDNA encoding a non-isopeptide-selective subtype of
            the endothelin receptor
  JOURNAL   Nature 348 (6303), 732-735 (1990)
   PUBMED   2175397
REFERENCE   10 (bases 1 to 2018)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from S65355.1.
            
            On Dec 17, 2003 this sequence version replaced XM_344451.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X57764.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5756307,
                                    SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q22"
     gene            1..2018
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /note="endothelin receptor type B"
                     /db_xref="GeneID:50672"
                     /db_xref="RGD:2536"
     exon            1..201
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /inference="alignment:Splign:2.1.0"
     exon            202..734
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1580
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /note="endothelin B receptor; ET-B; endothelin receptor
                     non-selective type; ET-BR"
                     /codon_start=1
                     /product="endothelin receptor type B precursor"
                     /protein_id="NP_059029.1"
                     /db_xref="GeneID:50672"
                     /db_xref="RGD:2536"
                     /translation="MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTK
                     EVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKY
                     INTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAY
                     KLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWT
                     AVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWW
                     LFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFAL
                     CWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKR
                     FKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS"
     exon            735..847
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1052
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1202
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1336
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1445
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..2012
                     /gene="Ednrb"
                     /gene_synonym="Ednra; Etb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgagcga actgctgagg atccgctgtc tggcattctc tcagcctttt gtccgagcca
       61 gagctgcatt cagaggagag aggcccgcta aggagcagct ggactcctgc tgcgagccga
      121 aagcccccta aggcagttga ggacctggga aggaggctcc ctgctggtgg cgcttctcct
      181 ggtgcttcca atccgtgcga gactgaaaac ggcggagcgg ctacgggact ctcacaggag
      241 caagctgcaa catgcaatcg tccgcaagcc ggtgcggacg cgccttggtg gcgctgctgc
      301 tggcctgtgg cttgttgggg gtatggggag agaaaagagg attcccacct gcccaggcca
      361 caccatctct tctcgggact aaagaagtta tgacgccacc cactaagacc tcctggacta
      421 gaggttccaa ctccagtctg atgcgttcct ccgcacctgc ggaggtgacc aaaggaggga
      481 gggtggctgg agtcccgcca agatccttcc ctcctccgtg ccaacgaaaa attgagatca
      541 acaagacttt taaatacatc aacacgattg tatcatgcct cgtgttcgtg ctaggcatca
      601 tcgggaactc cacactgcta agaatcatct acaagaacaa gtgcatgaga aatggtccca
      661 atatcttgat cgccagcctg gctctgggag atctgctaca catcatcatc gacattccca
      721 ttaatgccta caagctgctg gcaggggact ggccatttgg agctgagatg tgcaagctgg
      781 tgcccttcat acagaaggct tctgtgggga tcacagtgtt gagtctatgt gctctaagta
      841 ttgacagata tcgagctgtt gcttcttgga gtcgaattaa aggaattggg gttccaaaat
      901 ggacagcagt agaaattgtt ttaatttggg tggtctctgt ggttctggct gtccctgaag
      961 ccataggttt tgatgtgatt acgtcggact acaaaggaaa gcccctaagg gtctgcatgc
     1021 ttaatccctt tcagaaaaca gccttcatgc agttttacaa gacagccaaa gactggtggc
     1081 tgttcagttt ctacttctgc ttgccgctag ccatcactgc gatcttttac accctaatga
     1141 cctgtgagat gctcagaaag aaaagtggta tgcagattgc cttgaatgac cacttaaagc
     1201 agagacgaga agtggccaag acagtattct gcctggtcct cgtgtttgcc ctctgttggc
     1261 ttccccttca cctcagcagg attctgaagc tcacccttta tgaccagagc aatcctcaga
     1321 ggtgtgaact tctgagtttt ttgctggttt tggactacat tggtatcaac atggcttctt
     1381 tgaattcctg cattaatcca atcgctctgt atttggtgag caagagattc aaaaactgct
     1441 ttaagtcgtg tttgtgctgc tggtgccaaa cgtttgagga aaaacagtcc ttagaggaga
     1501 agcaatcctg cttgaagttc aaagctaacg atcacggata cgacaacttc cgctccagca
     1561 ataaatacag ctcatcttga aggaaggaac actcactgaa tctcattgtc ctcatcgtgg
     1621 acagatagca ttaaaacaaa atgaaacctt tgccaaaccc aaacggaaaa ccgtgcttgc
     1681 ggaaaggtgt gcacgcatgg gagagggatt gttttttaac cgttctaact ttccacacct
     1741 gatatttcac gggctgttta caacctaaga aagccatggg aatgaatgaa gcctcgggaa
     1801 agcacttaga ttcttagtca gcacttcagc acggctctta aaagccctca ctgcactcac
     1861 agcccactta catttaaaaa caagaactca aactctattc aggggtttat tatccagtcc
     1921 tatgaatctg gatacaggaa tgcatgacat tgcaaaacaa ttcttaaagc aaagtttcaa
     1981 ttgctcgatt tgagacaaaa aacaaaacaa aaaaaaaa
//
