LOCUS       NM_012550               4595 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus endothelin receptor type A (Ednra), mRNA.
ACCESSION   NM_012550 XM_001054233
VERSION     NM_012550.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4595)
  AUTHORS   Yang,P., Wu,Y., Li,F., Tang,J., Zheng,Z. and Tian,Q.
  TITLE     Activation of ETAR and ETBR in myocardial tissue characterizes
            heart failure induced by experimental autoimmune myocarditis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 11 (2024)
   PUBMED   38166688
  REMARK    GeneRIF: Activation of ETAR and ETBR in myocardial tissue
            characterizes heart failure induced by experimental autoimmune
            myocarditis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4595)
  AUTHORS   Matsuura,K., Sakai,A., Watanabe,Y., Mikahara,Y., Sakamoto,A. and
            Suzuki,H.
  TITLE     Endothelin receptor type A is involved in the development of
            oxaliplatin-induced mechanical allodynia and cold allodynia acting
            through spinal and peripheral mechanisms in rats
  JOURNAL   Mol Pain 17, 17448069211058004 (2021)
   PUBMED   34894846
  REMARK    GeneRIF: Endothelin receptor type A is involved in the development
            of oxaliplatin-induced mechanical allodynia and cold allodynia
            acting through spinal and peripheral mechanisms in rats.
REFERENCE   3  (bases 1 to 4595)
  AUTHORS   Gohar,E.Y. and Pollock,D.M.
  TITLE     Functional Interaction of Endothelin Receptors in Mediating
            Natriuresis Evoked by G Protein-Coupled Estrogen Receptor 1
  JOURNAL   J Pharmacol Exp Ther 376 (1), 98-105 (2021)
   PUBMED   33127751
  REMARK    GeneRIF: Functional Interaction of Endothelin Receptors in
            Mediating Natriuresis Evoked by G Protein-Coupled Estrogen Receptor
            1.
REFERENCE   4  (bases 1 to 4595)
  AUTHORS   Drott,C.J., Norman,D. and Espes,D.
  TITLE     CART decreases islet blood flow, but has no effect on total
            pancreatic blood flow and glucose tolerance in anesthetized rats
  JOURNAL   Peptides 135, 170431 (2021)
   PUBMED   33098940
  REMARK    GeneRIF: CART decreases islet blood flow, but has no effect on
            total pancreatic blood flow and glucose tolerance in anesthetized
            rats.
REFERENCE   5  (bases 1 to 4595)
  AUTHORS   Nkadimeng,S.M., Steinmann,C.M.L. and Eloff,J.N.
  TITLE     Effects and safety of Psilocybe cubensis and Panaeolus cyanescens
            magic mushroom extracts on endothelin-1-induced hypertrophy and
            cell injury in cardiomyocytes
  JOURNAL   Sci Rep 10 (1), 22314 (2020)
   PUBMED   33339902
  REMARK    GeneRIF: Effects and safety of Psilocybe cubensis and Panaeolus
            cyanescens magic mushroom extracts on endothelin-1-induced
            hypertrophy and cell injury in cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4595)
  AUTHORS   Bogoni,G., Rizzi,A., Calo,G., Campobasso,C., D'Orleans-Juste,P. and
            Regoli,D.
  TITLE     Characterization of endothelin receptors in the human umbilical
            artery and vein
  JOURNAL   Br J Pharmacol 119 (8), 1600-1604 (1996)
   PUBMED   8982507
REFERENCE   7  (bases 1 to 4595)
  AUTHORS   Gariepy,C.E., Cass,D.T. and Yanagisawa,M.
  TITLE     Null mutation of endothelin receptor type B gene in spotting lethal
            rats causes aganglionic megacolon and white coat color
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 867-872 (1996)
   PUBMED   8570650
REFERENCE   8  (bases 1 to 4595)
  AUTHORS   Hayzer,D.J., Cicila,G., Cockerham,C., Griendling,K.K.,
            Delafontaine,P., Ng,S.C. and Runge,M.S.
  TITLE     Endothelin A and B receptors are down-regulated in the hearts of
            hypertensive rats
  JOURNAL   Am J Med Sci 307 (3), 222-227 (1994)
   PUBMED   8160714
REFERENCE   9  (bases 1 to 4595)
  AUTHORS   Hori,S., Komatsu,Y., Shigemoto,R., Mizuno,N. and Nakanishi,S.
  TITLE     Distinct tissue distribution and cellular localization of two
            messenger ribonucleic acids encoding different subtypes of rat
            endothelin receptors
  JOURNAL   Endocrinology 130 (4), 1885-1895 (1992)
   PUBMED   1312429
REFERENCE   10 (bases 1 to 4595)
  AUTHORS   Lin,H.Y., Kaji,E.H., Winkel,G.K., Ives,H.E. and Lodish,H.F.
  TITLE     Cloning and functional expression of a vascular smooth muscle
            endothelin 1 receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (8), 3185-3189 (1991)
   PUBMED   1849646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB798671.1, DQ832324.1 and JAXUCZ010000019.1.
            
            On Jan 10, 2008 this sequence version replaced NM_012550.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.76027.1,
                                           SRR26360176.800510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               CB798671.1         1-249
            250-1435            DQ832324.1         1-1186
            1436-1681           DQ832324.1         1591-1836
            1682-4595           JAXUCZ010000019.1  47198372-47201285
FEATURES             Location/Qualifiers
     source          1..4595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..4595
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /note="endothelin receptor type A"
                     /db_xref="GeneID:24326"
                     /db_xref="RGD:2535"
     exon            1..236
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /inference="alignment:Splign:2.1.0"
     exon            237..712
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1573
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /note="endothelin-1 receptor; endothelin A receptor;
                     endothelin-1 receptor-like"
                     /codon_start=1
                     /product="endothelin-1 receptor precursor"
                     /protein_id="NP_036682.1"
                     /db_xref="GeneID:24326"
                     /db_xref="RGD:2535"
                     /translation="MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTE
                     FDFLGTTLRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLL
                     RIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKL
                     FPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAI
                     PEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYT
                     LMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYD
                     EMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSK
                     SLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN"
     exon            713..840
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1039
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1192
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1326
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1435
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..4595
                     /gene="Ednra"
                     /gene_synonym="Endor; ET-A; ET-AR; Eta; RGD1559432"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctggtctg gcagctgtgt ctaaagaggt ggggagcctc tctctgatcc aacggaccat
       61 cgcaggagct tgcaggctga gcgagatctc ctctagagaa gccgggccgt cctgggaagt
      121 ttcctccagc cgagactggg ctgcagccct ggtcgcgcgc caccctcgaa ctccagctca
      181 ggctccgtct ggctccggcg cggacctggc gctgtctgcg tccgaggagc tctaagggga
      241 aggaaaggtg tgagaccaac ataacaggac gtttcttcag atccacatta agatgggtgt
      301 cctttgcttt ctggcgtcct tttggctggc cctggtggga ggcgcaatcg ctgacaatgc
      361 tgagagatac agtgctaatc taagcagcca cgtggaggac ttcacccctt ttccagggac
      421 agagttcgac tttctgggca ccacccttcg accccctaat ttggccctgc ctagcaatgg
      481 ctcaatgcat ggctattgcc cacagcagac aaaaatcacg acggctttca aatatatcaa
      541 cactgtgata tcctgtacca ttttcatcgt gggaatggtg gggaacgcca ctctcctaag
      601 aatcatttac caaaacaagt gtatgaggaa cggccccaat gcgctcatag ccagcctggc
      661 ccttggagac cttatctacg tggtcattga tctccccatc aatgtgttta agctgttggc
      721 ggggcgctgg ccttttgacc acaatgattt tggagtgttt ctctgcaagc tgttcccctt
      781 tttgcagaag tcgtccgtgg gcatcactgt cctgaatctc tgcgctctca gtgtggacag
      841 gtacagagca gtggcttcct ggagccgggt tcaaggaatc gggatcccct tgattaccgc
      901 cattgaaatt gtctccatct ggatcctttc ctttatcttg gccatcccag aagcaatcgg
      961 cttcgtcatg gtacccttcg aatacaaggg cgagcagcac aggacctgca tgctcaacgc
     1021 cacgaccaag ttcatggagt tttaccaaga cgtgaaggac tggtggctct ttggattcta
     1081 cttctgcatg cccttggtgt gcacagcaat cttctatacc ctcatgacct gtgagatgct
     1141 caacagaagg aatgggagct tgcggattgc cctcagcgaa cacctcaagc agcgtcgaga
     1201 ggtggcaaag accgtcttct gcttggttgt catcttcgcc ctgtgctggt tccctcttca
     1261 cttaagccga attttgaaga aaaccgtcta tgatgagatg gataagaacc ggtgtgaact
     1321 gctcagcttc ttgctgctca tggattacat tggcattaac ctggcaacca tgaactcttg
     1381 cataaaccca atagctctgt attttgtgag caagaaattc aaaaattgtt ttcagtcatg
     1441 cctctgttgc tgttgtcacc agtccaaaag cctcatgacc tcggtcccca tgaatggaac
     1501 gagtatccag tggaagaacc aggagcagaa ccacaacaca gaacggagca gccacaagga
     1561 cagcatgaac taaccctgtg cagaagcacc gagcagtgtg ccttcgagtc ccaggatgaa
     1621 acggtcacgc agcagctgcg ctcccaaaac ctcccaggtc tctcccctgc tttttgtcta
     1681 agtccagcct aagagaagaa atgctctcct gccctcccaa cagcacatga cggaccggtt
     1741 ccactcacag ccatgggtct ttcctgagta ctgtccatga tttgcatacc gtgcctgtca
     1801 tttccaacac ttgaaaatca ggacaactga gggggaaggt gacagttcaa ggaaaccatg
     1861 tgtctgccac ctttgcttga acacagagtt tgcacgttca tttccagctt ccgtgcagtt
     1921 ctatggaaca gccagtgggc actgttcatc ctaagattct agagcagtgg ttctcaacct
     1981 tcccaatgct gcagcccctt aatacagttc cttatttccc agtgactccc caaccataaa
     2041 attttgttgc tacttcataa ctataatttt gcaactgtta tgacttgttt tatctatctg
     2101 atatttctga tagtcttagt ctgccctggt gaaagggcca ttcaattcga aaggggtcac
     2161 aacctacaag ttgagaacta cagctctaga aattatgttg aatttgaagc cccgtgtcta
     2221 aaatcctata actggagagg tgagggaaga tgatcaggtg ttcaaggaca gactcattta
     2281 cagagttcag aaaagccagg gctacataag attctcacaa aaatacaaac agacaaaaag
     2341 tgtttaaaag ttatgacaag attcattatt tttttacaac caaacacatt gtgaggttga
     2401 agtattcttt tggaaatgac attcagtgtt gggattttat aactgcgtgg caccttagaa
     2461 atgattgttt cctcttctat acatgcactt tgaaaaagaa gtgaggagga gaaagaggag
     2521 gaggaggagg aggaagagga agaggaggag gaaagggagg gcatctgata aggaactagg
     2581 ttctgtttct agggtactgc tttgtttgga aaagatgatt tccaaaggtg accaattacc
     2641 accagtcagt ctaataactg ttagccaaag aatttttaag aacctgtatt ttcttcttat
     2701 gttgttgttt ggttgggttt tttgcttgag gctggccttg aattcacaga ggtcttcctg
     2761 cttctgcctc caagggctgg gattgaggac acgtgcctag tactctagct tgggtatatg
     2821 tttatgctaa attaaaaata ataataatac ttaggagcta ggcaaggtgg cgcatgccac
     2881 aagcttccta ctcttaacat cctgaggctg aagcaggggg ctgtgagtgg gcgagtgccc
     2941 acactaacta gaggtacttg cctccaaata ataataatta ataataatac ttagggccaa
     3001 tggttctctc tttcataagc ccagtccttt gtaatgtgtt ttttaatgtg aaaccatgtc
     3061 ctgcagctta catgtcactg aagtatggcg agacttccag ccctacgtca gaagcattcc
     3121 taggaaaaac atgctggctg gttctggagg gcctggacat ctcgtacaag ctccacagta
     3181 gtagcacata tataatgcat gcttcctcct acgctctcag gtcctcctac tgtgaggact
     3241 ggctacactc ctgcccatgc cttcttccag acaggaaaca atgtctgagt ggccaaatga
     3301 gctgattgtg tcaggcgaaa tggacaccac cggccatgaa cctttaactc tttgctcctc
     3361 tatgattgtg agacgaactt aaattttcat cctgtcccca actcctcagt ggtcactatt
     3421 tcaaagggcc catggtaagt tactactggg cattttccca gatgtttaca gactgtgaga
     3481 acaacaaatg tcttttattt tgtgtgtata taaatatata aataattgta catttctttt
     3541 agccaaattt tctgtggtta tctctatgga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3601 gtgtgtgtgt gtgtgtgtgt tgtggtacat atagatctgg tgtaatctta gaatgccctg
     3661 tgtttgtgcc aaaacacata ttgggagtgg attctaggtg attactcatt atactaccca
     3721 ctttggtcag ttcttacaca taagaatctc aagcctccca cacttgctac ttagctacta
     3781 ttacagatct gagagctgcc atgcaaggga aagtgactgc aggagggatt tgttaggttg
     3841 gatgatctga ccaagtagga ttccgtcata gccttgtcct tgctggagca ggattccctg
     3901 tcatagcctt gtccttgctg gagccaagag tcctatactt ggaagtatta cacttttctc
     3961 tttactccct tgggtgttct ttttgtttct gttttttact gtttgctctg gggattaagc
     4021 ccaggacctc tgctatgcta ggcaagtgct ccacaacccc aaggaagtat tattttgttc
     4081 tagtccccag tggtagtgca actgacaagt cacctggagt ttctgtcaga taatcggtgg
     4141 aaaactagct atcttaattt ttgcatcata ttttaataca gttaaaaatg aatcaaatat
     4201 caaaatcaag attaaaaagt gcatcaagtt gcagttgctt gaatttcagg gctgagaaat
     4261 actacccctg tatgttagta gtcaagtgtg ccactgagta acacacaccc atacatgcct
     4321 agagtaagac atagatgcaa acagttttgt ttattagacc attatcttgt aaaagatgct
     4381 ttgtttttta tatataaaat gtatttttta ttcagaacat cgtaggtctg aatacacagg
     4441 cttcagtgtg cattttgttt atgactggta atgatttact catgaaaaca gttcaccaca
     4501 tttccgacaa ggaactttgt agaaatgatc cagaagctaa gggcctgtgt tggcagtggc
     4561 ccattaaaca gaaaataaaa gtttacagaa gcttt
//
