LOCUS       NP_001071118             167 aa            linear   ROD 27-MAR-2024
DEFINITION  endothelin-3 precursor [Rattus norvegicus].
ACCESSION   NP_001071118 XP_001072605
VERSION     NP_001071118.2
DBSOURCE    REFSEQ: accession NM_001077650.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 167)
  AUTHORS   Gisser,J.M., Cohen,A.R., Yin,H. and Gariepy,C.E.
  TITLE     A novel bidirectional interaction between endothelin-3 and retinoic
            acid in rat enteric nervous system precursors
  JOURNAL   PLoS One 8 (9), e74311 (2013)
   PUBMED   24040226
  REMARK    GeneRIF: A novel bidirectional interaction exists between
            endothelin-3 and retinoic acid in rat enteric nervous system
            precursors.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 167)
  AUTHORS   Sato,A. and Ebina,K.
  TITLE     Endothelin-3 at low concentrations attenuates inflammatory
            responses via the endothelin B2 receptor
  JOURNAL   Inflamm Res 62 (4), 417-424 (2013)
   PUBMED   23370722
  REMARK    GeneRIF: ET-3 at low concentrations may attenuate inflammatory
            responses via ETB2 activation and nitric oxide production
REFERENCE   3  (residues 1 to 167)
  AUTHORS   Rivera,A., Kam,S.Y., Ho,M., Romero,J.R. and Lee,S.
  TITLE     Ablation of the Kell/Xk complex alters erythrocyte divalent cation
            homeostasis
  JOURNAL   Blood Cells Mol Dis 50 (2), 80-85 (2013)
   PUBMED   23122227
  REMARK    Erratum:[Blood Cells Mol Dis. 2014 Jan;52(1):52]
REFERENCE   4  (residues 1 to 167)
  AUTHORS   Evangelisti,C., Bianco,F., Pradella,L.M., Puliti,A., Goldoni,A.,
            Sbrana,I., Rossi,M., Vargiolu,M., Seri,M., Romeo,G.,
            Stanghellini,V., de Giorgio,R. and Bonora,E.
  TITLE     Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB
            signalling pathways
  JOURNAL   Neurogastroenterol Motil 24 (10), e497-e508 (2012)
   PUBMED   22897442
REFERENCE   5  (residues 1 to 167)
  AUTHORS   Zhu,X., Rivera,A., Golub,M.S., Peng,J., Sha,Q., Wu,X., Song,X.,
            Kumarathasan,P., Ho,M., Redman,C.M. and Lee,S.
  TITLE     Changes in red cell ion transport, reduced intratumoral
            neovascularization, and some mild motor function abnormalities
            accompany targeted disruption of the Mouse Kell gene (Kel)
  JOURNAL   Am J Hematol 84 (8), 492-498 (2009)
   PUBMED   19544475
REFERENCE   6  (residues 1 to 167)
  AUTHORS   Turck,D.
  TITLE     [Nutritional requirements in infants, in children and in pregnant
            and breast-feeding women. Energy, iron, proteins, essential fatty
            acids, vitamin D, calcium]
  JOURNAL   Rev Prat 42 (20), 2647-2650 (1992)
   PUBMED   1299957
REFERENCE   7  (residues 1 to 167)
  AUTHORS   Gardiner,S.M., Kemp,P.A. and Bennett,T.
  TITLE     Inhibition by phosphoramidon of the regional haemodynamic effects
            of proendothelin-2 and -3 in conscious rats
  JOURNAL   Br J Pharmacol 107 (2), 584-590 (1992)
   PUBMED   1422599
REFERENCE   8  (residues 1 to 167)
  AUTHORS   Shiba,R., Sakurai,T., Yamada,G., Morimoto,H., Saito,A., Masaki,T.
            and Goto,K.
  TITLE     Cloning and expression of rat preproendothelin-3 cDNA
  JOURNAL   Biochem Biophys Res Commun 186 (1), 588-594 (1992)
   PUBMED   1378731
REFERENCE   9  (residues 1 to 167)
  AUTHORS   Samson,W.K. and Skala,K.D.
  TITLE     Comparison of the pituitary effects of the mammalian endothelins:
            vasoactive intestinal contractor (endothelin-beta, rat
            endothelin-2) is a potent inhibitor of prolactin secretion
  JOURNAL   Endocrinology 130 (5), 2964-2970 (1992)
   PUBMED   1533364
REFERENCE   10 (residues 1 to 167)
  AUTHORS   Sakamoto,A., Yanagisawa,M., Sakurai,T., Takuwa,Y., Yanagisawa,H.
            and Masaki,T.
  TITLE     Cloning and functional expression of human cDNA for the ETB
            endothelin receptor
  JOURNAL   Biochem Biophys Res Commun 178 (2), 656-663 (1991)
   PUBMED   1713452
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NP_001071118.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.17175.1,
                                           SRR26643298.20654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..167
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     Protein         1..167
                     /product="endothelin-3 precursor"
                     /note="preproendothelin-3; ET-3; PPET3"
                     /calculated_mol_wt=16525
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1930
     Region          22..45
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P13207.3)"
     Region          49..77
                     /region_name="Endothelin"
                     /note="Endothelin family; cl27714"
                     /db_xref="CDD:452774"
     mat_peptide     53..73
                     /product="Endothelin-3. /id=PRO_0000008121"
                     /note="propagated from UniProtKB/Swiss-Prot (P13207.3)"
                     /calculated_mol_wt=2647
     Site            73..74
                     /site_type="cleavage"
                     /note="Cleavage, by KEL. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P13207.3)"
     Region          85..112
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P13207.3)"
     Region          114..135
                     /region_name="END"
                     /note="Endothelin; smart00272"
                     /db_xref="CDD:197618"
     Region          115..135
                     /region_name="Endothelin-like"
                     /note="propagated from UniProtKB/Swiss-Prot (P13207.3)"
     Region          140..167
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P13207.3)"
     CDS             1..167
                     /gene="Edn3"
                     /gene_synonym="Et3; preproET-3; RGD1564825"
                     /coded_by="NM_001077650.2:171..674"
                     /db_xref="GeneID:366270"
                     /db_xref="RGD:2534"
ORIGIN      
        1 melglwlllg ltvtsaaaal paqpgnagqe rgpgrsgdqe ekrvpahhrp rrctcftykd
       61 kecvyychld iiwintpeqt vpyglsnhrg slrgkrssgp vpessqsspq trlrcacagv
      121 ddkacayfca hvtsysrrae kaaaeekqet ggprqrlksr tdkvhqp
//
