LOCUS       NM_012549               1135 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus endothelin 2 (Edn2), mRNA.
ACCESSION   NM_012549
VERSION     NM_012549.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1135)
  AUTHORS   Wang,F., Zhang,Z., Wang,Z., Xiao,K., Wang,Q., Su,J. and Wang,Z.
  TITLE     Expression and clinical significance of the HIF-1a/ET-2 signaling
            pathway during the development and treatment of polycystic ovary
            syndrome
  JOURNAL   J Mol Histol 46 (2), 173-181 (2015)
   PUBMED   25613530
  REMARK    GeneRIF: The HIF-1a-mediated ET-2 signaling pathway may be an
            important mechanism regulating polycystic ovary syndrome formation
            and treatment in mammalian ovaries.
REFERENCE   2  (bases 1 to 1135)
  AUTHORS   Compeer,M.G., Janssen,G.M. and De Mey,J.G.
  TITLE     Endothelin-1 and endothelin-2 initiate and maintain contractile
            responses by different mechanisms in rat mesenteric and cerebral
            arteries
  JOURNAL   Br J Pharmacol 170 (6), 1199-1209 (2013)
   PUBMED   23941276
  REMARK    GeneRIF: Endothelin-1 and endothelin-2 initiate and maintain
            contractile responses by different mechanisms in rat mesenteric and
            cerebral arteries.
REFERENCE   3  (bases 1 to 1135)
  AUTHORS   Chang,I., Bramall,A.N., Baynash,A.G., Rattner,A., Rakheja,D.,
            Post,M., Joza,S., McKerlie,C., Stewart,D.J., McInnes,R.R. and
            Yanagisawa,M.
  TITLE     Endothelin-2 deficiency causes growth retardation, hypothermia, and
            emphysema in mice
  JOURNAL   J Clin Invest 123 (6), 2643-2653 (2013)
   PUBMED   23676500
REFERENCE   4  (bases 1 to 1135)
  AUTHORS   Wang,Z., Zhang,Z., Wu,Y., Chen,L., Luo,Q., Zhang,J., Chen,J.,
            Luo,Z., Huang,X. and Cheng,Y.
  TITLE     Effects of echinomycin on endothelin-2 expression and ovulation in
            immature rats primed with gonadotropins
  JOURNAL   Exp Mol Med 44 (10), 615-621 (2012)
   PUBMED   22874467
  REMARK    GeneRIF: HIF-1alpha-mediated ET-2 transcriptional activation is one
            of the important mechanisms regulating gonadotropin-induced
            mammalian ovulatory precess in vivo.
REFERENCE   5  (bases 1 to 1135)
  AUTHORS   Zhang,J., Zhang,Z., Wu,Y., Chen,L., Luo,Q., Chen,J., Huang,X.,
            Cheng,Y. and Wang,Z.
  TITLE     Regulatory effect of hypoxia-inducible factor-1alpha on
            hCG-stimulated endothelin-2 expression in granulosa cells from the
            PMSG-treated rat ovary
  JOURNAL   J Reprod Dev 58 (6), 678-684 (2012)
   PUBMED   22972036
  REMARK    GeneRIF: HIF-1alpha-induced transcriptional activation may be one
            of the important mechanisms mediating the increase of ET-2
            expression in granulosa cells during the gonadotropin-induced
            mammalian ovulatory process.
REFERENCE   6  (bases 1 to 1135)
  AUTHORS   Brunner,F., du Toit,E.F. and Opie,L.H.
  TITLE     Endothelin release during ischaemia and reperfusion of isolated
            perfused rat hearts
  JOURNAL   J Mol Cell Cardiol 24 (11), 1291-1305 (1992)
   PUBMED   1479622
REFERENCE   7  (bases 1 to 1135)
  AUTHORS   Gardiner,S.M., Kemp,P.A. and Bennett,T.
  TITLE     Inhibition by phosphoramidon of the regional haemodynamic effects
            of proendothelin-2 and -3 in conscious rats
  JOURNAL   Br J Pharmacol 107 (2), 584-590 (1992)
   PUBMED   1422599
REFERENCE   8  (bases 1 to 1135)
  AUTHORS   Samson,W.K. and Skala,K.D.
  TITLE     Comparison of the pituitary effects of the mammalian endothelins:
            vasoactive intestinal contractor (endothelin-beta, rat
            endothelin-2) is a potent inhibitor of prolactin secretion
  JOURNAL   Endocrinology 130 (5), 2964-2970 (1992)
   PUBMED   1533364
REFERENCE   9  (bases 1 to 1135)
  AUTHORS   Guimaraes,C.L., Calixto,J.B. and Rae,G.A.
  TITLE     Potent constrictor actions of endothelin-1, endothelin-2, and
            endothelin-3 in rat isolated portal vein
  JOURNAL   Hypertension 19 (2 Suppl), II79-II86 (1992)
   PUBMED   1735599
REFERENCE   10 (bases 1 to 1135)
  AUTHORS   Sakamoto,A., Yanagisawa,M., Sakurai,T., Takuwa,Y., Yanagisawa,H.
            and Masaki,T.
  TITLE     Cloning and functional expression of human cDNA for the ETB
            endothelin receptor
  JOURNAL   Biochem Biophys Res Commun 178 (2), 656-663 (1991)
   PUBMED   1713452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2016 this sequence version replaced NM_012549.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1318171.1,
                                           SRR22582419.1103103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000005.1  139036576-139036633
            59-215              JAXUCZ010000005.1  139036940-139037096
            216-338             JAXUCZ010000005.1  139038362-139038484
            339-437             JAXUCZ010000005.1  139039334-139039432
            438-1135            JAXUCZ010000005.1  139041377-139042074
FEATURES             Location/Qualifiers
     source          1..1135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1135
                     /gene="Edn2"
                     /gene_synonym="ET-2; Et2; PPET2; RNEDN2S01; VIC"
                     /note="endothelin 2"
                     /db_xref="GeneID:24324"
                     /db_xref="RGD:2533"
     CDS             1..531
                     /gene="Edn2"
                     /gene_synonym="ET-2; Et2; PPET2; RNEDN2S01; VIC"
                     /note="preproendothelin-2; vasoactive intestinal
                     contractor; Endothelin isopeptide 2"
                     /codon_start=1
                     /product="endothelin-2 precursor"
                     /protein_id="NP_036681.2"
                     /db_xref="GeneID:24324"
                     /db_xref="RGD:2533"
                     /translation="MVSPAWCSIALALLLALHEGKGQAAATMEQPASAPKGRGPHLRF
                     RRCSCNSWLDKECVYFCHLDIIWVNTAGQTAPYGLGNPPRRRRRSLPKRCECSSAGDS
                     ACATFCHRRPWPEAEVTSSSQGPAAVLETSKTWTAAGDLLQKLRDISAAKLQFVRLRP
                     ELTREAIPAHSRRRKR"
     exon            1..58
                     /gene="Edn2"
                     /gene_synonym="ET-2; Et2; PPET2; RNEDN2S01; VIC"
                     /inference="alignment:Splign:2.1.0"
     exon            59..215
                     /gene="Edn2"
                     /gene_synonym="ET-2; Et2; PPET2; RNEDN2S01; VIC"
                     /inference="alignment:Splign:2.1.0"
     exon            216..338
                     /gene="Edn2"
                     /gene_synonym="ET-2; Et2; PPET2; RNEDN2S01; VIC"
                     /inference="alignment:Splign:2.1.0"
     exon            339..437
                     /gene="Edn2"
                     /gene_synonym="ET-2; Et2; PPET2; RNEDN2S01; VIC"
                     /inference="alignment:Splign:2.1.0"
     exon            438..1135
                     /gene="Edn2"
                     /gene_synonym="ET-2; Et2; PPET2; RNEDN2S01; VIC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtctccc cggcctggtg ttccattgct ctggccctac ttttggccct gcatgaaggg
       61 aagggccagg cagctgctac catggagcaa ccagcctcgg cacccaaggg ccgaggaccc
      121 cacctgcgtt ttcgtcgttg ctcctgcaac tcctggcttg acaaggaatg tgtgtacttc
      181 tgccacctgg acatcatctg ggtgaacact gcaggacaga cagctcccta tggcctggga
      241 aacccgccaa ggcgccggcg ccgctccctg ccaaagcgct gcgagtgctc ttctgctggg
      301 gactctgcct gtgccacctt ctgccatcga aggccctggc ctgaagctga ggtcacctca
      361 agtagccagg gccctgctgc tgtgttagag actagcaaga cgtggactgc tgcgggagac
      421 cttctccaaa agctgaggga catctcagct gccaagctcc aatttgtcag gctacggcca
      481 gagttgacaa gagaggccat ccctgcacac tctagacgga ggaagagata acaccatgag
      541 ctgcaggacc attgagaaag acgcccacgt ggagacggga ggaaatgggc agctactggg
      601 agaccctatg cctatctcct gggccaaggc ctcagatcct ggttagccag accaatctga
      661 tgggttcagc acaagctctg gcctctccta cagcagttct gtgccttttc actgccaggg
      721 ctaccctcag cacctggaca gcagtgcagc ctgctagtgc tggctgctgg ctaccgtcct
      781 gcttggagga gctatgtgca ggacaaatga acatgctacc tgtgtcctac agagtgtcct
      841 gcaatccagg agcaacccca cagcaggaca caattaccta agccacacct ggagactgga
      901 cagtcattag gatgactggc atcatagtcc tctctggttc cccttcccta gaggccttgc
      961 aacctgttct cttgggacac ttttgggaac acagagcctg ctatcctttg ttcgtctgta
     1021 tataacttat ttgctccgat aacgttgaga ttcttattat ttattttaat gtattttttt
     1081 agagcctcaa ttgtttactt atgaactcat gtttgtaata aaggatgaaa cgatc
//
