LOCUS       NM_012548               1390 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus endothelin 1 (Edn1), mRNA.
ACCESSION   NM_012548
VERSION     NM_012548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1390)
  AUTHORS   Wang,Z., Wu,Z., Hu,Z., Zheng,H. and Chen,Z.
  TITLE     ET1 acts as a potential plasma biomarker and therapeutic target in
            deep venous thrombosis rat model
  JOURNAL   J Thromb Thrombolysis 57 (6), 1067-1075 (2024)
   PUBMED   38824487
  REMARK    GeneRIF: ET1 acts as a potential plasma biomarker and therapeutic
            target in deep venous thrombosis rat model.
REFERENCE   2  (bases 1 to 1390)
  AUTHORS   Xu,H., Yu,X., Xie,R., Wang,Y. and Li,C.
  TITLE     RCOR1 improves neurobehaviors and neuron injury in rat cerebral
            palsy by Endothelin-1 targeting-induced Akt/GSK-3beta pathway
            upregulation
  JOURNAL   Brain Dev 46 (2), 93-102 (2024)
   PUBMED   37978036
  REMARK    GeneRIF: RCOR1 improves neurobehaviors and neuron injury in rat
            cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3beta
            pathway upregulation.
REFERENCE   3  (bases 1 to 1390)
  AUTHORS   Yang,T.C., Lu,M.H., Wang,W.J. and Chen,J.Y.
  TITLE     CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive
            SHR vascular smooth muscle cells
  JOURNAL   J Mol Endocrinol 71 (1), e220178 (2023)
   PUBMED   36942826
  REMARK    GeneRIF: CEBPB/POU2F2 modulates endothelin 1 expression in
            prehypertensive SHR vascular smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1390)
  AUTHORS   Costello,H.M., Juffre,A., Cheng,K.Y., Bratanatawira,P.,
            Crislip,G.R., Zietara,A., Spires,D.R., Staruschenko,A., Douma,L.G.
            and Gumz,M.L.
  TITLE     The circadian clock protein PER1 is important in maintaining
            endothelin axis regulation in Dahl salt-sensitive rats
  JOURNAL   Can J Physiol Pharmacol 101 (3), 136-146 (2023)
   PUBMED   36450128
  REMARK    GeneRIF: The circadian clock protein PER1 is important in
            maintaining endothelin axis regulation in Dahl salt-sensitive rats.
REFERENCE   5  (bases 1 to 1390)
  AUTHORS   Matsumoto,T., Takayanagi,K., Kojima,M., Taguchi,K. and Kobayashi,T.
  TITLE     Indoxyl sulfate enhances endothelin-1-induced contraction via
            impairment of NO/cGMP signaling in rat aorta
  JOURNAL   Pflugers Arch 473 (8), 1247-1259 (2021)
   PUBMED   34021781
  REMARK    GeneRIF: Indoxyl sulfate enhances endothelin-1-induced contraction
            via impairment of NO/cGMP signaling in rat aorta.
            Erratum:[Pflugers Arch. 2021 Aug;473(8):1329. doi:
            10.1007/s00424-021-02587-2.. PMID: 34137923]
REFERENCE   6  (bases 1 to 1390)
  AUTHORS   Samson,W.K. and Skala,K.D.
  TITLE     Comparison of the pituitary effects of the mammalian endothelins:
            vasoactive intestinal contractor (endothelin-beta, rat
            endothelin-2) is a potent inhibitor of prolactin secretion
  JOURNAL   Endocrinology 130 (5), 2964-2970 (1992)
   PUBMED   1533364
REFERENCE   7  (bases 1 to 1390)
  AUTHORS   D'Orleans-Juste,P., Telemaque,S., Claing,A., Ihara,M. and Yano,M.
  TITLE     Human big-endothelin-1 and endothelin-1 release prostacyclin via
            the activation of ET1 receptors in the rat perfused lung
  JOURNAL   Br J Pharmacol 105 (4), 773-775 (1992)
   PUBMED   1324048
REFERENCE   8  (bases 1 to 1390)
  AUTHORS   Simmet,T., Pritze,S., Thelen,K.I. and Peskar,B.A.
  TITLE     Release of endothelin in the oleic acid-induced respiratory
            distress syndrome in rats
  JOURNAL   Eur J Pharmacol 211 (3), 319-322 (1992)
   PUBMED   1618274
REFERENCE   9  (bases 1 to 1390)
  AUTHORS   Sakamoto,A., Yanagisawa,M., Sakurai,T., Takuwa,Y., Yanagisawa,H.
            and Masaki,T.
  TITLE     Cloning and functional expression of human cDNA for the ETB
            endothelin receptor
  JOURNAL   Biochem Biophys Res Commun 178 (2), 656-663 (1991)
   PUBMED   1713452
REFERENCE   10 (bases 1 to 1390)
  AUTHORS   Sakurai,T., Yanagisawa,M., Inoue,A., Ryan,U.S., Kimura,S.,
            Mitsui,Y., Goto,K. and Masaki,T.
  TITLE     cDNA cloning, sequence analysis and tissue distribution of rat
            preproendothelin-1 mRNA
  JOURNAL   Biochem Biophys Res Commun 175 (1), 44-47 (1991)
   PUBMED   1840483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Mar 31, 2010 this sequence version replaced NM_012548.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M64711.1, SRR26643289.39672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000017.1  22666435-22666687   c
            254-422             JAXUCZ010000017.1  22664602-22664770   c
            423-581             JAXUCZ010000017.1  22663132-22663290   c
            582-695             JAXUCZ010000017.1  22662868-22662981   c
            696-1390            JAXUCZ010000017.1  22660799-22661493   c
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1390
                     /gene="Edn1"
                     /gene_synonym="Et1"
                     /note="endothelin 1"
                     /db_xref="GeneID:24323"
                     /db_xref="RGD:2532"
     exon            1..253
                     /gene="Edn1"
                     /gene_synonym="Et1"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..798
                     /gene="Edn1"
                     /gene_synonym="Et1"
                     /note="ET-1; PPET1; preproendothelin-1"
                     /codon_start=1
                     /product="endothelin-1 preproprotein"
                     /protein_id="NP_036680.1"
                     /db_xref="GeneID:24323"
                     /db_xref="RGD:2532"
                     /translation="MDYFPVIFSLLFVAFQGAPETAVLGAELSPRAEKEVQSPPPSTS
                     WRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGSPSRSKRSLKDLLPTK
                     TTDQGNRCQCAHQKDKKCWNFCQADKELRAQSTMQKGVKDFKKGKPCPKLGKKCIYQQ
                     LVEGRKLRRLEAISNSIKTSFRVAKLKAELYRDQKLIHNRAH"
     exon            254..422
                     /gene="Edn1"
                     /gene_synonym="Et1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..581
                     /gene="Edn1"
                     /gene_synonym="Et1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..695
                     /gene="Edn1"
                     /gene_synonym="Et1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..1390
                     /gene="Edn1"
                     /gene_synonym="Et1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgacgctt tcgctccggt gaaggggcca ctttttgaag accgcgctga gatctccaaa
       61 agccagaggc gatcagagca accagacacc gtcctcttcg ttttgcattg agttccattt
      121 gcaaccgagt tttctttctt tctttttttt ttcttttttt ccctcctctt cttctgatcc
      181 ctttgcagaa tggattattt tcccgtgatc ttctctctgc tgtttgtggc tttccaagga
      241 gctccagaaa cagctgtctt gggagcagag ctcagccccc gagctgagaa ggaagtgcag
      301 agcccccctc ccagcacatc ctggagaccc cgcaggtcca agcgttgctc ctgctcctcc
      361 ttgatggaca aggagtgtgt ctacttctgc cacctggaca tcatctgggt caacactccc
      421 gagcgcgtcg tcccgtatgg actaggaagc ccttctaggt ctaagcgatc cttgaaagac
      481 ttacttccca caaagaccac agaccaaggg aacagatgcc agtgtgctca ccaaaaagac
      541 aagaagtgct ggaatttctg ccaagcagac aaagaactcc gagcccaaag taccatgcag
      601 aaaggcgtaa aagacttcaa gaagggaaaa ccctgtccca agctgggaaa gaagtgtatc
      661 tatcagcagc tggtggaggg aagaaaacta agaaggttgg aggccatcag caacagcatc
      721 aagacctcct ttcgagttgc aaagttgaaa gcggaactct acagagacca gaagttgata
      781 cacaaccgag cacattgact acagagcccc gtggtgtttt ggaagccatg acttacatag
      841 agcgagccct atggccaact ctgcgctctc catgctggct gggatcttag caagaacatc
      901 tgtccggctt ctacagtttc ttgttcagac tggcagagga ccagcgtcct tgttccaaac
      961 attccaagag aggttgaggt gttccctaac ctgtcttcgt ttgcatccgc tggtagcaag
     1021 tgattctctt gcctcttctt gctgtctggg gatggcctcg gacctctcgg agagcagaga
     1081 cacagtgcca ttcctgagtg gcatcatcca gagagccagg agattccata gcagggcgga
     1141 gtttctgtag aaagtcctta gggagtgttc gtgtctgact caggcgcctg gcacatttca
     1201 gggagaaact ccaaagtcca tgcaaaaaat tttctgagga atgcacaaat tgaaaacata
     1261 ctcgaaggac aaacacttga gttttttttt tttaaggact tttttttaag ttgtaaaatg
     1321 caaaactcaa agcaactgtt actactgtac attaggatat gtttcatgaa tatgagtcta
     1381 cctcaccttt
//
