LOCUS       NM_001191671            2917 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ER degradation enhancing alpha-mannosidase like
            protein 3 (Edem3), mRNA.
ACCESSION   NM_001191671 XM_222721
VERSION     NM_001191671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Ninagawa,S., Okada,T., Sumitomo,Y., Kamiya,Y., Kato,K.,
            Horimoto,S., Ishikawa,T., Takeda,S., Sakuma,T., Yamamoto,T. and
            Mori,K.
  TITLE     EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first
            mannose trimming step
  JOURNAL   J Cell Biol 206 (3), 347-356 (2014)
   PUBMED   25092655
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Hirao,K., Natsuka,Y., Tamura,T., Wada,I., Morito,D., Natsuka,S.,
            Romero,P., Sleno,B., Tremblay,L.O., Herscovics,A., Nagata,K. and
            Hosokawa,N.
  TITLE     EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic
            reticulum-associated degradation and mannose trimming
  JOURNAL   J Biol Chem 281 (14), 9650-9658 (2006)
   PUBMED   16431915
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Jul 17, 2010 this sequence version replaced XM_222721.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.44613.1,
                                           SRR26643298.51537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               JAXUCZ010000013.1  66408695-66408973
            280-325             JAXUCZ010000013.1  66412834-66412879
            326-426             JAXUCZ010000013.1  66421956-66422056
            427-466             JAXUCZ010000013.1  66422620-66422659
            467-579             JAXUCZ010000013.1  66426437-66426549
            580-733             JAXUCZ010000013.1  66427472-66427625
            734-868             JAXUCZ010000013.1  66433444-66433578
            869-974             JAXUCZ010000013.1  66435092-66435197
            975-1072            JAXUCZ010000013.1  66441729-66441826
            1073-1198           JAXUCZ010000013.1  66444112-66444237
            1199-1282           JAXUCZ010000013.1  66444417-66444500
            1283-1366           JAXUCZ010000013.1  66447373-66447456
            1367-1491           JAXUCZ010000013.1  66448065-66448189
            1492-1657           JAXUCZ010000013.1  66453556-66453721
            1658-1812           JAXUCZ010000013.1  66453955-66454109
            1813-1966           JAXUCZ010000013.1  66455080-66455233
            1967-2158           JAXUCZ010000013.1  66456635-66456826
            2159-2324           JAXUCZ010000013.1  66457417-66457582
            2325-2510           JAXUCZ010000013.1  66460516-66460701
            2511-2917           JAXUCZ010000013.1  66466738-66467144
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2917
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /note="ER degradation enhancing alpha-mannosidase like
                     protein 3"
                     /db_xref="GeneID:289085"
                     /db_xref="RGD:1561496"
     exon            1..279
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2917
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /EC_number="3.2.1.113"
                     /note="ER degradation-enhancing alpha-mannosidase-like 3;
                     ER degradation enhancer, mannosidase alpha-like 3"
                     /codon_start=1
                     /product="ER degradation-enhancing alpha-mannosidase-like
                     protein 3 precursor"
                     /protein_id="NP_001178600.1"
                     /db_xref="GeneID:289085"
                     /db_xref="RGD:1561496"
                     /translation="MSEAGGGRGCGCRVPQRASWSLVAATAALYLMLATTVCTAGAAP
                     MSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALG
                     KFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGH
                     SLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEAR
                     TGTETDTCTACAGTLILEFAALSRFTGATVFEEYARKALDFLWEKRQRSSNLVGVTIN
                     IHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLL
                     DVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTT
                     DFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDV
                     RTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNRNI
                     SKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVE
                     ESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSVDAE
                     DGLRFMQEMIELSSQQQKEQQLPPRAVQIISHPFFGRVVLTAGPAQFGLDLSKHKETR
                     GFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEG
                     SSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREHEQVEVLLSDKARDRD
                     PEVENEDQPSSENDSQNQSAEQMLPLPQTVGLADQESPGNPLESPSEPPSPADSEEAA
                     GFAPSEQISSPTETQETAGLDGECTDLDNQLQDQPETEEDPSPNVSWGTKAQPMDSIL
                     ADWNEDIEAFEMMEKDEL"
     exon            280..325
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            326..426
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            427..466
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            467..579
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            580..733
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            734..868
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            869..974
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1072
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1198
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1282
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1366
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1491
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1657
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1812
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1966
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2158
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2324
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2510
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2917
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagcctca ccccacagcc ggccctcgac acggctcgca gcctcctcgg cgccgccatc
       61 ccgcgatgtg gcccaccgtg cgggtgtagc agctgcgcgt gcgcggaacc gcggggccat
      121 gagcgaagcc ggcggcggcc ggggctgtgg gtgccgggtc ccccagcgag cgtcatggag
      181 cctggtggca gcgacggccg cgctctatct gatgttggcc acgaccgtgt gcacggcagg
      241 ggccgcgccc atgagtaggg aagagaagca gaagcttgga aatcaagtcc tggaaatgtt
      301 tgatcacgct tacggcaact atatggaaca tgcctaccca gctgatgaac tcatgccttt
      361 aacctgtcga ggtcgtgtca gaggccagga gccaagccgg ggtgacgtgg atgatgcctt
      421 gggaaagttc tccctaacac tgatcgattc tttggacact cttgtggtat taaacaaaac
      481 taaggaattt gaagatgcag tgagaaaagt tttaagggat gttaatctag ataatgatgt
      541 agttgtttca gtctttgaaa caaacatcag agttcttggg ggtcttttgg gtggacactc
      601 gctggcaatc atgctgaagg aaaaagggga atacatgcag tggtataacg acgagcttct
      661 ccaaatggca aagcagctgg gttacaagct ccttccagct ttcaacacta ccagtggcct
      721 tccatatccc aggattaatt taaagtttgg catcagaaaa ccggaagccc ggacgggaac
      781 tgagacggac acctgcacgg cctgtgcagg caccttgatc cttgagtttg ctgcattgag
      841 tcggttcaca ggagctacag tattcgagga atatgcaaga aaagctcttg attttctctg
      901 ggagaaaaga cagcgaagta gcaatttagt aggcgtgact atcaatattc atactggaga
      961 ctgggtgcgc aaagacagtg gagttggagc agggatcgac tcatattatg agtatctgtt
     1021 gaaagcctat gtcttgctcg gagatgacag ttttctggaa agatttaata cacattatga
     1081 tgccataatg aggtatatta gccagccccc tctcctgctc gatgtgcata tccacaaacc
     1141 aatgctcaat gcccggacct ggatggacgc actgcttgcc ttctttccag gtttgcaggt
     1201 tttaaagggt gatattagac ctgctattga aactcatgaa atgttatacc aggtgattaa
     1261 aaaacacaac ttcctaccag aggcatttac tacagatttc agggttcact gggctcagca
     1321 ccctctaagg ccagagtttg cagagagtac ctacttctta tataaggcta caggagaccc
     1381 ttactacctt gaagtaggga aaacacttat tgaaaatttg aataaatacg ctcgagtgcc
     1441 ttgcggattt gctgccatga aggatgttcg cactgggagt catgaggaca gaatggattc
     1501 gttcttcttg gctgaaatgt tcaaatatct gtacctgtta tttgctgata aagaagacat
     1561 tatttttgac atagaagact atatctttac aacagaggct catctgttac ctctttggct
     1621 ttctaccaca aaccgaaaca tctcgaagaa gaacacaacc tcagaataca cagaactgga
     1681 tgatagtaac tttgattgga cttgtccaaa cacgcagatt ctttttccta atgatccatt
     1741 gtatgcccag agcatccgtg aacccttgaa aaacgtggtg gataagagct gtccaagagg
     1801 catcatcaga gtagaggaga gtttcagaag tggagctaag cctcctctga gagccagaga
     1861 ttttatggcc actaaccctg aacatttaga aatcctgaag aagatggggg tgagtttgat
     1921 tcacctcaaa gatgggcgag tccagctggt ccaacatgca atccaagctg cgagttcagt
     1981 tgatgctgag gacgggttgc ggttcatgca ggagatgata gagttgtcca gtcagcaaca
     2041 gaaggagcag cagctgcctc ctcgagctgt acagattatc tcccacccat tttttggcag
     2101 ggtagtctta actgctggac cagctcagtt tgggctggat ctgtctaaac acaaagagac
     2161 aagaggattt gttgcaagca gtaaaccata taatggctgt tcggagctca ctaaccctga
     2221 ggcagtgatg ggaaaaattg ccttgataca aagaggacag tgcatgtttg cagaaaaggc
     2281 tcgaaacatc cagaatgctg gcgccatcgg tggcattgtg attgatgaca atgaggggag
     2341 cagcagtgac acagcccccc tgttccagat ggctggcgac gggaaagaca cagacgacat
     2401 caagatcccc atgctgttcc tgttcagcaa ggaaggcagc atcatcttgg acgccatccg
     2461 tgagcacgag caggtggagg tgctcctttc tgacaaagcg agagaccgag atcctgaggt
     2521 ggaaaatgaa gaccagccgt cttctgaaaa cgactctcag aatcaaagtg cagagcagat
     2581 gctgccactt cctcagacag tcggcttggc tgatcaggag agccctggaa accctctgga
     2641 gtctccctca gagccaccat cgccagcaga cagtgaagag gctgcgggct ttgcgccttc
     2701 tgaacagatc tctagcccca cagagaccca ggagacggca ggtcttgatg gtgagtgcac
     2761 agacttagat aaccagcttc aagatcaacc cgaaaccgag gaagacccca gtccgaacgt
     2821 cagctggggt acgaaggccc agcctatgga ctccatacta gcagactgga atgaagacat
     2881 agaagcattt gaaatgatgg agaaggacga actatga
//
