LOCUS       NM_001004230            1898 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ER degradation enhancing alpha-mannosidase like
            protein 2 (Edem2), mRNA.
ACCESSION   NM_001004230 XM_215899
VERSION     NM_001004230.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1898)
  AUTHORS   Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S,
            Ishikawa T, Takeda S, Sakuma T, Yamamoto T and Mori K.
  TITLE     EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first
            mannose trimming step
  JOURNAL   J Cell Biol 206 (3), 347-356 (2014)
   PUBMED   25092655
REFERENCE   2  (bases 1 to 1898)
  AUTHORS   Slominska-Wojewodzka M, Pawlik A, Sokolowska I, Antoniewicz J,
            Wegrzyn G and Sandvig K.
  TITLE     The role of EDEM2 compared with EDEM1 in ricin transport from the
            endoplasmic reticulum to the cytosol
  JOURNAL   Biochem J 457 (3), 485-496 (2014)
   PUBMED   24200403
REFERENCE   3  (bases 1 to 1898)
  AUTHORS   Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN and Moremen KW.
  TITLE     Human EDEM2, a novel homolog of family 47 glycosidases, is involved
            in ER-associated degradation of glycoproteins
  JOURNAL   Glycobiology 15 (4), 421-436 (2005)
   PUBMED   15537790
  REMARK    Erratum:[Glycobiology. 2005 May;15(5):13G]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079029.1.
            
            On Sep 10, 2004 this sequence version replaced XM_215899.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079029.1, SRR8487226.77010.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1898
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /note="ER degradation enhancing alpha-mannosidase like
                     protein 2"
                     /db_xref="GeneID:296304"
                     /db_xref="RGD:1303074"
     exon            1..170
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1794
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /note="ER degradation-enhancing-mannosidase-like protein
                     2; ER degradation-enhancing alpha-mannosidase-like 2; ER
                     degradation enhancer, mannosidase alpha-like 2"
                     /codon_start=1
                     /product="ER degradation-enhancing alpha-mannosidase-like
                     protein 2 precursor"
                     /protein_id="NP_001004230.1"
                     /db_xref="GeneID:296304"
                     /db_xref="RGD:1303074"
                     /translation="MPFRLLIPLGLVCVLLPLHHGAPGPEGTAPDPAHYRERVKAMFY
                     HAYDSYLENAFPYDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNTSEFQRVVEVLQ
                     DNVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARK
                     LLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVA
                     RVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKL
                     MAMFLEYNKAIRNYTHFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMR
                     TFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLEL
                     GRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFHPNNFIHNN
                     GSTFDSVMTPHGECILGAGGYIFNTEAHPIDPAALHCCRRLKEEQWEVEDLIKEFYSL
                     RQSRSRAQRKTVSSGPWEPPAGPGTLSSPENQPREKQPARQRAPLLSCPSQPFTSKLA
                     LLGQVFLDSS"
     exon            171..281
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            282..321
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            322..427
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            428..553
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            554..765
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            766..907
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1032
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1177
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1299
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1873
                     /gene="Edem2"
                     /gene_synonym="RGD1303074"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagaatga gcgggtggcc gtggctgcag ctgctgcggc ggcactgaca ggacacgagc
       61 tctatgcctt tccggctgct tatcccgctc ggcctcgtgt gcgtgctgct gcccctgcac
      121 catggtgcgc caggccccga aggcaccgcg cccgaccccg cccactacag ggagcgagtc
      181 aaggccatgt tctaccacgc ctacgacagt tacctggaaa atgcctttcc ctacgatgag
      241 ctgagacctc tcacctgtga cgggcacgac acctggggca gtttttctct gacactgatt
      301 gatgccctgg acaccttgct gattttgggg aatacctctg aattccaaag agtggtggag
      361 gttctccagg acaacgtgga ctttgatatc gacgtcaatg cctctgtgtt cgaaaccaac
      421 atccgagtgg taggaggact cctttctgct cacctcttgt caaagaaggc tggtgtggag
      481 gtggaagctg gatggccttg ttctggacct ctcctcagga tggcggagga agcagcccga
      541 aaactcctcc cagcgtttca gacccccacg ggcatgccct atggaactgt gaacctgctt
      601 catggcgtga accctggaga gactcctgtt acctgtacag cagggattgg gaccttcatt
      661 gtggaatttg ctaccctgag cagcctcacc ggtgaccctg tgtttgaaga tgtggccaga
      721 gtggccctga tgcgcctctg ggagagccgg tcagatattg ggctggtcgg caatcacatc
      781 gatgtgctca ctggcaaatg ggtggctcag gacgcaggca tcggggctgg tgtggattcc
      841 tattttgagt acctggtaaa aggagccatc ctccttcagg ataagaagct catggccatg
      901 tttctagagt acaacaaagc catccggaat tacacgcact tcgatgactg gtacctctgg
      961 gtgcagatgt acaaggggac cgtgtccatg cctgtcttcc agtccttgga ggcctactgg
     1021 cctggtcttc agagccttat tggggatatt gacaatgcca tgagaacctt cctcaactac
     1081 tacactgtat ggaagcagtt tggggggctg ccagaattct acaacattcc tcagggatac
     1141 acagtggaga agcgagaagg ctacccactc cgaccggagc tcatcgagag cgcaatgtac
     1201 ctctaccgtg ccacagggga tcccactctc ttagaactgg ggagagatgc tgtggagtcc
     1261 attgagaaaa tcagcaaggt ggagtgcggg ttcgccacga tcaaggacct ccgggatcac
     1321 aaacttgaca accgcatgga gtctttcttc ctggccgaga ctgtgaaata cctctacctt
     1381 ctgtttcacc caaacaactt catccacaac aatggctcca cttttgactc tgtgatgacc
     1441 ccccatgggg agtgcatcct gggagctggg ggctacatct tcaacacgga agctcacccc
     1501 atcgaccctg ccgccttgca ctgttgccgg aggctgaagg aagagcagtg ggaagtggag
     1561 gacttgataa aggagttcta ctctctcaga cagagcaggt caagagctca gagaaagaca
     1621 gtgagttcgg ggccctggga gcccccagca gggccaggca cactctcctc acctgaaaac
     1681 cagcccaggg agaagcagcc tgccaggcag agagccccgc tcctcagctg ccccagccag
     1741 cccttcactt ctaaactggc cctgctaggc caggttttcc tagactcctc ataaccactg
     1801 gataattttt ttaattttta tttttttgag actgagctat aataataaat ctgcttttag
     1861 ctatcaggtt ttaaaaaaaa aaaaaaaaaa aaaaaaaa
//
