LOCUS       NM_001305279            5707 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ER degradation enhancing alpha-mannosidase like
            protein 1 (Edem1), mRNA.
ACCESSION   NM_001305279 XM_001075943 XM_238366
VERSION     NM_001305279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5707)
  AUTHORS   Tan,Z., Zhang,W., Sun,J., Fu,Z., Ke,X., Zheng,C., Zhang,Y., Li,P.,
            Liu,Y., Hu,Q., Wang,H. and Zheng,Z.
  TITLE     ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of
            unfolded protein response in neural cells
  JOURNAL   J Neuroinflammation 15 (1), 275 (2018)
   PUBMED   30241539
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5707)
  AUTHORS   Ninagawa,S., Okada,T., Sumitomo,Y., Kamiya,Y., Kato,K.,
            Horimoto,S., Ishikawa,T., Takeda,S., Sakuma,T., Yamamoto,T. and
            Mori,K.
  TITLE     EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first
            mannose trimming step
  JOURNAL   J Cell Biol 206 (3), 347-356 (2014)
   PUBMED   25092655
REFERENCE   3  (bases 1 to 5707)
  AUTHORS   Slominska-Wojewodzka,M., Pawlik,A., Sokolowska,I., Antoniewicz,J.,
            Wegrzyn,G. and Sandvig,K.
  TITLE     The role of EDEM2 compared with EDEM1 in ricin transport from the
            endoplasmic reticulum to the cytosol
  JOURNAL   Biochem J 457 (3), 485-496 (2014)
   PUBMED   24200403
REFERENCE   4  (bases 1 to 5707)
  AUTHORS   Groisman,B., Shenkman,M., Ron,E. and Lederkremer,G.Z.
  TITLE     Mannose trimming is required for delivery of a glycoprotein from
            EDEM1 to XTP3-B and to late endoplasmic reticulum-associated
            degradation steps
  JOURNAL   J Biol Chem 286 (2), 1292-1300 (2011)
   PUBMED   21062743
REFERENCE   5  (bases 1 to 5707)
  AUTHORS   Hosokawa,N., Tremblay,L.O., Sleno,B., Kamiya,Y., Wada,I.,
            Nagata,K., Kato,K. and Herscovics,A.
  TITLE     EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C
            branch of N-glycans
  JOURNAL   Glycobiology 20 (5), 567-575 (2010)
   PUBMED   20065073
REFERENCE   6  (bases 1 to 5707)
  AUTHORS   Cormier,J.H., Tamura,T., Sunryd,J.C. and Hebert,D.N.
  TITLE     EDEM1 recognition and delivery of misfolded proteins to the
            SEL1L-containing ERAD complex
  JOURNAL   Mol Cell 34 (5), 627-633 (2009)
   PUBMED   19524542
REFERENCE   7  (bases 1 to 5707)
  AUTHORS   Zuber,C., Cormier,J.H., Guhl,B., Santimaria,R., Hebert,D.N. and
            Roth,J.
  TITLE     EDEM1 reveals a quality control vesicular transport pathway out of
            the endoplasmic reticulum not involving the COPII exit sites
  JOURNAL   Proc Natl Acad Sci U S A 104 (11), 4407-4412 (2007)
   PUBMED   17360537
  REMARK    GeneRIF: the endoplasmic reticulum quality control vesicular
            transport pathway using EDEM1 does not involve the COPII exit sites
REFERENCE   8  (bases 1 to 5707)
  AUTHORS   Bithell,A., Alberta,J., Hornby,F., Stiles,C.D. and Williams,B.P.
  TITLE     Expression of the guanine nucleotide exchange factor, mr-gef, is
            regulated during the differentiation of specific subsets of
            telencephalic neurons
  JOURNAL   Brain Res Dev Brain Res 146 (1-2), 107-118 (2003)
   PUBMED   14643017
REFERENCE   9  (bases 1 to 5707)
  AUTHORS   Molinari,M., Calanca,V., Galli,C., Lucca,P. and Paganetti,P.
  TITLE     Role of EDEM in the release of misfolded glycoproteins from the
            calnexin cycle
  JOURNAL   Science 299 (5611), 1397-1400 (2003)
   PUBMED   12610306
REFERENCE   10 (bases 1 to 5707)
  AUTHORS   Hosokawa,N., Wada,I., Hasegawa,K., Yorihuzi,T., Tremblay,L.O.,
            Herscovics,A. and Nagata,K.
  TITLE     A novel ER alpha-mannosidase-like protein accelerates ER-associated
            degradation
  JOURNAL   EMBO Rep 2 (5), 415-422 (2001)
   PUBMED   11375934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Mar 7, 2015 this sequence version replaced
            XM_238366.8, XM_001075943.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1606108.1,
                                           SRR23984936.306926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               JAXUCZ010000004.1  143353675-143354250
            577-649             JAXUCZ010000004.1  143362589-143362661
            650-753             JAXUCZ010000004.1  143366873-143366976
            754-925             JAXUCZ010000004.1  143368100-143368271
            926-1109            JAXUCZ010000004.1  143369988-143370171
            1110-1284           JAXUCZ010000004.1  143372003-143372177
            1285-1405           JAXUCZ010000004.1  143374276-143374396
            1406-1576           JAXUCZ010000004.1  143374981-143375151
            1577-1650           JAXUCZ010000004.1  143377142-143377215
            1651-1747           JAXUCZ010000004.1  143378674-143378770
            1748-1951           JAXUCZ010000004.1  143380701-143380904
            1952-5707           JAXUCZ010000004.1  143381938-143385693
FEATURES             Location/Qualifiers
     source          1..5707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..5707
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /note="ER degradation enhancing alpha-mannosidase like
                     protein 1"
                     /db_xref="GeneID:297504"
                     /db_xref="RGD:1563633"
     exon            1..576
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..2041
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /note="ER degradation-enhancing alpha-mannosidase-like 1;
                     ER degradation enhancer, mannosidase alpha-like 1"
                     /codon_start=1
                     /product="ER degradation-enhancing alpha-mannosidase-like
                     protein 1"
                     /protein_id="NP_001292208.1"
                     /db_xref="GeneID:297504"
                     /db_xref="RGD:1563633"
                     /translation="MQWRALVLGLVLLRLGLHAVLWLVFGLGPSMGFYQRFPLSFGFQ
                     RLRDPDGSGPVGPPGGPSWLHRPRRGTEGRLETPPGPGPGPGVCGPAHWGYALGGGGC
                     GLDEYERRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIYCRGRGPDL
                     GDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFE
                     ATIRVLGSLLSAHRIITDSKQPFGDMTIEDYDNELLYMAHDLAVRLLPAFENTKTGIP
                     YPRVNLKTGVPPDSNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRS
                     NDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSI
                     QSYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAIC
                     LHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGM
                     DILQSLEKYTKVKCGYATLHHVIDKSKEDRMESFFLSETCKYLYLLFDEENPVHKSGT
                     RYMFTTEGHIISVDKRLRELPWKEFFSEDGERDQEEKFVHRPKSQELRVINSSSNCNR
                     VPDERRYSLPLKSIYMRQIDQMVGLI"
     exon            577..649
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            650..753
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            754..925
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1109
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1284
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1405
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1576
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1650
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1747
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1951
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..5707
                     /gene="Edem1"
                     /gene_synonym="RGD1563633"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgggctc ccggcggacg cgcggggagg ccgtcggctg gggacgcgcc cggcgcttca
       61 aaataatgcc cgcggcggcc gcgcgaccat gcaatggcga gcgctcgtcc tggggctggt
      121 gctgctgcgc ctcggcctcc acgcagtgct ctggttggtc ttcgggctgg ggcccagcat
      181 gggcttctac cagcggtttc cgctcagttt cggcttccag cgcttgaggg accccgacgg
      241 ctcggggcca gttggtcctc cgggaggccc gtcctggctt catcggccaa ggcgcgggac
      301 agaggggcgg ctcgagaccc cgccgggacc agggccggga ccgggcgtgt gcggcccggc
      361 gcactggggc tatgctttgg gcggcggtgg ctgcggcctg gacgagtacg agcggcgcta
      421 cagcggcgcc ttcccgccgc agctgcgtgc ccagatgcgc gacctggcgc ggggcatgtt
      481 cgtcttcggc tatgacaact acatggcgca cgcctttccg caggacgagc tcaaccccat
      541 ctactgccgc ggccgggggc ctgacctcgg agacccttca aatctgaaca tcaacgatgt
      601 actaggaaat tactctctga ccctggttga tgccttggat acactcgcaa taatgggaaa
      661 ttcatccgag ttccagaaag cagtcaagtt agtgatcaac accgtttcat ttgacaaaga
      721 ttccaccgtc caagtctttg aggccacgat aagggttctg ggaagcctcc tttctgctca
      781 tagaataata actgactcca aacagccctt tggtgacatg acaattgagg attatgataa
      841 cgaattgttg tacatggccc atgacctggc tgtgcggctt cttccagctt ttgaaaacac
      901 caagacaggg atcccctatc ctcgggtgaa tctgaagacg ggtgtccctc ctgacagcaa
      961 taatgagacc tgcacagcag gggctggttc tctcctggtg gaatttggga ttctgagccg
     1021 actgctgggg gattccactt ttgagtgggt tgccagacga gctgtgaaag ccctctggaa
     1081 ccttcggagc aacgatacag gattattagg caatgttgtg aacatccaga caggccattg
     1141 ggttggaaag cagagtggct tgggtgctgg gctggattcc ttctatgaat acctcttgaa
     1201 atcttacatt ctttttggag aaaaagaaga tctagagatg tttaatgcag cttatcagag
     1261 catccagagc tacctgcgaa gaggccggga agcctgcaat gaaggagaag gagacccacc
     1321 gctctacgtc aacgtgaaca tgttcagtgg gcagctcatg aacacctgga ttgactctct
     1381 gcaggctttc ttcccggggc tgcaggttct gataggggat gtggaagacg ccatctgcct
     1441 acacgccttc tactacgcca tatggaaacg ctatggggcc ctccctgagc gctataactg
     1501 gcaactgcag gcccctgatg ttctcttcta ccccctgaga ccagagttag tggagtccac
     1561 atatctcctc taccaggcga ccaagaatcc cttctacctc catgtaggaa tggacattct
     1621 gcagagtctc gaaaaataca caaaagtcaa atgtggatat gccacgctgc accatgtcat
     1681 agacaagtct aaagaagacc ggatggagag cttcttcctc agcgagactt gcaaatactt
     1741 gtatctgctg tttgatgaag agaatccagt acacaaatct ggaaccagat acatgtttac
     1801 aactgagggc catatcatat ctgtggacaa acgtcttcgg gaattgcctt ggaaggaatt
     1861 cttctctgaa gatggggagc gggaccaaga ggaaaagttt gtgcacaggc ctaagtctca
     1921 ggagcttaga gtcattaact ccagttctaa ttgcaatcgt gttcctgatg agaggagata
     1981 ctccctgccc ttaaagagca tctacatgcg ccagatcgac cagatggttg gcttgatttg
     2041 acctgctcac ctcgatgtgg ccagacctta aaccaaaccc aagcatacca aaatctcctc
     2101 tgaggtggaa gcggtggagt ctgtccatct gtgatgctct agaagtttct gtccagctct
     2161 tactcacctc tggttgaatc ttgcacttag tgctttcctt ctgtttaata aaatactctt
     2221 attttttttt tttctgaagg ataaaattag aaatgggaag ctccgtggcg agcttcttgt
     2281 gatatactga tgttgttaag cacaatggat atagcctctc tggattattc ttcccaactt
     2341 catgactaga agcccctacg tgctgaagta tcgctacctc tttgctagag gatcaggaat
     2401 gcaattcctg tgtaaagatt ctgagggtca cttggcatca tacttactgc aatcgaagtg
     2461 tcatcctttg tctcttacgg gatcattggg ctgtccccga gatagccagc tgtggtcttt
     2521 ggatcacatg agggaaattc actgcatcct aaagtaattt attcagtgtt acttgtttta
     2581 gtgtaatggt ctagccaaaa aatctacagg cagcctttaa agttaagttg aaatctaaga
     2641 gataactaac agatctttta tactgtattt agcatttatt ttgaacatca ccttacctga
     2701 agaacttcca tggttccaga accaggtgcc ttctagggag aggaaagccc tagggttgtg
     2761 agcttccgtc cctcgtgctt catagccaag gatgcacaat gctgaccgtc tttggcttag
     2821 acttctgggt tgtttttttt tttttcttgg cttatgtgta gtgccaatta gctaatcagg
     2881 gacaaagaaa tgatcagatg actttctgac atccttgagc catttctctg tgtgatatgg
     2941 actttagatt agtgccttat gggttttgtt tgggccatgg gctgtcacaa ccactgctac
     3001 agatagccca ttttgtattg tcatatgatg ggaccaataa ggagcagggt gtgtgtgagg
     3061 acgattcctg gaaaccagtt tgtcagtctt tgcctttaac ctatgatttt tagccaggca
     3121 taaaggagga aattacgagg aagagctttt gttgtttcct ggtgaaatga gaagccctgc
     3181 gaatgggaag tttgctcaaa ctgttcctaa aaagcagagc tgggcctgcc cctggcttgg
     3241 cctcctttca ctgggacagg tcaaggcatc ctaggcaaag ggtaggaagt ttatgagaaa
     3301 gctggtctaa cctcacatat cttatgtctt ccctccacac tattaataga cacttaaaat
     3361 tatttcattc cagtctccta tagccaggga aaaaagcctc atctgaatca ttggattttt
     3421 agttaaaagg gagaaattat agtctttctt caatatgtgg tactgttttg aaaataaata
     3481 taattcagtt ccttggcaag tttagaaatg gggtttcaga agtgactgtc atcttttaaa
     3541 tacttactat gcaattggtt ttatttattt aagaatattg aatgtttttc ttttgatctc
     3601 acaagcattg ttctatgtct tcaatgtctc atctactgta tacaaagctt tctttgagca
     3661 gattatctgt tttacatatt tctctaactc agtaaaagta ttaaacatat gcatgcacag
     3721 gcctgtgtgt gcacacccct ttttaccttt gctccaggca cgtttacgtg tgactgtgaa
     3781 tgacccgcta gggacagtga agacatcagg gaaggaagcg cccctcaggc ttctcttttt
     3841 catcttcccc acatccgtct ggttgtttgg caatggcagt gtatgtcagc acccaacagt
     3901 tctctctcat ctgggttctt gttccgttgc tcttgagcca gcttgggtta cttcttcctg
     3961 tgctcttgca gtcgtgatct gtgtctggag gtaccatggt gccgtgagtg ctgccagtgg
     4021 gtctcgggta caggcagatg tgccatgtat ttttactaag tcgtaaaccc tcttgacatt
     4081 tgggtactat gtttcatctg ttaacaaggc tgagggtaag gaagataatg cctataaatt
     4141 ttattattga gcttctagac tgctcagacc aaagtcaatg atttgtgggg ctggatgaag
     4201 aacactgtct actgccagtc atataaagaa cattatttga gtcaagttcg aagcctactt
     4261 gcttgcttcc tgaatgccag cagctgcgat gtatatatta cagtatgttt gctattcctt
     4321 ccaatctgtg ctgaaatacg ggaaaaaatt tttctaactc actgctttgt tccagaaatg
     4381 gctggaatgt gaacagatag ctgcatggat gtttgtgacc atgcttgtgc tcccaggagt
     4441 agccagcatc tagtgtccag tttggccagc atatgcaaag ttgcagacta cgtggcaggc
     4501 tggctgtcgt atggttagtt gtggtagagc ccgttctaca accaacaggc ttgccttagc
     4561 tgctctaaat actgtgacag agcaactcca ttctcctgga agaggcgaca gaggaatgtt
     4621 tgcctttctg atagctttgg ttgctgtgga aaacaggctt gttttccaaa cctccctaga
     4681 gttctccctg ctcttttctc ggagcttgct tttggtaagt gggtctctag ttctgacgtc
     4741 tgggcttctc ttgtcttgga ctgtggactc tgcacatggc attcagatgg ttttctgtgt
     4801 gtcgaaataa aagcatgtga gggtagttcc tgcccggagg actctctcgg agtccatgct
     4861 ttcctggttt gaatgtacgc agttgtctct caagaaaagt gaccctctca cccatctccc
     4921 caccagctca gtgaatgagt gcccgctgcg gttcttcact ttggatcttg tagactctac
     4981 attagacatc gcttttcttc agggctctga ggtcgtgttc tcttgacatg gacaaaaata
     5041 gtgctggtca gagggtaggg cggctgggtc acctcaggcc cagagtggcc aagcagggac
     5101 ttgagaagaa ggtgctgctc tttgcttttc tgtccaagct gtccagcacc tgatctagtg
     5161 cctcttccct gcagggcagg gacccctagt gaattggagc caatgatggg tgtgggcctt
     5221 gtggctgtga ctcagtgggg ctcaggttaa ggtccccctt gaatttggat gcgaataacc
     5281 aacagatatc aagtacctgt gaaactgctt cactgcttct ctctctctga gagggaaaca
     5341 aataatattt ttcaggatat tttgttttag tgttaagtag catcccacaa gctgcgtttt
     5401 tatttattac acgcacaaaa agtaaatgtg tttctacaaa ataaaaagtc tagagttgga
     5461 cactctgggc aaacttactg agatgcacaa atgtttctct ctctctctgt gatgtgcaat
     5521 atgcttggcg accatagata tttcatgttt aatctgtaaa tatgaactgt atttaaatta
     5581 aatgagagat ttttgtaaaa ggaccagacg ttcttttata aatgtactaa ggaatatctt
     5641 gttctttgaa atttattagg atttttatgg ataattttta ttaaaagatt ctctttttga
     5701 gttgtca
//
