LOCUS       NM_001399316            3361 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus enhancer of mRNA decapping 3 (Edc3), mRNA.
ACCESSION   NM_001399316 XM_002729908
VERSION     NM_001399316.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3361)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3361)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (bases 1 to 3361)
  AUTHORS   Ahmed,I., Buchert,R., Zhou,M., Jiao,X., Mittal,K., Sheikh,T.I.,
            Scheller,U., Vasli,N., Rafiq,M.A., Brohi,M.Q., Mikhailov,A.,
            Ayaz,M., Bhatti,A., Sticht,H., Nasr,T., Carter,M.T., Uebe,S.,
            Reis,A., Ayub,M., John,P., Kiledjian,M., Vincent,J.B. and
            Jamra,R.A.
  TITLE     Mutations in DCPS and EDC3 in autosomal recessive intellectual
            disability indicate a crucial role for mRNA decapping in
            neurodevelopment
  JOURNAL   Hum Mol Genet 24 (11), 3172-3180 (2015)
   PUBMED   25701870
REFERENCE   4  (bases 1 to 3361)
  AUTHORS   Jonas,S. and Izaurralde,E.
  TITLE     The role of disordered protein regions in the assembly of decapping
            complexes and RNP granules
  JOURNAL   Genes Dev 27 (24), 2628-2641 (2013)
   PUBMED   24352420
  REMARK    Review article
REFERENCE   5  (bases 1 to 3361)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3361)
  AUTHORS   Ling,S.H., Decker,C.J., Walsh,M.A., She,M., Parker,R. and Song,H.
  TITLE     Crystal structure of human Edc3 and its functional implications
  JOURNAL   Mol Cell Biol 28 (19), 5965-5976 (2008)
   PUBMED   18678652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jan 6, 2022 this sequence version replaced XM_002729908.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1892833.1,
                                           SRR26360190.1388921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000008.1  67002032-67002114
            84-337              JAXUCZ010000008.1  67006359-67006612
            338-657             JAXUCZ010000008.1  67009433-67009752
            658-993             JAXUCZ010000008.1  67020482-67020817
            994-1147            JAXUCZ010000008.1  67036936-67037089
            1148-1365           JAXUCZ010000008.1  67041728-67041945
            1366-3361           JAXUCZ010000008.1  67045568-67047563
FEATURES             Location/Qualifiers
     source          1..3361
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3361
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /note="enhancer of mRNA decapping 3"
                     /db_xref="GeneID:315708"
                     /db_xref="RGD:1306898"
     exon            1..83
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /inference="alignment:Splign:2.1.0"
     exon            84..337
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1700
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /note="LSM16 homolog (EDC3, S. cerevisiae); enhancer of
                     mRNA decapping 3 homolog"
                     /codon_start=1
                     /product="enhancer of mRNA-decapping protein 3"
                     /protein_id="NP_001386245.1"
                     /db_xref="GeneID:315708"
                     /db_xref="RGD:1306898"
                     /translation="MDWLGSIVSINCGDSLGVYQGRVSAVDQVSQTISLTRPFHNGVK
                     CLVPEVTFRAGDITELKILEIPGPGDNQQFGDLHQTELGPSGVGYQMSINQNGTGKVV
                     KKPASSSSAPQSIPKRTDMKSQDVAISPQQQQCSKSYVDRHMESLSQSKSFRRRHNSW
                     SSSSRHPNQATPKKSGLKNGQMKNKDDECFGDDIEEIPDTDFDFEGNLALFDKAAVFE
                     EIDTYERRSGSRSRGVPNERPARYRHDENILESEPIVYRRITVPHSVSKEFCTDSGLV
                     VPSVSYELHKKLLSVAEKHGLTLERRLEMTGVCASQMALTLLGGPNRLNPKNVHQRPT
                     VALLCGPHVKGAQGISCGRHLANHDVQVILFLPNFVKMLESITNELSLFSKTQGQQVS
                     SLRDLPTSPVDLVINCLDCPENAFLRDQPWYKAAVAWANQNRAPVLSIDPPVHEVEQG
                     IDAKWSLALGLPLPLGEHAGRVYLCDIGIPQQVFQEVGIDYHSPFGCKFVIPLHSA"
     exon            338..657
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /inference="alignment:Splign:2.1.0"
     exon            658..993
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1147
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1365
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..3361
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacgcagg ggcgtttccg gcggaggtgg tggctgctcc tgtgtctgtg gaggtgggcg
       61 tgaagcccct cggcggtgtt ttggctttat caccttagtg gcagagtgtt atcaacagca
      121 ctgagcacag agcctgacgt actggttctg cacggagcct tcacatccga cacgaggcaa
      181 tggattggct aggcagtatt gtgtctatca actgtggaga tagcctgggc gtctaccagg
      241 gaagagtatc agcagtggat caggtcagcc agaccatttc tcttactcgg cccttccata
      301 atggggtgaa gtgtcttgta ccagaagtca ccttccgggc aggtgatatt acagaattaa
      361 aaatcttgga gataccaggt cctggagaca accagcagtt tggagacctt catcagacag
      421 aattaggccc ttctggtgtt gggtaccaaa tgagtatcaa tcagaatgga acaggcaagg
      481 tggtcaagaa gccagcctct tccagtagtg cccctcagag catccctaag aggacagata
      541 tgaagagcca ggacgttgcc atttctcctc agcagcagca gtgctcaaag agttatgtgg
      601 acaggcacat ggagtctttg agtcagtcca agagcttccg tcgtcggcac aactcctggt
      661 catctagtag caggcaccca aaccaagcaa ccccaaagaa aagtggttta aaaaatggcc
      721 aaatgaagaa taaagatgat gagtgctttg gagacgacat tgaggagatc ccagatactg
      781 attttgactt tgaggggaac ctagcccttt ttgacaaggc agctgtgttt gaggagatcg
      841 acacttacga gaggagaagt ggttcccgtt ctcggggtgt cccaaatgaa cggcccgcta
      901 ggtaccgtca tgatgaaaac atcctggaat cggagccaat cgtgtaccgt aggatcacag
      961 ttccacacag tgtgagcaag gagttctgca cagactctgg cctggtagtc ccaagtgttt
     1021 cctatgagct acataaaaaa ctgttgtctg tggccgagaa gcatgggctg accctagagc
     1081 ggagacttga gatgactggt gtgtgtgcca gtcagatggc cctgactctc cttggaggac
     1141 ccaacaggtt gaatcctaag aatgtccacc agaggcctac agtagctctg ctgtgcgggc
     1201 cccatgtgaa gggggctcag ggtatcagtt gtgggaggca cctagccaac catgatgtac
     1261 aagtcatcct ctttctgccc aactttgtca agatgctgga gtctattacc aatgaactgt
     1321 ctctcttcag caagacccaa ggtcagcaag tgtccagcct aagagatctc cccaccagcc
     1381 ctgtggacct ggttatcaac tgcctggatt gtcctgagaa tgccttcctg cgggatcagc
     1441 cctggtacaa ggcagctgtg gcctgggcca accagaaccg ggcaccagtg ctcagcatag
     1501 accctcctgt acatgaagtt gaacagggca ttgatgccaa atggtccctg gccctgggcc
     1561 tgccgctgcc gctcggggag cacgcaggtc gagtctatct gtgtgacatt ggcattcccc
     1621 agcaagtctt ccaggaggtc ggcattgact accactcacc ctttggctgc aagtttgtca
     1681 ttcccctaca ctctgcctag aggctctggg cagctgggcc tgtattccct gcacttccgc
     1741 cgccagaccc accaagggac gccttaagga tgtgaagctt tgtggacctt gtagactatc
     1801 tcttgggttt atttcttctg tgagagaaca aaacatactt aaaacttgcc tgccacctgc
     1861 ccttaaccag ggaatgcttt cccactggca tgtatgtcag gggtagacca gtggctccag
     1921 gtagctttct atcctaccct gcctccattc aattggggct ttgtttacag acataggcag
     1981 ctctaagact gtttcaggtt tacagccact ggacatgggc tggcacattg tggggtgagc
     2041 tgttagggcc tccagccact ctgatttcag aaggttttgt gttctatgct tcctctggcc
     2101 ctgcaaccag gcacacactc ttctgtaatc atgtgatcag gctgcatggc agctatccag
     2161 aagacaaacc tgtgctgtct ctgcttcccc ccccaaagcc accagagttt gtttggaaaa
     2221 ctttggaccc tcctcagatg tcccagtttt atgtagggac ttttcctgaa gatgatgatg
     2281 accatggtga gattttgggc tggctgctct gctgtcacct ttagcagttt tgtgcccgtc
     2341 atgctataat gcccatctcc tagttgggaa ccagaccttc aggatgcagc ttttcagtat
     2401 tggggagacc ctgggggagc ttggtgctga gccataggag gctccctggt gcttcagtcc
     2461 taccatcagt tcctacctcc ttgtccatga ataacactcc gtctgcccct tctccctgtc
     2521 tctcgccgcc ccccccccat cccctgccac ggttccactc cagttcttat gtttaggctt
     2581 taatccttta tagttgccct ccccaggtat gcagactagt atgggactac tggcctgtct
     2641 caaacatgcc aaaaacaaac cgttccagat ggccatagtg gtgggattca gccacaggaa
     2701 catgttcaga tcgaggatct tcctgggctt aggtccttca ggttagtagg ataggaccat
     2761 gccttggagc cttagcagag acctttgtaa agtttttccc cacaggcttt ctgctgtgcc
     2821 catcaatagt tgagggggta taggtggaca ggcagatggg ctcactaaaa tgtttgggta
     2881 catgggtaaa ccctggtacc ttaatttcag gctgctgtct tgtaggaaca tggccagaac
     2941 agatggtgat agcttttcct ttcctatctt tttctcttta gttatttcca actgcaagaa
     3001 agaggccaaa ggattggggg cctcagctgc acgacaggac tttgtagctt tcaaactggg
     3061 cctcttttct aaaggcaggg ttatagcagg cagccggtat aggttactag acataggcta
     3121 ctagacacgc ataaaatgag gtagaactct ggtcctgaag gtggctaaca ggtagttctc
     3181 cctgctcttg gcctggacct ccctagagtt gaaagtgtgt tactccttcc tccaactctt
     3241 tttggcagtt cctgctcaat ggctggtttc agtcaggtgg tcaaccctgt cactaatgca
     3301 tgcagctctt ggggaaccca aagccagcac aataaagtga cagtaacctg tgctatctaa
     3361 a
//
