LOCUS       NP_001386245             506 aa            linear   ROD 01-APR-2024
DEFINITION  enhancer of mRNA-decapping protein 3 [Rattus norvegicus].
ACCESSION   NP_001386245 XP_002729954
VERSION     NP_001386245.1
DBSOURCE    REFSEQ: accession NM_001399316.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 506)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 506)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (residues 1 to 506)
  AUTHORS   Ahmed,I., Buchert,R., Zhou,M., Jiao,X., Mittal,K., Sheikh,T.I.,
            Scheller,U., Vasli,N., Rafiq,M.A., Brohi,M.Q., Mikhailov,A.,
            Ayaz,M., Bhatti,A., Sticht,H., Nasr,T., Carter,M.T., Uebe,S.,
            Reis,A., Ayub,M., John,P., Kiledjian,M., Vincent,J.B. and
            Jamra,R.A.
  TITLE     Mutations in DCPS and EDC3 in autosomal recessive intellectual
            disability indicate a crucial role for mRNA decapping in
            neurodevelopment
  JOURNAL   Hum Mol Genet 24 (11), 3172-3180 (2015)
   PUBMED   25701870
REFERENCE   4  (residues 1 to 506)
  AUTHORS   Jonas,S. and Izaurralde,E.
  TITLE     The role of disordered protein regions in the assembly of decapping
            complexes and RNP granules
  JOURNAL   Genes Dev 27 (24), 2628-2641 (2013)
   PUBMED   24352420
  REMARK    Review article
REFERENCE   5  (residues 1 to 506)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (residues 1 to 506)
  AUTHORS   Ling,S.H., Decker,C.J., Walsh,M.A., She,M., Parker,R. and Song,H.
  TITLE     Crystal structure of human Edc3 and its functional implications
  JOURNAL   Mol Cell Biol 28 (19), 5965-5976 (2008)
   PUBMED   18678652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jan 6, 2022 this sequence version replaced XP_002729954.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1892833.1,
                                           SRR26360190.1388921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     Protein         1..506
                     /product="enhancer of mRNA-decapping protein 3"
                     /note="LSM16 homolog (EDC3, S. cerevisiae); enhancer of
                     mRNA decapping 3 homolog"
                     /calculated_mol_wt=55762
     Region          2..64
                     /region_name="LSm16_N"
                     /note="Like-Sm protein 16, N-terminal domain; cd01737"
                     /db_xref="CDD:212484"
     Site            order(3,26,31,54,57..62)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212484"
     Site            order(8..13,17..28,31..34)
                     /site_type="other"
                     /note="Sm1 motif"
                     /db_xref="CDD:212484"
     Site            order(27,53)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:212484"
     Site            49..60
                     /site_type="other"
                     /note="Sm2 motif"
                     /db_xref="CDD:212484"
     Region          100..192
                     /region_name="Edc3_linker"
                     /note="Linker region of enhancer of mRNA-decapping protein
                     3; pfam16598"
                     /db_xref="CDD:465188"
     Region          196..299
                     /region_name="FDF"
                     /note="FDF domain; pfam09532"
                     /db_xref="CDD:430668"
     Region          300..453
                     /region_name="YjeF_N"
                     /note="YjeF-related protein N-terminus; pfam03853"
                     /db_xref="CDD:427546"
     CDS             1..506
                     /gene="Edc3"
                     /gene_synonym="Lsm16; RGD1306898"
                     /coded_by="NM_001399316.1:180..1700"
                     /db_xref="GeneID:315708"
                     /db_xref="RGD:1306898"
ORIGIN      
        1 mdwlgsivsi ncgdslgvyq grvsavdqvs qtisltrpfh ngvkclvpev tfragditel
       61 kileipgpgd nqqfgdlhqt elgpsgvgyq msinqngtgk vvkkpassss apqsipkrtd
      121 mksqdvaisp qqqqcsksyv drhmeslsqs ksfrrrhnsw ssssrhpnqa tpkksglkng
      181 qmknkddecf gddieeipdt dfdfegnlal fdkaavfeei dtyerrsgsr srgvpnerpa
      241 ryrhdenile sepivyrrit vphsvskefc tdsglvvpsv syelhkklls vaekhgltle
      301 rrlemtgvca sqmaltllgg pnrlnpknvh qrptvallcg phvkgaqgis cgrhlanhdv
      361 qvilflpnfv kmlesitnel slfsktqgqq vsslrdlpts pvdlvincld cpenaflrdq
      421 pwykaavawa nqnrapvlsi dppvheveqg idakwslalg lplplgehag rvylcdigip
      481 qqvfqevgid yhspfgckfv iplhsa
//
