LOCUS       NM_001191899            3685 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ectodysplasin-A receptor (Edar), mRNA.
ACCESSION   NM_001191899 XM_006256381 XM_345109
VERSION     NM_001191899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3685)
  AUTHORS   Del-Pozo,J., MacIntyre,N., Azar,A., Headon,D., Schneider,P. and
            Cheeseman,M.
  TITLE     Role of ectodysplasin signalling in middle ear and nasal pathology
            in rat and mouse models of hypohidrotic ectodermal dysplasia
  JOURNAL   Dis Model Mech 12 (4) (2019)
   PUBMED   31028034
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3685)
  AUTHORS   Fliniaux,I., Mikkola,M.L., Lefebvre,S. and Thesleff,I.
  TITLE     Identification of dkk4 as a target of Eda-A1/Edar pathway reveals
            an unexpected role of ectodysplasin as inhibitor of Wnt signalling
            in ectodermal placodes
  JOURNAL   Dev Biol 320 (1), 60-71 (2008)
   PUBMED   18508042
REFERENCE   3  (bases 1 to 3685)
  AUTHORS   Jaskoll,T., Zhou,Y.M., Trump,G. and Melnick,M.
  TITLE     Ectodysplasin receptor-mediated signaling is essential for
            embryonic submandibular salivary gland development
  JOURNAL   Anat Rec A Discov Mol Cell Evol Biol 271 (2), 322-331 (2003)
   PUBMED   12629675
REFERENCE   4  (bases 1 to 3685)
  AUTHORS   Yan,M., Wang,L.C., Hymowitz,S.G., Schilbach,S., Lee,J., Goddard,A.,
            de Vos,A.M., Gao,W.Q. and Dixit,V.M.
  TITLE     Two-amino acid molecular switch in an epithelial morphogen that
            regulates binding to two distinct receptors
  JOURNAL   Science 290 (5491), 523-527 (2000)
   PUBMED   11039935
REFERENCE   5  (bases 1 to 3685)
  AUTHORS   Monreal,A.W., Ferguson,B.M., Headon,D.J., Street,S.L.,
            Overbeek,P.A. and Zonana,J.
  TITLE     Mutations in the human homologue of mouse dl cause autosomal
            recessive and dominant hypohidrotic ectodermal dysplasia
  JOURNAL   Nat Genet 22 (4), 366-369 (1999)
   PUBMED   10431241
REFERENCE   6  (bases 1 to 3685)
  AUTHORS   Crocker,M. and Cattanach,B.M.
  TITLE     The genetics of Sleek: a possible regulatory mutation of the
            tabby-crinkled-downless syndrome
  JOURNAL   Genet Res 34 (3), 231-238 (1979)
   PUBMED   544312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Sep 19, 2022 this sequence version replaced
            XM_006256381.4, NM_001191899.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.78508.1,
                                           SRR26643290.54771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               JAXUCZ010000020.1  27209373-27209630   c
            259-327             JAXUCZ010000020.1  27161320-27161388   c
            328-450             JAXUCZ010000020.1  27160603-27160725   c
            451-632             JAXUCZ010000020.1  27159770-27159951   c
            633-718             JAXUCZ010000020.1  27151949-27152034   c
            719-805             JAXUCZ010000020.1  27142336-27142422   c
            806-931             JAXUCZ010000020.1  27140907-27141032   c
            932-1006            JAXUCZ010000020.1  27140734-27140808   c
            1007-1079           JAXUCZ010000020.1  27140399-27140471   c
            1080-1239           JAXUCZ010000020.1  27137729-27137888   c
            1240-1300           JAXUCZ010000020.1  27136431-27136491   c
            1301-3685           JAXUCZ010000020.1  27130934-27133318   c
FEATURES             Location/Qualifiers
     source          1..3685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..3685
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /note="ectodysplasin-A receptor"
                     /db_xref="GeneID:365581"
                     /db_xref="RGD:1561714"
     exon            1..258
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            259..327
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1623
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /note="tumor necrosis factor receptor superfamily member
                     EDAR"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member EDAR precursor"
                     /protein_id="NP_001178828.1"
                     /db_xref="GeneID:365581"
                     /db_xref="RGD:1561714"
                     /translation="MAHVGDCKWMSWLPVLVVSLMCSAKAEDSNCGENEYHNQTTGLC
                     QQCPPCRPGEEPYMSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVL
                     TPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGVSAHSS
                     STSGGSTLSPFQHAHKELSSQGHLATALIIAMSTIFIMAIAIVLIIMFYIMKTKPSAP
                     ACCSSPPGKSAEAPANTHEEKKEAPDSVVTFPENGEFQKLTATPTKTPKSENDASSEN
                     EQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSVASNKSAGIQSRRKKILDVYA
                     NVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMT
                     DGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASPPPAAS"
     exon            328..450
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            451..632
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            633..718
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            719..805
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            806..931
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1006
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1079
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1239
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1300
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..3685
                     /gene="Edar"
                     /gene_synonym="RGD1561714"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccaggcta gaagcaatca agagagagag agttcccagg gagcccttca aaatagaaag
       61 tggagctggc ggcagaggtg tgcctggccg ctgtcacccg gctggcctca ggattgttga
      121 gaactgcttt tgagagaacg tcgacggctg cctgtgaagc ctgcccccca tctcttacct
      181 gctcgtcttc tccgtcttct ccgtcttctc cgtagatcca tcctctgctg gaaaaagctg
      241 acctcactcg ggtaccaggt gtacttccaa gagaacatgg cccacgtcgg ggactgcaag
      301 tggatgtcct ggctcccagt gctggtggtg tctctgatgt gctcagccaa ggcagaggac
      361 tccaactgtg gcgagaatga ataccacaac caaactaccg ggctgtgcca gcagtgtcct
      421 ccatgcagac caggggagga gccctacatg tcctgtggtt acggcaccaa agatgaggac
      481 tatggctgcg tgccctgccc tgcagagaag ttctccaaag gaggttatca gatatgcagg
      541 cgccacaagg actgtgaggg cttcttccgg gccaccgtac tgacaccagg agacatggaa
      601 aatgatgctg agtgtggccc gtgtctgcct ggctactaca tgctggaaaa cagacccagg
      661 aacatctacg gcatggtctg ctactcctgc ctcttggcac ctcccaacac caaggaatgt
      721 gtgggagcca cttccggggt ttcagctcac tcctccagca cttcaggcgg cagcaccttg
      781 tcccccttcc agcatgctca caaagagctc tcaagtcaag gacacctggc caccgccctg
      841 attattgcca tgtctacaat cttcatcatg gccatagcca ttgtcctcat catcatgttc
      901 tatatcatga agactaagcc ttcagctcca gcctgctgta gcagtccccc aggaaaaagt
      961 gcagaagccc cagctaacac acatgaggag aaaaaagagg ccccagacag tgtggtgact
     1021 ttccctgaga atggtgaatt ccagaagttg acagcaacac ccacaaagac cccaaaaagt
     1081 gagaacgatg cctcctctga gaatgagcag ctgctgagtc gcagtgtgga cagtgatgaa
     1141 gagccagccc cggacaagca ggggtcccca gagctatgcc tgctgtcgct agttcatctg
     1201 gccagggaga agtctgtagc cagtaacaag tctgctggga tccaaagccg aaggaaaaag
     1261 atattggatg tgtatgcgaa cgtgtgtggt gttgttgaag gtctcagccc cacggagctg
     1321 ccttttgatt gccttgaaaa gacaagcaga atgctcagtt ctacctacaa ctctgagaaa
     1381 gcagtcgtga aaacgtggcg ccaccttgct gagagctttg gactgaagag ggatgagatt
     1441 gggggcatga ctgatggcat gcagctcttt gaccgcatca gcactgcggg ctacagcatc
     1501 ccagagctgc tcacgaagct ggtacagatc gagaggctgg atgctgtgga gtccttgtgt
     1561 gcagacatat tggagtgggc tggggttgta ccccctgcct ccccaccccc agctgcatcc
     1621 tgaagagttt gccttggact atcttccctg ggaccagatg gggacccaat gaagccatgg
     1681 cagctgtgag tgatgccatc ggactgccag agttcaaggc atttcctggt gggtcactgt
     1741 actccttagg ctgccctaag gagctcactg agcacccaaa tgaaccaaac catgtgtgag
     1801 gtcacaggtg aagaatctga ttctgtcttt taaggaagca cttagtgaga gccaggggac
     1861 atggcataga ccatgttacc aaacatcact aggcaaataa ggggatgcta aaaagtaatg
     1921 tagcaaaagt tataagaagg gtgatggagt ctcaagttga aaatgggagc atcctaatga
     1981 agaaactagt gtgaaggttt tagtaaaatg gttacaaagt acagacatcc cacttctgca
     2041 ttgcttcaga ccgaacaggg tttgttggct tgttctatgg tttcaggggt aacgacctat
     2101 gtttacagtc acccgcaatg gtacaagcct tgcagtcagt agtgaaagaa ctcactgtat
     2161 ggacagtcaa ggcatatctg tccagacaaa agtgagagca gatttggcca ttcacaggca
     2221 cagtagttat aatgtgtgag gctgttttta cttcaaacag atgtgtgttc taagtagaca
     2281 gtgaaatggt gacttgctaa gagtttggtc atgcctggtt tgtgggtggg gcttgtgcga
     2341 gttcagacac agcatcctca gccagtgaga gataatgcag cctgaggtgc agtacagagc
     2401 tgggacctgg aatcctggac cctggtggaa tcatccaaag catctgtctc ctgccccaga
     2461 cttagcttct cttctgcaaa tgagaggttg gtcttcatgt ctgtagtcag gcaagttgaa
     2521 gctctggtga gcataggatg agcaaaagaa aggagaggcc aagggagctc catgggggta
     2581 attacagtgt gggtgaccac acaaaatggg aatcgaggga aattcacagc cgccatgctc
     2641 atgtaagggc aactgtagga cagaacattt acagagctaa taaacaggca ctgtacaggc
     2701 agattctctt actacacctg taactgccag gaaatgggaa gtcaaggaaa ctttccaggc
     2761 agggggttaa tgccaagctg ggaagttaat gctgctgggc tccctcctgg agtgccgact
     2821 gtagagactg tttcctttgg ataaagcctc tggtttagaa ggctgttggg tttgttttcg
     2881 tttcgttttg ttttgttttt acaaatcata tgactgaaca aaggctttgg aggggaatca
     2941 gttgtatgtt taaaaccatc aagcaatttc ccaccacaga atatagacca tactgtgaga
     3001 ggaccataat taggtcctga atatttaata tgatcatttt actgtgtctg tctgtgctgg
     3061 ttttttagaa ggcattttct atatcctgca agttaaatag tctgcttaat tgtcctttta
     3121 attcctcttt gagatcctgc agtgtccctt acctctgatc ttctataatg acactgagct
     3181 tccccttaat tagacttgta aatgtcatct gtgatgagtg tgcaggtcta agacagcagt
     3241 ctcttctcca actgtcattc tgctgaagaa tgggcagctg cagccagcag tgtgggctag
     3301 cctccattcg ccctattagg tttcaaggtt ggaggcagcc agcatccttg ttgtttcatt
     3361 gactcccatc ttgctgcttt aggggagcta gtccctcgtc atgtacttta tttggcaata
     3421 aatccaggaa gggtttgctt cagtgagctt tgcccatgct gtagaattcc gaaccaacaa
     3481 gaccacagtg actcttactg gaactccatg ctgccatttt tttgtctgaa aactgtcagt
     3541 acttaaaagt atttaggaaa cactcgagct agatctgagg accttagcta gtgaagtctt
     3601 aattgtggat attttatata attctgttta tgtaacttat tatatttcta caagtccaat
     3661 aaactaaata aaaaggagac ctaca
//
