LOCUS       NM_001401114            6206 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ectodysplasin A2 receptor (Eda2r), mRNA.
ACCESSION   NM_001401114 XM_006257051
VERSION     NM_001401114.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6206)
  AUTHORS   Brosh,R., Sarig,R., Natan,E.B., Molchadsky,A., Madar,S.,
            Bornstein,C., Buganim,Y., Shapira,T., Goldfinger,N., Paus,R. and
            Rotter,V.
  TITLE     p53-dependent transcriptional regulation of EDA2R and its
            involvement in chemotherapy-induced hair loss
  JOURNAL   FEBS Lett 584 (11), 2473-2477 (2010)
   PUBMED   20434500
REFERENCE   2  (bases 1 to 6206)
  AUTHORS   Sinha,S.K., Zachariah,S., Quinones,H.I., Shindo,M. and
            Chaudhary,P.M.
  TITLE     Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK
            pathways by X-linked ectodermal dysplasia receptor
  JOURNAL   J Biol Chem 277 (47), 44953-44961 (2002)
   PUBMED   12270937
REFERENCE   3  (bases 1 to 6206)
  AUTHORS   Yan,M., Wang,L.C., Hymowitz,S.G., Schilbach,S., Lee,J., Goddard,A.,
            de Vos,A.M., Gao,W.Q. and Dixit,V.M.
  TITLE     Two-amino acid molecular switch in an epithelial morphogen that
            regulates binding to two distinct receptors
  JOURNAL   Science 290 (5491), 523-527 (2000)
   PUBMED   11039935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Feb 2, 2022 this sequence version replaced XM_006257051.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.1598963.1,
                                           SRR21887622.3400570.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000021.1  66280541-66280620   c
            81-176              JAXUCZ010000021.1  66274708-66274803   c
            177-281             JAXUCZ010000021.1  66266131-66266235   c
            282-460             JAXUCZ010000021.1  66248171-66248349   c
            461-546             JAXUCZ010000021.1  66247636-66247721   c
            547-711             JAXUCZ010000021.1  66245953-66246117   c
            712-1104            JAXUCZ010000021.1  66242562-66242954   c
            1105-6206           JAXUCZ010000021.1  66236111-66241212   c
FEATURES             Location/Qualifiers
     source          1..6206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..6206
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /note="ectodysplasin A2 receptor"
                     /db_xref="GeneID:296872"
                     /db_xref="RGD:1564025"
     exon            1..80
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /inference="alignment:Splign:2.1.0"
     exon            81..176
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /inference="alignment:Splign:2.1.0"
     exon            177..281
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1094
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 27"
                     /protein_id="NP_001388043.1"
                     /db_xref="GeneID:296872"
                     /db_xref="RGD:1564025"
                     /translation="MMDCQENEYRDQWGRCVTCQQCGPGQELSKDCGYGEGGDAYCIA
                     CPPRKYKSTWGHHRCQTCITCAVINRVQKANCTNTSNAICGDCLPRFYRKTRIGGLQD
                     QECIPCTKQTPSSEVQCTFQLSLVKVDTHTLPPKEATLVALVGSLLVVFALAFLGLFF
                     LYCKQIFNRHCQCVAGGSLQYEAEKAVQEDSLLTTPPGQETSPEFPANGSIFEIKPLN
                     SILDDDCSSTRGFPTQESFTMASCASESHSQWVHTPIECTELDLQKFSSSVPCPGAET
                     LRENTAEHSGDRLDLYVPFEVPSL"
     exon            282..460
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /inference="alignment:Splign:2.1.0"
     exon            461..546
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /inference="alignment:Splign:2.1.0"
     exon            547..711
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /inference="alignment:Splign:2.1.0"
     exon            712..1104
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..6206
                     /gene="Eda2r"
                     /gene_synonym="RGD1564025"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatctgttgt tgccacacgt ggaagtgaaa tgactccagc agaacactgg ttgcaacgga
       61 ttccacctat tgtgagaacg tgacaactgc cttgaaaaag aacagatatt tctgcctacc
      121 tcagatggac catcacctct tgctgtgtgc actggaataa aagacaaagt aaaccatttt
      181 tttttttttt catgatggat tgtcaagaaa atgagtaccg ggaccaatgg gggcgctgtg
      241 tcacctgcca acaatgtggc cctggacagg agctctctaa ggattgtggt tatggagaag
      301 gtggagatgc gtactgcata gcctgccctc ctcgaaagta taaaagcact tggggacatc
      361 acagatgtca gacatgcatc acttgtgctg tcatcaatcg ggtccagaag gccaactgca
      421 caaatacctc taatgctatc tgtggagact gtctgcccag gttctaccga aagacacgca
      481 ttgggggcct gcaggaccaa gaatgcatcc cgtgtacaaa gcagactcct tcttctgagg
      541 ttcagtgtac cttccagctg agcttagtga aggtagacac acacactctt cctcctaagg
      601 aagccacact tgtcgcactg gtaggaagtc tgctagtggt ctttgccctg gccttccttg
      661 gactcttctt cctttattgc aagcaaatat tcaacagaca ttgtcagtgt gttgcaggag
      721 gttcattgca atatgaggct gaaaaggcag tgcaggagga ttctctttta accacaccac
      781 ctggccagga gaccagtcct gagtttccag caaatgggag catctttgag atcaagcccc
      841 ttaactccat cctggatgat gactgcagct ccactcgcgg cttccccact caggaatcct
      901 tcaccatggc ttcctgcgcc tcagagagcc attctcagtg ggtccatacc cccattgaat
      961 gtacagagct ggacctgcaa aagttttcca gctctgtccc ctgtcctgga gctgaaacct
     1021 tgagagagaa cacagctgaa cactcaggag acaggctgga cctctatgta ccttttgaag
     1081 ttcccagcct ttaactctac caaggtctct ttcactcttg acaagcttgc cagtgcttgt
     1141 tgctgggctt tcctgctcct cttttattca acaacagtag caggagcctg ggatgtaggt
     1201 cctgcaataa ccagcactcg aaatggggta tacagagccc cacactacga gaggattgat
     1261 tccccaatga ctgactttga acactttttg ttttcttatt ctagtctggg gatccagatt
     1321 ccgtagccat gggactactg ggtctgttct ttctctttaa ttaattatag aaatgagggg
     1381 gataacaatg agtgaggtag agttctcctg cctgtatgtt tcctgcctat attttttaac
     1441 aagttgattt acaaaaagga gtacacagaa ctatgttggc atttacctac caccttgaag
     1501 agaaaaatga aatacttccc cctttagcct tctgttttga ctcgctccct cccctataca
     1561 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cacaaacatg
     1621 tacacagaat gaggggataa tgaggaagat atcaaggaca ggcctgaagc ctgggtttta
     1681 caaatcatat cctagacttc tacagctatg acactgtcca gccagtatat ttcttagacc
     1741 tttcattctc agagacaggc tatcaatact ctctagtggg gatacaaatt agtgtctcct
     1801 agattttttt tagattgttg tttccttaac ttcttttcat ttttattact acaatattct
     1861 taccttttcc cccttcatag tcaggtgctg actgtgaagt ttctcaggtg caggagtagt
     1921 gccctgtgga actgcgggga ccatttggtg ctttcttggc ttagagaata gtctttctat
     1981 ttctcttaag cctaaacctc cagttttaca tgcttctcag catgaattga aacctttttc
     2041 ttcctttttt ttctttttgt ggaacatgtc agatgtgatc ctaaggactt agatgtgact
     2101 atcccgtatt ggctttactt atgcctgcat gttcaaagtg agccactagg attgatgcct
     2161 agtccctcat cgtggttcag gtttcaatgg gaaaaagtcc ttaaatgagt aaagcaactg
     2221 gatcttggga gttatatata ctatcctgaa tgctggtgtg atttagctta ttaaaaaaca
     2281 aattgaagac acacacagtt attgtgggtc aaagatgtaa agatgcacta aagctgtccg
     2341 tgctgcactt tgcattattc acattataga tgtcctctcc atgactcagt gcacaaactt
     2401 tgatataggt agtgcagggg ttgctcagtg cagtaggagt gcatagaaag gcttgaatgg
     2461 ttttagtcat ttttcctcat ttgacactgc cgactcttaa aaggtagaag cgcagggcat
     2521 gtattcttct catatcaagg tagcagaagc agaagtaatg gaatttggaa gcaaactgcc
     2581 cttgcattgt aagactctca gaaacacaag ggatagggat ttagatagtg ttggagtact
     2641 tgcatttagc atgatcaagg tattatatcc atcctagcat tgcaaaataa agagatgggt
     2701 ggatgagggg ggaaaagaaa ggaagtaaag aagaaaataa aacatttcca ccaccaagaa
     2761 atgtaccaga ttccataatt ggctaagtgc tactgaggct gtcgtggagt tttccattgg
     2821 aaaatatcac acgaggtcat cttatattaa aaggtttttc ttgcctttag ctcttaaaca
     2881 ctgcttataa taattttctg tttgtttctt gattccctag actcatagca ctctgtgagt
     2941 ttgctggaag gtctgatgga tgttcgaaga gcagtggttc tgagttgtag tgtaacacat
     3001 aaacaatttt aatatgggtc tcccgggcct tatctaatat ttgacgttct ttttctctac
     3061 ccccagcaga aagccagaca aaagtttgat ctttcaggac cctacagtac atttttgagc
     3121 caatttttcc tttcctatgt ctgggctccc caagcaaccg tgcaccacgc cttcaaagtt
     3181 acccacagca tttttcaagt tagctaagtg aggatgtgaa gggtccccca aggtatgggt
     3241 atttctttga catgtcggtt cgatgcatac tttattgtcc atttggttct ttttgaaaat
     3301 tcattttgcc tttagctctt acctgtacat ctcaagagca aagaaaacag gaatctcctt
     3361 agagattcta ttattctttt ttatctccaa gtctttatga agcttctcag ccagtttcta
     3421 tcctataagt gattggtggg ttatgtaaaa tgtggacttc atcacgggga cttatcctta
     3481 acagagagta ttctccacaa gattctgtta agtgtatctt taataacggc tcatccacaa
     3541 acactgatta agggccttaa ggtcaaacca ctgataagta ttaaaagcac aaaattacaa
     3601 aatgctaaaa ggtcccattg tacttggcag gggattagaa gcaattgaat cacaagtctg
     3661 taccaggcaa cctggtctca tgcaagcatt agcaaatatg tgtgagccaa ggtttagacc
     3721 ttggtctttg ggctctctgt acttttttct gggacagttt atgcttatct caccaacttt
     3781 aattagtcat atctatactt gggtggagaa gaactagcac ccaatctgag gtggattcag
     3841 cttaagtagg ttccagctgc agaaaggtca ccgtgtgcct ggcactgctt caaactccag
     3901 tacaccaccg cttctcagtg aaaaggactg tgatgatacg acagcaaaaa caaagtgatt
     3961 aaatgaccta ggcaccctgc ttcactgtgc ctatacatag caaggtcatt ctacattcat
     4021 actgagaatg gctttgcttc cagttttctt gaattgacca gtttgagttg gtaattcaag
     4081 gaaggtgaac ttttgctttg ctttgctttc tatggcatct tgggaataat caaagtgaag
     4141 actggttttc ttttttcttt gtaattggta tgtggccttg gcttacttta catttgcata
     4201 tttgctcaag tagtgtcctt ttaaagtgga atcactttgg gtactatgct tttatgtgtc
     4261 ttctatttga agatatcttg agaaatatat ataacataac tctgagcctg gacagtagtt
     4321 gtgttttaca tatttgaact agcaacagaa aatattttgt ttacaaggga gaggtaggta
     4381 tttagtggag gtgagtcagg cttcagggtt cactttttcc tccacttaaa aatgtcactg
     4441 gaattttgaa aggtggtatg tagtatgaga gatcaacttt cttccctaag gtcgttaata
     4501 ttagattaag taaaaatgtc aacactacac cacttttacc aacacatagt cctggcacac
     4561 tgagatgtca ccctcattcc cctcattcaa tttattgcca aggtctttga tgttttttgt
     4621 ttaatggagg caggttttaa ttattgtttt ccttaaaatg agctatttat agagattttg
     4681 ttaaattttg agccatatgc atgagtggat cctgacaagt tgtgtttggt ttatgataat
     4741 ctgcaaacaa ttcatattaa tcaataaaca gaagtacatc cagatgcttt gtttattcct
     4801 ctgctttcag agaactggtg tgactcattc agttgttttg tatgtctgct tagtcagtac
     4861 agaaagaaat gtgtttctaa tcattgggtg tagcaccagg gctatggcaa ttccgactag
     4921 tcacccagga gatctgagtt atagtctaca ttctcctgct ttcaattgtt tatgacattt
     4981 agtatcttgt ctggttacag acccaccaga catttttgta ttctgaatgt ataatccttt
     5041 tctttttctg ttgttttgtt ttgttttgag acaaggtttc tctgtgtgat acagccttag
     5101 gtgtcctggt ctcgatttgt agaccatgct ggctgcaaac tcacagagat ctgtctgact
     5161 ctgactccca agtgctggga ttaaaggtgt tgtgcttcca ctcccaggcc taaatttaca
     5221 attcttaagg agggttgtaa agtcttcaga ctgtgtgcat atgtttaaag gtatgaacca
     5281 atctcttgta atttatatgt gcacatttcc atttgaccat actattttaa gaatagatgc
     5341 acacatgcat gcatgcctgc acacatacac acatacatat acaaactaga gaatctgtag
     5401 gattgcctct taagaacatt gctttgccat tgtttgatct gtatttttgt ttatggtgtt
     5461 attagattca agggacaaca tttgatttga aatgttcttc actactataa ttttatttaa
     5521 aaccaggcaa attaaatttc ttcctatctc aaatgttggc taatcgtaat agacatacat
     5581 actgacgagg atgtgaaaaa aaaagaaaat tcatacagtg tcggtgggat tgtaaaatgg
     5641 catgaccttt ttgaaacagt ctggcagttc ttataaaatt taaagcttca gttgacatat
     5701 ggttcaataa ttctactcat caatatatga tgaagataat taaaaacatg aacatttata
     5761 ctctttaaaa cagtgtttat aataatcagt tgtttacagt tgcaacccat tgtcatcaac
     5821 tgattgatga ataaaccagt tgtaataaaa cataagatat taaacaatta aaataattga
     5881 agttatgata cttgatatgt cagagttcaa gctcaaatca tactaagttg tcgaatccag
     5941 gtacctgaaa gcacatcttg tatagttgca gtcatagtaa atgtttacag aatgtaagca
     6001 aatagtgaca gaatgtaaat tagtggtctc ttggtactga gtacaagaga aacaactaat
     6061 gttagcagtc atatgtgatc ttgtttagaa gaaaaactgt tatgatgata gttgcaattc
     6121 tcagtaaatt tattaaaaac tgctgacagg catactggaa atgaatgaat tttattatat
     6181 aaaaatattc aataaagctg ttaaaa
//
