LOCUS       NM_001108547            4043 bp    mRNA    linear   ROD 01-FEB-2021
DEFINITION  Rattus norvegicus epithelial cell transforming 2 (Ect2), mRNA.
ACCESSION   NM_001108547 XM_001057016 XM_342220
VERSION     NM_001108547.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Jing J, Chen L, Fu HY, Fan K, Yao Q, Ge YF, Lu JC and Yao B.
  TITLE     Annexin V-induced rat Leydig cell proliferation involves Ect2 via
            RhoA/ROCK signaling pathway
  JOURNAL   Sci Rep 5, 9437 (2015)
   PUBMED   25807302
  REMARK    GeneRIF: We thus conclude that Ect2 is involved in annexin
            V-induced rat Leydig cell proliferation through the RhoA/ROCK
            pathway
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4043)
  AUTHORS   Tsuji T, Higashida C, Yoshida Y, Islam MS, Dohmoto M, Koizumi K and
            Higashida H.
  TITLE     Ect2, an ortholog of Drosophila's pebble, negatively regulates
            neurite outgrowth in neuroblastoma x glioma hybrid NG108-15 cells
  JOURNAL   Cell. Mol. Neurobiol. 31 (5), 663-668 (2011)
   PUBMED   21350944
REFERENCE   3  (bases 1 to 4043)
  AUTHORS   Srougi MC and Burridge K.
  TITLE     The nuclear guanine nucleotide exchange factors Ect2 and Net1
            regulate RhoB-mediated cell death after DNA damage
  JOURNAL   PLoS ONE 6 (2), E17108 (2011)
   PUBMED   21373644
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4043)
  AUTHORS   Fontana GA.
  TITLE     Downregulation of cough by exercise and voluntary hyperpnea
  JOURNAL   Lung 188 (SUPPL 1), S95-S98 (2010)
   PUBMED   20047078
REFERENCE   5  (bases 1 to 4043)
  AUTHORS   Justilien V and Fields AP.
  TITLE     Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and
            cellular transformation
  JOURNAL   Oncogene 28 (41), 3597-3607 (2009)
   PUBMED   19617897
REFERENCE   6  (bases 1 to 4043)
  AUTHORS   Kim JE, Billadeau DD and Chen J.
  TITLE     The tandem BRCT domains of Ect2 are required for both negative and
            positive regulation of Ect2 in cytokinesis
  JOURNAL   J. Biol. Chem. 280 (7), 5733-5739 (2005)
   PUBMED   15545273
REFERENCE   7  (bases 1 to 4043)
  AUTHORS   Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T,
            Hiraoka Y, Haraguchi T and Narumiya S.
  TITLE     Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in
            mitosis
  JOURNAL   J. Cell Biol. 168 (2), 221-232 (2005)
   PUBMED   15642749
REFERENCE   8  (bases 1 to 4043)
  AUTHORS   Liu XF, Ishida H, Raziuddin R and Miki T.
  TITLE     Nucleotide exchange factor ECT2 interacts with the polarity protein
            complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates
            PKCzeta activity
  JOURNAL   Mol. Cell. Biol. 24 (15), 6665-6675 (2004)
   PUBMED   15254234
REFERENCE   9  (bases 1 to 4043)
  AUTHORS   Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y,
            Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H and Sugano S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 4043)
  AUTHORS   Miki T, Smith CL, Long JE, Eva A and Fleming TP.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AAHX01015906.1.
            
            [WARNING] On Jun 29, 2023 this sequence was replaced by
            NM_001108547.3.
            
            On Sep 8, 2012 this sequence version replaced NM_001108547.1.
            
            Sequence Note: Sequence Note: This RefSeq record was created from
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMD00132261,
                              SAMD00132262 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AAHX01015906.1     79295-79408         c
            115-266             AAHX01015906.1     74136-74287         c
            267-346             AAHX01015906.1     73461-73540         c
            347-439             AAHX01015906.1     73263-73355         c
            440-622             AAHX01015906.1     72153-72335         c
            623-712             AAHX01015906.1     71538-71627         c
            713-820             AAHX01015906.1     70515-70622         c
            821-894             AAHX01015906.1     66710-66783         c
            895-1025            AAHX01015906.1     65125-65255         c
            1026-1141           AAHX01015906.1     64647-64762         c
            1142-1204           AAHX01015906.1     64479-64541         c
            1205-1427           AAHX01015906.1     63634-63856         c
            1428-1564           AAHX01015906.1     62053-62189         c
            1565-1684           AAHX01015906.1     57376-57495         c
            1685-1753           AAHX01015906.1     55673-55741         c
            1754-1864           AAHX01015906.1     53761-53871         c
            1865-1961           AAHX01015906.1     52874-52970         c
            1962-2043           AAHX01015906.1     50055-50136         c
            2044-2122           AAHX01015906.1     48884-48962         c
            2123-2242           AAHX01015906.1     48415-48534         c
            2243-2381           AAHX01015906.1     43824-43962         c
            2382-2536           AAHX01015906.1     40843-40997         c
            2537-2644           AAHX01015906.1     23540-23647         c
            2645-2788           AAHX01015906.1     22009-22152         c
            2789-4043           AAHX01015906.1     17364-18618         c
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..4043
                     /gene="Ect2"
                     /note="epithelial cell transforming 2"
                     /db_xref="GeneID:361921"
                     /db_xref="RGD:1308524"
     CDS             137..2878
                     /gene="Ect2"
                     /note="ect2 oncogene; epithelial cell transforming
                     sequence 2 oncogene"
                     /codon_start=1
                     /product="protein ECT2"
                     /protein_id="NP_001102017.2"
                     /db_xref="GeneID:361921"
                     /db_xref="RGD:1308524"
                     /translation="MADDSVLPSPTEITSLADTSVFDSKVTETSKENLCMVSTSNVDE
                     EMPQVEARVVVVQEAGKQEELLKALKTVKIMEVPVIKIKESCPGKSDEKLIKSIINME
                     IKVPCVKMDSMEEFGSLDSPEFENIFVVTDFQTSVFNDLYKADCRIVGPPVILNCAQM
                     GEPLPFSCRPLYCTSMLNLVLCFTGFRKKEELVKLVTLVHHMGGVIRKECNSKVTHLV
                     ANCTQGEKFRVAVSLGTPIMRPGWIYEAWERRNEQCFCAADDDFRNEFKVPPFQDCIL
                     SFLGFSDEEKHSMEEMTEMQGGTYLPVGDERCTHLIVDENTVKELPFEPSKKLFVVKQ
                     EWFWGSIQMDARAGETMYLYEKANTPELKKSVSLLSLSTPNSNRKRRRLKESLAQLSR
                     ETDLSPFPPRKRPSAEHSLSIGSLLDISNTPDSSIHYGETPKSCAKSSRSSTPVPPKQ
                     SARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDI
                     FDVHMKIKDDLEDLIANWDESRSIGDIFLKYSKDLVKTYPPFVNFFEMSKEMIIKCEK
                     QKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTL
                     EKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLIQRVETVSLG
                     EHPCDRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHDRTRPPASLKHIHLMPLSQIKK
                     VLDIRETEDCHNAFALLVRPPTEQANVLLSFQMTSEELPKESWLKMLCRHVANTICKA
                     DAENLMYVTDPESFEVNTKDMDSTLSRASRAIKKTSKKVTRAFSFSKTPKRALRMALS
                     SSHSSEGRSPPSSGKLAVSRLSSTSSLAGIPSPSLVSLPSFFERRSHTLSRSTTHLI"
ORIGIN      
        1 gtagcctcct tcgagccatg gcggccccag tgaggagact cagtgtttga gaaggttaag
       61 cgaggactgc gccgcagtgg ttcatttttc ttttttttaa aatatctgaa cgtgccttca
      121 taaagtagtt caaacaatgg cggacgacag tgtgttacca tctcctactg agataactag
      181 cttggcagac acttcagttt ttgattctaa agttacagaa acatccaagg aaaacttgtg
      241 catggtgtct acttcaaatg ttgacgaaga aatgcctcag gtggaagcaa gagtggtagt
      301 ggtccaggaa gctgggaaac aagaggagct cctaaaggcc ttaaagactg ttaagataat
      361 ggaagtccct gttataaaga taaaagaaag ttgtcctggg aaatcggatg aaaagttaat
      421 aaaaagtatt attaatatgg aaattaaagt gccctgtgta aagatggatt caatggaaga
      481 atttggaagt ttggattccc cagaatttga gaatatattt gtagttactg acttccagac
      541 atctgtcttc aatgacttat acaaggctga ttgtaggatt gttggaccac cagttatact
      601 caactgtgca caaatgggag agcccttgcc gttctcctgc cggccgctgt actgcacgag
      661 catgctgaat ctggtgctct gcttcactgg attcaggaag aaggaggagc tcgtcaaatt
      721 ggtgacattg gttcatcata tgggtggagt tattcgaaaa gaatgcaatt ccaaagtaac
      781 acatctggtg gcaaattgta cgcaaggaga aaagtttagg gttgctgtga gcctggggac
      841 tccaattatg aggccaggat ggatttatga agcatgggaa agacgcaatg aacagtgttt
      901 ctgtgcagca gatgatgact ttagaaatga atttaaagtt cctccattcc aagattgcat
      961 tttaagtttt ctgggatttt cagatgaaga gaaacacagt atggaagaaa tgactgaaat
     1021 gcaaggaggt acctatttac cagttgggga tgaaaggtgc actcacctta ttgttgatga
     1081 gaacacagta aaggaacttc catttgaacc ttccaagaaa ctttttgtgg tcaagcaaga
     1141 gtggttctgg ggaagcattc agatggatgc ccgggctggt gaaactatgt atttgtatga
     1201 aaaggctaat actcctgagc tcaagaaatc cgtgtctttg ctgtctctga gtactccaaa
     1261 cagcaaccgc aaaagacgga ggttgaaaga aagcctggct cagctctcca gagagaccga
     1321 cctctctcct ttccctccgc gcaagcggcc ctcagcagag cattcccttt ctatcggctc
     1381 gctcctggat atctccaaca caccggactc cagcattcac tatggagaaa caccgaagtc
     1441 ttgtgctaag tcttccagga gttcaactcc agttcctcca aagcagtcgg ccaggtggca
     1501 ggtggcaaaa gagctctacc agactgagag caactatgtc aatatactgg ccaccatcat
     1561 tcaattattt caggtaccct tagaagaaga aggacaacgg ggtgggccta ttcttgcacc
     1621 cgaggaaatc aagactattt ttgggagcat cccagacatc tttgacgtac atatgaagat
     1681 aaaggatgat cttgaagacc ttattgctaa ctgggatgag agcagaagta ttggtgacat
     1741 ctttcttaaa tattccaaag atttggtaaa aacctatcct ccatttgtaa acttctttga
     1801 aatgagcaag gaaatgatta ttaaatgtga aaaacagaag cccagatttc atgcttttct
     1861 caagataaat caagctaaac cagagtgtgg acggcaaagc cttgtggaac ttctcattcg
     1921 gccagtacag cggttaccca gtgttgcctt acttttaaac gatcttaaaa agcatacagc
     1981 tgatgaaaat ccagacaaaa gcacgttaga aaaagctatt ggatcactaa aagaagtaat
     2041 gacacatatc aatgaggata agagaaaaac agaagcacag aagcaaattt ttgatgttgt
     2101 ttatgaagta gatggatgcc cagctaatct attatcttct catcgaagcc tgatacaaag
     2161 agtggaaaca gtttctcttg gtgagcaccc ctgtgaccga ggagaacaag tcactctctt
     2221 cctcttcaat gactgccttg agatagcaag aaaacggcac aaggttattg gcacttttag
     2281 aagtcctcat gaccgcaccc ggccaccagc ttctctgaag cacattcatc taatgcctct
     2341 ttctcagatt aagaaggtgc tggacatcag agagacagaa gattgtcata atgcctttgc
     2401 cttgcttgtg aggccaccaa cagagcaggc caacgtgctg ctcagcttcc agatgacgtc
     2461 agaggagctt ccaaaggaga gctggctgaa gatgctgtgt cgacatgttg ccaacaccat
     2521 ttgtaaagca gatgctgaga atcttatgta cgtgactgat ccagaatctt ttgaagtaaa
     2581 tacaaaagat atggatagta cacttagtcg agcatctaga gcaataaaaa agacttcaaa
     2641 aaaggttaca agggcattct ctttttccaa aactcccaag agagccctgc ggatggctct
     2701 gtcatcatcc catagctcag agggaaggag tcctccgagt agtggcaaac ttgctgtgag
     2761 ccgtctgtcc agcacatctt ccttagcagg tattccatcg ccttcccttg tcagcctccc
     2821 ttctttcttt gaacggagaa gtcatacatt aagtcgatct acaactcact tgatatgaaa
     2881 cttaaatccc aagggacctc atacttcaat aagatgctga cttacatggt actttgaatt
     2941 agcacttggt aaaagttgta gagaagataa gtaacactaa ccaacagttt tattttcttg
     3001 aaatacattt tcaagatagt ctatgtaaaa aaatactaat tttgatgtaa tttatctctt
     3061 tgtttgaatc tcacatcaga agaccagtgg ctttaagtta ttcatgataa tcagtagctt
     3121 tgtaaccctg atacagtaaa ctattgtgta tttgtacagt agcttgaatg aattttggga
     3181 agtacatatt tgtgtatctc aatttgtaca gagactaaac atcaattcga ttcctgctga
     3241 ataaaagcct ctgattgtcg tctggaggct tgttcttcag ctggattgtt tgatgtactc
     3301 aactgcgctt ttgcagttta ttttcttttt aaataaaaga tctaacacat gaattttaaa
     3361 agacacaccg ttattaacca tataattaag atcactcgaa ttctttttgc aaattgagat
     3421 aagagaaaga ttacaaaaca ttgtatatgt tgcaaagaca agatattagt gtgtacttta
     3481 taattgtttc agaaactttt ttttttattt tatttccttg ttctagacac tagcaaatct
     3541 tggtttagtt ttgactactg tattgaattt atttcaaagg ataagaccac ggggaagctg
     3601 ttaagaattg cttctgttct ctgtatagtt gttctgaggt tgtcttcact cttgctaagt
     3661 gcctgtgaaa tgcatggatg taatgtatgg tcaactcttt attgtgccca tgtcattaaa
     3721 tacaagattt ggaagtttat tgtcagaaat tttgcaagtc tgccattatc ttgtactata
     3781 acatttctta tagtcagtaa ggcagaatga ctgggttcct atggccaaat gtattttatt
     3841 tcctacatgt tcaagggaat attgcaagat tccttgttac ggacttttca gtaatctgct
     3901 ttgatagttt agctgactgg attttttttc tataccatgc atgtgctact tcacaggtta
     3961 gtaagtggcc ttgttttgct gtatttttaa aagcagttat attagcaaga actttgtaaa
     4021 taaatagctt taaaatgcaa gta
//
