LOCUS       NP_001102017             913 aa            linear   ROD 03-APR-2024
DEFINITION  protein ECT2 [Rattus norvegicus].
ACCESSION   NP_001102017 XP_001057016 XP_342221
VERSION     NP_001102017.2
DBSOURCE    REFSEQ: accession NM_001108547.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 913)
  AUTHORS   Jing,J., Chen,L., Fu,H.Y., Fan,K., Yao,Q., Ge,Y.F., Lu,J.C. and
            Yao,B.
  TITLE     Annexin V-induced rat Leydig cell proliferation involves Ect2 via
            RhoA/ROCK signaling pathway
  JOURNAL   Sci Rep 5, 9437 (2015)
   PUBMED   25807302
  REMARK    GeneRIF: We thus conclude that Ect2 is involved in annexin
            V-induced rat Leydig cell proliferation through the RhoA/ROCK
            pathway
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 913)
  AUTHORS   Tsuji,T., Higashida,C., Yoshida,Y., Islam,M.S., Dohmoto,M.,
            Koizumi,K. and Higashida,H.
  TITLE     Ect2, an ortholog of Drosophila's pebble, negatively regulates
            neurite outgrowth in neuroblastoma x glioma hybrid NG108-15 cells
  JOURNAL   Cell Mol Neurobiol 31 (5), 663-668 (2011)
   PUBMED   21350944
REFERENCE   3  (residues 1 to 913)
  AUTHORS   Srougi,M.C. and Burridge,K.
  TITLE     The nuclear guanine nucleotide exchange factors Ect2 and Net1
            regulate RhoB-mediated cell death after DNA damage
  JOURNAL   PLoS One 6 (2), e17108 (2011)
   PUBMED   21373644
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 913)
  AUTHORS   Fontana,G.A.
  TITLE     Downregulation of cough by exercise and voluntary hyperpnea
  JOURNAL   Lung 188 Suppl 1, S95-S98 (2010)
   PUBMED   20047078
REFERENCE   5  (residues 1 to 913)
  AUTHORS   Justilien,V. and Fields,A.P.
  TITLE     Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and
            cellular transformation
  JOURNAL   Oncogene 28 (41), 3597-3607 (2009)
   PUBMED   19617897
REFERENCE   6  (residues 1 to 913)
  AUTHORS   Kim,J.E., Billadeau,D.D. and Chen,J.
  TITLE     The tandem BRCT domains of Ect2 are required for both negative and
            positive regulation of Ect2 in cytokinesis
  JOURNAL   J Biol Chem 280 (7), 5733-5739 (2005)
   PUBMED   15545273
REFERENCE   7  (residues 1 to 913)
  AUTHORS   Oceguera-Yanez,F., Kimura,K., Yasuda,S., Higashida,C., Kitamura,T.,
            Hiraoka,Y., Haraguchi,T. and Narumiya,S.
  TITLE     Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in
            mitosis
  JOURNAL   J Cell Biol 168 (2), 221-232 (2005)
   PUBMED   15642749
REFERENCE   8  (residues 1 to 913)
  AUTHORS   Liu,X.F., Ishida,H., Raziuddin,R. and Miki,T.
  TITLE     Nucleotide exchange factor ECT2 interacts with the polarity protein
            complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates
            PKCzeta activity
  JOURNAL   Mol Cell Biol 24 (15), 6665-6675 (2004)
   PUBMED   15254234
REFERENCE   9  (residues 1 to 913)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (residues 1 to 913)
  AUTHORS   Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Sep 8, 2012 this sequence version replaced NP_001102017.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     Protein         1..913
                     /product="protein ECT2"
                     /note="ect2 oncogene; epithelial cell transforming
                     sequence 2 oncogene"
                     /calculated_mol_wt=102905
     Region          176..251
                     /region_name="BRCT_Ect2_rpt1"
                     /note="first BRCT domain of epithelial cell-transforming
                     sequence 2 protein (ECT2) and similar proteins; cd17733"
                     /db_xref="CDD:349365"
     Region          270..349
                     /region_name="BRCT_Ect2_rpt2"
                     /note="second BRCT domain of epithelial cell-transforming
                     sequence 2 protein (ECT2) and similar proteins; cd17732"
                     /db_xref="CDD:349364"
     Site            order(280..283,285,302..303,315..316,318..322)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:349364"
     Region          456..640
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(459,463,562,590..591,594..595,597..598,601..602,
                     605..606,609,635,639)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          631..804
                     /region_name="PH_Ect2"
                     /note="Epithelial cell transforming 2 (Ect2) pleckstrin
                     homology (PH) domain; cd01229"
                     /db_xref="CDD:269936"
     CDS             1..913
                     /gene="Ect2"
                     /coded_by="NM_001108547.3:149..2890"
                     /db_xref="GeneID:361921"
                     /db_xref="RGD:1308524"
ORIGIN      
        1 maddsvlpsp teitsladts vfdskvtets kenlcmvsts nvdeempqve arvvvvqeag
       61 kqeellkalk tvkimevpvi kikescpgks dekliksiin meikvpcvkm dsmeefgsld
      121 spefenifvv tdfqtsvfnd lykadcrivg ppvilncaqm geplpfscrp lyctsmlnlv
      181 lcftgfrkke elvklvtlvh hmggvirkec nskvthlvan ctqgekfrva vslgtpimrp
      241 gwiyeawerr neqcfcaadd dfrnefkvpp fqdcilsflg fsdeekhsme emtemqggty
      301 lpvgdercth livdentvke lpfepskklf vvkqewfwgs iqmdaraget mylyekantp
      361 elkksvslls lstpnsnrkr rrlkeslaql sretdlspfp prkrpsaehs lsigslldis
      421 ntpdssihyg etpkscakss rsstpvppkq sarwqvakel yqtesnyvni latiiqlfqv
      481 pleeegqrgg pilapeeikt ifgsipdifd vhmkikddle dlianwdesr sigdiflkys
      541 kdlvktyppf vnffemskem iikcekqkpr fhaflkinqa kpecgrqslv ellirpvqrl
      601 psvalllndl kkhtadenpd kstlekaigs lkevmthine dkrkteaqkq ifdvvyevdg
      661 cpanllsshr sliqrvetvs lgehpcdrge qvtlflfndc leiarkrhkv igtfrsphdr
      721 trppaslkhi hlmplsqikk vldiretedc hnafallvrp pteqanvlls fqmtseelpk
      781 eswlkmlcrh vantickada enlmyvtdpe sfevntkdmd stlsrasrai kktskkvtra
      841 fsfsktpkra lrmalssshs segrsppssg klavsrlsst sslagipsps lvslpsffer
      901 rshtlsrstt hli
//
