LOCUS       NM_001006986            1478 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ECSIT signaling integrator (Ecsit), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001006986 XM_217092
VERSION     NM_001006986.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Kondo,T., Watanabe,M. and Hatakeyama,S.
  TITLE     TRIM59 interacts with ECSIT and negatively regulates NF-kappaB and
            IRF-3/7-mediated signal pathways
  JOURNAL   Biochem Biophys Res Commun 422 (3), 501-507 (2012)
   PUBMED   22588174
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Vogel,R.O., Janssen,R.J., van den Brand,M.A., Dieteren,C.E.,
            Verkaart,S., Koopman,W.J., Willems,P.H., Pluk,W., van den
            Heuvel,L.P., Smeitink,J.A. and Nijtmans,L.G.
  TITLE     Cytosolic signaling protein Ecsit also localizes to mitochondria
            where it interacts with chaperone NDUFAF1 and functions in complex
            I assembly
  JOURNAL   Genes Dev 21 (5), 615-624 (2007)
   PUBMED   17344420
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Xiao,C., Shim,J.H., Kluppel,M., Zhang,S.S., Dong,C., Flavell,R.A.,
            Fu,X.Y., Wrana,J.L., Hogan,B.L. and Ghosh,S.
  TITLE     Ecsit is required for Bmp signaling and mesoderm formation during
            mouse embryogenesis
  JOURNAL   Genes Dev 17 (23), 2933-2949 (2003)
   PUBMED   14633973
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Kopp,E., Medzhitov,R., Carothers,J., Xiao,C., Douglas,I.,
            Janeway,C.A. and Ghosh,S.
  TITLE     ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1
            signal transduction pathway
  JOURNAL   Genes Dev 13 (16), 2059-2071 (1999)
   PUBMED   10465784
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083762.1.
            
            On Nov 22, 2004 this sequence version replaced XM_217092.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083762.1, FQ209658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1478
                     /gene="Ecsit"
                     /note="ECSIT signaling integrator"
                     /db_xref="GeneID:300447"
                     /db_xref="RGD:1359488"
     exon            1..52
                     /gene="Ecsit"
                     /inference="alignment:Splign:2.1.0"
     exon            53..170
                     /gene="Ecsit"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1379
                     /gene="Ecsit"
                     /note="evolutionarily conserved signaling intermediate in
                     Toll pathway, mitochondrial; ECSIT signalling integrator;
                     ECSIT homolog"
                     /codon_start=1
                     /product="evolutionarily conserved signaling intermediate
                     in Toll pathway, mitochondrial precursor"
                     /protein_id="NP_001006987.1"
                     /db_xref="GeneID:300447"
                     /db_xref="RGD:1359488"
                     /translation="MSWVQVNLLARGLSRGWGSICRTVLSGTPFAQPSLQARGLHCSA
                     VTHKDDVWLVPRPSEPQKKPIKVPAMHEDLFRPSGNGEQDKASFLNAVRSFGEHNVRK
                     RGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNAIQRIFVHYPRQQECG
                     VAVLEQMERHGVMPNTETEFLLIQVFGHKSYPMLKFLRMKLWFTRFKNINPYPVPRDL
                     PQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSESTGIEDPTQPHIVGIQSPDQQAALA
                     RHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEETVEEIPEEWNLYYPMQLDLE
                     YSRSAWDNYEFDMDEVTEGPVFAMCMTGAHDQATLVKWIQGLQETNPTLAQIPVVFRL
                     ARSTGELLATTRLEGQSPPHSPPKGPEEDDEAIQAQQRQGQS"
     exon            171..585
                     /gene="Ecsit"
                     /inference="alignment:Splign:2.1.0"
     exon            586..809
                     /gene="Ecsit"
                     /inference="alignment:Splign:2.1.0"
     exon            810..867
                     /gene="Ecsit"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1016
                     /gene="Ecsit"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1122
                     /gene="Ecsit"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1453
                     /gene="Ecsit"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagcggt cccagctagc ctgctcgggt gtgcgggtgg ccgcgtgagt aggtgtggtg
       61 gaatctacag aggcatgagc tgggtacagg tcaacttgct ggcccgaggc ctctccaggg
      121 gctggggcag catctgcagg actgtgctct cagggacccc ctttgctcag ccgtcccttc
      181 aggctcgagg cctccattgt agtgcagtca cacacaagga tgacgtgtgg ttggttcctc
      241 gaccctccga gccccaaaag aaacccatca aggttccagc aatgcacgaa gacctgttca
      301 ggccatcagg aaacggggag caggacaagg caagcttcct gaatgcagtg cgcagttttg
      361 gggagcacaa tgtgcgcaag cgcggccacg tggacttcat ctacctagca cttcgcaaga
      421 tgccagagtt tggtgtggaa cgggacttgt cagtatacaa cctgctgctg gacgttttcc
      481 ccaaggaggt cttccggccc cgcaacgcta tccagcgcat ctttgtccac tacccacggc
      541 agcaggagtg tggagtcgct gtcctggagc agatggaacg acatggagtt atgcccaaca
      601 cagagactga gttcctgctg atccaggtgt tcgggcacaa aagttacccc atgctcaagt
      661 tcctgcggat gaagctgtgg ttcacccgct tcaagaatat caacccctac ccagtgcccc
      721 gagatcttcc ccaggaccct ttggacctgg ccaaactagg cctgcgacac atggagcctg
      781 atctcagtgc taaagtcact gtctaccaga tgtctttgcc cagtgagtcg acaggcattg
      841 aagatcccac acagcctcac attgtaggaa tccagagtcc agatcagcaa gctgccctgg
      901 cccgacacaa cccatccagg cctgtttttg ttgagggccc cttccctctc tggcttcgta
      961 ataagtgcgt ctattatcac atcctaagag ctgacctgcc accccctgag gaagagacag
     1021 tagaggagat cccagaagaa tggaacctgt actacccaat gcagctggac ctggaatatt
     1081 caaggagtgc ttgggacaac tatgaatttg acatggatga agtgacagaa ggccccgtct
     1141 tcgccatgtg catgactggt gcccatgatc aggcaacgtt ggtcaagtgg atccaaggct
     1201 tgcaggagac caacccaacg ctggcacaga tcccagtggt attccgcctg gccaggtcca
     1261 caggagagct cctggcaacc acaaggctgg agggacagtc ccctccccac agccctccca
     1321 agggtcctga ggaagatgat gaggccattc aggcacagca gcggcaaggt caaagctgag
     1381 tcagagctgg catgaggaga aaagactgga ctggtatgaa atattatgga gaaaataaaa
     1441 aagtcaaaac ctcaaaaaaa aaaaaaaaaa aaaaaaaa
//
