LOCUS       NM_001271051             906 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ECRG4 augurin precursor (Ecrg4), mRNA.
ACCESSION   NM_001271051 XM_001060972 XM_343562
VERSION     NM_001271051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Porzionato,A., Rucinski,M., Macchi,V., Sarasin,G., Malendowicz,L.K.
            and De Caro,R.
  TITLE     ECRG4 expression in normal rat tissues: expression study and
            literature review
  JOURNAL   Eur J Histochem 59 (2), 2458 (2015)
   PUBMED   26150152
  REMARK    GeneRIF: ur identification of ECRG4 in many structures suggests the
            involvement of ECRG4 in the tumorigenesis of other organs
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Kurabi,A., Pak,K., Dang,X., Coimbra,R., Eliceiri,B.P., Ryan,A.F.
            and Baird,A.
  TITLE     Ecrg4 attenuates the inflammatory proliferative response of mucosal
            epithelial cells to infection
  JOURNAL   PLoS One 8 (4), e61394 (2013)
   PUBMED   23626679
  REMARK    GeneRIF: Ecrg4 plays a role in coordinating the inflammatory and
            proliferative response to infection of mucosal epithelium
            suggesting a possible mechanism for its putative anti-tumor
            activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 906)
  AUTHORS   Gonzalez,A.M., Podvin,S., Lin,S.Y., Miller,M.C., Botfield,H.,
            Leadbeater,W.E., Roberton,A., Dang,X., Knowling,S.E.,
            Cardenas-Galindo,E., Donahue,J.E., Stopa,E.G., Johanson,C.E.,
            Coimbra,R., Eliceiri,B.P. and Baird,A.
  TITLE     Ecrg4 expression and its product augurin in the choroid plexus:
            impact on fetal brain development, cerebrospinal fluid homeostasis
            and neuroprogenitor cell response to CNS injury
  JOURNAL   Fluids Barriers CNS 8 (1), 6 (2011)
   PUBMED   21349154
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 906)
  AUTHORS   Podvin,S., Gonzalez,A.M., Miller,M.C., Dang,X., Botfield,H.,
            Donahue,J.E., Kurabi,A., Boissaud-Cooke,M., Rossi,R.,
            Leadbeater,W.E., Johanson,C.E., Coimbra,R., Stopa,E.G.,
            Eliceiri,B.P. and Baird,A.
  TITLE     Esophageal cancer related gene-4 is a choroid plexus-derived injury
            response gene: evidence for a biphasic response in early and late
            brain injury
  JOURNAL   PLoS One 6 (9), e24609 (2011)
   PUBMED   21935431
  REMARK    GeneRIF: Augurin would play a constitutive inhibitory function in
            normal CNS while down regulation of Ecrg4 gene expression in
            injury, like in cancer, dysinhibits proliferation.
REFERENCE   5  (bases 1 to 906)
  AUTHORS   Kujuro,Y., Suzuki,N. and Kondo,T.
  TITLE     Esophageal cancer-related gene 4 is a secreted inducer of cell
            senescence expressed by aged CNS precursor cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (18), 8259-8264 (2010)
   PUBMED   20404145
REFERENCE   6  (bases 1 to 906)
  AUTHORS   Tadross,J.A., Patterson,M., Suzuki,K., Beale,K.E., Boughton,C.K.,
            Smith,K.L., Moore,S., Ghatei,M.A. and Bloom,S.R.
  TITLE     Augurin stimulates the hypothalamo-pituitary-adrenal axis via the
            release of corticotrophin-releasing factor in rats
  JOURNAL   Br J Pharmacol 159 (8), 1663-1671 (2010)
   PUBMED   20233222
REFERENCE   7  (bases 1 to 906)
  AUTHORS   Mirabeau,O., Perlas,E., Severini,C., Audero,E., Gascuel,O.,
            Possenti,R., Birney,E., Rosenthal,N. and Gross,C.
  TITLE     Identification of novel peptide hormones in the human proteome by
            hidden Markov model screening
  JOURNAL   Genome Res 17 (3), 320-327 (2007)
   PUBMED   17284679
REFERENCE   8  (bases 1 to 906)
  AUTHORS   Xiao,H.S., Huang,Q.H., Zhang,F.X., Bao,L., Lu,Y.J., Guo,C.,
            Yang,L., Huang,W.J., Fu,G., Xu,S.H., Cheng,X.P., Yan,Q., Zhu,Z.D.,
            Zhang,X., Chen,Z., Han,Z.G. and Zhang,X.
  TITLE     Identification of gene expression profile of dorsal root ganglion
            in the rat peripheral axotomy model of neuropathic pain
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8360-8365 (2002)
   PUBMED   12060780
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Aug 30, 2012 this sequence version replaced
            XM_343562.5, XM_001060972.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI294831.1, CB324926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               JAXUCZ010000009.1  53485040-53485405
            367-414             JAXUCZ010000009.1  53491443-53491490
            415-572             JAXUCZ010000009.1  53499873-53500030
            573-906             JAXUCZ010000009.1  53504358-53504691
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..906
                     /gene="Ecrg4"
                     /gene_synonym="RGD1305645"
                     /note="ECRG4 augurin precursor"
                     /db_xref="GeneID:363225"
                     /db_xref="RGD:1305645"
     exon            1..366
                     /gene="Ecrg4"
                     /gene_synonym="RGD1305645"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..734
                     /gene="Ecrg4"
                     /gene_synonym="RGD1305645"
                     /note="esophageal cancer related gene 4 protein; augurin;
                     esophageal cancer-related gene 4 protein homolog"
                     /codon_start=1
                     /product="augurin precursor"
                     /protein_id="NP_001257980.1"
                     /db_xref="GeneID:363225"
                     /db_xref="RGD:1305645"
                     /translation="MGTSSARPAVLALAGLALLLLLCLGPGDVSGNKLKKMLQKREGP
                     VPSKTNVAVSEHTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVN
                     YWLNRNQNGHDYYGDYYQRHYDEDAAIGPRSREGFRHGASVNYDDY"
     exon            367..414
                     /gene="Ecrg4"
                     /gene_synonym="RGD1305645"
                     /inference="alignment:Splign:2.1.0"
     exon            415..572
                     /gene="Ecrg4"
                     /gene_synonym="RGD1305645"
                     /inference="alignment:Splign:2.1.0"
     exon            573..906
                     /gene="Ecrg4"
                     /gene_synonym="RGD1305645"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagccagc attctctgtc cagcctggtt gggctgtgcc tggcatccgt cttgccctct
       61 cccctttagc cacgcggctc ctctcagtga tttgcagcag acccgcaggg cagtgtgcct
      121 cggtggcatt gaattgaagc ttggcccacg gcctggcctt ctggctagtt gcccgcccgg
      181 tgggtcccgc cccgagcaaa gacacccgag ctctctcgcg cctgcctctc tgagcctggg
      241 tccccgctcc agtcatccct ccagccactt tgcagcacac tgccgccatg ggcacctcct
      301 ctgctcggcc tgcagtcctg gccctagctg ggctcgcgct gctccttctg ctgtgtctgg
      361 gtccaggtga cgtaagtgga aacaaactca agaagatgct tcagaaacga gaaggacctg
      421 ttccatcaaa gacgaacgta gctgtttctg agcacacagc aaaggaattc ctaggtggcc
      481 tgaagcgtgc caaacgacag ctgtgggacc gtacacgacc tgaggtacag cagtggtacc
      541 agcagttcct gtacatgggc ttcgatgagg cgaaatttga agatgatgtc aactattggc
      601 taaacagaaa ccaaaatggc catgactact atggtgacta ctaccagcgt cactatgatg
      661 aagatgcggc cattggtccc cgcagccggg aaggctttag gcacggagcc agtgtcaact
      721 atgatgacta ttaaagctcc ctgaggtgcc acagagcctg tgccttgctt cagcagacct
      781 tccccactgt aacacgtgga catcaggcta aaggaaagaa tatcagtgcc ttttatattt
      841 catgcatgca cttaacaata cgtctccctt aaaaatagaa ataaaagcat ttttttaaaa
      901 agagaa
//
