LOCUS       NM_053882               1913 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus extracellular matrix protein 1 (Ecm1), mRNA.
ACCESSION   NM_053882 XM_215645
VERSION     NM_053882.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Li,Z., Zhang,Y., Liu,Z., Wu,X., Zheng,Y., Tao,Z., Mao,K., Wang,J.,
            Lin,G., Tian,L., Ji,Y., Qin,M., Sun,S., Zhu,X. and Sun,B.
  TITLE     ECM1 controls T(H)2 cell egress from lymph nodes through
            re-expression of S1P(1)
  JOURNAL   Nat Immunol 12 (2), 178-185 (2011)
   PUBMED   21217760
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Merregaert,J., Van Langen,J., Hansen,U., Ponsaerts,P., El
            Ghalbzouri,A., Steenackers,E., Van Ostade,X. and Sercu,S.
  TITLE     Phospholipid scramblase 1 is secreted by a lipid raft-dependent
            pathway and interacts with the extracellular matrix protein 1 in
            the dermal epidermal junction zone of human skin
  JOURNAL   J Biol Chem 285 (48), 37823-37837 (2010)
   PUBMED   20870722
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Kong,L., Tian,Q., Guo,F., Mucignat,M.T., Perris,R., Sercu,S.,
            Merregaert,J., Di Cesare,P.E. and Liu,C.J.
  TITLE     Interaction between cartilage oligomeric matrix protein and
            extracellular matrix protein 1 mediates endochondral bone growth
  JOURNAL   Matrix Biol 29 (4), 276-286 (2010)
   PUBMED   20138147
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   Mongiat,M., Fu,J., Oldershaw,R., Greenhalgh,R., Gown,A.M. and
            Iozzo,R.V.
  TITLE     Perlecan protein core interacts with extracellular matrix protein 1
            (ECM1), a glycoprotein involved in bone formation and angiogenesis
  JOURNAL   J Biol Chem 278 (19), 17491-17499 (2003)
   PUBMED   12604605
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Hamada,T., McLean,W.H., Ramsay,M., Ashton,G.H., Nanda,A.,
            Jenkins,T., Edelstein,I., South,A.P., Bleck,O., Wessagowit,V.,
            Mallipeddi,R., Orchard,G.E., Wan,H., Dopping-Hepenstal,P.J.,
            Mellerio,J.E., Whittock,N.V., Munro,C.S., van Steensel,M.A.,
            Steijlen,P.M., Ni,J., Zhang,L., Hashimoto,T., Eady,R.A. and
            McGrath,J.A.
  TITLE     Lipoid proteinosis maps to 1q21 and is caused by mutations in the
            extracellular matrix protein 1 gene (ECM1)
  JOURNAL   Hum Mol Genet 11 (7), 833-840 (2002)
   PUBMED   11929856
REFERENCE   8  (bases 1 to 1913)
  AUTHORS   Han,Z., Ni,J., Smits,P., Underhill,C.B., Xie,B., Chen,Y., Liu,N.,
            Tylzanowski,P., Parmelee,D., Feng,P., Ding,I., Gao,F., Gentz,R.,
            Huylebroeck,D., Merregaert,J. and Zhang,L.
  TITLE     Extracellular matrix protein 1 (ECM1) has angiogenic properties and
            is expressed by breast tumor cells
  JOURNAL   FASEB J 15 (6), 988-994 (2001)
   PUBMED   11292659
REFERENCE   9  (bases 1 to 1913)
  AUTHORS   Deckers,M.M., Smits,P., Karperien,M., Ni,J., Tylzanowski,P.,
            Feng,P., Parmelee,D., Zhang,J., Bouffard,E., Gentz,R., Lowik,C.W.
            and Merregaert,J.
  TITLE     Recombinant human extracellular matrix protein 1 inhibits alkaline
            phosphatase activity and mineralization of mouse embryonic
            metatarsals in vitro
  JOURNAL   Bone 28 (1), 14-20 (2001)
   PUBMED   11165938
REFERENCE   10 (bases 1 to 1913)
  AUTHORS   Bhalerao,J., Tylzanowski,P., Filie,J.D., Kozak,C.A. and
            Merregaert,J.
  TITLE     Molecular cloning, characterization, and genetic mapping of the
            cDNA coding for a novel secretory protein of mouse. Demonstration
            of alternative splicing in skin and cartilage
  JOURNAL   J Biol Chem 270 (27), 16385-16394 (1995)
   PUBMED   7608209
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085879.1.
            
            On Nov 22, 2004 this sequence version replaced XM_215645.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085879.1, SRR8487227.274131.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132291,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1913
                     /gene="Ecm1"
                     /note="extracellular matrix protein 1"
                     /db_xref="GeneID:116662"
                     /db_xref="RGD:620357"
     exon            1..177
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1796
                     /gene="Ecm1"
                     /note="secretory component p85"
                     /codon_start=1
                     /product="extracellular matrix protein 1 precursor"
                     /protein_id="NP_446334.1"
                     /db_xref="GeneID:116662"
                     /db_xref="RGD:620357"
                     /translation="MGTIRSSALILACLALASAASEGAFKVSDQREMKPEHLFQHLHE
                     VGYAAPPSPPQTRRLQVHHSETSPHDPPLFEEQKEVQPPSSPEDIPVYEEEWLTFLNP
                     NVGKVDPALPQEAIPLQKEQPPPRIPIEQKEIDPPVQHQEEIVQSRQKEEKPPTLTGQ
                     HPPEPRTWNPARHCQQGRRGIWGHRLDGFPPGRPSPDNLKQICLPERQHVVYGPWNLP
                     QTGYSHLSRQGEALNLLETGYSRCCRCRSDTNRLDCVKLVWEDAMTQFCEAEFSVKTR
                     PHLCCKQRGEERFSCFQKEAPRPDYLLRPCPIHQTGISSGTQLPFPPGLPTPDNVKNI
                     CLLRRFRSVPRNLPATDAIQRQLQALTRLETEFQRCCRQGHNHTCTWKAWEDTLDGYC
                     DRELAIKTHPHSCCHYPPSPARDECFAHLAPYPNYDRDLLTVDLSRVTPNLMDHLCGN
                     GRVLSKHKQIPGLIQNMTVRCCELPYPEQACCGEEEKLAFIEDLCGPRRNSWKDPALC
                     CTLSPGDKQANCFNTNYLRNVALVAGDTGNATGLGQQGPTGGTNVGPAPGSKEE"
     exon            178..240
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..345
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..426
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..507
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..561
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..881
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1256
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1477
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1565
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1889
                     /gene="Ecm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcagcca gaggagcagg cttgcagcaa gtggcccagc cccttcaggt ctagatctgc
       61 ctgtgacaac tgctgctggg tgacccgtga ccagttctta ccccaggatg gggaccatac
      121 gcagctcagc cttgatcttg gcctgcttgg ctcttgcttc tgctgcctct gagggagcct
      181 tcaaggtttc agaccagaga gagatgaagc cagagcacct cttccagcac ctccatgaag
      241 taggctatgc agcaccccct tccccaccac aaacccggag actccaagtt caccactccg
      301 aaacttctcc gcatgaccct cccctctttg aggaacaaaa agaagtgcag cccccttctt
      361 ccccagaaga catccctgtg tatgaggagg aatggctcac tttcctaaac cctaatgtag
      421 gtaaagtgga tcctgctctc cctcaagaag ccatccccct gcagaaagag cagccccctc
      481 ctcgaatccc aattgaacag aaggaaatag acccacctgt ccaacatcag gaggagattg
      541 ttcagtcccg gcagaaagag gagaagccac ccaccttgac gggccagcat cctccagagc
      601 cccgaacttg gaatccagcc cgtcactgcc agcagggacg gagaggtatc tggggccacc
      661 ggctggatgg cttccctcct ggacggcctt ctccagacaa tctgaagcag atctgccttc
      721 ctgagcgcca gcacgtggtc tatggcccct ggaacctgcc acagactggc tactctcacc
      781 ttagtcgcca gggagaggcc ctcaatttgc tggagaccgg atattcccgc tgctgtcgct
      841 gccgcagcga cacaaatcgc ctagactgtg tgaagcttgt gtgggaggac gcaatgaccc
      901 agttctgtga ggctgaattc tctgtcaaga cccgacccca cctgtgctgc aaacagcgtg
      961 gggaggagcg attctcttgc ttccagaagg aagctcctcg gcccgactac ctgctccgac
     1021 cctgccccat ccaccagact ggcatttcct caggaaccca actgcctttc cctccggggt
     1081 tgcccacacc ggacaatgtc aaaaacatct gtctcctgag acgcttccgc tccgtgccgc
     1141 gcaacctccc agctactgac gccatccaga ggcagctgca ggctctgacc cggctggaga
     1201 cggagttcca gcgctgctgc cgccagggtc acaaccacac ttgcacatgg aaggcctggg
     1261 aggataccct ggatggatac tgtgatcggg agctggctat aaagacccac ccccactcgt
     1321 gctgccacta ccctccaagt cctgcccgtg atgaatgttt tgcccacctc gctccctatc
     1381 ccaactatga ccgggatctc ttgaccgttg accttagccg agtcaccccc aacctcatgg
     1441 accatctctg tggaaacgga agagttctca gcaagcataa acagatccct ggcctgatcc
     1501 agaacatgac tgtccgctgc tgcgagctgc catacccaga acaggcctgc tgtggtgagg
     1561 aggagaaact ggctttcatt gaggatctct gtggtccccg gaggaactcc tggaaagatc
     1621 ctgccctctg ctgtaccttg tctcctggag ataaacaagc caactgcttc aataccaact
     1681 acctgaggaa tgtggcttta gtggctggag acactgggaa tgccactggc ctggggcagc
     1741 agggcccaac tgggggaaca aatgtcggcc ccgcccctgg gtccaaggaa gaatgagtca
     1801 ccctgagcct cagaggatta gatggggtac cccgccctac tccaccctcc ttgaacactc
     1861 attacaataa atgcctcttg gatttggcaa aaaaaaaaaa aaaaaaaaaa aaa
//
