LOCUS       NM_022594               1097 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus enoyl-CoA hydratase 1 (Ech1), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_022594
VERSION     NM_022594.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Mao,X., Huang,D., Rao,C., Du,M., Liang,M., Li,F., Liu,B. and
            Huang,K.
  TITLE     Enoyl coenzyme A hydratase 1 combats obesity and related metabolic
            disorders by promoting adipose tissue browning
  JOURNAL   Am J Physiol Endocrinol Metab 318 (3), E318-E329 (2020)
   PUBMED   31961704
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1097)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1097)
  AUTHORS   Modis,Y., Filppula,S.A., Novikov,D.K., Norledge,B., Hiltunen,J.K.
            and Wierenga,R.K.
  TITLE     The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution
            reveals the importance of aspartate and glutamate sidechains for
            catalysis
  JOURNAL   Structure 6 (8), 957-970 (1998)
   PUBMED   9739087
REFERENCE   7  (bases 1 to 1097)
  AUTHORS   Filppula,S.A., Yagi,A.I., Kilpelainen,S.H., Novikov,D.,
            FitzPatrick,D.R., Vihinen,M., Valle,D. and Hiltunen,J.K.
  TITLE     Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular
            characterization
  JOURNAL   J Biol Chem 273 (1), 349-355 (1998)
   PUBMED   9417087
REFERENCE   8  (bases 1 to 1097)
  AUTHORS   FitzPatrick,D.R., Germain-Lee,E. and Valle,D.
  TITLE     Isolation and characterization of rat and human cDNAs encoding a
            novel putative peroxisomal enoyl-CoA hydratase
  JOURNAL   Genomics 27 (3), 457-466 (1995)
   PUBMED   7558027
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U08976.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08976.1, BC060565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1097
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /note="enoyl-CoA hydratase 1"
                     /db_xref="GeneID:64526"
                     /db_xref="RGD:69353"
     exon            1..62
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..994
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /note="enoyl hydratase-like protein, peroxisomal;
                     delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase,
                     mitochondrial; Peroxisomal enoyl hydratase-like protein;
                     enoyl coenzyme A hydratase 1, peroxisomal; enoyl CoA
                     hydratase 1, peroxisomal"
                     /codon_start=1
                     /product="delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase,
                     mitochondrial precursor"
                     /protein_id="NP_072116.1"
                     /db_xref="GeneID:64526"
                     /db_xref="RGD:69353"
                     /translation="MATAMTVSSKLLGLLMQQLRGTRQLYFNVSLRSLSSSAQEASKR
                     IPEEVSDHNYESIQVTSAQKHVLHVQLNRPEKRNAMNRAFWRELVECFQKISKDSDCR
                     AVVVSGAGKMFTSGIDLMDMASDILQPPGDDVARIAWYLRDLISRYQKTFTVIEKCPK
                     PVITAIHGGCIGGGVDLISACDIRYCTQDAFFQVKEVDVGLAADVGTLQRLPKVIGNR
                     SLVNELTFTARKMMADEALDSGLVSRVFPDKDVMLNAAFALAADISSKSPVAVQGSKI
                     NLIYSRDHSVDESLDYMATWNMSMLQTQDIIKSVQAAMEKKDSKSITFSKL"
     exon            63..267
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     exon            268..356
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     exon            357..481
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     exon            482..530
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     exon            531..595
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     exon            596..666
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     exon            667..738
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     exon            739..889
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1097
                     /gene="Ech1"
                     /gene_synonym="Pxel"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccagag atggctaccg cgatgacagt ttccagcaaa ctcctcggcc tgctgatgca
       61 gcagctgaga ggtacccgcc agctgtactt caacgtcagc cttcgatctc tgagctcctc
      121 tgcacaagag gcgtccaaaa gaatccctga ggaagtctca gaccacaact acgagtctat
      181 tcaagtaaca tctgcccaga agcatgttct gcatgtacaa ctaaaccggc cggagaagag
      241 gaatgccatg aacagggctt tctggaggga gttggtggaa tgcttccaaa agatatctaa
      301 agactccgac tgtcgggctg ttgtggtctc tggtgcagga aagatgttca cttcaggtat
      361 tgacctcatg gacatggcat cagacatcct gcagccccca ggagacgatg tggcccgcat
      421 agcctggtac ctccgagacc tcatcagccg ataccaaaag actttcactg tcattgagaa
      481 gtgccccaag ccggtgatca ccgcaattca cggaggctgc attggtggag gcgtggatct
      541 tatttctgcc tgtgacattc gctactgcac tcaggatgct ttcttccaag tcaaggaggt
      601 ggatgtgggc ctggctgctg atgtaggaac gctgcagcga ctgcccaagg tcattgggaa
      661 ccggagcctg gtcaacgagc tgaccttcac cgcccgcaag atgatggctg acgaggccct
      721 ggacagtggg ctggtcagcc gcgtgttccc agataaggac gtcatgctga atgcagcctt
      781 tgccctggcg gccgatattt ccagcaagag tcctgtggct gtgcaggggt caaaaatcaa
      841 tttaatctac tcccgagacc attctgtgga cgagagcctt gactatatgg ccacttggaa
      901 catgagcatg ctgcagaccc aggacatcat caagtcagtc caggcagcca tggagaagaa
      961 ggactcaaaa agcatcacct tctccaagct ctgagtgcct tcctgaccct ggtcccctca
     1021 gtgcctcctc ccggtgtata actttatgac ttagttcttc agttcccggg gccttatctc
     1081 cactgtgaac aataaag
//
