LOCUS       NM_021776               2750 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus endothelin converting enzyme-like 1 (Ecel1),
            mRNA.
ACCESSION   NM_021776
VERSION     NM_021776.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2750)
  AUTHORS   Kiryu-Seo,S., Kato,R., Ogawa,T., Nakagomi,S., Nagata,K. and
            Kiyama,H.
  TITLE     Neuronal injury-inducible gene is synergistically regulated by
            ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged
            neurons
  JOURNAL   J Biol Chem 283 (11), 6988-6996 (2008)
   PUBMED   18192274
  REMARK    GeneRIF: Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the
            requisite synergistic effect in neuronal injury through DINE
            neuronal injury-inducible gene
REFERENCE   2  (bases 1 to 2750)
  AUTHORS   Nagata,K., Kiryu-Seo,S. and Kiyama,H.
  TITLE     Localization and ontogeny of damage-induced neuronal endopeptidase
            mRNA-expressing neurons in the rat nervous system
  JOURNAL   Neuroscience 141 (1), 299-310 (2006)
   PUBMED   16675137
  REMARK    GeneRIF: Damage-induced neuronal endopeptidase play an important
            role in embryonic neural development, in particular in peripheral
            ganglia derived from the neural crest, and in some neurons from the
            basal plate such as the hypothalamus and cranial motor neurons.
REFERENCE   3  (bases 1 to 2750)
  AUTHORS   Kato,R., Kiryu-Seo,S. and Kiyama,H.
  TITLE     Damage-induced neuronal endopeptidase (DINE/ECEL) expression is
            regulated by leukemia inhibitory factor and deprivation of nerve
            growth factor in rat sensory ganglia after nerve injury
  JOURNAL   J Neurosci 22 (21), 9410-9418 (2002)
   PUBMED   12417666
  REMARK    GeneRIF: DINE gene expression is regulated separately by both LIF
            and NGF deprivation, and this regulation pattern is similar to that
            of galanin gene expression after nerve injury
REFERENCE   4  (bases 1 to 2750)
  AUTHORS   Kiryu-Seo,S., Sasaki,M., Yokohama,H., Nakagomi,S., Hirayama,T.,
            Aoki,S., Wada,K. and Kiyama,H.
  TITLE     Damage-induced neuronal endopeptidase (DINE) is a unique
            metallopeptidase expressed in response to neuronal damage and
            activates superoxide scavengers
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4345-4350 (2000)
   PUBMED   10759559
REFERENCE   5  (bases 1 to 2750)
  AUTHORS   Schweizer,A., Valdenaire,O., Koster,A., Lang,Y., Schmitt,G.,
            Lenz,B., Bluethmann,H. and Rohrer,J.
  TITLE     Neonatal lethality in mice deficient in XCE, a novel member of the
            endothelin-converting enzyme and neutral endopeptidase family
  JOURNAL   J Biol Chem 274 (29), 20450-20456 (1999)
   PUBMED   10400672
REFERENCE   6  (bases 1 to 2750)
  AUTHORS   Valdenaire,O., Richards,J.G., Faull,R.L. and Schweizer,A.
  TITLE     XCE, a new member of the endothelin-converting enzyme and neutral
            endopeptidase family, is preferentially expressed in the CNS
  JOURNAL   Brain Res Mol Brain Res 64 (2), 211-221 (1999)
   PUBMED   9931490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 18, 2021 this sequence version replaced NM_021776.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023896.1, SRR26643298.49991.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-885               JAXUCZ010000009.1  95273688-95274572   c
            886-954             JAXUCZ010000009.1  95273042-95273110   c
            955-1065            JAXUCZ010000009.1  95272822-95272932   c
            1066-1158           JAXUCZ010000009.1  95272641-95272733   c
            1159-1283           JAXUCZ010000009.1  95272354-95272478   c
            1284-1506           JAXUCZ010000009.1  95271492-95271714   c
            1507-1605           JAXUCZ010000009.1  95270956-95271054   c
            1606-1680           JAXUCZ010000009.1  95270633-95270707   c
            1681-1784           JAXUCZ010000009.1  95270398-95270501   c
            1785-1843           JAXUCZ010000009.1  95270104-95270162   c
            1844-1895           JAXUCZ010000009.1  95269974-95270025   c
            1896-1963           JAXUCZ010000009.1  95269509-95269576   c
            1964-2088           JAXUCZ010000009.1  95269224-95269348   c
            2089-2154           JAXUCZ010000009.1  95268884-95268949   c
            2155-2250           JAXUCZ010000009.1  95268405-95268500   c
            2251-2327           JAXUCZ010000009.1  95267979-95268055   c
            2328-2750           JAXUCZ010000009.1  95267417-95267839   c
FEATURES             Location/Qualifiers
     source          1..2750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2750
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /note="endothelin converting enzyme-like 1"
                     /db_xref="GeneID:60417"
                     /db_xref="RGD:61806"
     exon            1..885
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2427
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /EC_number="3.4.24.11"
                     /note="xce protein; damage-induced neuronal endopeptidase;
                     metallopeptidase"
                     /codon_start=1
                     /product="endothelin-converting enzyme-like 1"
                     /protein_id="NP_068544.2"
                     /db_xref="GeneID:60417"
                     /db_xref="RGD:61806"
                     /translation="MEAPYSMTAHYDEFQEVKYVSRCGTGGARGTSLPPGFPRSSGRS
                     ASGARSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGTGGACPEGCPE
                     RKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEE
                     RLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAA
                     DRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLY
                     LAQDEESEKVLAAYKVFMERLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRD
                     VSSVYNKVTLGQLQKITPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRST
                     PRRILHNYLVWRVVVVLSEHLSPPFREALHELAKEMEGNDKPQELARVCLGQANRHFG
                     MALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMV
                     MVGYPDFLLKPEAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLP
                     PQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQ
                     YDRSGNLLHWWTEASYSRFLHKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKL
                     AYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPE
                     HYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW"
     exon            886..954
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1065
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1158
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1283
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1506
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1605
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1680
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1784
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1843
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1895
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1963
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2088
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2154
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2250
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2327
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2750
                     /gene="Ecel1"
                     /gene_synonym="Dine"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgaccga gggccatgtg ggcgccgacc agaaagcccg cagacagaag caacccataa
       61 ctgaccaaac aaggggtctg cagccaaagc ctcggcacaa tggaggcccc gtattccatg
      121 acagcgcact atgatgagtt ccaggaagtc aagtacgtga gccggtgtgg caccgggggc
      181 gcccgaggga cctccctacc tccaggcttc ccgaggagct cagggcgcag tgctagcggg
      241 gcccggtcgg ggctaccgcg ctggaaccga cgggaggtgt gcctgttgtc cgggctggtg
      301 ttcgccgccg gcctctgtgc catcttggca gccatgctgg cgctcaaata cctgggccct
      361 ggcgcggcgg gcactggcgg agcctgtccc gagggctgcc ccgagcgcaa ggccttcgcg
      421 cgcgccgccc gcttcctgtc tgccaacctg gacgccagca tcgacccgtg ccaggacttc
      481 tactcgttcg cgtgcggggg ctggctgcgg cgccacgcca tccccgacga caagctcacc
      541 tatggcacga tcgcggccat cggagagcag aacgaggagc gcctgcggcg cctgctggcg
      601 agacccacgg gaggcccggg cggcgctgcg cagcgcaagg tgcgcgcctt cttccgctcg
      661 tgcctcgaca tgcgcgagat cgagaggctc gggccgcggc ccatgctgga ggtcatcgag
      721 gactgcggcg gctgggacct aggcggcgcg gccgatcgcc cgggggcggc tcgctgggac
      781 ctcaaccgac tgttgtacaa ggcacagggt gtgtacagcg cggccgcgct cttctcgctt
      841 acagtcagcc tggacgacag gaactcctcg cgctacgtca tccgtattga ccaggacggg
      901 ctcaccctgc cagagagaac cctgtaccta gctcaagatg aggagagtga gaaggtcctg
      961 gccgcataca aggtgttcat ggagcgccta ctcagactac tgggtgcaga cgctgtggaa
     1021 cagaaggctc aggaaatcct tcaactggag cagaggctag ctaatatctc tgtgtcagaa
     1081 tatgatgatc tccgtcgaga tgtcagctcc gtgtacaaca aagtgactct ggggcagctg
     1141 cagaagatca ccccccattt gcagtggaaa tggctgctgg accagatctt ccaggaggac
     1201 ttctctgaag aggaggaggt ggtgctgctg gccacagact acatgcagca ggtgtcccag
     1261 ctcatccgat ccacaccccg aaggatcctt cacaactacc tagtgtggcg tgtggtggtg
     1321 gttctgagtg agcacctgtc cccaccattc cgagaggcac tgcatgagct ggccaaagag
     1381 atggagggca atgacaaacc ccaggagttg gcccgagtct gcctgggcca ggccaaccgc
     1441 cacttcggca tggctcttgg tgccctcttt gtacacgaac acttctcagc tgccagtaaa
     1501 gccaaggtac agcagctggt ggaagatatc aagtacatct taggccagcg cctggaggag
     1561 ctggactgga tggacgccca gaccaaggca gctgctcggg ctaagctcca gtacatgatg
     1621 gtcatggttg gctatccaga cttcctgctg aaacctgagg ctgtagacaa agagtatgag
     1681 tttgaggtcc acgagaagac ctacttcaag aacattttga acagcatccg attcagcatc
     1741 cagttgtctg tcaagaagat ccgacaggag gtggacaaat ccacgtggct gctccctccg
     1801 caggcgctca atgcctacta tctgcccaac aagaaccaaa tggtattccc agctggcatc
     1861 ctgcagccca ccctgtatga cccagacttc ccgcagtctt tgaactacgg gggcatcggt
     1921 accatcattg ggcatgaact gacccacggc tatgatgact ggggaggaca gtatgaccgc
     1981 tcaggaaacc tgctgcactg gtggactgag gcctcctaca gccgctttct gcacaaggcc
     2041 gagtgcattg ttcgcctcta tgacaacttc accgtctaca accagcgggt gaatgggaaa
     2101 cacacacttg gcgagaacat cgcagacatg ggaggcctca agctggccta ctatgcctat
     2161 cagaagtggg tccgggagca tggcccagaa cacccgctgc accggctcaa gtacacccac
     2221 aaccagcttt tcttcattgc ctttgcccag aactggtgca tcaagcgacg gtcacagtcc
     2281 atctacctgc aggtgctgac agacaaacac gcacctgagc actaccgggt cctgggtagc
     2341 gtgtcccagt ttgaggaatt cggccgggcc ttccactgtc ccaaggactc tcccatgaac
     2401 cctgtccata aatgctctgt gtggtgagcc tgtctacctg cacgtcccca ctgccctgca
     2461 cggatcacct ctgccagctg ctggggcaac gtcagtcccc tatgtccctg ctccaggtct
     2521 atcttccttc ccaactttta tgtgattttc ttcccacccc ctgcagtcct tcacttcagc
     2581 aagggcctgg agtaggggtg aggctgggtt ctgggtgcac tcgaagggga aatctgaggt
     2641 ccccacacct ggctctaggc agctggaccc ctctggggct gggctgtaca ggccccactg
     2701 ctgtgtgtgc tcttgctgag aagtctggtc aataaagctg ctgtactata
//
