LOCUS       NM_001002815            3010 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus endothelin-converting enzyme 2 (Ece2), mRNA.
ACCESSION   NM_001002815 XM_579085
VERSION     NM_001002815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3010)
  AUTHORS   Gupta,A., Gomes,I., Wardman,J. and Devi,L.A.
  TITLE     Opioid receptor function is regulated by post-endocytic peptide
            processing
  JOURNAL   J Biol Chem 289 (28), 19613-19626 (2014)
   PUBMED   24847082
  REMARK    GeneRIF: a role for differential modulation of opioid receptor
            signaling by post-endocytic processing of peptide agonists by ECE2.
REFERENCE   2  (bases 1 to 3010)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   3  (bases 1 to 3010)
  AUTHORS   Lorenzo,M.N., Khan,R.Y., Wang,Y., Tai,S.C., Chan,G.C., Cheung,A.H.
            and Marsden,P.A.
  TITLE     Human endothelin converting enzyme-2 (ECE2): characterization of
            mRNA species and chromosomal localization
  JOURNAL   Biochim Biophys Acta 1522 (1), 46-52 (2001)
   PUBMED   11718899
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BN000328.1, CB606217.1 and JAXUCZ010000011.1.
            
            On Jul 27, 2007 this sequence version replaced NM_001002815.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.67515.1,
                                           SRR26643429.41830.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               BN000328.1         1-251
            252-493             CB606217.1         171-412
            494-2298            BN000328.1         488-2292
            2299-3010           JAXUCZ010000011.1  93767559-93768270   c
FEATURES             Location/Qualifiers
     source          1..3010
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3010
                     /gene="Ece2"
                     /note="endothelin-converting enzyme 2"
                     /db_xref="GeneID:408243"
                     /db_xref="RGD:1303039"
     CDS             1..2298
                     /gene="Ece2"
                     /EC_number="3.4.24.71"
                     /codon_start=1
                     /product="endothelin-converting enzyme 2"
                     /protein_id="NP_001002815.2"
                     /db_xref="GeneID:408243"
                     /db_xref="RGD:1303039"
                     /translation="MNVALQELGSGGSMVEYKRAKLQDEELPEVTVEGRAIQDSLEVG
                     SQKRTRQLFGSHTQLELVLAGLILVLAALLLGCLVALWVQYHRDPVHSTCITEACIRV
                     AGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQAILKHLLE
                     NSTFNSSSEAERKTRSFYLSCLHLERIEKLGAKPLQDLIDKIGGWNITGPWDEDNFME
                     VLKAVAGTYRAAPFFTVYVGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLAA
                     YLDYMVELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQDQRRDEEKIYHKMSISEL
                     QTLAPSMDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWN
                     LVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKAT
                     FDRQSKEIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIGFPDFILEP
                     RELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLP
                     TKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPW
                     WQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLR
                     KHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSN
                     SRDFLRHFGCPVGSPMNPGQLCEVW"
     exon            1..39
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            40..126
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            127..262
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            263..478
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..603
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..750
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..816
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1005
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1148
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1263
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1374
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1473
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1551
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1655
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1766
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1834
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2025
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2121
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..3010
                     /gene="Ece2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaacgtcg cgctgcagga gctgggtagc ggaggcagta tggtggagta caaacgagct
       61 aagcttcagg atgaagaatt accagaggtg acagtagaag gcagggccat ccaggactca
      121 ctggaggtgg gatcccagaa gaggacaaga caactctttg gctcacacac acagttggag
      181 ctggtcttgg caggcctcat tctagtgttg gctgcccttc ttttgggctg cctcgtggct
      241 ctgtgggtcc agtaccacag agacccagtc cacagcacct gcatcacaga agcctgcatt
      301 cgagtggctg gaaaaatcct ggagtcttta gaccgtgggg tgagcccctg tcaggacttt
      361 taccagttct cctgtggagg ctggattcga agaaaccctc tacccagtgg acgttctcgc
      421 tggaacacct tcaacagcct ttgggaccag aatcaggcca tactgaagca cctacttgag
      481 aatagcactt tcaattccag cagtgaagcc gagcggaaga ctcggagttt ctacctgtcc
      541 tgcctgcacc tggagcgcat cgagaagcta ggagccaagc cacttcaaga cctcattgac
      601 aagatcggtg gttggaacat cacggggccc tgggatgagg acaacttcat ggaagtgcta
      661 aaggcagtag cagggaccta tagagccgcc ccattcttca ctgtctatgt cggtgctgat
      721 tcgaagagtt ctaacagcaa catcatccag gtggaccagt ctgggctttt tctaccctct
      781 cgtgattact acctaaatag aactgccaat gagaaagttc tcgctgccta cctggactac
      841 atggtggagc tgggaatgct gctgggtgga cagccgacct ccacccgggc gcagatgcag
      901 caggtgctgg aactggagat acaactggct accatcactg tgccccagga ccagcggcgt
      961 gatgaggaga agatctatca caagatgagc atctcagagc tgcagactct agcaccctcc
     1021 atggactggc tggagttcct ttctttcttg ttgtcgccac ttgagttggg cgattctgag
     1081 cctgtggtgg tgtatgggac tgagtattta cagcaggtgt cggagctcat taaccgtacg
     1141 gaaccaagca tcctgaacaa ttacctaatt tggaacctgg tgcagaagac aacctcgagc
     1201 ctcgaccagc gctttgagac tgcacaggag aagctactgg agaccctcta cggtaccaag
     1261 aagtcctgca ccccgaggtg gcagacctgc atctccaata cagatgatgc ccttggcttc
     1321 gctctgggct cgctctttgt gaaggccaca tttgaccgac aaagcaagga aattgccgag
     1381 gggatgatca gtgaaatccg tgctgctttt gaggagactc tggaaaactt ggtttggatg
     1441 gacgagaaga cccggctggc agccaaggag aaagcagatg ccatctatga tatgattggt
     1501 ttccctgatt tcatcttgga gcccagagaa ctggatgatg tttatgatgg gtatgaagtc
     1561 tctgaagatt cttttttcca aaacatgctg aacctataca acttctcagc taaggtgatg
     1621 gctgaccagc tccgcaaacc tcccagccga gaccagtgga gcatgacgcc tcagactgtg
     1681 aacgcttact accttccaac caagaatgaa atcgtcttcc ctgctggcat cttgcaggcc
     1741 cccttctatg ctcacaacca cccaaaggct ttgaacttcg gtggcatcgg tgtggtgatg
     1801 ggccacgagt tgacacatgc ctttgatgac caagggcgag agtatgacca agaagggaat
     1861 ctgcggcctt ggtggcagaa tgagtcactc acggctttcc agaatcatac agcctgcatg
     1921 gaagaacagt acaaccagta ccaggtcaat ggagagaggc tcaacggact ccagaccctg
     1981 ggggaaaaca tcgccgataa tgggggcctc aaggctgctt acaatgcata caaagcatgg
     2041 ctgaggaagc atggggagga gcagccgctg cctgctgtgg ggctcaccaa tcaccagctg
     2101 ttcttcgtgg gatttgctca ggtgtggtgc tcggtccgca caccagagag ctctcacgag
     2161 gggctggtga ccgaccccca cagccctgcc cgtttccgag tgctgggcac tctctccaac
     2221 tcccgagact tccttcggca cttcggctgc cctgtcggct cccccatgaa cccagggcag
     2281 ctatgtgagg tgtggtagac ttgggtgggg gaagaaacgg gcaactgtgg ccagggactg
     2341 gggcttccaa gctaggagag agtgaatatc agcttacggt atggtcgtct ctccatagca
     2401 caagtgagat gactctagac ccccccccca ccaccacatt gtgcctctgc tttaggggtg
     2461 cctgtgcctc tagcagagat cccgccattt actgtgacat cctttcacgt gtcaccctgg
     2521 agggagtcta ggcagaagtg tcagttccca cagagatgac tgtctctttt ggagtccaag
     2581 cttacttagt ttcaggggtt gggcgggggg tgggggggga ggtcaagagg atatgcctgg
     2641 ggtgtgccta tctctcccca gggcatgctc agtgctccga gttgagctca gctcccttca
     2701 gcccaccctc aggctgcccc cacccatgtt ccttatgctc ctcctagtac tgctgctccc
     2761 ctccaggaca gaccaactga agtcaagtgg aaggccaagg gctcttttga gtgagaggag
     2821 aaatatgtat gctcagtggg tgctgcttcc ctgggtttca aggtgtgagt ctcaggggtg
     2881 actgactgtc cccggggcca agcagatcta gtagaaaaag agaaagttta tttttgcagg
     2941 gaagagagtg gggagggtgt ggtcttgcct ttataggacc cgttgctaat aaatagattc
     3001 atatcagcca
//
