LOCUS       NM_053596               2808 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus endothelin converting enzyme 1 (Ece1), mRNA.
ACCESSION   NM_053596
VERSION     NM_053596.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2808)
  AUTHORS   Bao,N., Fang,B., Lv,H., Jiang,Y., Chen,F., Wang,Z. and Ma,H.
  TITLE     Upregulation of miR-199a-5p Protects Spinal Cord Against
            Ischemia/Reperfusion-Induced Injury via Downregulation of ECE1 in
            Rat
  JOURNAL   Cell Mol Neurobiol 38 (6), 1293-1303 (2018)
   PUBMED   29948551
  REMARK    GeneRIF: that miR-199a-5p might protect the spinal cord against
            I/R-induced injury by negatively regulating the ECE1 which could
            aid in developing new therapeutic strategies for I/R-induced spinal
            cord injury
REFERENCE   2  (bases 1 to 2808)
  AUTHORS   Sotnikova,R., Okruhlicova,L., Vlkovicova,J., Navarova,J.,
            Gajdacova,B., Pivackova,L., Fialova,S. and Krenek,P.
  TITLE     Rosmarinic acid administration attenuates diabetes-induced vascular
            dysfunction of the rat aorta
  JOURNAL   J Pharm Pharmacol 65 (5), 713-723 (2013)
   PUBMED   23600389
REFERENCE   3  (bases 1 to 2808)
  AUTHORS   McNeish,A.J., Roux,B.T., Aylett,S.B., Van Den Brink,A.M. and
            Cottrell,G.S.
  TITLE     Endosomal proteolysis regulates calcitonin gene-related peptide
            responses in mesenteric arteries
  JOURNAL   Br J Pharmacol 167 (8), 1679-1690 (2012)
   PUBMED   22881710
  REMARK    GeneRIF: ECE1 regulated the resensitization of responses to
            calcitonin gene-related peptide in rat mesenteric artery smooth
            muscle cells and mesenteric arteries, hence, ECE1 inhibitors may
            attenuate an important vasodilatory pathway implicated in headaches
REFERENCE   4  (bases 1 to 2808)
  AUTHORS   Pelayo,J.C., Poole,D.P., Steinhoff,M., Cottrell,G.S. and
            Bunnett,N.W.
  TITLE     Endothelin-converting enzyme-1 regulates trafficking and signalling
            of the neurokinin 1 receptor in endosomes of myenteric neurones
  JOURNAL   J Physiol 589 (Pt 21), 5213-5230 (2011)
   PUBMED   21878523
REFERENCE   5  (bases 1 to 2808)
  AUTHORS   Wengenmayer,C., Krikov,M., Mueller,S., Lucht,K., Villringer,A.,
            Hocher,B., Unger,T. and Thoene-Reineke,C.
  TITLE     Novel therapy approach in primary stroke prevention: simultaneous
            inhibition of endothelin converting enzyme and neutral
            endopeptidase in spontaneously hypertensive, stroke-prone rats
            improves survival
  JOURNAL   Neurol Res 33 (2), 201-207 (2011)
   PUBMED   21801596
  REMARK    GeneRIF: The protective effect of blocking endothelin converting
            enzyme and inhibiting neutral endopeptidase offers primary stroke
            prevention outcome as well as improvement of mortality.
REFERENCE   6  (bases 1 to 2808)
  AUTHORS   Deng,A.Y. and Rapp,J.P.
  TITLE     Linkage mapping of the endothelin-converting enzyme gene (Ednce) to
            rat chromosome 5
  JOURNAL   Mamm Genome 6 (10), 759-760 (1995)
   PUBMED   8563183
REFERENCE   7  (bases 1 to 2808)
  AUTHORS   Shimada,K., Takahashi,M., Ikeda,M. and Tanzawa,K.
  TITLE     Identification and characterization of two isoforms of an
            endothelin-converting enzyme-1
  JOURNAL   FEBS Lett 371 (2), 140-144 (1995)
   PUBMED   7672114
REFERENCE   8  (bases 1 to 2808)
  AUTHORS   Shimada,K., Matsushita,Y., Wakabayashi,K., Takahashi,M.,
            Matsubara,A., Iijima,Y. and Tanzawa,K.
  TITLE     Cloning and functional expression of human endothelin-converting
            enzyme cDNA
  JOURNAL   Biochem Biophys Res Commun 207 (2), 807-812 (1995)
   PUBMED   7864876
REFERENCE   9  (bases 1 to 2808)
  AUTHORS   Schmidt,M., Kroger,B., Jacob,E., Seulberger,H., Subkowski,T.,
            Otter,R., Meyer,T., Schmalzing,G. and Hillen,H.
  TITLE     Molecular characterization of human and bovine endothelin
            converting enzyme (ECE-1)
  JOURNAL   FEBS Lett 356 (2-3), 238-243 (1994)
   PUBMED   7805846
REFERENCE   10 (bases 1 to 2808)
  AUTHORS   Shimada,K., Takahashi,M. and Tanzawa,K.
  TITLE     Cloning and functional expression of endothelin-converting enzyme
            from rat endothelial cells
  JOURNAL   J Biol Chem 269 (28), 18275-18278 (1994)
   PUBMED   8034569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072504.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053596.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072504.1, D29683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2808
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2808
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /note="endothelin converting enzyme 1"
                     /db_xref="GeneID:94204"
                     /db_xref="RGD:620293"
     exon            1..64
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2326
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /EC_number="3.4.24.71"
                     /note="ECE-1"
                     /codon_start=1
                     /product="endothelin-converting enzyme 1"
                     /protein_id="NP_446048.2"
                     /db_xref="GeneID:94204"
                     /db_xref="RGD:620293"
                     /translation="MMSSYKRATLDEEDLVDSLSEGDVYPNGLQVNFRSPRSGQRCWA
                     ARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPT
                     VDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEK
                     KAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTS
                     PFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLL
                     GGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLP
                     FLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQ
                     RFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASE
                     IILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYT
                     AVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGI
                     LQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQ
                     QTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTL
                     GLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCP
                     LGSPMNPRHKCEVW"
     exon            65..151
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            152..293
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            294..506
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            507..628
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            629..775
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            776..841
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1033
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1176
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1291
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1402
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1501
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1579
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1683
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1794
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1862
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2053
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2149
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2784
                     /gene="Ece1"
                     /gene_synonym="Ece"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagccgg agccttagcg ggaggtgcat ccaaagcccg gccgttcgga gcccgcgagc
       61 gatgatgtca tcctacaagc gggccacgct ggacgaagag gatctggtgg actcactctc
      121 cgagggcgat gtgtacccca atggcctaca ggtgaacttc cgcagccccc ggagcggaca
      181 gaggtgctgg gcagctcgga cctcggtgga gaagcggctg gtggttctgg tgacgcttct
      241 ggcagcaggg ctggtggcct gcctggcagc cctaggcatc cagtaccgga caagaacgcc
      301 tccggtatgt ctgactgagg cctgtgtctc agtgaccagc tccatcctaa actccatgga
      361 ccccacggta gacccctgcc aggacttctt cagctacgcc tgtggtggct ggatcaaggc
      421 caaccccgtt cccgacggtc actcacgctg ggggaccttc agcaacctct gggagcacaa
      481 ccaagccatc attaagcatc tgctggaaaa ttccacggcc agcgcgagcg aggcagagaa
      541 aaaggcgcaa gtgtactacc gtgcgtgtat gaacgaaact aggatcgagg agcttcgggc
      601 caagcccctg atggagctga ttgagaagct cggaggttgg aatatcacag gaccctgggc
      661 caaggacaac ttccaggaca cgctgcaggt ggtcacagcg cactaccgca cctcaccctt
      721 cttctctgtc tatgtcagtg ccgactccaa gaactccaac agcaatgtga tccaggtgga
      781 ccagtccggc cttggcttgc cctccagaga ctattacctg aacaagacgg aaaatgaaaa
      841 ggtactgact ggctatctga actacatggt ccagctgggg aaactgctgg gtggtgggga
      901 cgaggactcc atccggcccc agatgcagca gatcctggat tttgagaccg ctctggccaa
      961 catcaccatc ccccaggaga agcgccggga tgaagagctc atctaccaca aagtcacggc
     1021 tgctgagctg cagaccttgg cacccgccat caactggtta ccctttctga atgccatttt
     1081 ttacccagtg gagatcaatg agtctgagcc catcgtggtc tacgacaagg aatacctcag
     1141 acaagtctcc acactcatca acagcaccga caaatgcctg ctcaacaact acatgatgtg
     1201 gaacctggta cggaaaacaa gctcctttct cgaccagcgc tttcaggatg ccgatgagaa
     1261 gttcatggag gttatgtacg ggacaaagaa gacctgtctt ccccgctgga agttttgcgt
     1321 gagtgacaca gaaaacaacc tgggctttgc cctgggcccc atgtttgtga aagcaacctt
     1381 tgcggaggac agcaagaaca tagccagcga gatcatcctg gagatcaaga aggcattcga
     1441 ggagagcctg agcaccctga aatggatgga tgaagatact cggaggtcag ccaaggagaa
     1501 ggcggacgcc atctacaaca tgataggcta ccccaacttc atcatggacc ccaaggagct
     1561 ggacaaagtg ttcaatgact acacagcagt tcccgatctc tactttgaga acgccatgcg
     1621 atttttcaac ttctcatgga gggtcacagc cgaccagctc aggaaagccc ccaacagaga
     1681 tcagtggagt atgaccccgc ccatggtgaa cgcctactac tcgcccacca agaacgagat
     1741 tgtgtttcca gctggaatcc tgcaggcgcc attttatacc cgctcttcgc ccaacgcctt
     1801 gaactttggt ggtatcgggg tcgttgtggg ccacgagctg actcatgctt tcgacgatca
     1861 aggccgggag tatgacaagg atgggaacct ccggccctgg tggaagaact cgtcggtgga
     1921 ggcattcaag cagcagaccg agtgcatggt acagcagtat aacaactaca gtgtgaacgg
     1981 agagcccgtg aatgggcggc acaccctcgg ggagaacatc gcggacaacg ggggactcaa
     2041 ggcagcctac cgggcgtacc agaactgggt aaagaagaac ggagctgagc agatactgcc
     2101 caccctgggt ctcaccagca accagctctt cttcctggga ttcgcacagg tctggtgctc
     2161 ggtccgcaca ccagagagct cccacgaagg cctcatcacc gatccgcaca gcccctcccg
     2221 cttccgggtc atcggctcac tctccaactc caaggagttc tcagaacact tccgctgccc
     2281 gctcggctcc cccatgaacc ctcgccacaa atgcgaagtc tggtaagggc tgaagcgcag
     2341 agaacacagg tggaagaagg gaaggggcct gcagccagct cccgggaaca gggccgcgct
     2401 gtcaccctcc ttccagcccc tcggccgagg gccccttccc caccctggag ggtatgcagc
     2461 catcttgtct aagcctatgc cagaggctca gcactggaag ccaacatttg acccccttcg
     2521 aagctccagc atcccagaca cccttgagtg atgctatacc gggcctttgg gtgtgtcaag
     2581 ctggtggctt gccagccctg ggcctcacac tgacaatggc agtgggacag gaccctttgc
     2641 cacgtccaat gccagatata ccacaatacc actgtgtcaa atgctttaaa gatatatttt
     2701 ttggggagac tattttttaa gcattatgga atacactgga aatcttcagg gaaaatgcat
     2761 ttaaaacact tttttttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
